An interdisciplinary analysis of sex and gender in relation to the pathogenesis of bronchial asthma

Respiratory Medicine

Volumn 103, Issue 5, 2009, Pages 637-649

  Lux, Richard ^a   Awa, Wendy ^a   Walter, Ulla ^a  

^a Health Services Research   (Germany)

Author keywords

Bronchial asthma; Complex interactions; Endogenous factors; Exogenous influences; Sex gender

Indexed keywords

ASTHMA; BODY MASS; ENVIRONMENTAL FACTOR; GENE INTERACTION; GYNECOLOGICAL EXAMINATION; HEREDITY; HORMONE ACTION; HUMAN; IMMUNE SYSTEM; IMMUNOLOGICAL PARAMETERS; INTERDISCIPLINARY RESEARCH; NONHUMAN; NUTRITIONAL ASSESSMENT; OBESITY; PATHOGENESIS; PREGNANCY; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE;

AGE FACTORS; ASTHMA; DISEASE SUSCEPTIBILITY; FEMALE; HUMANS; MALE; PREGNANCY; PREVALENCE; RISK FACTORS; SEX FACTORS; SOCIAL ENVIRONMENT;

EID: 63149127343     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rmed.2009.01.006     Document Type: Review

References (142)

1. Breton C.V., Zhang Z., Hunt P.R., Pechter E., and Davis L. Characteristics of work related asthma: results from a population based survey. Occup Environ Med 63 6 (2006) 411-415
2. Toelle B.G., Ng K., Belousova E., Salome C.M., Peat J.K., and Marks G.B. Prevalence of asthma and allergy in schoolchildren in Belmont, Australia: three cross sectional surveys over 20 years. BMJ 328 7436 (2004) 386-387
3. Irvin C.G. Interaction between the growing lung and asthma: role of early intervention. J Allergy Clin Immunol 105 2 Pt 2 (2000) S540-S546
4. PausJenssen E.S., and Cockcroft D.W. Sex differences in asthma, atopy, and airway hyperresponsiveness in a university population. Ann Allergy Asthma Immunol 91 1 (2003) 34-37
5. Kurukulaaratchy R.J., Fenn M., Twiselton R., Matthews S., and Arshad S.H. The prevalence of asthma and wheezing illnesses amongst 10-year-old schoolchildren. Respir Med 96 3 (2002) 163-169
6. Kjellman B., and Gustafsson P.M. Asthma from childhood to adulthood: asthma severity, allergies, sensitization, living conditions, gender influence and social consequences. Respir Med 94 5 (2000) 454-465
7. Watson L., Turk F., James P., and Holgate S.T. Factors associated with mortality after an asthma admission: a national United Kingdom database analysis. Respir Med 101 8 (2007) 1659-1664
8. Ensom M.H.H. Gender-based differences and menstrual cycle-related changes in specific diseases: implications for pharmacotherapy. Pharmacotherapy 20 5 (2000) 523-539
9. Marketos S.G., and Ballas C.N. Bronchial asthma in the medical literature of Greek antiquity. J Asthma 19 4 (1982) 263-269
10. Jaeger A. Über Asthma bronchiale. J Mol Med 4 34 (1925) 1652-1656
11. Baagöe K.H. Untersuchungen über Asthma, besonders bei Kindern. J Mol Med 7 11 (1928) 507-510
12. Baagöe K.H. Asthma im Verhältnis zu Alter und Geschlecht. J Mol Med 10 29 (1931) 1352-1354
13. Hunt H.B. Some observations on the blood eosinophil count in asthmatics. J Allergy 10 2 (1939) 146-155
14. Zondek B., and Bromberg Y.M. Endocrine allergy. I. Allergic sensitivity to endogenous hormones. J Allergy 16 1 (1945) 1-16
15. Hendeles L., Vaughan L., Weinberger M., and Smith G. Influence of gender on theophylline dosage requirements in children with chronic asthma. Drug Intell Clin Pharm 15 5 (1981) 338-340
16. Janson-Bjerklie S., Kohlman Carrieri V., and Hudes M. The sensations of pulmonary dyspnea. Nurs Res 35 3 (1986) 154-159
17. Grassi M., Bugiani M., and de Marco R. Investigating indicators and determinants of asthma in young adults. Eur J Epidemiol 21 11 (2006) 831-842
