Determinants of the dual cofactor specificity and substrate cooperativity of the human mitochondrial NAD(P)+-dependent malic enzyme: Functional roles of glutamine 362

Journal of Biological Chemistry

Volumn 281, Issue 32, 2006, Pages 23237-23245

  Hsieh, Ju Yi ^a   Liu, Guang Yaw ^b   Chang, Gu Gang ^c   Hung, Hui Chih ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BIOCHEMICAL ENGINEERING; CATALYSIS; MUTAGENESIS; SUBSTRATES;

BINDING COOPERATIVITY; COFACTOR SPECIFICITY; MALIC ENZYMES;

ENZYMES;

ADENOSINE TRIPHOSPHATE; ALANINE; ASPARAGINE; GLUTAMINE; MALATE DEHYDROGENASE (DECARBOXYLATING); MITOCHONDRIAL ENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RECOMBINANT ENZYME;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC SITE; CATALYSIS; FUMARATES; GLUTAMINE; HUMANS; KINETICS; LYSINE; MALATE DEHYDROGENASE; MITOCHONDRIA; NADP; PROTEIN BINDING; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

COLUMBA;

EID: 33747369870     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M603451200     Document Type: Article

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