Progesterone and medroxyprogesterone acetate differentially regulate α4 subunit expression of GABAA receptors in the CA1 hippocampus of female rats

Physiology and Behavior

Volumn 97, Issue 1, 2009, Pages 58-61

  Pazol, Karen ^a   Northcutt, Katharine V ^b   Patisaul, Heather B ^c   Wallen, Kim ^d   Wilson, Mark E ^d  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

^d EMORY UNIVERSITY   (United States)

Author keywords

Allopregnanolone; GABAa receptors; Neurosteroids

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ESTRADIOL BENZOATE; MEDROXYPROGESTERONE ACETATE; MESSENGER RNA; PROGESTERONE;

ANIMAL EXPERIMENT; ARTICLE; EMOTION; ENZYME INHIBITION; ENZYME SYNTHESIS; FEMALE; HIPPOCAMPUS; IN SITU HYBRIDIZATION; NEUROENDOCRINOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; DRUG INTERACTIONS; ESTRADIOL; FEMALE; HIPPOCAMPUS; MEDROXYPROGESTERONE 17-ACETATE; OVARIECTOMY; PROGESTERONE; RATS; RATS, LONG-EVANS; RECEPTORS, GABA-A; RNA, MESSENGER;

EID: 62749106722     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2009.01.021     Document Type: Article

References (47)