18. Melén E., Kere J., Pershagen G., Svartengren M., and Wickman M. Influence of male sex and parental allergic disease on childhood wheezing: role of interactions. Clin Exp Allergy 34 6 (2004) 839-844
19. Mandhane P.J., Greene J.M., Cowan J.O., Taylor D.R., and Sears M.R. Sex differences in factors associated with childhood- and adolescent-onset wheeze. Am J Respir Crit Care Med 172 1 (2005) 45-54
20. Karjalainen J., Nieminen M.M., Aromaa A., Klaukka T., and Hurme M. The IL-1β genotype carries asthma susceptibility only in men. J Allergy Clin Immunol 109 3 (2002) 514-516
21. Melén E., Gullstén H., Zucchelli M., Lindstedt A., Nyberg F., Wickman M., Pershagen G., and Kere J. Sex specific protective effects of interleukin-9 receptor haplotypes on childhood wheezing and sensitisation. J Med Genet 41 12 (2004) e123
22. -765C in bronchial asthma. J Allergy Clin Immunol 114 2 (2004) 248-253
23. Cheong H.S., Park C.S., Kim L.H., Park B.L., Uh S.T., Kim Y.H., Lym G.I., Lee J.Y., Lee J.K., Kim H.T., Ryu H.J., Han B.G., Kim J.W., Park C., Kimm K., Shin H.D., and Oh B. CXCR3 polymorphisms associated with risk of asthma. Biochem Biophys Res Commun 334 4 (2005) 1219-1225
24. Dijkstra A., Howard T.D., Vonk J.M., Ampleford E.J., Lange L.A., Bleecker E.R., Meyers D.A., and Postma D.S. Estrogen receptor 1 polymorphisms are associated with airway hyperresponsiveness and lung function decline, particularly in female subjects with asthma. J Allergy Clin Immunol 117 3 (2006) 604-611
25. Oryszczyn M.P., Bouzigon E., Maccario J., Siroux V., Nadif R., Wright A., and Kauffmann F. Interrelationships of quantitative asthma-related phenotypes in the epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness, and atopy. J Allergy Clin Immunol 119 1 (2007) 57-63
26. Xu J., Meyers D.A., Ober C., Blumenthal M.N., Mellen B., Barnes K.C., King R.A., Lester L.A., Howard T.D., Solway J., Langefeld C.D., Beaty T.H., Rich S.S., Bleecker E.R., Cox N.J., and Collaborative Study on the Genetics of Asthma. Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: Collaborative Study on the Genetics of Asthma. Am J Hum Genet 68 6 (2001) 1437-1446
27. Howard T.D., Koppelman G.H., Xu J., Zheng S.L., Postma D.S., Meyers D.A., and Bleecker E.R. Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am J Hum Genet 70 1 (2002) 230-236
28. Chan I.H.S., Leung T.F., Tang N.L.S., Li C.Y., Sung Y.M., Wong G.W.K., Wong C.K., and Lam C.W.K. Gene-gene interactions for asthma and plasma total IgE concentration in Chinese children. J Allergy Clin Immunol 117 1 (2006) 127-133
29. Eyster K.M., Mark C.J., Gayle R., and Martin D.S. The effects of estrogen and testosterone on gene expression in the rat mesenteric arteries. Vascul Pharmacol 47 4 (2007) 238-247
30. Lee S.G., Kim B.S., Kim J.H., Lee S.Y., Choi S.O., Shim J.Y., Hong T.J., and Hong S.J. Gene-gene interaction between interleukin-4 and interleukin-4 receptor α in Korean children with asthma. Clin Exp Allergy 34 8 (2004) 1202-1208
31. Beghé B., Barton S., Rorke S., Peng Q., Sayers I., Gaunt T., Keith T.P., Clough J.B., Holgate S.T., and Holloway J.W. Polymorphisms in the interleukin-4 and interleukin-4 receptor α chain genes confer susceptibility to asthma and atopy in a Caucasian population. Clin Exp Allergy 33 8 (2003) 1111-1117
32. Ådjers K., Karjalainen J., Pessi T., Eklund C., and Hurme M. Epistatic effect of TLR4 and IL4 genes on the risk of asthma in females. Int Arch Allergy Immunol 138 3 (2005) 251-256
