Effects of repeatedly heated palm oil on serum lipid profile, lipid peroxidation and homocysteine levels in a post-menopausal rat model

McGill Journal of Medicine

Volumn 11, Issue 2, 2008, Pages 145-151

  Adam, Siti Khadijah ^a   Soelaiman, Ima Nirwana ^a   Umar, Nor Aini ^a   Mokhtar, Norhayati ^a   Mohamed, Norazlina ^a   Jaarin, Kamsiah ^a  

^a DEPARTMENT OF PHARMACOLOGY   (Malaysia)

Author keywords

Atherosclerosis; Heated oil; Lipid peroxidation; Menopause; Palm oil

Indexed keywords

ESTROGEN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PALM OIL; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DISEASE PREDISPOSITION; ESTROGEN DEFICIENCY; FEMALE; HEATING; LIPID BLOOD LEVEL; LIPID PEROXIDATION; NONHUMAN; OVARIECTOMY; PATHOGENESIS; POSTMENOPAUSE; PROTEIN BLOOD LEVEL; RAT; SPRAGUE DAWLEY RAT;

EID: 63049130460     PISSN: 1201026X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Rossouw JE. Hormones, genetic factors and gender differences in cardiovascular disease. Cardiovasc Res. 2002; 53(3): 550-557.
2. Baker L, Meldrum KK, Wang M, et al. The role of estrogen in cardiovascular disease. J Surg Res. 2003; 115(2): 325-344.
3. Nabulsi AA, Folsom AR, White A, et al. Association of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women. The Atherosclerosis Risk in Communities Study Investigators. N Eng J Med. 1993; 328(15): 1069-1075.
4. Ayres S, Tang M, Ravi Subbiah MT. Estradiol-17β as an antioxidant: some distinct features when compared with common fat-soluble antioxidants. J Lab ClinMed. 1996; 128(4): 367-375.
5. Badeau M, Adlercreutz H, Kaihovaara P, Tikkanen MJ. Estrogen A-ring structure and antioxidative effect on lipoproteins. J Steroid Biochem Mol Biol. 2005; 96(3-4): 271-278.
6. Osterud B, Bjorklid E. Role of monocytes in atherogenesis. Physiol Rev. 2003; 83(4): 1069-1112.
7. Plutzky J, Libby P. Pathophysiology of atherosclerotic heart disease. In: Tonkin AM, editor. Atherosclerosis and heart disease. London, UK: Martin Dunitz; 2003. p. 1-12.
8. Steinberg D, Witztum JL. Lipoproteins and atherogenesis. Current concepts. JAMA. 1990; 264(23): 3047-3052.
9. Su SJ, Huang LW, Pai LS, Liu HW, Chang KL. Homocysteine at pathophysiologic concentrations activates human monocyte and induces cytokine expression and inhibits macrophage migration inhibitory factor expression. Nutrition 2005; 21(10): 994-1002.
10. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med. 1998; 338(15): 1042-1050
11. Olszewski AJ, McCully KS. Homocysteine metabolism and the oxidative modification of proteins and lipids. Free Radic Biol Med. 1993; 14(6): 683-693.
12. Dobarganes C, Márquez-Ruiz G. Oxidized fats in foods. Curr Opin Clin Nutr Metab Care 2003; 6(2): 157-163.
13. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med. 1991; 11(1): 81-128.
14. Owu DU, Osim EE, Ebong PE. Serum liver enzymes profile of Wistar rats following chronic consumption of fresh or oxidized palm oil diets. Acta Trop. 1998; 69(1): 65-73.
15. Izaki Y, Yoshikawa S, Uchiyama M. Effect of ingestion thermally oxidized frying oil on peroxidative criteria in rats. Lipids 1984; 19(5): 324-331.
16. Staprans I, Rapp JH, Pan XM, Hardman DA, Feingold KR. Oxidized lipids in the diet accelerate the development of fatty streaks in cholesterol-fed rabbits. Arterioscl Throm Vasc Biol. 1996; 16(4): 533-538.
17. Benedetti PC, D'Aquino M, Di Felice M, Gentili V, Tagliamonte B, Tomassi G. Effects of a fraction of thermally oxidized soy bean oil on growing rats. Nutr Rep Int. 1987; 36(2): 387-401.
18. Ledwozyw A, Michalak J, Stepien A, Kadziolka A. The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis. Clin Chim Acta 1986; 155(3): 275-283.
19. Lowry OH, Rosebrugh NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951; 193(1): 265-75.
20. Maxwell SRJ, Lip GYH. Free radicals and antioxidants in cardiovascular disease. Br J Clin Pharmacol 1997; 44(4): 307-317.
21. Kamsiah J, Nafeeza MI, Ngang AC. Suppression of atherogenesis in cholesterol-fed rabbits treated with nicardipine. Asia Pac J Pharm. 1994; 9(3): 183-187.
22. Nwanguma BC, Achebe AC, Ezeanyika LUS, Eze LC. Toxicity of oxidized fats II: tissue levels of lipid peroxides in rats fed a thermally oxidized corn oil diet. Food Chem Toxicol. 1999; 37(4): 413-416.
23. Cottrell RC. Introduction: nutritional aspects of palm oil. Am J Clin Nutr. 1991; 53(4 Suppl): 989S-1009S.
24. Hageman G, Verhagen H, Schutte B, Kleinjans J. Biological effects of short-term feeding to rats of repeatedly used deep-frying fats in relation to fat mutagen content. Food Chem Toxicol. 1991; 29(10): 689-698.
25. Hur SJ, Du M, Nam K, Williamson M, Ahn DU. Effect of dietary fats on blood cholesterol and lipid and the development of atherosclerosis in rabbits. Nutr Res. 2005; 25(10): 925-935.
26. Adam SK, Sulaiman NA,Md Top AG, Jaarin K. Heating reduces vitamin E content in palm and soy oils. Malays J Biochem Molec Biol. 2007; 15(2): 76-79.
27. Kamsiah J, Norhayati M, Norzana G, Nor Aini U, Ima-Nirwana S. Effects of heated vegetable oils on serum lipids and aorta of ovariectomized rats. Pak J Nutr. 2006; 5(1): 19-29.
28. Rueda-Clausen CF, Silva FA, Lindarte MA, et al. Olive, soybean and palm oils intake have a similar acute detrimental effect over the endotelial function in healthy young subjects. Nutr Metab Cardiovas Dis. 2007; 17(1): 50-57.
29. Adam SK, Das S, Soelaiman IN, Umar NA, Jaarin K. Consumption of repeatedly heated soy oil increases the serum parameters related to atherosclerosis in ovariectomised rats. Tohoku J Exp Med. 2008; 215(3): 219-226.
30. Witztum JL, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest. 1991; 88(6): 1785-1792.
31. Lapointe A, Couillard C, Lemieux S. Effects of dietary factors on oxidation of low-density lipoprotein particles. J Nutr Biochem. 2006; 17(10): 645-658.
32. Shuid AN, Chuan LH, Mohamed N, Jaarin K, Fong YS,