Cross talk between angiotensin II type 1 and type 2 receptors: Cellular mechanism of angiotensin type 2 receptor-mediated cell growth inhibition

Hypertension Research - Clinical and Experimental

Volumn 22, Issue 2, 1999, Pages 67-74

  Horiuchi, Masatsugu ^a   Hamai, Meiko ^a   Cui, Tai Xing ^a   Iwai, Masaru ^a   Minokoshi, Yasuhiko ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiotensin II; Cell growth; Receptor; Signaling

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE RECEPTOR; PHOSPHATASE; RECEPTOR SUBTYPE;

CARDIOVASCULAR SYSTEM; CELL GROWTH; ENZYME ACTIVATION; HEMODYNAMICS; MOLECULAR CLONING; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION;

EID: 0032808774     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.22.67     Document Type: Review

References (70)

1. Dzau VJ: Cardiac renin-angiotensin system: molecular and functional aspects. Am J Med 1988; 84 (Suppl 3A): 22-27.
2. Dzau VJ, Gibbons GH, Pratt RE: Molecular mechanism of vascular renin-angiotensin system in mypintimal hyperplasia. Hypertension 1991; 18 (Suppl II): II-100-II-105.
3. Whitebread S, Mele M, Kamber B, de Gasparo M: Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochem Biophys Res Commun 1989; 163: 284-291.
4. Chiu AT, Herblin WF, McCall DE, et al: Identification of angiotensin II receptor subtypes. Biochem Biophys Res Commun 1989; 165: 196-203.
5. Sasaki K, Yamano Y, Bardhan S, et al: Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor. Nature 1991; 351: 230-233.
6. Murphy TJ, Alexander RW, Griendling KK, Runge MS, Bernstein KE: Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature 1991; 351: 233-236.
7. Mukoyama M, Nakajima M, Horiuchi M, Sasamura H, Pratt RE, Dzau VJ: Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors. J Biol Chem 1993; 268: 24539-24542.
8. Kambayashi Y, Bardhan S, Takahashi K, et al: Molecular cloning of novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. J Biol Chem 1993; 268: 24543-24546.
9. Matsubara H: Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases. Circ Res 1998; 83: 1182-1191.
10. Horiuchi M, Akishita M, Dzau VJ: Recent progress in angiotensin II type 2 receptor research in the cardiovascular system. Hypertension 1999; 33: 613-621.
11. Grady EF, Sechi LA, Griffin CA, Schambelan M, Kalinyak JE: Expression of AT2 receptors in the developing rat fetus. J Clin Invest 1991; 88: 921-933.
12. Millan MA, Jacobowitz DM, Aguilera G, Catt KJ: Differential distribution of ATI and AT2 angiotensin II receptor subtypes in the rat brain during development. Proc Natl Acad Sci USA 1991; 88: 11440-11444.
13. Lopez J, Lorell BH, Ingelfinger JR, et al. Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. Am J Physiol 1994; 36: H844-H852.
14. Nio Y, Matsubara H, Murasawa S, Kanasaki M, Inada M: Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarction. J Clin Invest 1995; 95: 46-54.
15. Nakajima M, Hutchinson H, Fujinaga M, et al: The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer. Proc Natl Acad Sci USA 1995; 92; 10663-10667.
16. Dzau VJ, Horiuchi M: Differential expression of angiotensin receptor subtypes in the myocardium: a hypothesis. Eur Heart J 1996; 17: 978-980.
17. Ohkubo N, Matsubara H, Nozawa Y, et al: Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism. Circulation 1997; 96: 3954-3962.
18. Haywood GA, Gullestad L, Katsuya T, et al: AT1 and AT2 receptor gene expression in human heart failure. Circulation 1997; 95: 1201-1206.
19. Wharton J, Morgan K, Rutherford RA, et al: Differential distribution of angiotensin AT2 receptors in the normal and failing human heart. J Pharmacol Exp Ther 1998; 284: 323-336.
20. Liu Y-H, Yang X-P, Sharov VG, et al: Effect of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. J Clin Invest 1997; 99: 1926-1935.
21. Akishita M, Horiuchi M, Yamada H, Zhang L, Dzau VJ: Accentuated vascular proliferation and altered remodeling afer injury in mice lacking angiotensin II type 2 receptor. Circulation 1997; 96 (Suppl 1): I-547 (Abstract).
22. Stoll M, Steckelings UM, Paul M, Bottari SP, Metzger R, Unger T: The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells. J Clin Invest 1995; 95, 651-657.
