Study of the association between the CAPSL-IL7R locus and type 1 diabetes

Diabetologia

Volumn 51, Issue 9, 2008, Pages 1653-1658

  Santiago, J L ^a   Alizadeh, B Z ^b   Martinez A ^a   Espino, L ^a   De La Calle, H ^c   Fernandez Arquero M ^a   Figueredo, M A ^a   De La Concha, E G ^a   Roep, B O ^d   Koeleman, B P C ^b   Urcelay, E ^a  

^a HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Age at onset; CAPSL; Diabetes; IL7R; Polymorphisms

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CHILD; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENE MUTATION; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MANTEL HAENSZEL TEST; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

ADOLESCENT; AGE OF ONSET; CHILD; DIABETES MELLITUS, TYPE 1; FEMALE; GENOME, HUMAN; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-7; REFERENCE VALUES;

EID: 49249118750     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-008-1070-4     Document Type: Article

References (19)

1. P Concannon HA Erlich C Julier 2005 Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families Diabetes 54 2995 3001
2. F Pociot MF McDermott 2002 Genetics of type 1 diabetes mellitus Genes Immun 3 235 249
3. BJ Barratt F Payne CE Lowe 2004 Remapping the insulin gene/IDDM2 locus in type 1 diabetes Diabetes 53 1884 1889
4. GI Bell S Horita JH Karam 1984 A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus Diabetes 33 176 183
5. L Nistico R Buzzetti LE Pritchard 1996 The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry Hum Mol Genet 5 1075 1080
6. H Ueda JM Howson L Esposito 2003 Association of the T cell regulatory gene CTLA4 with susceptibility to autoimmune disease Nature 423 506 511
7. N Bottini L Musumeci A Alonso 2004 A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes Nat Genet 36 337 338
8. DJ Smyth JD Cooper R Bailey 2006 A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region Nat Genet 38 617 619
9. JA Todd NM Walker JD Cooper 2007 Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes Nat Genet 39 857 864
10. Wellcome Trust Case Control Consortium 2007 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls Nature 447 661 678
11. DA Hafler A Compston S Sawcer 2007 Risk alleles for multiple sclerosis identified by a genomewide study N Engl J Med 357 851 862
12. M Kondo T Takeshita M Higuchi 1994 Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes Science 263 1453 1454
13. CM Roifman J Zhang D Chitayat N Sharfe 2000 A partial deficiency of interleukin-7R alpha is sufficient to abrogate T cell development and cause severe combined immunodeficiency Blood 96 2803 2807
14. S Giliani L Mori G de Saint Basile 2005 Interleukin-7 receptor alpha (IL-7Ralpha) deficiency: cellular and molecular bases. Analysis of clinical, immunological, and molecular features in 16 novel patients Immunol Rev 203 110 126
15. JC Barrett B Fry J Maller MJ Daly 2005 Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 21 263 265
16. SB Gabriel SF Schaffner H Nguyen 2002 The structure of haplotype blocks in the human genome Science 296 2225 2229
17. M Watanabe Y Ueno T Yajima 1995 Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes J Clin Invest 95 2945 2953
18. J Machen J Harnaha R Lakomy A Styche M Trucco N Giannoukakis 2004 Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells J Immunol 173 4331 4341
19. J Harnaha J Machen M Wright 2006 Interleukin-7 is a survival factor for CD4+ CD25+ T cells and is expressed by diabetes-suppressive dendritic cells Diabetes 55 158 170