1. Hersh A.L., Stefanick M.L., and Stafford R.S. National use of postmenopausal hormone therapy: annual trends and response to recent evidence. JAMA 291 (2004) 47-53
2. Sitruk-Ware R. Progestins in hormonal replacement therapy and prevention of endometrial disease. In: Sitruk-Ware R., and Mischell Jr. D.R. (Eds). Progestins and antiprogestins in clinical practice (2000), Marcel Dekker, Inc., New York 269-277
3. The Writing Group for the PEPI Trial. Effects of hormone replacement therapy on endometrial histology in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. JAMA 275 (1996) 370-375
4. Anderson G.L., Limacher M., Assaf A.R., Bassford T., Beresford S.A., Black H., et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA 291 (2004) 1701-1712
5. Rossouw J.E., Anderson G.L., Prentice R.L., LaCroix A.Z., Kooperberg C., Stefanick M.L., et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288 (2002) 321-333
6. Boothby L.A., Doering P.L., and Kipersztok S. Bioidentical hormone therapy: a review. Menopause 11 (2004) 356-367
7. Koh K.K., Jin D.K., Yang S.H., Lee S.K., Hwang H.Y., Kang M.H., et al. Vascular effects of synthetic or natural progestagen combined with conjugated equine estrogen in healthy postmenopausal women. Circulation 103 (2001) 1961-1966
8. McNeill A.M., Zhang C., Stanczyk F.Z., Duckles S.P., and Krause D.N. Estrogen increases endothelial nitric oxide synthase via estrogen receptors in rat cerebral blood vessels: effect preserved after concurrent treatment with medroxyprogesterone acetate or progesterone. Stroke 33 (2002) 1685-1691
9. Sunday L., Tran M.M., Krause D.N., and Duckles S.P. Estrogen and progestagens differentially modulate vascular proinflammatory factors. Am J Physiol Endocrinol Metab 291 (2006) E261-267
10. Franke H.R., and Vermes I. Differential effects of progestogens on breast cancer cell lines. Maturitas 46 Suppl 1 (2003) S55-S58
11. Wood C.E., Register T.C., Lees C.J., Chen H., Kimrey S., and Cline J.M. Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys. Breast Cancer Res Treat 101 (2007) 125-134
12. Seeger H., Wallwiener D., and Mueck A.O. The effect of progesterone and synthetic progestins on serum- and estradiol-stimulated proliferation of human breast cancer cells. Horm Metab Res (2003) 76-80
13. Simoncini T., Mannella P., Fornari L., Caruso A., Willis M.Y., Garibaldi S., et al. Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells. Endocrinology 145 (2004) 5745-5756
14. Otsuki M., Saito H., Xu X., Sumitani S., Kouhara H., Kishimoto T., et al. Progesterone, but not medroxyprogesterone, inhibits vascular cell adhesion molecule-1 expression in human vascular endothelial cells. Arterioscler Thromb Vasc Biol 21 (2001) 243-248
15. Nilsen J., and Brinton R.D. Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling. Proc Natl Acad Sci U S A 100 (2003) 10506-10511
16. Bjorn I., Bixo M., Nojd K.S., Collberg P., Nyberg S., Sundstrom-Poromaa I., et al. The impact of different doses of medroxyprogesterone acetate on mood symptoms in sequential hormonal therapy. Gynecol Endocrinol 16 (2002) 1-8
17. Bjorn I., Bixo M., Nojd K.S., Nyberg S., and Backstrom T. Negative mood changes during hormone replacement therapy: a comparison between two progestogens. Am J Obstet Gynecol 183 (2000) 1419-1426
18. Sherwin B.B. The impact of different doses of estrogen and progestin on mood and sexual behavior in postmenopausal women. J Clin Endocrinol Metab 72 (1991) 336-343
19. Majewska M.D., Harrison N.L., Schwartz R.D., Barker J.L., and Paul S.M. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science 232 (1986) 1004-1007
20. Jarrell J. Studies on the developmental pattern of rat ovarian 3α-hydroxysteroid dehydrogenase: inhibition of the postpubertal activity with medroxyprogesterone acetate in vivo. J Steroid Biochem 21 (1984) 151-156
21. Lee T.C., Miller W.L., and Auchus R.J. Medroxyprogesterone acetate and dexamethasone are competitive inhibitors of different human steroidogenic enzymes. J Clin Endocrinol Metab 84 (1999) 2104-2110
22. Penning T.M., Sharp R.B., and Krieger N.R. Purification and properties of 3α-hydroxysteroid dehydrogenase from rat brain cytosol. Inhibition by nonsteroidal anti-inflammatory drugs and progestins. J Biol Chem 260 (1985) 15266-15272
23. Bernardi F., Pluchino N., Pieri M., Begliuomini S., Lenzi E., Puccetti S., et al. Progesterone and medroxyprogesterone acetate effects on central and peripheral allopregnanolone and beta-endorphin levels. Neuroendocrinology 83 (2006) 348-359
24. A receptors. J Neuroendocrinol 7 (1995) 171-177
25. Bitran D., Dugan M., Renda P., Ellis R., and Foley M. Anxiolytic effects of the neuroactive steroid pregnanolone (3α-OH-5β-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum. Brain Res 850 (1999) 217-224
26. A receptors triggers anxiety at puberty. Nat Neurosci 10 (2007) 469-477
27. A receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects. Neuropharmacology 49 (2005) 573-586
28. A receptor pharmacology in adult rats. J Pharmacol Exp Ther 305 (2003) 541-548
29. A receptor subunit levels in association with increased anxiety in the female rat. Brain Res 910 (2001) 55-66
30. Smith S.S., Ruderman Y., Frye C., Homanics G., and Yuan M. Steroid withdrawal in the mouse results in anxiogenic effects of 3α,5β-THP: a possible model of premenstrual dysphoric disorder. Psychopharmacology 186 (2006) 323-333
31. A receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid. Nature 392 (1998) 926-930
32. A receptor α4 subunit in association with increased anxiety. J Neurosci 18 (1998) 5275-5284
33. Wang Z.X., Liu Y., Young L.J., and Insel T.R. Hypothalamic vasopressin gene expression increases in both males and females postpartum in a biparental rodent. J Neuroendocrinol 12 (2000) 111-120
34. Lauren H.B., Pitkanen A., Nissinen J., Soini S.L., Korpi E.R., and Holopainen I.E. Selective changes in gamma-aminobutyric acid type A receptor subunits in the hippocampus in spontaneously seizing rats with chronic temporal lobe epilepsy. Neurosci Lett 349 (2003) 58-62
35. Paxinos G., and Watson C. The Rat Brain in Stereotaxic Coordinates. 4th edition (1988), Academic Press, San Diego
36. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci 12 (1992) 1040-1062
37. Castensson A., Emilsson L., Preece P., and Jazin E.E. High-resolution quantification of specific mRNA levels in human brain autopsies and biopsies. Genome Res 10 (2000) 1219-1229
38. Lott D.C., Kim S.J., Cook Jr. E.H., and de Wit H. Dopamine transporter gene associated with diminished subjective response to amphetamine. Neuropsychopharmacology 30 (2005) 602-609
39. A receptors: focus on the α4 and δ subunits. Pharmacol Ther 116 (2007) 58-76
40. A receptor in rat thalamus. Mol Pharmacol 56 (1999) 110-115
41. A receptors containing the α4 subunit. Mol Pharmacol 50 (1996) 670-678
42. A receptors. Neuropharmacology 43 (2002) 651-661
43. A receptors containing the δ subunit. J Neurosci 22 (2002) 1541-1549
44. Sundstrom Poromaa I., Smith S., and Gulinello M. GABA receptors, progesterone and premenstrual dysphoric disorder. Arch Women Ment Health 6 (2003) 23-41
45. Gulledge A.T., and Stuart G.J. Excitatory actions of GABA in the cortex. Neuron 37 (2003) 299-309
46. A receptor-mediated postsynaptic conductance. J Neurophysiol 68 (1992) 197-212
47. - transport. J Physiol 519 (1999) 693-712