23. Booz GW, Baker KM: Role of type 1 and type 2 angiotensin receptors in angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy. Hypertension 1996; 28, 635-640.
24. Hayashida W, Horiuchi M, Dzau VJ: Intracellular third loop domain of angiotensin II type 2 receptor: role in the cellular signal transduction and functional expression. J Biol Chem 1996; 271: 21985-21992.
25. Tsuzuki S, Eguchi S, Inagami T: Inhibition of cell proliferation and activation of protein tyrosine phosphatase mediated by angiotensin II type 2 (AT2) receptor in R3T3 cells. Biochem Biophys Res Commun 1996; 228: 825-830.
26. Tsuzuki S, Matoba T, Eguchi S, Inagami T: Angiotensin II type 2 receptor inhibits cell proliferation and activates tyrosine phosphatase. Hypertension 1996; 28; 916-918.
27. Goto M, Mukoyama M, Suga S, et al: Growth-dependent induction of angiotensin II type 2 receptor in rat mesangial cells. Hypertension 1997; 30: 358-362.
28. van Kesteren CA, van Heugten HA, Lamers JM, Saxena PR, Schalekamp MA, Danser AH: Angiotensin II-mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblasts. J Mol Cell Cardiol 1997; 29: 2147-2157.
29. Laflamme L, de Gasparo M, Gallo JM, Payet MD, Gallo-Payet N: Angiotensin II induction of neurite outgrowth by AT2 receptors in NG108-15 cells: Effect counteracted by the ATI receptors. J Biol Chem 1996; 271: 22729-22735.
30. Meffert S, Stoll M, Steckelings UM, Bottari SP, Unger T: The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells. Mol Cell Endocrinol 1996; 122: 59-67.
31. Yamada H, Akishita M, Ito M, et al: AT2 Receptor and vascular smooth muscle cell differentiation in vascular development. Hypertension 1999 (in press).
32. Yamada T, Horiuchi M, Dzau VJ: The novel angiotensin II type 2 receptor mediates programmed cell death. Proc Natl Acad Sci USA 1996; 93: 156-160.
33. Horiuchi M, Yamada T, Hayashida W, Dzau VJ: Interferon regulatory factor-1 upregulates angiotensin type 2 receptor and induces apoptosis. J Biol Chem 1997; 272: 11952-11958.
34. Horiuchi M, Hayashida W, Kambe T, Yamada T, Dzau VJ: Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. J Biol Chem 1997; 272: 19022-19026.
35. Yamada T, Akishita M, Pollman M, Gibbons GH, Dzau VJ, Horiuchi M: Angiotenisn II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin type 1 receptor action: an in vitro gene transfer study. Life Sci 1998; 63: PL289-PL295.
36. Dimmeler S, Rippmann V, Weiland U, Haendeler J, Zeiher AM: Angiotensin II induces apoptosis of human endothelial cells: protective effect of nitric oxide. Circ Res 1997; 81: 970-976.
37. Daviet L, Horiuchi M, Hayashida W, Lethonen JYA, Bishopric NH, Dzau VJ: Antagomistic actins of type-1 and type-2 angiotensin II receptors on rat cardiomyocyte apoptosis. Circulation 1998; 98 (Suppl 1): I-741 (Abstract).
38. Li W, Ye Y, Fu B, et al: Genetic deletion of AT2 receptor antagonizes angiotensin II-induced apoptosis in fibroblasts of the mouse embryo. Biochem Biophys Res Commun 1998; 250: 72-76.
39. Gallinat S, Busche S, Schutze S, Kronke M, Unger T: AT2 receptor stimulation induces generation of ceramides in PC12W cells. FEBS Lett 1999; 443: 75-79.
40. Lehtonen JYA, Horiuchi M, Daviet L, Akishita M, Dzau VJ: Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis. J Biol Chem 1999; 274: 16901-16906.
41. Pollman M, Yamada M, Horiuchi M, Gibbons GH: Vasoactive substances regulate vascular smooth muscle cell apoptosis: countervailing influences of nitric oxide and angiotensin II. Circ Res 1996; 79: 748-756.
42. Kajstura J, Cigola E, Malhotra A, et al. Angiotensin II induces apoptosis of adult ventricular myocytes in vitro. J Mol Cell Cardiol 1997; 29: 859-870.
43. Pierzchalski P, Reiss K, Cheng W, et al: p53 Induces myocyte apoptosis via the activation of the renin-angiotensin system. Exp Cell Res 1997; 234: 57-65
44. Leri A, Claudio PP, Li Q, et al. Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell. J Clin Invest 1998; 101: 1326-1342.
45. Shanmugam S, Corvol P, Gasc J-M: Angiotensin II type 2 receptor mRNA expression in the developing cardiopulmonary system of the rat. Hypertension 1996; 28: 91-97.
