Differentiation, expansion, and homeostasis of autoreactive T cells in type 1 diabetes mellitus

Current Diabetes Reports

Volumn 9, Issue 2, 2009, Pages 113-118

  Monti, Paolo ^a   Heninger, Anne Kristin ^b   Bonifacio, Ezio ^b  

^a CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; GAMMA INTERFERON; GLUTAMATE DECARBOXYLASE 65; INSULIN; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR;

AUTOIMMUNE DISEASE; CELL EXPANSION; CYTOKINE PRODUCTION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HOMEOSTASIS; HUMAN; IMMUNOMODULATION; IMMUNOPATHOGENESIS; IMMUNOSTIMULATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; NONHUMAN; PHENOTYPE; REGULATORY T LYMPHOCYTE; REVIEW; T LYMPHOCYTE;

ANIMALS; AUTOANTIGENS; CELL DIFFERENTIATION; CELL PROLIFERATION; DIABETES MELLITUS, TYPE 1; HOMEOSTASIS; HUMANS; T-LYMPHOCYTES;

EID: 63349109137     PISSN: 15344827     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11892-009-0020-y     Document Type: Review

References (42)

1. Roep BO: The role of T-cells in the pathogenesis of type 1 diabetes: from cause to cure. Diabetologia 2003, 46:305-321.
2. Di Lorenzo TP, Peakman M, Roep BO: Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol 2007, 148:1-16.
3. Oling V, Marttila J, Ilonen J, et al.: GAD65- and proinsulinspecific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects. J Autoimmun 2005, 25:235-243.
4. Reijonen H, Mallone R, Heninger AK, et al.: GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes. Diabetes 2004, 53:1987-1994.
5. Seyfert-Margolis V, Gisler TD, Asare AL, et al.: Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: results of a blinded controlled study. Diabetes 2006, 55:2588-2594.
6. Danke NA, Koelle DM, Yee C, et al.: Autoreactive T cells in healthy individuals. J Immunol 2004, 172:5967-5972.
7. Viglietta V, Kent SC, Orban T, Hafler DA: GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J Clin Invest 2002, 109:895-903.
8. Endl J, Rosinger S, Schwarz B, et al.: Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetes. Diabetes 2006, 55:50-60.
9. Monti P, Scirpoli M, Rigamonti A, et al.: Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes. J Immunol 2007, 179:5785-5792.
10. Bingley PJ, Bonifacio E, Mueller PW: Diabetes Antibody Standardization Program: First assay proficiency evaluation. Diabetes 2003, 52:1128-1136.
11. Torn C, Mueller PW, Schlosser M, et al.: Diabetes Antibody Standardization Program: Evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2. Diabetologia 2008, 51:846-852.
12. Martinuzzi E, Novelli G, Scotto M, et al.: The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment. Diabetes 2008, 57:1312-1320.
13. Schloot NC, Meierhoff G, Karlsson Faresjö M,: Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop. J Autoimmun 2003, 21:365-376.
14. Mannering SI, Morris JS, Stone NL, et al.: CD4+ T cell proliferation in response to GAD and proinsulin in healthy, pre-diabetic, and diabetic donors. Ann N Y Acad Sci 2004, 1037:16-21.
15. Nepom GT, Buckner TH, Novak EJ, et al.: HLA class II tetramers: tools for direct analysis of antigen-specific CD4+ T cells. Arthritis Rheum 2002, 46:5-12.
16. Yang J, Brook MO, Carvalho-Gaspar M, et al.: Allograft rejection mediated by memory T cells is resistant to regulation. Proc Natl Acad Sci U S A 2007, 104:19954-19959.
17. Valujskikh A, Li XC: Frontiers in nephrology: T cell memory as a barrier to transplant tolerance. J Am Soc Nephrol 2007, 18:2252-2261.
18. Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial.iThe Diabetes Control and Complications Trial Research Group [no authors listed]. Ann Intern Med 1998, 128: 517-523.
19. Bonifacio E, Scirpoli M, Kredel K, et al.: Early autoantibody responses in prediabetes are IgG1 dominated and suggest antigen-specific regulation. J Immunol 1999, 163:525-532.
20. von Herrath M, Sanda S, Herold K: Type 1 diabetes as a relapsing-remitting disease? Nat Rev Immunol 2007, 7:988-994.
21. Schluns KS, Kieper WC, Jameson SC, Lefrancois L: Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat Immunol 2000, 1:426-432.
22. Soares MV, Borthwick NJ, Maini MK, et al.: IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire. J Immunol 1998, 161:5909-5917.
23. Monti P, Scirpoli M, Maffi P, et al.: Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J Clin Invest 2008, 118:1806-1814.
24. Sportes C, Hakim FT, Memon SA, et al.: Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J Exp Med 2008, 205:1701-1714.
25. Goldrath AW, Bevan MJ: Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. Immunity 1999, 11:183-190.
26. King C, Ilic A, Koelsch K, Sarvetnick N: Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 2004, 117:265-277.
27. Santiago JL, Alizadeh BZ, Martinez A, et al.: Study of the association between the CAPSL-IL7R locus and type 1 diabetes. Diabetologia 2008, 51:1653-1658.
28. Smyth DJ, Cooper JD, Bailey R, et al.: A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet 2006, 38:617-619.
29. Todd JA, Walker NM, Cooper JD, et al.: Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007, 39:857-864.
30. Hafler DA, Compston A, Sawcer S, et al.: Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007, 57:851-862.
31. Liu W, Putnam AL, Xu-Yu Z, et al.: CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med 2006, 203:1701-1711.
32. Maki K, Sunaga S, Komagata Y, et al.: Interleukin 7 receptor-deficient mice lack gammadelta T cells. Proc Natl Acad Sci U S A 1996, 93:7172-7177.
33. von Freeden-Jeffry U, Vieira P, Lucian LA, et al.: Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 1995, 181:1519-1526.
34. Vrisekoop N, den Braber I, de Boer AB, et al.: Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool. Proc Natl Acad Sci U S A 2008, 105:6115-6120.
35. Vukmanovic-Stejic M, Zhang Y, Cook JE, et al.: Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J Clin Invest 2006, 16:2423-2433.
36. Fearon DT, Manders P, Wagner SD: Arrested differentiation, the self-renewing memory lymphocyte, and vaccination. Science 2001, 293:248-250.
37. Reiner SL, Sallusto F, Lanzavecchia A: Division of labor with a workforce of one: Challenges in specifying effector and memory T cell fate. Science 2007, 317:622-625.
38. Chang JT, Palanivel VR, Kinjyo I, et al.: Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 2007, 315:1687-1691.
39. Snyder CM, Cho KS, Bonnett EL, et al.: Memory inflation during chronic viral infection is maintained by continuous production of short-lived, functional T cells. Immunity 2008, 29:650-659.
40. Li R, Perez N, Karumuthil-Melethil S, Vasu C: Bone marrow is a preferential homing site for autoreactive T-cells in type 1 diabetes. Diabetes 2007, 56:2251-2259.
41. Dubois-Laforgue D, Hendel H, Caillat-Zucman S, et al.: A common stromal cell-derived factor-1 chemokine gene variant is associated with the early onset of type 1 diabetes. Diabetes 2001, 50:1211-1213.
42. Leng Q, Nie Y, Zou Y, Chen J: Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development. BMC Immunol 2008, 9:51.