메뉴 건너뛰기




Volumn 15, Issue 6, 2008, Pages 1151-1156

Effect of the Pro12Ala polymorphism of the PPARγ32 gene on response to pioglitazone treatment in menopausal women

Author keywords

Menopausal women; Pioglitazone treatment; Pro12Ala polymorphism

Indexed keywords

ADIPONECTIN; ALANINE; ESTRONE; FOLLITROPIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PIOGLITAZONE; PRASTERONE; PRASTERONE SULFATE; PROLINE; TESTOSTERONE; TRIACYLGLYCEROL; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; CONJUGATED ESTROGEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 63349105328     PISSN: 10723714     EISSN: None     Source Type: Journal    
DOI: 10.1097/gme.0b013e31816d5b2d     Document Type: Article
Times cited : (20)

References (46)
  • 1
    • 0038645816 scopus 로고    scopus 로고
    • The emergence of the metabolic syndrome with menopause
    • Carr MC. The emergence of the metabolic syndrome with menopause. J Clin Endocrinol Metab 2003;88:2404-2411.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2404-2411
    • Carr, M.C.1
  • 3
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueli K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2005;116:1784-1792.
    • (2005) J Clin Invest , vol.116 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4    Ueli, K.5    Tobe, K.6
  • 4
    • 0036789137 scopus 로고    scopus 로고
    • The effect of thiazolidinediones on plasma adiponectin levels in normal, obese and type 2 diabetic subjects
    • Yu JG, Javoschi S, Hevener A, et al. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese and type 2 diabetic subjects. Diabetes 2002;51:2968-2974.
    • (2002) Diabetes , vol.51 , pp. 2968-2974
    • Yu, J.G.1    Javoschi, S.2    Hevener, A.3
  • 5
    • 0033515761 scopus 로고    scopus 로고
    • Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
    • Arita Y, Kihara S, Ouchi N, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commum 1999;257:79-83.
    • (1999) Biochem Biophys Res Commum , vol.257 , pp. 79-83
    • Arita, Y.1    Kihara, S.2    Ouchi, N.3
  • 6
    • 0037380664 scopus 로고    scopus 로고
    • Association between adiponectin and mediators of inflammation in obese women
    • Engeli S, Feldpausch M, Gorzelniak K, et al. Association between adiponectin and mediators of inflammation in obese women. Diabetes 2003;52:942-947.
    • (2003) Diabetes , vol.52 , pp. 942-947
    • Engeli, S.1    Feldpausch, M.2    Gorzelniak, K.3
  • 7
    • 0034999667 scopus 로고    scopus 로고
    • Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia
    • Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 2001;86:1930-1935.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1930-1935
    • Weyer, C.1    Funahashi, T.2    Tanaka, S.3
  • 8
    • 1442326009 scopus 로고    scopus 로고
    • Discrimination between obesity and insulin resistance in the relationship with adiponectin
    • Abbasi F, Chu JW, Lamendola C, et al. Discrimination between obesity and insulin resistance in the relationship with adiponectin. Diabetes 2004;53:585-590.
    • (2004) Diabetes , vol.53 , pp. 585-590
    • Abbasi, F.1    Chu, J.W.2    Lamendola, C.3
  • 9
    • 0034096988 scopus 로고    scopus 로고
    • Plasma concentrations of a novel adipose-specific protein, adiponectin, in type 2 diabetes patients
    • Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel adipose-specific protein, adiponectin, in type 2 diabetes patients. Arterioscler Thromb Vac Biol 2000;20:1595-1599.
    • (2000) Arterioscler Thromb Vac Biol , vol.20 , pp. 1595-1599
    • Hotta, K.1    Funahashi, T.2    Arita, Y.3
  • 10
    • 0035039227 scopus 로고    scopus 로고
    • Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys
    • Hotta K, Funahashi T, Bodkin NL, et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 2001;50:1126-1133.