33. Hong S.J., Lee S.Y., Kim H.B., Kim J.H., Kim B.S., Choi S.O., Lee S.G., Shin E.S., and Hong T.J. IL-5 and thromboxane A2 receptor gene polymorphisms are associated with decreased pulmonary function in Korean children with atopic asthma. J Allergy Clin Immunol 115 4 (2005) 758-763
34. 2 receptor density and aggregability. QJM 98 5 (2005) 349-356
35. Wjst M. Is the increase in allergic asthma associated with an inborn Th1 maturation or with an environmental Th1 trigger defect?. Allergy 59 2 (2004) 148-150
36. Melgert B.N., Postma D.S., Kuipers I., Geerlings M., Luinge M.A., van der Strate B.W.A., Kerstjens H.A.M., Timens W., and Hylkema M.N. Female mice are more susceptible to the development of allergic airway inflammation than male mice. Clin Exp Allergy 35 11 (2005) 1496-1503
37. Silverman E.S., Breault D.T., Vallone J., Subramanian S., Yilmaz A.D., Mathew S., Subramaniam V., Tantisira K., Pacák K., Weiss S.T., and Majzoub J.A. Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma. J Allergy Clin Immunol 114 4 (2004) 747-754
38. H2 cytokine production in an asthma model in mice. J Allergy Clin Immunol 120 1 (2007) 48-55
39. Uekert S.J., Akan G., Evans M.D., Li Z., Roberg K., Tisler C., DaSilva D., Anderson E., Gangnon R., Allen D.B., Gern J.E., and Lemanske Jr. R.F. Sex-related differences in immune development and the expression of atopy in early childhood. J Allergy Clin Immunol 118 6 (2006) 1375-1381
40. Kolb M., Martin G., Medina M., Ask K., and Gauldie J. Gene therapy for pulmonary diseases. Chest 130 3 (2006) 879-884
41. Kim T.S., Kang B.Y., Cho D., and Kim S.H. Induction of interleukin-12 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid, deviates CD4+ T cells from a Th2 to a Th1 response. Immunology 109 3 (2003) 407-414
42. Khoo S.K., Hayden C.M., Roberts M., Horak E., de Klerk N., Zhang G., Robertson C.F., Goldblatt J., and Le Souëf P. Associations of the IL12B promoter polymorphism in longitudinal data from asthmatic patients 7 to 42 years of age. J Allergy Clin Immunol 113 3 (2004) 475-481
43. Balzano G., Fuschillo S., Melillo G., and Bonini S. Asthma and sex hormones. Allergy 56 1 (2001) 13-20
44. Erden S., Buyukozturk S., Ozdaş B., and Sennazlý G. Do sex hormones influence airway mucosa?. Allergy 57 8 (2002) 755-756
45. Riffo-Vasquez Y., Ligeiro de Oliveira A.P., Page C.P., Spina D., and Tavares-de-Lima W. Role of sex hormones in allergic inflammation in mice. Clin Exp Allergy 37 3 (2007) 459-470
46. Carey M.A., Card J.W., Bradbury J.A., Moorman M.P., Haykal-Coates N., Gavett S.H., Graves J.P., Walker V.R., Flake G.P., Voltz J.W., Zhu D., Jacobs E.R., Dakhama A., Larsen G.L., Loader J.E., Gelfand E.W., Germolec D.R., Korach K.S., and Zeldin D.C. Spontaneous airway hyperresponsiveness in estrogen receptor-α-deficient mice. Am J Respir Crit Care Med 175 2 (2007) 126-135
47. Dimitropoulou C., White R.E., Ownby D.R., and Catravas J.D. Estrogen reduces carbachol-induced constriction of asthmatic airways by stimulating large-conductance voltage and calcium-dependent potassium channels. Am J Respir Cell Mol Biol 32 3 (2005) 239-247
48. Siroux V., Curt F., Oryszczyn M.P., Maccario J., and Kauffmann F. Role of gender and hormone-related events on IgE, atopy, and eosinophils in the Epidemiological Study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy. J Allergy Clin Immunol 114 3 (2004) 491-498
49. Salam M.T., Wenten M., and Gilliland F.D. Endogenous and exogenous sex steroid hormones and asthma and wheeze in young women. J Allergy Clin Immunol 117 5 (2006) 1001-1007
50. Lange P., Parner J., Prescott E., Suppli Ulrik C., and Vestbo J. Exogenous female sex steroid hormones and risk of asthma and asthma-like symptoms: a cross sectional study of the general population. Thorax 56 8 (2001) 613-616
