Functional effects and gender association of COX-2 gene polymorphism G -765C in bronchial asthma

Journal of Allergy and Clinical Immunology

Volumn 114, Issue 2, 2004, Pages 248-253

  Szczeklik, Wojciech ^b   Sanak, Marek ^b   Szczeklik, Andrew ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b NONE

Author keywords

AIA; aspirin; aspirin induced asthma; Aspirin induced asthma; Aspirin tolerant asthma; ATA; bronchial asthma; Cyclooxygenase; gender; genetic polymorphism; Nonsteroidal anti inflammatory drug; NSAID; PGD 2; Prostaglandin D2; prostaglandins

Indexed keywords

ACETYLSALICYLIC ACID; CORTICOSTEROID; CYCLOOXYGENASE 2; IMMUNOGLOBULIN E; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN D2; PROSTAGLANDIN E2;

ADULT; ARTICLE; ASTHMA; BLOOD; CELL COUNT; CITY; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DISEASE COURSE; DRUG TOLERANCE; EOSINOPHIL; EX VIVO STUDY; FEMALE; GENDER; GENE FREQUENCY; GENE FUNCTION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HOMOZYGOTE; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; MALE; MEASUREMENT; MONOCYTE; PRIORITY JOURNAL; PROMOTER REGION; RISK; SAMPLE; SEX DIFFERENCE;

ASTHMA; CYCLOOXYGENASE 2; DINOPROSTONE; FEMALE; GENOTYPE; HUMANS; ISOENZYMES; MALE; MEMBRANE PROTEINS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); PROSTAGLANDIN D2; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 4344568553     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2004.05.030     Document Type: Article

References (36)

