Older individuals appear to acquire mitotically older colorectal cancers

Journal of Pathology

Volumn 217, Issue 4, 2009, Pages 483-488

  Woo, Yen Jung ^a   Siegmund, Kimberly D ^a   Tavaré, Simon ^b,c   Shibata, Darryl ^a,d  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d NONE   (United States)

Author keywords

Ageing Copyright; Cancer; Colon; Genealogy; Methylation; Molecular clock; Stem cell

Indexed keywords

ADULT; AGED; AGING; ARTICLE; CANCER CELL; CANCER INCIDENCE; CELL DIVISION; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA REPLICATION; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MITOSIS; PRIORITY JOURNAL; ZYGOTE; CANCER STAGING; CANCER STEM CELL; CASE CONTROL STUDY; COLON; COLORECTAL TUMOR; COMPARATIVE STUDY; CYTOLOGY; GENETICS; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY;

ADULT; AGED; AGING; CASE-CONTROL STUDIES; COLON; COLORECTAL NEOPLASMS; CPG ISLANDS; DNA METHYLATION; HUMANS; MALE; MIDDLE AGED; MITOSIS; NEOPLASM STAGING; NEOPLASTIC STEM CELLS;

EID: 62849112584     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2506     Document Type: Article

References (24)

1. Nowell PC. The clonal evolution of tumor cell populations. Science 1976;194:23-28.
2. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-170.
3. Armitage P, Doll R. The age distribution of cancer and multistage theory of carcinogenesis. Br J Cancer 1954;1:1-12.
4. Preston-Martin S, Pike MC, Ross RK, Jones PA, Henderson BE. Increased cell division as a cause of human cancer. Cancer Res 1990;50:7415- 7421.
5. Cairns J. Mutation selection and the natural history of cancer. Nature 1975;255:197-200.
6. Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007;449:1003-1007.
7. Yatabe Y, Tavaré S, Shibata D. Investigating stem cells in human colon by using methylation patterns. Proc Natl Acad Sci USA 2001;98:10839-10844.
8. Shibata D, Tavaré S. Counting divisions in a human somatic cell tree: how, what and why? Cell Cycle 2006;5:610-614.
9. Wang TL, Rago C, Silliman N, Ptak J, Markowitz S, Willson JK, et al. Prevalence of somatic alterations in the colorectal cancer cell genome. Proc Natl Acad Sci USA 2002;99:3076-3080.
10. Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, et al. The consensus coding sequences of human breast and colorectal cancers. Science 2006;314:268-274.
11. Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, Leary RJ, et al. The genomic landscapes of human breast and colorectal cancers. Science 2007;318:1108-1113.
12. Holliday R, Pugh JE. DNA modification mechanisms and gene activity during development. Science 1975;187:226-232.
13. Issa JP. CpG-island methylation in aging and cancer. Curr Top Microbiol Immunol 2000;249:101-118.
14. Chu M, Siegmund KD, Hao QL, Crooks GM, Tavaré S, Shi bata D. Inferring relative numbers of human leucocyte genome replications. Br J Haematol 2008;141:862-871.
15. Kim JY, Siegmund KD, Tavare S, Shibata D. Age-related human small intestine methylation: evidence for stem cell niches. BMC Med 2005;3:10.
16. Kim JY, Tavaré S, Shibata D. Counting human somatic cell replications: Methylation mirrors endometrial stem cell divisions. Proc Natl Acad Sci USA 2005;102:17739-17744.
17. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
18. Campbell F, Appleton MA, Shields CJ, Williams GT. No differ ence in stem cell somatic mutation between the background mucosa of right- and left-sided sporadic colorectal carcinomas. J Pathol 1998;186:31-35.
19. Okayasu I, Hana K, Tsuruta T, Okamura N, Ogawa T, Tokuyama W, et al. Significant increase of colonic mutated crypts correlates with age in sporadic cancer and diverticulosis cases, with higher frequency in the leftthan right-side colorectum. Cancer Sci 2006;97:362-367.
20. Jones S, Chen WD, Parmigiani G, Diehl F, Beerenwinkel N, Antal T, et al. Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci USA 2008;105:4283-4288.
21. Calabrese P, Tavaré S, Shibata D. Pre-tumor progression: clonal evolution of human stem cell populations. Am J Pathol 2004;164:1337-1346.
22. Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. Creation of human tumour cells with defined genetic elements. Nature 1999;400:464-468.
23. Bernards R, Weinberg RA. A progression puzzle. Nature 2002;418:823.
24. Weinberg RA. Mechanisms of malignant progression. Carcinogen esis 2008;29:1092-1095.