Evidence for a modulatory role of orexin A on the nitrergic neurotransmission in the mouse gastric fundus

Regulatory Peptides

Volumn 154, Issue 1-3, 2009, Pages 54-59

  Baccari, Maria Caterina ^a   Bani, Daniele ^a   Calamai, Franco ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Neuromodulation; Nitric oxide; Non adrenergic; Non cholinergic

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; 1,1 DIMETHYL 4 PHENYLPIPERAZINIUM; 1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CARBACHOL; GUANETHIDINE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; OREXIN 1 RECEPTOR; OREXIN A; PAPAVERINE; SPASMOLYTIC AGENT; TETRODOTOXIN; VASOACTIVE INTESTINAL POLYPEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; ELECTRIC FIELD; ELECTROSTIMULATION; FEMALE; IMMUNOCYTOCHEMISTRY; MODULATION; MOUSE; NEUROTRANSMISSION; NITRERGIC NERVE; NONHUMAN; POSTGANGLIONIC NERVE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; STOMACH FUNDUS; STOMACH MOTILITY;

ANIMALS; BENZOXAZOLES; CARBACHOL; CHOLINERGIC AGONISTS; DIMETHYLPHENYLPIPERAZINIUM IODIDE; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; FEMALE; GASTRIC FUNDUS; GUANETHIDINE; GUANYLATE CYCLASE; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED STRAINS; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; NEUROPEPTIDES; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OXYTOCIN; PAPAVERINE; SYNAPTIC TRANSMISSION; TETRODOTOXIN; UREA; VASOACTIVE INTESTINAL PEPTIDE;

EID: 63049103317     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2008.12.005     Document Type: Article

References (34)