51. Gómez Real F., Svanes C., Björnsson E.H., Franklin K.A., Gislason D., Gislason T., Gulsvik A., Janson C., Jögi R., Kiserud T., Norbäck D., Nyström L., Torén K., Wentzel-Larsen T., and Omenaas E. Hormone replacement therapy, body mass index and asthma in perimenopausal women: a cross sectional survey. Thorax 61 1 (2006) 34-40
52. Tantisira K.G., Hwang E.S., Raby B.A., Silverman E.S., Lake S.L., Richter B.G., Peng S.L., Drazen J.M., Glimcher L.H., and Weiss S.T. TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Proc Natl Acad Sci U S A 101 52 (2004) 18099-18104
53. Sternberg E.M. Neuroendocrine regulation of autoimmune/inflammatory disease. J Endocrinol 169 3 (2001) 429-435
54. Buske-Kirschbaum A., von Auer K., Krieger S., Weis S., Rauh W., and Hellhammer D. Blunted cortisol responses to psychosocial stress in asthmatic children: a general feature of atopic disease?. Psychosom Med 65 5 (2003) 806-810
55. Dery R.E., Mathison R., Davison J., and Befus A.D. Inhibition of allergic inflammation by C-terminal peptides of the prohormone submandibular rat 1 (SMR-1). Int Arch Allergy Immunol 124 1-3 (2001) 201-204
56. Dery R.E., Ulanova M., Puttagunta L., Stenton G.R., James D., Merani S., Mathison R., Davison J., and Befus A.D. Frontline: Inhibition of allergen-induced pulmonary inflammation by the tripeptide feG: a mimetic of a neuro-endocrine pathway. Eur J Immunol 34 12 (2004) 3315-3325
57. Putnam K., Chrousos G.P., Nieman L.K., and Rubinow D.R. Sex-related differences in stimulated hypothalamic-pituitary-adrenal axis during induced gonadal suppression. J Clin Endocrinol Metab 90 7 (2005) 4224-4231
58. Rubinow D.R. Reproductive steroids in context. Arch Womens Ment Health 8 1 (2005) 1-5
59. Rubinow D.R., Roca C.A., Schmidt P.J., Danaceau M.A., Putnam K., Cizza G., Chrousos G., and Nieman L. Testosterone suppression of CRH-stimulated cortisol in men. Neuropsychopharmacology 30 10 (2005) 1906-1912
60. Vicennati V., Ceroni L., Genghini S., Patton L., Pagotto U., and Pasquali R. Sex difference in the relationship between the hypothalamic-pituitary-adrenal axis and sex hormones in obesity. Obesity 14 2 (2006) 235-243
61. Bouman A., Heineman M.J., and Faas M.M. Sex hormones and the immune response in humans. Hum Reprod Update 11 4 (2005) 411-423
62. Loza M.J., and Chang B.L. Association between Q551R IL4R genetic variants and atopic asthma risk demonstrated by meta-analysis. J Allergy Clin Immunol 120 3 (2007) 578-585
63. Guerra S., Wright A.L., Morgan W.J., Sherrill D.L., Holberg C.J., and Martinez F.D. Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of puberty. Am J Respir Crit Care Med 170 1 (2004) 78-85
64. Clifton V.L. Sexually dimorphic effects of maternal asthma during pregnancy on placental glucocorticoid metabolism and fetal growth. Cell Tissue Res 322 1 (2005) 63-71
65. Murphy V.E., Gibson P.G., Giles W.B., Zakar T., Smith R., Bisits A.M., Kessell C.G., and Clifton V.L. Maternal asthma is associated with reduced female fetal growth. Am J Respir Crit Care Med 168 11 (2003) 1317-1323
66. Kwon H.L., Belanger K., Holford T.R., and Bracken M.B. Effect of fetal sex on airway lability in pregnant women with asthma. Am J Epidemiol 163 3 (2006) 217-221
67. Murphy V.E., Zakar T., Smith R., Giles W.B., Gibson P.G., and Clifton V.L. Reduced 11β-hydroxysteroid dehydrogenase type 2 activity is associated with decreased birth weight centile in pregnancies complicated by asthma. J Clin Endocrinol Metab 87 4 (2002) 1660-1668
