Significance of salivary adrenomedullin in the maintenance of oral health: Stimulation of oral cell proliferation and antibacterial properties

Regulatory Peptides

Volumn 154, Issue 1-3, 2009, Pages 16-22

  Gröschl, Michael ^a   Wendler, Olaf ^a   Topf, Hans Georg ^a   Bohlender, Jörg ^b   Köhler, Henrik ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Adrenomedullin; Antibacterial defense; Cell proliferation; Keratinocytes; Saliva

Indexed keywords

ADRENOMEDULLIN; AGAROSE; BROXURIDINE; MESSENGER RNA; RECEPTOR ACTIVITY MODIFYING PROTEIN 2; RECEPTOR ACTIVITY MODIFYING PROTEIN 3;

ADOLESCENT; ADULT; AGED; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; CELL NUCLEUS; CELL PROLIFERATION; CHILD; CONTROLLED STUDY; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MALE; MICROTITER PLATE ASSAY; MOUTH CAVITY; MOUTH FLORA; MOUTH HYGIENE; PHOTOMETRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SALIVA; SALIVARY GLAND; SALIVARY GLAND DUCT; STAINING; WESTERN BLOTTING; YEAST;

ADOLESCENT; ADRENOMEDULLIN; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CELL PROLIFERATION; CELLS, CULTURED; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT DYES; HUMANS; IMMUNOHISTOCHEMISTRY; INDOLES; KERATINOCYTES; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MOUTH MUCOSA; PSEUDOMONAS; RHODAMINES; SALIVA; SALIVARY GLANDS; STAPHYLOCOCCUS EPIDERMIDIS; YOUNG ADULT;

BACTERIA (MICROORGANISMS);

EID: 63049122659     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2008.12.007     Document Type: Article

References (53)