    • (2001) Diabetes , vol.50 , pp. 1126-1133
    • Hotta, K.1    Funahashi, T.2    Bodkin, N.L.3
  • 11
    • 0036075053 scopus 로고    scopus 로고
    • Decreased plasma adiponectin concentrations in women with dyslipidemia
    • Matsubara M, Maruoka S, Katayose S. Decreased plasma adiponectin concentrations in women with dyslipidemia. J Clin Endocrinol Metab 2002;87:2764-2769.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2764-2769
    • Matsubara, M.1    Maruoka, S.2    Katayose, S.3
  • 12
    • 13244284806 scopus 로고    scopus 로고
    • Adiponectin journey from an adipocyte secretory protein to biomarker of the metabolic syndrome
    • Trujillo ME, Scherer PE. Adiponectin journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. J Intern Med 2005;257:167-175.
    • (2005) J Intern Med , vol.257 , pp. 167-175
    • Trujillo, M.E.1    Scherer, P.E.2
  • 13
    • 0035462629 scopus 로고    scopus 로고
    • PPARF ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
    • Maeda N, Takahashi M, Funahashi T, et al. PPARF ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001;50:2094-2099.
    • (2001) Diabetes , vol.50 , pp. 2094-2099
    • Maeda, N.1    Takahashi, M.2    Funahashi, T.3
  • 14
    • 0036481709 scopus 로고    scopus 로고
    • Synthetic peroxisome proliferator- activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients
    • Yang WS, Jeng CY, Wu TJ, et al. Synthetic peroxisome proliferator- activated receptor-gamma agonist, rosiglitazone, increases plasma levels of adiponectin in type 2 diabetic patients. Diabetes Care 2002;25:376-380.
    • (2002) Diabetes Care , vol.25 , pp. 376-380
    • Yang, W.S.1    Jeng, C.Y.2    Wu, T.J.3
  • 15
    • 18344417084 scopus 로고    scopus 로고
    • Analysis of the relationship between the Pro12Ala variant in the PPAR-γ2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes
    • Blüler M, Lübben G, Paschke R. Analysis of the relationship between the Pro12Ala variant in the PPAR-γ2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes. Diabetes Care 2003;26:825-831.
    • (2003) Diabetes Care , vol.26 , pp. 825-831
    • Blüler, M.1    Lübben, G.2    Paschke, R.3
  • 16
    • 0031898610 scopus 로고    scopus 로고
    • PPARF: Adipogenic regulator and thiazolidinedione receptor
    • Spiegelman BM. PPARF: adipogenic regulator and thiazolidinedione receptor. Diabetes 1998;47:507-514.
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.M.1
  • 17
    • 0031964987 scopus 로고    scopus 로고
    • Depot-specific differences in adipose tissue gene expression in lean and obese subjects
    • Lefebvre A, Laville M, Vega N, et al. Depot-specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes 1998;47:98-103.
    • (1998) Diabetes , vol.47 , pp. 98-103
    • Lefebvre, A.1    Laville, M.2    Vega, N.3
  • 18
    • 0345164399 scopus 로고    scopus 로고
    • Molecular scanning of the human peroxisome proliferator activated receptorF (hPPARγ) gene in diabetic Caucasians: Identification of a Pro12Ala PPARγ2 missense mutation
    • Yen CJ, Beamer BA, Negri C, et al. Molecular scanning of the human peroxisome proliferator activated receptorF (hPPARγ) gene in diabetic Caucasians: identification of a Pro12Ala PPARγ2 missense mutation. Biochem Biophys Res Commun 1997;241:270-274.
    • (1997) Biochem Biophys Res Commun , vol.241 , pp. 270-274
    • Yen, C.J.1    Beamer, B.A.2    Negri, C.3
  • 19
    • 0036320603 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ2 Pro12Ala polymorphism
    • Stumvoll M, Häring H. The peroxisome proliferator-activated receptor-γ2 Pro12Ala polymorphism. Diabetes 2002;51:2341-2347.
    • (2002) Diabetes , vol.51 , pp. 2341-2347
    • Stumvoll, M.1    Häring, H.2
  • 20
    • 0031595923 scopus 로고    scopus 로고
    • Pro12 Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • Deeb SS, Fajas L, Nemoto M, et al. Pro12 Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998;20:284-287.