68. Namazy J., Schatz M., Long L., Lipkowitz M., Lillie M.A., Voss M., Deitz R.J., and Petitti D. Use of inhaled steroids by pregnant asthmatic women does not reduce intrauterine growth. J Allergy Clin Immunol 113 3 (2004) 427-432
69. Bakhireva L.N., Jones K.L., Schatz M., Johnson D., Chambers C.D., and Organization of Teratology Information Services Research Group. Asthma medication use in pregnancy and fetal growth. J Allergy Clin Immunol 116 3 (2005) 503-509
70. u B., Pekkanen J., Husman T., Keski-Nisula L., and Koskela P. Maternal sex hormones in early pregnancy and asthma among offspring: a case-control study. J Allergy Clin Immunol 112 6 (2003) 1101-1104
71. Tan K.S., and Thomson N.C. Asthma in pregnancy. Am J Med 109 9 (2000) 727-733
72. Shaheen S.O., Hines M., Newson R.B., Wheeler M., Herrick D.R.M., Strachan D.P., Jones R.W., Burney P.G.J., and Henderson A.J. Maternal testosterone in pregnancy and atopic outcomes in childhood. Allergy 62 1 (2007) 25-32
73. Castro-Rodríguez J.A. Relationship between obesity and asthma. Arch Bronconeumol 43 3 (2007) 171-175
74. Paeratakul S., Lovejoy J.C., Ryan D.H., and Bray G.A. The relation of gender, race and socioeconomic status to obesity and obesity comorbidities in a sample of US adults. Int J Obes 26 9 (2002) 1205-1210
75. Eder W., Ege M.J., and von Mutius E. The asthma epidemic. N Engl J Med 355 21 (2006) 2226-2235
76. von Mutius E., Schwartz J., Neas L.M., Dockery D., and Weiss S.T. Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax 56 11 (2001) 835-838
77. Gilliland F.D., Berhane K., Islam T., McConnell R., Gauderman W.J., Gilliland S.S., Avol E., and Peters J.M. Obesity and the risk of newly diagnosed asthma in school-age children. Am J Epidemiol 158 5 (2003) 406-415
78. Castro-Rodríguez J.A., Holberg C.J., Morgan W.J., Wright A.L., and Martinez F.D. Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. Am J Respir Crit Care Med 163 6 (2001) 1344-1349
79. Hancox R.J., Milne B.J., Poulton R., Taylor D.R., Greene J.M., McLachlan C.R., Cowan J.O., Flannery E.M., Herbison G.P., and Sears M.R. Sex differences in the relation between body mass index and asthma and atopy in a birth cohort. Am J Respir Crit Care Med 171 5 (2005) 440-445
80. Matricardi P.M., Grüber C., Wahn U., and Lau S. The asthma-obesity link in childhood: open questions, complex evidence, a few answers only. Clin Exp Allergy 37 4 (2007) 476-484
81. Tollefsen E., Bjermer L., Langhammer A., Johnsen R., and Holmen T.L. Adolescent respiratory symptoms - girls are at risk: the Young-HUNT study. Norway. Respir Med 100 3 (2006) 471-476
82. Burgess J.A., Walters E.H., Byrnes G.B., Giles G.G., Jenkins M.A., Abramson M.J., Hopper J.L., and Dharmage S.C. Childhood adiposity predicts adult-onset current asthma in females: a 25-yr prospective study. Eur Respir J 29 4 (2007) 668-675
83. Guerra S., Sherrill D.L., Bobadilla A., Martinez F.D., and Barbee R.A. The relation of body mass index to asthma, chronic bronchitis, and emphysema. Chest 122 4 (2002) 1256-1263
84. Kim S., and Camargo Jr. C.A. Sex-race differences in the relationship between obesity and asthma: the Behavioral Risk Factor Surveillance System, 2000. Ann Epidemiol 13 10 (2003) 666-673
85. Weiss S.T. Obesity: insight into the origins of asthma. Nat Immunol 6 6 (2005) 537-539
86. Chen Y., Rennie D., Cormier Y., and Dosman J. Sex specificity of asthma associated with objectively measured body mass index and waist circumference: the Humboldt study. Chest 128 4 (2005) 3048-3054