1. Nuki C., Kawasaki H., Kitamura K., Takenaga M., Kangawa K., Eto T., et al. Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds. Biochem Biophys Res Commun 196 1 (1993) 245-251
2. Ishiyama Y., Kitamura K., Ichiki Y., Nakamura S., Kida O., Kangawa K., et al. Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats. Eur J Pharmacol 241 2-3 (1993) 271-273
3. Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Nakamura S., Matsuo H., et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 192 2 (1993) 553-560
4. Ichiki Y., Kitamura K., Kangawa K., Kawamoto M., Matsuo H., and Eto T. Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma. FEBS Lett 338 1 (1994) 6-10
5. Wimalawansa S.J. Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. Crit Rev Neurobiol 11 2-3 (1997) 167-239
6. Albertin G., Carraro G., Parnigotto P.P., Conconi M.T., Ziolkowska A., Malendowicz L.K., et al. Human skin keratinocytes and fibroblasts express adrenomedullin and its receptors, and adrenomedullin enhances their growth in vitro by stimulating proliferation and inhibiting apoptosis. Int J Mol Med 11 (2003) 635-639
7. Autelitano D.J., and Ridings R. Adrenomedullin signalling in cardiomyocytes is dependent upon CRLR and RAMP2 expression. Peptides 22 11 (2001) 1851-1857
8. Schwarz N., Renshaw D., Kapas S., and Hinson J.P. Adrenomedullin increases the expression of calcitonin-like receptor and receptor activity modifying protein 2 mRNA in human microvascular endothelial cells. J Endocrinol 190 2 (2006) 505-514
9. Ando K., and Fuijta T. Lessons from the adrenomedullin knockout mouse. Regul Pept 112 (2003) 185-188
10. Belloni A.S., Trejter M., Malendowicz L.K., and Nussdorfer G.G. Adrenomedullin stimulates proliferation and inhibits apoptosis of immature rat thymocytes cultured in vitro. Peptides 24 (2003) 295-300
11. Allaker R.P., and Kapas S. Adrenomedullin and mucosal defence: interaction between host and microorganism. Regul Pept 112 (2003) 147-152
12. Kapas S., Bansal A., Bhargava V., Maher R., Malli D., Hagi-Pavli E., et al. Adrenomedullin expression in pathogen-challenged oral epithelial cells. Peptides 22 9 (2001) 1485-1489
13. Tache Y. Inhibition of gastric acid secretion and ulcers by calcitonin [correction of calciton] gene-related peptide. Ann N Y Acad Sci 657 (1992) 240-247
14. Martinez V., Barquist E., Rivier J., and Tache Y. Central CRF inhibits gastric emptying of a nutrient solid meal in rats: the role of CRF2 receptors. Am J Physiol 274 5 Pt 1 (1998) G965-G970
15. Rossowski W.J., Jiang N.Y., and Coy D.H. Adrenomedullin, amylin, calcitonin gene-related peptide and their fragments are potent inhibitors of gastric acid secretion in rats. Eur J Pharmacol 336 1 (1997) 51-63
16. Fukuda K., Tsukada H., Onomura M., Saito T., Kodama M., Nakamura H., et al. Effect of adrenomedullin on ion transport and muscle contraction in rat distal colon. Peptides 19 6 (1998) 1043-1047
17. Fernandez de Arcaya I., Lostao M.P., Martinez A., Berjon A., and Barber A. Effect of adrenomedullin and proadrenomedullin N-terminal 20 peptide on sugar transport in the rat intestine. Regul Pept 129 1-3 (2005) 147-154
18. Mulder H., Ahren B., Karlsson S., and Sundler F. Adrenomedullin: localization in the gastrointestinal tract and effects on insulin secretion. Regul Pept 62 2-3 (1996) 107-112
19. Kaneko H., Mitsuma T., Nagai H., Mori S., Iyo T., Kusugami K., et al. Central action of adrenomedullin to prevent ethanol-induced gastric injury through vagal pathways in rats. Am J Physiol 274 6 Pt 2 (1998) R1783-R1788
20. Fukuda K., Tsukada H., Oya M., Onomura M., Kodama M., Nakamura H., et al. Adrenomedullin promotes epithelial restitution of rat and human gastric mucosa in vitro. Peptides 20 1 (1999) 127-132
21. Olsen P.S., Poulsen S.S., Kirkegaard P., and Nexo E. Role of submandibular saliva and epidermal growth factor in gastric cytoprotection. Gastroenterology 87 1 (1984) 103-108
22. Thulesen J., Bor M.V., Thulesen S., Nexo E., Poulsen S.S., and Jorgensen P.E. Altered secretion and processing of epidermal growth factor in adrenergic-induced growth of the rat submandibular gland. Regul Pept 106 1-3 (2002) 105-114
23. Watson A.Y., Anderson J.K., Siminoski K., Mole J.E., and Murphy R.A. Cellular and subcellular colocalization of nerve growth factor and epidermal growth factor in mouse submandibular glands. Anat Rec 213 3 (1985) 365-376
24. Gröschl M., Rauh M., Wagner R., Neuhuber W., Metzler M., Tamgüney G., et al. Identification of leptin in human saliva. J Clin Endocrinol Metab 86 11 (2001) 5234-5239
25. Gröschl M., Topf H.G., Bohlender J., Zenk J., Klussmann S., Dötsch J., et al. Identification of ghrelin in human saliva: expression by the salivary glands and potential role on the proliferation of oral keratinocytes. Clin Chem 51 6 (2005) 997-1006
26. Goebel C., Mackay L.G., Vickers E.R., and Mather L.E. Determination of defensin HNP-1, HNP-2, and HNP-3 in human saliva by using LC/MS. Peptides 21 6 (2000) 757-765
27. Murakami M., Ohtake T., Dorschner R.A., and Gallo R.L. Cathelicidin antimicrobial peptides are expressed in salivary glands and saliva. J Dent Res 81 12 (2002) 845-850
