Drosophila melanogaster deoxyribonucleoside kinase activates gemcitabine

Biochemical and Biophysical Research Communications

Volumn 382, Issue 2, 2009, Pages 430-433

  Knecht, Wolfgang ^a   Mikkelsen, Nils Egil ^b   Clausen, Anders Ranegaard ^c   Willer, Mette ^d   Eklund, Hans ^b   Gojković, Zoran ^d   Piškur, Jure ^a,c  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c LUND UNIVERSITY   (Sweden)

^d ZGene AS   (Denmark)

Author keywords

Cancer; Deoxyribonucleoside kinase; Gene therapy; Nucleoside analogs; Salvage pathway; Structure function relationship

Indexed keywords

DEOXYRIBONUCLEOSIDE; DEOXYRIBONUCLEOSIDE KINASE; FLUORIDE; GEMCITABINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ATOM; CANCER CELL CULTURE; DROSOPHILA MELANOGASTER; GENE THERAPY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL LINE, TUMOR; DEOXYCYTIDINE; DROSOPHILA MELANOGASTER; DRUG RESISTANCE, NEOPLASM; HUMANS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

DROSOPHILA MELANOGASTER;

EID: 63349095879     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.03.041     Document Type: Article

References (23)

1. Arner E.S., and Eriksson S. Mammalian deoxyribonucleoside kinases. Pharmacology & Therapeutics 67 (1995) 155-186
2. Knecht W., Petersen G.E., Munch-Petersen B., and Piskur J. Deoxyribonucleoside kinases belonging to the thymidine kinase 2 (TK2)-like group vary significantly in substrate specificity, kinetics and feed-back regulation. Journal of Molecular Biology 315 (2002) 529-540
3. Knecht W., Petersen G.E., Sandrini M.P., Sondergaard L., Munch-Petersen B., and Piskur J. Mosquito has a single multisubstrate deoxyribonucleoside kinase characterized by unique substrate specificity. Nucleic Acids Research 31 (2003) 1665-1672
4. Munch-Petersen B., Piskur J., and Sondergaard L. Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase. Journal of Biological Chemistry 273 (1998) 3926-3931
5. Knecht W., Sandrini M.P., Johansson K., Eklund H., Munch-Petersen B., and Piskur J. A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purines. EMBO Journal 21 (2002) 1873-1880
6. Knecht W., Munch-Petersen B., and Piskur J. Identification of residues involved in the specificity and regulation of the highly efficient multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster. Journal of Molecular Biology 301 (2000) 827-837
7. Knecht W., Rozpedowska E., Le Breton C., Willer M., Gojkovic Z., Sandrini M.P., Joergensen T., Hasholt L., Munch-Petersen B., and Piskur J. Drosophila deoxyribonucleoside kinase mutants with enhanced ability to phosphorylate purine analogs. Gene Therapy 14 (2007) 1278-1286
8. Culver K.W., Ram Z., Wallbridge S., Ishii H., Oldfield E.H., and Blaese R.M. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256 (1992) 1550-1552
9. Moolten F.L. Tumor chemosensitivity conferred by inserted Herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Research 46 (1986) 5276-5281
10. Zheng X., Johansson M., and Karlsson A. Retroviral transduction of cancer cell lines with the gene encoding Drosophila melanogaster multisubstrate deoxyribonucleoside kinase. Journal of Biological Chemistry 275 (2000) 39125-39129
11. Jordheim L.P., Galmarini C.M., and Dumontet C. Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells. Cancer Chemotherapy & Pharmacology 58 (2006) 547-554
12. Toschi L., Finocchiaro G., Bartolini S., Gioia V., and Cappuzzo F. Role of gemcitabine in cancer therapy. Future Oncology 1 (2005) 7-17
13. Munch-Petersen B., Knecht W., Lenz C., Sondergaard L., and Piskur J. Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants. Journal of Biological Chemistry 275 (2000) 6673-6679
14. Knecht W., Bergjohann U., Gonski S., Kirschbaum B., and Loffler M. Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme. European Journal of Biochemistry 240 (1996) 292-301
15. Liebecq C. IUBMB Biochemical Nomenclature and Related Documents, Ed. (1992), Portland Press Ltd., London
16. Cornish-Bowden A. Fundamentals of enzyme kinetics, Ed. (1995), Portland Press Ltd., London
17. A.G.W. Leslie, in Joint CCP4 + ESF-EAMCB Newsletter on Protein Crystallography, 1992.
18. Collaborative Computational Project, The CCP4 suite: programs for protein crystallography, Acta Crystallographica Section D-Biological Crystallography 50 (1994) 760-763.
19. Jones T.A., Zou J.Y., Cowan S.W., and Kjeldgaard M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallographica Section A-Foundations of Crystallography 47 (1991) 110-119
20. Emsley P., and Cowtan K. Coot: model-building tools for molecular graphics. Acta Crystallographica Section D-Biological Crystallography 60 (2004) 2126-2132
21. McSorley T., Ort S., Hazra S., Lavie A., and Konrad M. Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues. FEBS Letters 582 (2008) 720-724
22. Mikkelsen N.E., Munch-Petersen B., and Eklund H. Structural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinase. FEBS Journal 275 (2008) 2151-2160
23. Johansson K., Ramaswamy S., Ljungcrantz C., Knecht W., Piskur J., Munch-Petersen B., Eriksson S., and Eklund H. Structural basis for substrate specificities of cellular deoxyribonucleoside kinases. Nature Structural Biology 8 (2001) 616-620