87. Beckett W.S., Jacobs Jr. D.R., Yu X., Iribarren C., and Williams O.D. Asthma is associated with weight gain in females but not males, independent of physical activity. Am J Respir Crit Care Med 164 11 (2001) 2045-2050
88. Chen Y., Dales R., Tang M., and Krewski D. Obesity may increase the incidence of asthma in women but not in men: longitudinal observations from the Canadian National Population Health Surveys. Am J Epidemiol 155 3 (2002) 191-197
89. Luder E., Ehrlich R.I., Lou W.Y.W., Melnik T.A., and Kattan M. Body mass index and the risk of asthma in adults. Respir Med 98 1 (2004) 29-37
90. Chen Y., Dales R., and Jiang Y. The association between obesity and asthma is stronger in nonallergic than allergic adults. Chest 130 3 (2006) 890-895
91. Varraso R., Siroux V., Maccario J., Pin I., and Kauffmann F. Epidemiological Study on the Genetics and Environment of Asthma. Asthma severity is associated with body mass index and early menarche in women. Am J Respir Crit Care Med 171 4 (2005) 334-339
92. Hallstrand T.S., Fischer M.E., Wurfel M.M., Afari N., Buchwald D., and Goldberg J. Genetic pleiotropy between asthma and obesity in a community-based sample of twins. J Allergy Clin Immunol 116 6 (2005) 1235-1241
93. Sengler C., Lau S., Wahn U., and Nickel R. Interactions between genes and environmental factors in asthma and atopy: new developments. Respir Res 3 1 (2002) 7
94. Barr R.G., Cooper D.M., Speizer F.E., Drazen J.M., and Camargo Jr. C.A. β2-Adrenoceptor polymorphism and body mass index are associated with adult-onset asthma in sedentary but not active women. Chest 120 5 (2001) 1474-1479
95. Faggioni R., Feingold K.R., and Grunfeld C. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J 15 14 (2001) 2565-2571
96. Halle M., and Persson P.B. Role of leptin and leptin receptor in inflammation. Am J Physiol Regul Integr Comp Physiol 284 3 (2003) R760-R762
97. Mai X.M., Böttcher M.F., and Leijon I. Leptin and asthma in overweight children at 12 years of age. Pediatr Allergy Immunol 15 6 (2004) 523-530
98. Guler N., Kirerleri E., Ones U., Tamay Z., Salmayenli N., and Darendeliler F. Leptin: does it have any role in childhood asthma?. J Allergy Clin Immunol 114 2 (2004) 254-259
99. Sood A., Ford E.S., and Camargo Jr. C.A. Association between leptin and asthma in adults. Thorax 61 4 (2006) 300-305
100. Li Y.F., Gilliland F.D., Berhane K., McConnell R., Gauderman W.J., Rappaport E.B., and Peters J.M. Effects of in utero and environmental tobacco smoke exposure on lung function in boys and girls with and without asthma. Am J Respir Crit Care Med 162 6 (2000) 2097-2104
101. Lødrup Carlsen K.C., Løvik M., Granum B., Mowinckel P., and Carlsen K.H. Soluble CD14 at 2 yr of age: gender-related effects of tobacco smoke exposure, recurrent infections and atopic diseases. Pediatr Allergy Immunol 17 4 (2006) 304-312
102. Holmen T.L., Barrett-Connor E., Clausen J., Langhammer A., Holmen J., and Bjermer L. Gender differences in the impact of adolescent smoking on lung function and respiratory symptoms. The Nord-Trøndelag Health Study, Norway, 1995-1997. Respir Med 96 10 (2002) 796-804
103. Satoh H., Hasegawa T., Suzuki E., Terada M., Nakayama H., Toyabe S., Akazawa K., Kondoh A., Arakawa M., Yoshizawa H., and Gejyo F. Gender differences in susceptibility of asthma to active smoking. Questionnaire based analysis in the Niigata Prefecture, Japan. Allergol Int 54 3 (2005) 401-410
104. Hellings P.W., Vandekerckhove P., Claeys R., Billen J., Kasran A., and Ceuppens J.L. Progesterone increases airway eosinophilia and hyper-responsiveness in a murine model of allergic asthma. Clin Exp Allergy 33 10 (2003) 1457-1463
