Ascaris suum NAD-malic enzyme is activated by L-malate and fumarate binding to separate allosteric sites

Biochemistry

Volumn 42, Issue 32, 2003, Pages 9712-9721

  Karsten, William E ^a   Pais, June E ^a,c   Jagannatha Rao, G S ^a   Harris, Ben G ^b   Cook, Paul F ^a  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLATION; ENZYMES; MUTAGENESIS; REACTION KINETICS;

MUTANTS;

BIOCHEMISTRY;

ALANINE; BACTERIAL ENZYME; FUMARIC ACID; MALATE DEHYDROGENASE (DECARBOXYLATING); PYRUVIC ACID;

ALLOSTERISM; ARTICLE; ASCARIS SUUM; CARBOXYLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DECARBOXYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; HUMAN; MITOCHONDRION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN BINDING; REACTION ANALYSIS; SITE DIRECTED MUTAGENESIS;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ASCARIS SUUM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FUMARATES; HUMANS; KINETICS; MALATE DEHYDROGENASE; MALATES; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PYRUVATES; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, FLUORESCENCE;

ASCARIS SUUM; BACTERIA (MICROORGANISMS); NEMATODA;

EID: 0042026574     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034101w     Document Type: Article

References (26)

1. Saz, H. J. (1971) Am. Zool. 11, 125-135.
2. Saz, H. J., and Lescure, O. L. (1969) Comp. Biochem. Physiol. 30, 49-60.
3. Papa, S., Cheah, K. S., Rasmussen, H. N., Lee, I. Y., and Chance, B. (1970) Eur. J. Biochem. 12, 540-543.
4. Fodge, D. W., Gracy, R. W., and Harris, B. G. (1972) Biochim. Biophys. Acta 268, 271-284.
5. Kmetec, E., and Bueding, E. (1961) J. Biol. Chem. 236, 584-591.
6. Seidman, I., and Entner, N. (1961) J. Biol. Chem. 236, 915-919.
7. Rew, R. S., and Saz, H. J. (1974) J. Biol. Chem. 63, 125-135.
8. Landsperger, W. J., and Harris, B. G. (1976) J. Biol. Chem. 251, 3599-3602.
9. Lai, C.-J., Harris, B. G., and Cook, P. F. (1992) Arch. Biochem. Biophys. 299, 214-219.
10. Mallick, S., Harris, B. G., and Cook, P. F. (1991) J. Biol. Chem. 266, 2732-2738.
11. Xu, Y., Bhargava, G., Wu, H., Loeber, G., and Tong, L (1999) Structure 7, 877-889.
12. Coleman, D. E., Rao, G. S., Goldsmith, E. J., Cook, P. F., and Harris, B. G. (2002) Biochemistry 41, 6928-6938.
13. Yang, Z., Lanks, C. W., and Tong, L. (2002) Structure 10, 951-960.
14. Rao, G. S. J., Coleman, D. E., Karsten, W. E., Cook, P. F., and Harris, B. G. (2003) J. Biol. Chem. 278, (in press).
15. Karsten, W. E., Chooback, L., Liu, D., Hwang, C.-C., Lynch, C., and Cook P. F. (1999) Biochemistry 38, 10527-10532.
16. Park, S.-H., Kiick, D. M., Harris, B. G., and Cook, P. F. (1984) Biochemistry 23, 5446-5453.
17. Martell, A. E., and Smith, R. M. (1977) Critical Stability Constants, Vol 3, Plenum Press, New York.
18. Martell, A. E., and Smith, R. M. (1982) Critical Stability Constants, Vol 5, Plenum Press, New York.
19. Cleland, W. W. (1979) Methods Enzymol. 63, 103-108.
20. Barrett, J., and Beis, I. (1973) Comp. Biochem. Physiol. B 44, 751-761.
21. Rajapaksa, R., Abu-Soud, H., Rauschel, F. M., Harris, B. G., and Cook, P. F. (1993) Biochemistry 32, 1928-1934.
22. Weiss, P. M., Gavva, S. R., Harris, B. G., Urbauer, J. C., Cleland, W. W., and Cook P. F. (1991) Biochemistry 30, 5755-5763.
23. Karsten, W. E., and Cook, P. F. (1994) Biochemistry 33, 2096-2103.
24. Kiick, D. M., Harris, B. G., and Cook, P. F. (1986) Biochemistry 25, 227-236.
25. Cha, S. (1968) J. Biol. Chem. 243, 820-825.
26. Reinhart, G. D. (1983) Arch. Biochem. Biophys. 224, 389-395.