Hypoglycemic detection at the portal vein: Absent in humans or yet to be elucidated?

Diabetes

Volumn 58, Issue 1, 2009, Pages 21-23

  Donovan, Casey M ^a   Bohland, Maryann ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; ANTIDIABETIC AGENT; INSULIN;

HUMAN; HYPOGLYCEMIA; NONHUMAN; NOTE; ORAL GLUCOSE TOLERANCE TEST; PORTAL VEIN; PRIORITY JOURNAL; CHEMICALLY INDUCED DISORDER; GLUCOSE BLOOD LEVEL; METABOLISM;

BLOOD GLUCOSE; GLUCOSE; HUMANS; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; PORTAL VEIN;

EID: 63249114833     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db08-1437     Document Type: Note

References (19)

1. Cryer PE: Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes. Diabetes 54:3592-3601, 2005
2. Levin BE, Routh VH, Kang L, Sanders NM, Dunn Meynell AA: Neuronal glucosensing: what do we know after 50 years? Diabetes 53:2521-2528, 2004
3. Marty N, Dallaporta M, Thorens B: Brain glucose sensing, counterregula- tion, and energy homeostasis. Physiology 22:241-251, 2007
4. Koyama Y, Coker RH, Stone EE, Lacy B, Jabbour K, Williams PE, Wasserman DH: Evidence that carotid bodies play an important role in glucoregulation in vivo. Diabetes 49:1434-1442, 2000
5. Berthoud H-R: Vagal and hormonal gut-brain communication: from satiation to satisfaction. Neurogastroenterol Motil 20:64-72, 2008
6. Donovan CM: Portal vein glucose sensing. Diabetes Nutr Metab 15:308-312, 2002
7. Donovan C, Hamilton-Wessler M, Halter J, Bergman R: Primacy of liver glucosensors in the sympathetic response to progressive hypoglycemia. Proc Natl Acad Sci 91:2863-2867, 1994
8. Fujita S, Bohland MA, Sanchez-Watts G, Watts AG, Donovan CM: Hypo- glycemic detection at the portal vein is mediated by capsaicin-sensitive primary sensory neurons. Am J Physiol 293:E96-E101, 2007
9. Saberi M, Bohland MA, Donovan CM: The locus for hypoglycemic detection shifts with the rate of fall in glycemia: the role of the portal-superior mesenteric vein in glucose sensing. Diabetes 57:1380-1386, 2008
10. Burcelin R, Dolci W, Thorens B: Glucose sensing by the hepatoportal sensor is GLUT2-dependent. Diabetes 49:1643-1648, 2000
11. Rossetti P, Porcellati F, Lucidi P, Busciantella Ricci N, Candeloro P, Cioli P, Santeusanio F, Bolli GB, Fannelli CG: Portal vein glucose sensors do not play a major role in modulating physiological responses to insulin-induced hypoglycemia in humans. Diabetes 58:194-202, 2009
12. Ertl AC, Mann S, Richardson A, Briscoe VJ, Tate HB, Davis SN: Effects of oral carbohydrate on autonomic nervous system counterregulatory responses during hyperinsulinemic hypoglycemica and euglycemia. Am J Physiol 295:E618-E625, 2008
13. Heptulla RA, Tamborlane WV, Ma TY-Z, Rife F, Sherwin RS: Oral glucose augments the counterregulatory hormone response during insulin-induced hypoglycemia in humans. J Clin Endocrinol Metabol 86:645-648, 2001 14. Smith D, Pernet A, Reid H, Bingham E, Rosenthal J, Macdonald I, Umpleby A, Amiel SA: The role of hepatic portal glucose sensing in modulating responses to hypoglycemia in man. Diabetologia 45:1416-1424, 2002
14. Basu R, Di Camillo B, Toffolo G, Basu A, Shah P, Vella A, Rizza R, Cobelli C: Use of a novel triple-tracer approach to assess postprandial glucose metabolism. Am J Physiol 284:E55-E69, 2003
15. Livesey G, Wilson PDG, Dainty JR, Brown JC, Faulks RM, Roe MA, Newman TA, Eagles J, Mellon FA, Greenwood RH: Simultaneous time- varying systemic appearance of oral and hepatic glucose in adults monitored with stable isotopes. Am J Physiol 275:E717-E728, 1998
16. Tamada T, Moriyasu F, Ono S, Shimizu K, Kajimura K, Soh Y, Kawasaki T,Kimura T, Yamashita Y, Someda H: Portal blood flow: measurement with MR imaging. Radiology 173:639 -644, 1989
17. Nauck MA, Heimesaat MM, Behle K, Holst JJ, Nauck MS, Ritzel R, Hufner M, Schmiegel WH: Effects ofglucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers. J Clin Endocrinol Metab 87:1239-1246, 2002
18. Nakabayashi H, Nishizawa M, Nakagawa A, Takeda R, Niijima A: Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1. Am J Physiol 271:E803-E813, 1996
19. Jackson P, Pagliassotti M, Shiota M, Neal D, Cardin S, Cherrington A: Effects of vagal blockade on the counterregulatory response to insulin- induced hypoglycemia in the dog. Am J Physiol 273:E1178-E1188, 1997