105. Mitchell V.L., and Gershwin L.J. Progesterone and environmental tobacco smoke act synergistically to exacerbate the development of allergic asthma in a mouse model. Clin Exp Allergy 37 2 (2007) 276-286
106. Jaakkola J.J.K., Jaakkola N., Piipari R., and Jaakkola M.S. Pets, parental atopy, and asthma in adults. J Allergy Clin Immunol 109 5 (2002) 784-788
107. Chen Y., Dales R., Tang M., and Krewski D. Sex-related interactive effect of smoking and household pets on asthma incidence. Eur Respir J 20 5 (2002) 1162-1166
108. Mendonça E.M.C., Algranti E., de Freitas J.B.P., Rosa E.A., dos Santos Freire J.A., .de Paula Santos U., Pinto J., and Bussacos M.A. Occupational asthma in the city of São Paulo, 1995-2000, with special reference to gender analysis. Am J Ind Med 43 6 (2003) 611-617
109. Bakke P.S., and Gulsvik A. Work-related asthma: prevalence estimates by sex, age and smoking habits in a community sample. Int J Tuberc Lung Dis 4 7 (2000) 649-656
110. Colilla S., Nicolae D., Pluzhnikov A., Blumenthal M.N., Beaty T.H., Bleecker E.R., Lange E.M., Rich S.S., Meyers D.A., Ober C., Cox N.J., and Collaborative Study for the Genetics of Asthma. Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure. J Allergy Clin Immunol 111 4 (2003) 840-846
111. Gohlke H., Illig T., Bahnweg M., Klopp N., André E., Altmüller J., Herbon N., Werner M., Knapp M., Pescollderungg L., Boner A., Malerba G., Pignatti P.F., and Wjst M. Association of the interleukin-1 receptor antagonist gene with asthma. Am J Respir Crit Care Med 169 11 (2004) 1217-1223
112. Ramadas R.A., Sadeghnejad A., Karmaus W., Arshad S.H., Matthews S., Huebner M., Kim D.Y., and Ewart S.L. Interleukin-1R antagonist gene and pre-natal smoke exposure are associated with childhood asthma. Eur Respir J 29 3 (2007) 502-508
113. Martin A.C., Laing I.A., Khoo S.K., Zhang G., Rueter K., Teoh L., Taheri S., Hayden C.M., Geelhoed G.C., Goldblatt J., and LeSouëf P.N. Acute asthma in children: relationships among CD14 and CC16 genotypes, plasma levels, and severity. Am J Respir Crit Care Med 173 6 (2006) 617-622
114. Choudhry S., Avila P.C., Nazario S., Ung N., Kho J., Rodriguez-Santana J.R., Casal J., Tsai H.J., Torres A., Ziv E., Toscano M., Sylvia J.S., Alioto M., Salazar M., Gomez I., Fagan J.K., Salas J., Lilly C., Matallana H., Castro R.A., Selman M., Weiss S.T., Ford J.G., Drazen J.M., Rodriguez-Cintron W., Chapela R., Silverman E.K., and Burchard E.G. CD14 tobacco gene-environment interaction modifies asthma severity and immunoglobulin E levels in Latinos with asthma. Am J Respir Crit Care Med 172 2 (2005) 173-182
115. Osman M. Therapeutic implications of sex differences in asthma and atopy. Arch Dis Child 88 7 (2003) 587-590
116. hi regulatory T cells in pediatric asthma. J Allergy Clin Immunol 119 5 (2007) 1258-1266
117. Weiner P., Magadle R., Massarwa F., Beckerman M., and Berar-Yanay N. Influence of gender and inspiratory muscle training on the perception of dyspnea in patients with asthma. Chest 122 1 (2002) 197-201
118. Wickman M., Melén E., Berglind N., Lennart Nordvall S., Almqvist C., Kull I., Svartengren M., and Pershagen G. Strategies for preventing wheezing and asthma in small children. Allergy 58 8 (2003) 742-747
119. Mai X.M., Becker A.B., Sellers E.A.C., Liem J.J., and Kozyrskyj A.L. The relationship of breast-feeding, overweight, and asthma in preadolescents. J Allergy Clin Immunol 120 3 (2007) 551-556
120. Mandhane P.J., Greene J.M., and Sears M.R. Interactions between breast-feeding, specific parental atopy, and sex on development of asthma and atopy. J Allergy Clin Immunol 119 6 (2007) 1359-1366