1. Malkowski M.G., Ginell S.L., Smith W.L., Garavito R.M. The productive conformation of arachidonic acid bound to prostaglandin synthase. Science. 289:2000;1933-1937
2. Vane J.R., Botting R.M. Mechanism of action of anti-inflammatory drugs. Szczeklik A., Gryglewski R.J., Vane J.R. Eicosanoids, aspirin and asthma. 1998;1-24 Marcel Dekker, New York
3. Chandrasekharan N.V., Dai H., Roos K.L., Evanson N.K., Tomsik J., Elton T.S., et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 99:2002;13926-13931
4. Schwab J.M., Schluesener H.J., Meyermann R., Serhan C.N. COX-3 the enzyme and the concept: steps towards highly specialized pathways and precision therapeutics? Prostaglandins Leukot Essent Fatty Acids. 69:2003;339-343
5. FitzGerald G.A., Patrono C. The coxibs: selective inhibitors of cyclooxygenase-2. N Engl J Med. 345:2001;433-442
6. Tazawa R., Xu X.M., Wu K.K., Wang L.H. Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene. Biochem Biophys Res Commun. 203:1994;190-199
7. Fritsche E.S., Baek J., King L.M., Zeldin D.C., Eling T.E., Bell D.A. Functional characterisation of cyclooxygenase-2 polymorphisms. J Pharmacol Exp Ther. 299:2001;468-476
8. Cipollone F., Patrono C. Cyclooxygenase-2 polymorphism: putting a brake on the inflammatory response to vascular injury? Arterioscler Thromb Vasc Biol. 22:2002;1516-1518
9. Papafili A., Hill M.R., Brull D.J., McAnulty R.J., Marshall R.P., Humphries S.E., et al. Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response. Arterioscler Thromb Vasc Biol. 22:2002;1631-1636
10. Mitchell J.A., Belvisi M.G., Akarasereenont P., Robbins R.A., Kwon O., Croxtall J., et al. Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone. Br J Pharamcol. 113:1994;1008-1014
11. Vigano T., Habib A., Hernandez A., Bonazzi A., Boraschi D., Lebret M., et al. Cyclooxygenase-2 and synthesis of PGE2 in human bronchial smooth-muscle cells. Am J Respir Crit Care Med. 155:1997;864-868
12. Belvisi M.G., Saunders M.A., Haddadel B., Hirst S.J., Yacoub M.H., Barnes P.J., et al. Induction of cyclo-oxygenase-2 by cytokines in human cultured airway smooth muscle cells: novel inflammatory role of this cell type. Br J Pharmacol. 120:1997;910-916
13. Demoly P., Jaffuel D., Lequeux N., Weksler B., Creminon C., Michel F.B., et al. Prostaglandin H synthase 1 and 2 immunoreactivities in the bronchial mucosa of asthmatics. Am J Respir Crit Care Med. 155:1997;670-675
14. Taha R., Olivenstein R., Utsumi T., Ernst P., Barnes P.J., Rodger I.W., et al. Prostaglandin H synthase 2 expression in airway cells from patients with asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 161:2000;636-640
15. Szczeklik A., Sanak M. The role of COX-1 and COX-2 in asthma pathogenesis and significance in the use of selective inhibitors. Clin Exp Allergy. 32:2002;339-342
16. Szczeklik A., Stevenson D.D. Aspirin-induced asthma: advances in pathogenesis, diagnosis, and management. J Allergy Clin Immunol. 111:2003;913-921
17. Szczeklik A., Nizankowska E., Bochenek G., Nagraba K., Mejza F., Swierczyńska M. Safety of specific COX-2 inhibitor in aspirin-induced asthma. Clin Exp Allergy. 31:2001;219-225
18. Stevenson D.D., Simon R.A. Lack of cross-reactivity between rofecoxib and aspirin in aspirin sensitive patients with asthma. J Allergy Clin Immunol. 108:2001;47-51
19. Picado C., Fernandez-Morata J.C., Juan M., Roca-Ferrer J., Fuentes M., Xaube A., et al. Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics. Am J Respir Cell Mol Biol. 160:2000;291-296
20. Picado C., Bioque G., Roca-Ferrer J., Pujols L., Mullol J., Benitez P., et al. Nuclear factor-kappaB activity is down-regulated in nasal polyps from aspirin-sensitive asthmatics. Allergy. 58:2003;122-126
21. 4 synthase in bronchial biopsies from patients with aspirin-intolerant asthma. J Clin Invest. 101:1998;834-846
22. Kowalski M.L., Pawliczak R., Wozniak J., Sluda M., Poniatowska J., Iwaszkiewicz T., et al. Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients. Am J Respir Crit Care Med. 161:2000;391-398
23. Pierzchalska M., Szabo Z., Sanak M., Soja J., Szczeklik A. Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients with special reference to aspirin-induced asthma. J Allergy Clin Immunol. 111:2003;1041-1048
24. Nizankowska E., Bestynska-Krypel A., Cmiel A., Szczeklik A. Oral and bronchial provocation tests with aspirin for diagnosis of aspirin-induced asthma. Eur Respir J. 15:2000;863-869
25. Kato M., Nishida S., Kitasato H., Sakata N., Kawai S. Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes. J Pharm Pharmacol. 53:2001;1679-1685
26. Bjornson C.L., Mitchell I. Gender differences in asthma in childhood and adolescence. J Gend Specif Med. 3:2000;57-61
27. Boschetto P., Miotto D., Mapp C.E. Asthma and women. Buist S., Mapp C.E. Respiratory diseases in women. European Respiratory Monograph. Vol. 8. Monograph 25. 2003;90-103 Maney Publishing, Leeds, United Kingdom
28. Miyagi M., Morishita M., Iwamoto Y. Effects of sex hormones on production of prostaglandin E2 by human peripheral monocytes. J Periodontol. 64:1993;1075-1078
29. Wingender E., Chen X., Fricke E., Geffers R., Hehl R., Liebich I., et al. The TRANSFAC system on gene expression regulation. Nucleic Acids Res. 29:2001;281-283
30. Troisi R.J., Speizer F.E., Willett W.C., Trichopoulos D., Rosner B. Menopause, postmenopausal oestrogen preparations, and the risk of adult-onset asthma: a prospective cohort study. Am J Repir Crit Care Med. 152:1995;1183-1188
31. Gavett S.H., Madison S.L., Chulada P.C., Scarborough P.E., Qu W., Boyle J.E., et al. Allergic lung responses are increased in prostaglandin H synthase-deficient mice. J Clin Investig. 104:1999;721-732
32. Pavord I.D., Tattersfield A.E. Bronchoprotective role for endogenous prostaglandin E2. Lancet. 345:1995;436-438
33. Vignola A.M., Bellia V. Transcriptional regulation of COX-2: a key mechanism in the pathogenesis of nasal polyposis in aspirin-sensitive asthmatics? Allergy. 58:2003;95-97
34. 2 metabolite) in plasma and urine of patients with bronchial asthma and healthy controls following the aspirin challenge. J Allergy Clin Immunol. 11:2003;743-749
35. 2 concentrations and cyclooxygenase-2 expression in asthmatic subjects with sputum eosinophilia. J Allergy Clin Immunol. 112:2003;709-716
36. The ENFUMOSA Study Group. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. Eur Respir J. 22:2003;470-477