28. Geetha C., Venkatesh S.G., Dunn B.H., and Gorr S.U. Expression and anti-bacterial activity of human parotid secretory protein (PSP). Biochem Soc Trans 31 Pt 4 (2003) 815-818
29. MacKay B.J., Goodman H., Cox D., Grossbard B.L., Iacono V.J., and Pollock J.J. Development of an enzyme-linked immunosorbent assay for determination of lysozyme in human parotid and submandibular-sublingual salivas. J Clin Microbiol 19 6 (1984) 844-848
30. Sakata J., Shimokubo T., Kitamura K., Nishizono M., Iehiki Y., Kangawa K., et al. Distribution and characterization of immunoreactive rat adrenomedullin in tissue and plasma. FEBS Lett 352 (1994) 105-108
31. Cameron V.A., and Fleming A.M. Novel sites of adrenomedullin gene expression in mouse and rat tissues. Endocrinology 139 5 (1998) 2253-2264
32. Kapas S., Brown D.W., Farthing P.M., and Hagi-Pavli E. Adrenomedullin has mitogenic effects on human oral keratinocytes: involvement of cyclic AMP. FEBS Lett 418 3 (1997) 287-290
33. Allaker R.P., Zihni C., and Kapas S. An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, respiratory tract and gut microflora. FEMS Immunol Med Microbiol 23 4 (1999) 289-293
34. Kapas S., Pahal K., Cruchley A.T., Hagi-Pavli E., and Hinson J.P. Expression of adrenomedullin and its receptors in human salivary tissue. J Dent Res 83 4 (2004) 333-337
35. Gröschl M., Köhler H., Topf H.G., Rupprecht T., and Rauh M. Evaluation of saliva collection devices for the analysis of steroids, peptides and therapeutic drugs. J Pharm Biomed Anal 47 (2008) 478-486
36. Livesey J.H., and Donald R.A. Prevention of adsorption losses during radioimmunoassay of polypeptide hormones: effectiveness of albumins, gelatin, caseins, Tween 20 and plasma. Clin Chim Acta 123 1-2 (1982) 193-198
37. Moriyama T., Otani T., and Maruo T. Expression of adrenomedullin by human placental cytotrophoblasts and choriocarcinoma JAr cells. J Clin Endocrinol Metab 86 8 (2001) 3958-3961
38. Lauer G., Schimming R., and Frankenschmidt A. Intraoral wound closure with tissue-engineered mucosa: new perspectives for urethra reconstruction with buccal mucosa grafts. Plast Reconstr Surg 107 1 (2001) 25-33
39. Gröschl M., Topf H.G., Kratzsch J., Dötsch J., Rascher W., and Rauh M. Salivary leptin induces increased expression of growth factors in oral keratinocytes. J Mol Endocrinol 34 1 (2005) 353-366
40. Wang H., Tomikawa M., Jones M.K., Sarfeh I.J., and Tarnawski A.S. Ethanol injury triggers activation of adrenomedullin and its receptor genes in gastric mucosa. Dig Dis Sci 44 7 (1999) 1390-1400
41. Zhou M., Chaudry I.H., and Wang P. The small intestine is an important source of adrenomedullin release during polymicrobial sepsis. Am J Physiol Regul Integr Comp Physiol 281 2 (2001) R654-R660
42. Kitani M., Sakata J., Asada Y., Kitamura K., and Eto T. Distribution and expression of adrenomedullin in human gastrointestinal tissue. Ann Clin Biochem 35 Pt 5 (1998) 643-648
43. Gröschl M. Current status of salivary hormone analysis. Clin Chem 54 11 (2008) 1759-1769
44. Hirayama N., Kitamura K., Imamura T., Kato J., Koiwaya Y., and Eto T. Secretion and clearance of the mature form of adrenomedullin in humans. Life Sci 64 26 (1999) 2505-2509
45. Kinoshita H., Fujimoto S., Kitamura K., Matsuura Y., Uezono S., Hisanaga S., et al. Increased plasma levels of mature adrenomedullin in chronic glomerulonephritis. Nephron 86 3 (2000) 333-338
46. Yamaga J., Hashida S., Kitamura K., Tokashiki M., Aoki T., Inatsu H., et al. Direct measurement of glycine-extended adrenomedullin in plasma and tissue using an ultrasensitive immune complex transfer enzyme immunoassay in rats. Hypertens Res 26 Suppl (2003) S45-S53
47. Kapas S., Tenchini M.L., and Farthing P.M. Regulation of adrenomedullin secretion in cultured human skin and oral keratinocytes. J Invest Dermatol 117 2 (2001) 353-359
48. Hussain Q.A., Sheehan B.E., McKay I.J., and Allaker R.P. Antimicrobial activity does not predict cytokine response to adrenomedullin or its shortened derivatives. Mediat Inflamm 2007 (2007) 10.1155/2007/30987 (Article ID 30987):4 pages
49. Allaker R.P., Grosvenor P.W., McAnerney D.C., Sheehan B.E., Srikanta B.H., Pell K., et al. Mechanisms of adrenomedullin antimicrobial action. Peptides 27 (2005) 661-666
50. Christensen B., Fink J., Merrifield R.B., and Mauzerall D. Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes. Proc Natl Acad Sci USA 85 (1988) 5072-5076
51. Julian M., Cacho M., Garcia M.A., Martin-Santamaria S., de Pascual-Teresa B., Ramos A., et al. Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities. Eur J Med Chem 40 8 (2005) 737-750
52. Garcia M.A., Martin-Santamaria S., Pascual-Teresa B., Ramos A., Julian M., and Martinez A. Adrenomedullin: a new and promising target for drug discovery. Expert Opin Ther Targets 10 2 (2006) 303-317
53. Garcia M.A., Martin-Santamaria S., Cacho M., de la Llave F.M., Julian M., Martinez A., et al. Synthesis, biological evaluation, and three-dimensional quantitative structure-activity relationship study of small-molecule positive modulators of adrenomedullin. J Med Chem 48 12 (2005) 4068-4075