    • (1998) Nat Genet , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3
  • 21
    • 0034745183 scopus 로고    scopus 로고
    • Pro12 Ala polymorphism in the peroxisome proliferator-activated receptor-γ2 gene is associated with increased antilipolytic insulin sensitivity
    • Stumvoll M, Günther H, Löblein K, et al. Pro12 Ala polymorphism in the peroxisome proliferator-activated receptor-γ2 gene is associated with increased antilipolytic insulin sensitivity. Diabetes 2001;50:876-881.
    • (2001) Diabetes , vol.50 , pp. 876-881
    • Stumvoll, M.1    Günther, H.2    Löblein, K.3
  • 22
    • 4243353569 scopus 로고    scopus 로고
    • Studies of Pro12Ala polymorphism of the PPAR-γ gene in the Danish MONICA cohort: Homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome
    • Frederiksen L, Brødbaek K, Fenger M, et al. Studies of Pro12Ala polymorphism of the PPAR-γ gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome. J Clin Endocrinol Metab 2002;87:3989-3992.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3989-3992
    • Frederiksen, L.1    Brødbaek, K.2    Fenger, M.3
  • 23
    • 0033624575 scopus 로고    scopus 로고
    • The common PPAR-γ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D, Hirschhorn JN, Klannemark M, et al. The common PPAR-γ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000;26:76-80.
    • (2000) Nat Genet , vol.26 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3
  • 24
    • 0034745185 scopus 로고    scopus 로고
    • 12 → Ala substitution in PPAR-γ is associated with resistance to development of diabetes in the general population. Possible involvement of insulin secretion in individual with type 2 diabetes
    • 12 → Ala substitution in PPAR-γ is associated with resistance to development of diabetes in the general population. Possible involvement of insulin secretion in individual with type 2 diabetes. Diabetes 2001;50:890-891.
    • (2001) Diabetes , vol.50 , pp. 890-891
    • Mori, H.1    Ikegami, H.2    Kawaguchi, Y.3
  • 25
    • 0004509649 scopus 로고    scopus 로고
    • The Pro115Gln and Pro12Ala PPAR-γ gene mutations in obesity and type 2 diabetes
    • Clement K, Hercberg S, Passinge B, et al. The Pro115Gln and Pro12Ala PPAR-γ gene mutations in obesity and type 2 diabetes. Int J Obes Relat Metab Disord 2000;24:391-393.
    • (2000) Int J Obes Relat Metab Disord , vol.24 , pp. 391-393
    • Clement, K.1    Hercberg, S.2    Passinge, B.3
  • 26
    • 0033060302 scopus 로고    scopus 로고
    • Pro12Ala substitution in the peroxisome proliferator-activated receptor-γ2 is not associated with type 2 diabetes
    • Mancini F, Vaccaro O, Sabatino L, et al. Pro12Ala substitution in the peroxisome proliferator-activated receptor-γ2 is not associated with type 2 diabetes. Diabetes 1999;48:1466-1468.
    • (1999) Diabetes , vol.48 , pp. 1466-1468
    • Mancini, F.1    Vaccaro, O.2    Sabatino, L.3
  • 27
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5
  • 28
    • 0036316168 scopus 로고    scopus 로고
    • Menopause, energy expenditure, and body composition
    • Poehman ET. Menopause, energy expenditure, and body composition. Acta Obstet Scand 2002;81:603-611.
    • (2002) Acta Obstet Scand , vol.81 , pp. 603-611
    • Poehman, E.T.1
  • 29
    • 33846616398 scopus 로고    scopus 로고
    • Body mass index, percent body fat, and regional body fat distribution in relation to leptin concentrations in healthy, non-smoking postmenopausal women in a feeding study
    • Mahabir S, Baer D, Johnson LL, et al. Body mass index, percent body fat, and regional body fat distribution in relation to leptin concentrations in healthy, non-smoking postmenopausal women in a feeding study. Nutr J 2007;17:6. 3.