1. Chemelli R.M., Willie J.T., Sinton C.M., Elmquist J.K., Scammell T., Lee C., Richardson J.A., Wiliams S.C., Xiong Y., Kisanuki Y., Fitch T.E., Nakazato M., Hammer R.E., Saper C.B., and Yanagisawa M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98 (1999) 437-451
2. Kirchgessner A.L. Orexins in the brain-gut axis. Endocr Rev 23 (2002) 1-15
3. Lin L., Faraco J., Li R., Kadotani H., Rogers W., Lin X., Qiu X., de Jong P.J., Nishino S., and Mignon E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98 (1999) 365-376
4. Sakurai T. Orexin: a link between energy homeostasis and adaptive behaviour. Curr Opin Clin Nutr Metab Care 6 (2003) 353-360
5. Burdyga G., Lal S., Spiller D., Jiang W., Thompson D., Attwood S., Saeed S., Grundy D., Varro A., Dimaline R., and Dockray G.J. Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans. Gastroenterology 124 (2003) 129-139
6. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliff J.G., and Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18 (1998) 9996-10015
7. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanka H., Williams S.C., Richarson J.A., Kozlowski G.P., Wilson S., Arch J.R., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 (1998) 573-585
8. Doane D.F., Lawson M.A., Meade J.R., Kotz C.M., and Beverly J.L. Orexin-induced feeding requires NMDA receptor activation in the perifornical region of the lateral hypothalamus. Am J Physiol 293 (2007) R1022-R1026
9. Edwards C.M., Abusnana S., Sunter D., Murphy K.G., Ghatei M.A., and Bloom S.R. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J Endocrinol 160 (1999) R7-R12
10. Kunii K., Yamanaka A., Nambu T., Matsuzaki I., Goto K., and Sakurai T. Orexins/hypocretins regulate drinking behaviour. Brain Res 842 (1999) 256-261
11. Takahashi N., Okumura T., Yamada H., and Kohgo Y. Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats. Biochem Biophys Res Commun 254 (1999) 623-627
12. Thorpe A.J., Mullett M.A., Wang C., and Kotz C.M. Peptides that regulate food intake: regional, metabolic, and circadian specificity of lateral hypothalamic orexin A feeding stimulation. Am J Physiol 284 (2003) R1409-R1417
13. Kirchgessner A.L., and Liu M. Orexin synthesis and response in the gut. Neuron 24 (1999) 941-951
14. Korczynski W., Ceregrzyn M., Matyjek R., Kato I., Kuwahara A., Wolinski J., and Zabielski R. Central and local (enteric) action of orexins. J Physiol Pharmacol 57 suppl. 6 (2006) 17-42
15. Näslund E., Ehrström M., Ma J., Hellström P.M., and Kirchgessner A.L. Localization and effects of orexin on fasting motility in the rat duodenum. Am J Physiol 282 (2002) G470-G479
16. Bult H., Boeckxstaens G.E., Pelckmans P.A., Jordaens F.H., Van Maercke Y.M., and Herman A.G. Nitric oxide as an inhibitory non-adrenergic, non-cholinergic neurotransmitter. Nature 345 (1990) 346-347
17. Lefebvre R.A. Non-adrenergic, non-cholinergic neurotransmission in the proximal stomach. Gen Pharmacol 24 (1993) 257-266
18. Rand M.J. Nitrergic neurotransmission: nitric oxide as a mediator of non-adrenergic, non-cholinergic neuro-effector transmission. Clin Exp Pharmacol Physiol 19 (1992) 147-169
19. Ehrström M., Näslund E., Ma J., Kirchgessner A.L., and Hellström P.M. Physiological regulation and NO-dependent inhibition of migrating myoelectric complex in the rat small bowel by OXA. Am J Physiol 285 (2003) G688-G695
20. Ehrström M., Levin F., Kirchgessner A.L., Schmidt P.T., Hilsted L.M., Gryback P., Jacobsson H., Hellström P.M., and Näslund E. Stimulatory effect of endogenous orexin A on gastric emptying and acid secretion independent of gastrin. Regul Pept 132 (2005) 9-16
21. Satoh Y., Uchida M., Fujita A., Nishio H., Takeuchi T., and Hata F. Possible role of orexin A in nonadrenergic, non-cholinergic inhibitory response of muscle of the mouse small intestine. Eur J Pharmacol 428 (2001) 337-342
22. Baccari M.C., and Calamai F. Influence of orexin A on the mechanical activity of mouse gastric strips. Regul Pept 146 (2008) 67-72
23. Matsuo K., Kaibara M., Uezono Y., Hayashi H., Taniyama K., and Natane Y. Involvement of cholinergic neurons in orexin-induced contraction of guinea pig ileum. Eur J Pharmacol 452 (2002) 105-109
24. Baccari M.C., and Calamai F. Modulation of nitrergic relaxant responses by peptides in the mouse gastric fundus. Regul Pept 98 (2001) 27-32
25. Baccari M.C., Bani D., Bigazzi M., and Calamai F. Influence of relaxin on the neurally-induced relaxant responses of the mouse gastric fundus. Biol Reprod 71 (2004) 1325-1329
26. Desai K.M., Zembowicz A., Sessa W.C., and Vane J.R. Nitroxidergic nerves mediate vagally-induced relaxation in the isolated stomach of the guinea-pig. Proc Natl Acad Sci (U S A) 88 (1991) 11490-11494
27. Lefebvre R.A., Smits G.J., and Timmermans J.P. Study of NO and VIP as non-adrenergic, non-cholinergic neurotransmitters in the pig gastric fundus. Br J Pharmacol 116 (1995) 2017-2026
28. Meulemans A.L., Eelen J.G.M.G., and Schuurkes J.A.J. NO mediates gastric relaxation after brief vagal stimulation in anesthetized dogs. Am J Physiol 269 (1995) G255-G261
29. Mule F., and Serio R. NANC inhibitory neurotransmission in mouse isolated stomach: involvement of nitric oxide, ATP and vasoactive intestinal polypeptide. Br J Pharmacol 140 (2003) 431-437
30. Takahashi T., and Owyang C. Vagal control of nitric oxide and vasoactive intestinal polypeptide release in the regulation of gastric relaxation in rat. J. Physiol 484 (1995) 481-492
31. Kobashi M., Furudono Y., Matsuo R., and Yamamoto T. Central orexin facilitates gastric relaxation and contractility in rats. Neurosci Lett 332 (2002) 171-174
32. Krowicki Z.K., Burmeister M.A., Berthoud H.R., Scullion R.T., Fuchs K., and Hornby P.J. Orexins in rat dorsal motor nucleus of the vagus potently stimulate gastric motor function. Am J Physiol 283 (2002) G465-472
33. Ehrström M., Gustafsson T., Finn A., Kirchgessner A., Gryback P., Jacobsson H., Hellström P.M., and Näslund E. Inhibitory effect of exogenous orexin A on gastric emptying, plasma leptin, and the distribution of orexin and orexin receptors in the gut and pancreas in man. J Clin Endocrinol Met 90 (2005) 2370-2377
34. Korczynski W., Ceregrzyn M., Kato I., Wolinski J., and Zabielski R. The effect of orexins on intestinal motility in vitro in fed and fasted rats. J Physiol Pharmacol 57 (2006) 43-54