Dominant mutants of ceruloplasmin impair the copper loading machinery in aceruloplasminemia

Journal of Biological Chemistry

Volumn 284, Issue 7, 2009, Pages 4545-4554

  di Patti, Maria Carmela Bonaccorsi ^a   Maio, Nunziata ^a   Rizzo, Gianluca ^b   De Francesco, Giovanni ^a   Persichini, Tiziana ^b   Colasanti, Marco ^b   Polticelli, Fabio ^b   Musci, Giovanni ^a,c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ROMA TRE UNIVERSITY   (Italy)

^c UNIVERSITY OF MOLISE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C6 CELLS; CELL SURFACES; CERULOPLASMIN; COPPER BINDING; COPPER LOADING; DELETERIOUS EFFECTS; DOMINANT NEGATIVE; FERROXIDASE ACTIVITY; GLUTATHIONE; IRON HOMEOSTASIS; IRREVERSIBLE LOSS; METAL LOADINGS; MOLECULAR DEFECTS; MULTICOPPER OXIDASE; NEURODEGENERATIVE DISEASE; NEUROLOGICAL PROBLEMS; RE-LOCALIZATION; SUB-CELLULAR; THERAPEUTIC STRATEGY; WILD TYPES;

ABILITY TESTING; CELL MEMBRANES; MACHINERY; MAMMALS;

COPPER;

ADENOSINE TRIPHOSPHATASE; CERULOPLASMIN; COPPER; FERROPORTIN; GLUTATHIONE; SMALL INTERFERING RNA; CATION TRANSPORT PROTEIN; CCC2 PROTEIN, S CEREVISIAE; IRON; METAL TRANSPORTING PROTEIN 1; SACCHAROMYCES CEREVISIAE PROTEIN; WILSON DISEASE PROTEIN;

ACERULOPLASMINEMIA; ANIMAL CELL; ARTICLE; AUTOSOMAL DISORDER; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE SEVERITY; GENETIC TRANSFECTION; GLIOMA CELL; HETEROZYGOSITY; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; MISSENSE MUTATION; MUTANT; NEUROLOGIC DISEASE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; DEMYELINATING DISEASE; DISORDERS OF METAL METABOLISM; ENZYMOLOGY; GENE EXPRESSION; GENE SILENCING; GENETICS; METABOLISM; TUMOR CELL LINE;

MAMMALIA; RATTUS;

ADENOSINE TRIPHOSPHATASES; AMINO ACID SUBSTITUTION; ANIMALS; CATION TRANSPORT PROTEINS; CELL LINE, TUMOR; CERULOPLASMIN; COPPER; GENE EXPRESSION; GENE SILENCING; HEREDODEGENERATIVE DISORDERS, NERVOUS SYSTEM; HOMEOSTASIS; HUMANS; IRON; METAL METABOLISM, INBORN ERRORS; MUTATION, MISSENSE; PROTEIN BINDING; RATS; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 63249102412     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M805688200     Document Type: Article

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