    • (2007) Nutr J , vol.17 , Issue.6 , pp. 3
    • Mahabir, S.1    Baer, D.2    Johnson, L.L.3
  • 30
    • 0035400822 scopus 로고    scopus 로고
    • Gonadotropins at menopause: The influence of obesity, insulin resistance, and estrogens
    • Malacara JM, Fajardo ME, Nava LE. Gonadotropins at menopause: the influence of obesity, insulin resistance, and estrogens. Steroids 2001;66:559-567.
    • (2001) Steroids , vol.66 , pp. 559-567
    • Malacara, J.M.1    Fajardo, M.E.2    Nava, L.E.3
  • 31
    • 33846837398 scopus 로고    scopus 로고
    • Relation of BMI and physical activity to sex hormones in postmenopausal women
    • McTiernan A, Wu L, Chen C, et al. Relation of BMI and physical activity to sex hormones in postmenopausal women. Obesity 2006;14:1662-1677.
    • (2006) Obesity , vol.14 , pp. 1662-1677
    • McTiernan, A.1    Wu, L.2    Chen, C.3
  • 32
    • 33846016572 scopus 로고    scopus 로고
    • Usefulness of body mass index as a sufficient adiposity measurement for sex hormone concentration associations in postmenopausal women
    • Mahabir S, Baer D, Johnson LL, et al. Usefulness of body mass index as a sufficient adiposity measurement for sex hormone concentration associations in postmenopausal women. Cancer Epidemiol Biomarkers Prev 2006;15:2502-2507.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 2502-2507
    • Mahabir, S.1    Baer, D.2    Johnson, L.L.3
  • 33
    • 0037989013 scopus 로고    scopus 로고
    • Extragonadal synthesis of sex steroids: Intracrinology
    • Labrie F. Extragonadal synthesis of sex steroids: intracrinology. Ann Endocrinol 2003;64:95-107.
    • (2003) Ann Endocrinol , vol.64 , pp. 95-107
    • Labrie, F.1
  • 35
    • 34248672258 scopus 로고    scopus 로고
    • Comparison of adiponectin, leptin and blood lipid levels in normal and obese postmenopausal women
    • Jaleel F, Jaleel A, Rahman MA, Alam E. Comparison of adiponectin, leptin and blood lipid levels in normal and obese postmenopausal women. J Pak Med Assoc 2006;56:391-394.
    • (2006) J Pak Med Assoc , vol.56 , pp. 391-394
    • Jaleel, F.1    Jaleel, A.2    Rahman, M.A.3    Alam, E.4
  • 36
    • 33847263026 scopus 로고    scopus 로고
    • Sex-specific determinants of serum adiponectin in older adults: The role of endogenous sex hormones
    • Laughlin GA, Barrett-Connor E, May S. Sex-specific determinants of serum adiponectin in older adults: the role of endogenous sex hormones. Int J Obes 2007;31:457-465.
    • (2007) Int J Obes , vol.31 , pp. 457-465
    • Laughlin, G.A.1    Barrett-Connor, E.2    May, S.3
  • 37
    • 33845636922 scopus 로고    scopus 로고
    • The transition to menopause reinforces adiponectin production and its contributions to improvement to insulin-resistant states
    • Tamakoshi K, Yatsuya H, Wada K, et al. The transition to menopause reinforces adiponectin production and its contributions to improvement to insulin-resistant states. Clin Endocrinol 2007;66:65-71.
    • (2007) Clin Endocrinol , vol.66 , pp. 65-71
    • Tamakoshi, K.1    Yatsuya, H.2    Wada, K.3
  • 38
    • 33845472305 scopus 로고    scopus 로고
    • Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ with prediabetic phenotypes
    • Tönjes A, Scholz M, Loeffleer M, Stumvoll M. Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ with prediabetic phenotypes. Diabetes Care 2006;29:2489-2497.