121. Gilliland F.D., Berhane K.T., Li Y.F., Gauderman W.J., McConnell R., and Peters J. Children's lung function and antioxidant vitamin, fruit, juice, and vegetable intake. Am J Epidemiol 158 6 (2003) 576-584
122. Romieu I., Varraso R., Avenel V., Leynaert B., Kauffmann F., and Clavel-Chapelon F. Fruit and vegetable intakes and asthma in the E3 N study. Thorax 61 3 (2006) 209-215
123. Raby B.A., Lazarus R., Silverman E.K., Lake S., Lange C., Wjst M., and Weiss S.T. Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med 170 10 (2004) 1057-1065
124. Szalai C., Kozma G.T., Nagy A., Bojszkó A., Krikovszky D., Szabó T., and Falus A. Polymorphism in the gene regulatory region of MCP-1 is associated with asthma susceptibility and severity. J Allergy Clin Immunol 108 3 (2001) 375-381
125. Weiss S.T., and Raby B.A. Asthma genetics 2003. Hum Mol Genet 13 1 (2004) R83-R89
126. Wills-Karp M., and Ewart S.L. Time to draw breath: asthma-susceptibility genes are identified. Nat Rev Genet 5 5 (2004) 376-387
127. Nicholson P.J., Cullinan P., Newman Taylor A.J., Burge P.S., and Boyle C. Evidence based guidelines for the prevention, identification, and management of occupational asthma. Occup Environ Med 62 5 (2005) 290-299
128. Dehner W. Beitrag zur Pathologie des Asthma bronchiale. J Mol Med 6 30 (1927) 1412-1417
129. Rosenberg H.F., Phipps S., and Foster P.S. Eosinophil trafficking in allergy and asthma. J Allergy Clin Immunol 119 6 (2007) 1303-1310
130. Osler W. The principles and practice of medicine: designed for the use of practitioners and students of medicine. 4th ed. (1901), D Appleton and Company, New York
131. Shepherd J.M., Duddleston D.N., Hicks G.S., Low A.K., Russell L.D., and Brown C.A. Asthma: a brief overview. Am J Med Sci 324 4 (2002) 174-179
132. Caracta C.F. Gender differences in pulmonary disease. Mt Sinai J Med 70 4 (2003) 215-224
133. Dombrowski M.P. Asthma and pregnancy. Obstet Gynecol 108 3 Pt 1 (2006) 667-681
134. Salvi S.S., Babu K.S., and Holgate S.T. Is asthma really due to a polarized T cell response toward a helper T cell type 2 phenotype?. Am J Respir Crit Care Med 164 8 Pt 1 (2001) 1343-1346
135. Wolthers O.D. Eosinophil granule proteins in the assessment of airway inflammation in pediatric bronchial asthma. Pediatr Allergy Immunol 14 4 (2003) 248-254
136. Heaton T., Rowe J., Turner S., Aalberse R.C., de Klerk N., Suriyaarachchi D., Serralha M., Holt B.J., Hollams E., Yerkovich S., Holt K., Sly P.D., Goldblatt J., Le Souef P., and Holt P.G. An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children. Lancet 365 9454 (2005) 142-149
137. Douwes J., and Pearce N. Asthma and the westernization 'package'. Int J Epidemiol 31 6 (2002) 1098-1102
138. Mead M.N. Environmental roots of asthma. Environ Health Perspect 113 1 (2005) A32-A33
139. Pearce N., and Douwes J. The global epidemiology of asthma in children. Int J Tuberc Lung Dis 10 2 (2006) 125-132
140. Barbato A., Turato G., Baraldo S., Bazzan E., Calabrese F., Tura M., Zuin R., Beghé B., Maestrelli P., Fabbri L.M., and Saetta M. Airway inflammation in childhood asthma. Am J Respir Crit Care Med 168 7 (2003) 798-803
141. Baker K.M., Brand D.A., and Hen Jr. J. Classifying asthma: disagreement among specialists. Chest 124 6 (2003) 2156-2163
142. Busse W., Banks-Schlegel S., Noel P., Ortega H., Taggart V., Elias J., and NHLBI Working Group. Future research directions in asthma: an NHLBI Working Group report. Am J Respir Crit Care Med 170 6 (2004) 683-690