46. Akishita M, Ito M, Lehtonen JYA, Daviet L, Dzau VJ, Horiuchi M: Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth. J Clin Invest 1999; 103: 63-71.
47. Sun H, Charles CH, Lau LF, Tonks NK: MKP-1 (3CH134), an immediate early gene product, is dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell 1993; 75: 487-493.
48. Bottari SP, King IN, Reichlin S, Dahlstroem I, Lydon N, de Gasparo M: The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclase. Biochem Biophys Res Commun 1992; 183: 206-211.
49. Buisson B, Laflamme L, Bottari SP, de Gasparo M, Gallo-Payet N, Payet MD: A G protein is involved in the angiotensin AT2 receptor inhibition of the T-type calcium current in non-differentiated NG108-15 cells. J Biol Chem 1995; 270: 1670-1674.
50. Bedecs K, Elbaz N, Sutren M, et al: Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphatase. Biochem J 1997; 325: 449-454.
51. Huang XC, Richards EM, Sumners C: Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type 1 receptors and inhibited by angiotensin II type 2 receptors. J Biol Chem 1996; 271: 15635-15641.
52. Masaki H, Kurihara T, Yamaki A, et al: Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. J Clin Invest 1998; 101: 527-535.
53. Horiuchi M, Hayashida W, Akishita M, et al: Stimulation of different subtypes of angiotensin II receptors, AT1 and AT2 receptors, regulate STAT activation by negative cross talk. Circ Res 1999; 84: 876-882.
54. Lai K, Wang H, Lee WS, Jain MK, Lee ME, Haber E: Mitogen-activated protein kinase phosphatase-1 in rat arterial smooth muscle cell proliferation. J Clin Invest 1996; 98: 1560-1567.
55. Xu Q, Fawcett TW, Gorospe M, Guyton KZ, Liu Y, Holbrook NJ: Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension. Hypertension 1997; 30: 106-111.
56. Kudoh S, Komuro I, Mizuno T, et al: Angiotensin II stimulates c-Jun NH2-terminal kinase in cultured cardiac myocytes of neonatal rats. Circ Res 1997; 80: 139-146
57. Kim S, Izumi Y, Yano M, Hamaguchi A, Miura K, Yamanaka S: Angiotensin blockade inhibits activation of mitogen-activated protein kinases in rat balloon-injured artery. Circulation 1998; 97: 1731-1737.
58. Zhang J, Pratt RE: The AT2 receptor selectively associates with Giα2 and Giα3 in the rat fetus. J Biol Chem 1996; 271: 15026-15033.
59. - current in neurons by an angiotensin II type 2 receptor fragment. Am J Physiol 1995; 268: C278-C282.
60. Haithcock D, Jiao H, Cui XL, Hopfer U, Douglas JG: Renal proximal tubular AT2 receptor: signaling and transport. J Am Soc Nephrol 1999; 10 (Suppl 11): S69-S74.
61. Siragy HM, Carey RM: The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3′, 5′-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats. J Clin Invest 1996; 97: 1978-1982.
62. Siragy HM, Carey RM: The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats. J Clin Invest 1997; 100: 264-269.
63. Seyedi N, Xu X, Nasjletti A, Hintze TH: Coronary kinin generation mediates nitric oxide release after angiotensin receptor stimulation. Hypertension 1995; 26: 164-170.
64. Gohlke P, Pees C, Unger T: AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism. Hypertension 1998; 31: 349-355.
65. Madrid MI, Garcia-Salom M, Tornel J, De Gasparo M, Fenoy FJ: Effect of interactions between nitric oxide and angiotensin II on pressure diuresis and natriuresis. Am J Physiol 1997; 273: R1676-R1682.
66. Jin XH, Wang ZQ, Siragy HM, Guerrant RL, Carey RM: Regulation of jejunal sodium and water absorption by angiotensin subtype receptors. Am J Physiol 1998; 275: R515-R523.
67. Arima S, Endo Y, Yaoita H, et al: Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole. J Clin Invest 1997; 100: 2816-2823.
68. Campbell DJ, Kladis A, Valentijn AJ: Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme. J Cardiovasc Pharmacol 1995; 26: 233-240.
69. Gavras I, Manolis A, Gavras H: Effects of ACE inhibition on the heart. J Hum Hypertens 1995; 9: 455-458.
70. Gavras H, Gavras I: Cardioprotective potential of angiotensin converting enzyme inhibitors. J Hypertens 1991; 9: 385-392.