    • (2006) Diabetes Care , vol.29 , pp. 2489-2497
    • Tönjes, A.1    Scholz, M.2    Loeffleer, M.3    Stumvoll, M.4
  • 39
    • 0038321225 scopus 로고    scopus 로고
    • Pro12Ala of the peroxisome proliferator-activated receptor γ gene is associated with lower serum insulin levels in non-obese African Americans
    • Kao WHL, Coresh J, Shuldiner AR, Boerwinkle E, Bray MS, Brancati FL. Pro12Ala of the peroxisome proliferator-activated receptor γ gene is associated with lower serum insulin levels in non-obese African Americans. Diabetes 2003;52:1568-1572.
    • (2003) Diabetes , vol.52 , pp. 1568-1572
    • Kao, W.H.L.1    Coresh, J.2    Shuldiner, A.R.3    Boerwinkle, E.4    Bray, M.S.5    Brancati, F.L.6
  • 40
    • 33645062714 scopus 로고    scopus 로고
    • ACDC/adiponectin and PPARγ gene polymorphisms: Implications for features of obesity
    • Tankó LB, Siddiq A, Lecoeur C, et al. ACDC/adiponectin and PPARγ gene polymorphisms: implications for features of obesity. Obesity 2005;13:2113-2121.
    • (2005) Obesity , vol.13 , pp. 2113-2121
    • Tankó, L.B.1    Siddiq, A.2    Lecoeur, C.3
  • 41
    • 34147106645 scopus 로고    scopus 로고
    • Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to tioglitazone
    • Florez JC, Jablonski KA, Sun MW, et al. Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to tioglitazone. J Clin Endocrinol Metab 2007;92:1502-1509.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1502-1509
    • Florez, J.C.1    Jablonski, K.A.2    Sun, M.W.3
  • 42
    • 24944509975 scopus 로고    scopus 로고
    • Pioneer Study: PPARγ activation results in overall improvement of clinical and metabolic markers associated with insulin resistance independent of long-term glucose control
    • Pfutzner A, Hohberg C, Lubben G, et al. Pioneer Study: PPARγ activation results in overall improvement of clinical and metabolic markers associated with insulin resistance independent of long-term glucose control. Horm Metab Res 2005;37:510-515.
    • (2005) Horm Metab Res , vol.37 , pp. 510-515
    • Pfutzner, A.1    Hohberg, C.2    Lubben, G.3
  • 44
    • 23444457610 scopus 로고    scopus 로고
    • Effects of Pro12Ala polymorphism of peroxisome proliferator-activated receptor γ2 gene on rosiglitazone response in type 2 diabetes
    • Kang ES, Park SY, Kim HJ, et al. Effects of Pro12Ala polymorphism of peroxisome proliferator-activated receptor γ2 gene on rosiglitazone response in type 2 diabetes. Clin Pharmacol Ther 2005;78:202-208.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 202-208
    • Kang, E.S.1    Park, S.Y.2    Kim, H.J.3
  • 45
    • 2542443906 scopus 로고    scopus 로고
    • Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common functional Pro12Ala peroxisome proliferator-activated receptor γ2 gene variant: Results from the Troglitazone in Prevention of Diabetes (TRIPOD) study
    • Snitker S, Watanabe RM, Ani I, et al. Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common functional Pro12Ala peroxisome proliferator-activated receptor γ2 gene variant: results from the Troglitazone in Prevention of Diabetes (TRIPOD) study. Diabetes Care 2004;27:1365-1368.
    • (2004) Diabetes Care , vol.27 , pp. 1365-1368
    • Snitker, S.1    Watanabe, R.M.2    Ani, I.3
  • 46
    • 0033554614 scopus 로고    scopus 로고
    • Inhibition of adipogenesis by a COOH-terminally truncated mutant of PPARγ2 in 3T3-L1 cells
    • Masugi J, Tamori Y, Kasuga M. Inhibition of adipogenesis by a COOH-terminally truncated mutant of PPARγ2 in 3T3-L1 cells. Biochem Biophys Res Commun 1999;264:93-99.
    • (1999) Biochem Biophys Res Commun , vol.264 , pp. 93-99
    • Masugi, J.1    Tamori, Y.2    Kasuga, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.