Hypoglycemic detection at the portal vein is mediated by capsaicin-sensitive primary sensory neurons

American Journal of Physiology - Endocrinology and Metabolism

Volumn 293, Issue 1, 2007, Pages

  Fujita, Satoshi ^a   Bohland, Maryann ^a   Sanchez Watts, Graciela ^a   Watts, Alan G ^a   Donovan, Casey M ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Calcitonin gene related peptide; Glucose sensing; Sympathoadrenal response

Indexed keywords

ADRENALIN; CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; GLUCOSE; INSULIN; NORADRENALIN;

ADRENERGIC STIMULATION; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; DENERVATION; IMMUNOHISTOCHEMISTRY; JUGULAR VEIN; MALE; NERVE FIBER; NONHUMAN; PATCH CLAMP; PORTAL VEIN; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL;

ANIMALS; CAPSAICIN; DEOXYGLUCOSE; HYPOGLYCEMIA; INSULIN; MALE; NEURONS, AFFERENT; PORTAL VEIN; RATS; RATS, WISTAR; SYMPATHECTOMY, CHEMICAL;

EID: 34547106283     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00415.2006     Document Type: Article

References (30)

1. Amann R, Lembeck F. Capsaicin sensitive afferent neurons from peripheral glucose receptors mediate the insulin-induced increase in adrenaline secretion. Naunyn Schmiedebergs Arch Pharmacol 334: 71-76, 1986.
2. Barja F, Mathison R. Adrenergic and peptidergic (substance P and vasoactive intestinal polypeptide) innervation of the rat portal vein. Blood Vessels 19: 263-272, 1982.
3. Barja F, Mathison R. Sensory innervation of the rat portal vein and the hepatic artery. J Auton Nerv Syst 10: 117-125, 1984.
4. Berthoud HR. Anatomy and function of sensory hepatic nerves (Abstract). Anat Rec 280A: 827-835, 2004.
5. Borg WP, Sherwin RS, During MJ, Borg MA, Shulman GI. Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release. Diabetes 44: 180-184, 1995.
6. Buck SH, Burks TF. The neuropharmacology of capsaicin: review of some recent observations. Pharmacol Rev 38: 179-226, 1986.
7. Cryer PE. Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes. Diabetes 54: 3592-3601, 2005.
8. Donnerer J. Reflex activation of the adrenal medulla during hypoglycemia and circulatory dysregulations is regulated by capsaicin-sensitive afferents. Naunyn Schmiedebergs Arch Pharmacol 338: 282-286, 1988.
9. Donovan CM, Halter JB, Bergman RN. Importance of hepatic glucoreceptors in sympathoadrenal response to hypoglycemia. Diabetes 40: 155-158, 1991.
10. Donovan CM, Hamilton-Wessler M, Halter JB, Bergman RN. Primacy of liver glucosensors in the sympathetic response to progressive hypoglycemia. Proc Natl Acad Sci USA 91: 2863-2867, 1994.
11. Fujita S, Donovan CM. Celiac-superior mesenteric ganglionectomy, but not vagotomy, suppresses the sympathoadrenal response to insulin-induced hypoglycemia. Diabetes 54: 3258-3264, 2005.
12. Goehler LE, Sternini C. Calcitonin gene-related peptide innervation of the rat hepatobiliary system. Peptides 17: 209-217, 1996.
13. Hamilton-Wessler M, Bergman RN, Halter JB, Watanabe RM, Donovan CM. The role of liver glucosensors in the integrated sympathetic response induced by deep hypoglycemia in dogs. Diabetes 43: 1052-1060, 1994.
14. Hevener AL, Bergman RN, Donovan CM. Novel glucosensor for hypoglycemic detection localized to the portal vein. Diabetes 46: 1521-1525, 1997.
15. Hevener AL, Bergman RN, Donovan CM. Portal vein afferents are critical for the sympathoadrenal response to hypoglycemia. Diabetes 49: 8-12, 2000.
16. Horowitz SH. Recent clinical advances in diabetic polyneuropathy. Curr Opn Anethesiol 19: 573-578, 2006.
17. Jackson PA, Cardin S, Coffey CS, Neal DW, Allen EJ, Penaloza AR, Snead WL, Cherrington AD. Effect of hepatic denervation on the counterregulatory response to insulin-induced hypoglycemia in the dog. Am J Physiol Endocrinol Metab 279: E1249-E1257, 2000.
18. Jackson PA, Pagliassotti MJ, Shiota M, Neal DW, Cardin S, Cherrington AD. Effects of vagal blockade on the counterregulatory response to insulin-induced hypoglycemia in the dog. Am J Physiol Endocrinol Metab 273: E1178-E1188, 1997.
19. Leow MKS, Wyckoff J. Under-recognised paradox of neuropathy from rapid glycaemic control. Postgrad Med J 81: 103-107, 2007.
20. Maggi CA, Lippe IT, Giuliani S, Abelli L, Somma V, Geppetti P, Jancso G, Santicioli P, Meli A. Topical versus systemic capsaicin desensitization: specific and unspecific effects as indicated by modification or reflex micturition in rats. Neuroscience 31: 745-756, 1989.
21. McHugh JM, McHugh WB. Diabetes and peripheral sensory neurons. AACN Clin Issues 15: 136-149, 2004.
22. Niijima A. Visceral afferents and metabolic function. Diabetologia 20, Suppl: 325-330, 1981.
23. Niijima A. Glucose-sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea-pig. J Physiol 332: 315-323, 1982.
24. Peuler JD, Johnson GA. Simultaneous single isotope radioenzymatic assay of plasma norepinephrine, epinephrine and dopamine. Life Sci 21: 625-636, 1977.
25. Raybould HE, Tache Y. Capsaicin-sensitive vagal afferent fibers and stimulation of gastric acid secretion in anesthetized rats. Eur J Pharmacol 167: 237-243, 1989.
26. Ritter S, Dinh TT. Capsaicin-induced neuronal degeneration in the brain and retina of preweanling rats. J Comp Neurol 296: 447-461, 1990.
27. Sasaki Y, Hayashi N, Kasahara A, Matsuda H, Fusamoto H, Sato N, Hillyard CJ, Girgis S, MacIntyre I, Emson PC. Calcitonin gene-related peptide in the hepatic and splanchnic vascular systems of the rat. Hepatology 6: 676-681, 1986.
28. Szallasi A, Blumberg PM. Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev 51: 159-212, 1999.
29. Taborsky GJ Jr, Halter JB, Baum D, Best JD, Porte D Jr. Pentobarbital anesthesia suppresses basal and 2-deoxy-D-glucose-stimulated plasma catecholamines. Am J Physiol Regul Integr Comp Physiol 247: R905-R910, 1984.
30. Zhou XF, Jhamandas KH, Livett BG. Capsaicin-sensitive nerves are required for glucostasis but not for catecholamine output during hypoglycemia in rats. Am J Physiol Endocrinol Metab 258: E212-E219, 1990.