The immunosuppressor ST1959, a 3,5-diaryl-s-triazole derivative, inhibits cell activation by reducing NFAT nuclear residency

International Journal of Immunopathology and Pharmacology

Volumn 22, Issue 1, 2009, Pages 29-42

  Lindstedt, R ^a   Ruggiero, V ^a   D'Alessio, V ^a   Manganello, S ^a   Petronzelli, F ^a   Stasi, M A ^a   Vendetti, S ^b   Assandri, A ^c   Carminati, P ^a   De Santis, Rita ^a  

^a Sigma Tau SpA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c CROSS SA   (Switzerland)

Author keywords

Immunoregulation; NFAT; ST1959; T cell activation; TNBS colitis

Indexed keywords

3 (2 ETHYLPHENYL) 5 (3 METHOXYPHENYL) 1H 1,2,4 TRIAZOLE; CYCLOSPORIN A; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 4; INTERLEUKIN 9; IONOMYCIN; LEPTOMYCIN B; PHORBOL 12 ACETATE 13 MYRISTATE; ST 1959; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT 1; TRINITROBENZENESULFONIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; IMMUNOMODULATION; LEUKEMIA CELL LINE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SWISS JAMES LAMBERT MOUSE;

EID: 62649127612     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200902200105     Document Type: Article

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