Plant-derived recombinant F1, V, and F1-V fusion antigens of Yersinia pestis activate human cells of the innate and adaptive immune system

International Journal of Immunopathology and Pharmacology

Volumn 22, Issue 1, 2009, Pages 133-143

  Del Prete, Gianfranco ^a   Santi, L ^b   Andrianaivoarimanana, V ^c   Amedei, A ^a   Domarle, O ^c   D'Elios, M M ^a   Arntzen, C J ^d   Rahalison, L ^c   Mason, H S ^d  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c Institut Pasteur de Madagascar   (Italy)

^d ARIZONA STATE UNIVERSITY   (United States)

Author keywords

Effect on human innate immunity; Oral anti plague vaccine; Plant derived vaccine for Y. pestis infection; Recognition by human serum antibodies; Recognition by human T cells

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; PLANT EXTRACT; RECOMBINANT FRACTION 1 CAPSULAR ANTIGEN; RECOMBINANT FRACTION 1 CAPSULAR V ANTIGEN; RECOMBINANT V ANTIGEN; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOREACTIVITY; INNATE IMMUNITY; MALE; MEDICINAL PLANT; MEMORY T LYMPHOCYTE; MONOCYTE; NICOTIANA BENTHAMIANA; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLAGUE; PLANT LEAF; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; YERSINIA PESTIS;

EID: 62649094571     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200902200115     Document Type: Article

References (37)

1. Perry RD, Fetherston JD. Yersinia pestis - etiologic agent of plague. Clin Microbiol Rev 1997; 10:35-66.
2. Jones SM, Griffin KF, Hodgson I, Williamson ED. Protective efficacy of a fully recombinant plague vaccine in the guinea pig. Vaccine 2003; 21:3912-18.
3. Meyer KF, Hightower JA, McCrumb FR. Plague immunization. VI. Vaccination with the fraction I antigen of Yersinia pestis. J Infect Dis 1974; 129: S41-5.
4. Heath DG, Anderson J, George W, Mauro JM, Welkos SL, Andrews GP, Adamovicz J, Friedlander AM. Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine. Vaccine 1998; 16: 1131-7.
5. Glynn A, Roy CJ, Powell BS, Adamovicz JJ, Freytag LC, Clements JD. Protection against aerosolized Yersinia pestis challenge following homologous and heterologous prime-boost with recombinant plague antigens. Infect Immun 2005; 73:5256-61.
6. Andrews G, Heath D, Anderson G, Welkos S, Friedlander A. Fraction I capsular antigen (F1) purification from Yersinia pestis CO92 and from an Escherichia coli recombinant strain and efficacy against lethal plague challenge. Infect Immun 1996; 64:2180-7.
7. Une T, Brubaker RR. Roles of V antigen in promoting virulence and immunity in yersiniae. J Immunol 1984; 133:2226-30.
8. Leary SE, Williamson ED, Griffin KF, Russell P, Eley SM, Titball RW. Active immunization with recombinant V antigen from Yersinia pestis protects mice against plague. Infect Immun 1995; 63:2854-8.
9. Hill J, Leary S, Griffin K, Williamson E, Titball RW. Regions of Yersinia pestis V antigen that contribute to protection against plague identified by passive and active immunization. Infect Immun 1997; 65:4476-82.
10. Haq TA, Mason HS, Clements JD, Arntzen CJ. Oral immunization with a recombinant bacterial antigen produced in transgenic plants. Science 1995; 268: 714-16.
11. Mason HS, Haq TA, Clements JD, Arntzen CJ. Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene. Vaccine 1998; 16:1336-43.
12. Marillonnet S, Giritch A, Gils M, Kandzia R, Klimyuk V, Gleba Y. In planta engineering of viral RNA replicons: Efficient assembly by recombination of DNA modules delivered by Agrobacterium. Proc Natl Acad Sci USA 2004; 101:6852-7.
13. Gleba Y, Klimyuk V, Marillonnet S. Magnifection - a new platform for expressing recombinant vaccines in plants. Vaccine 2005; 23:2042-28.
14. Santi L, Giritch A, Roy CJ, et al. Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system. Proc Natl Acad Sci USA 2006; 103:861-6.
15. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol 2003; 21:335-76.
16. Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat Immunol 2005; 6:769-76.
17. Baker EE, Sommer H, Foster LE, Meyer E, Meyer KF. Studies on immunization against plague. I. The isolation and characterization of the soluble antigen of pasteurella pestis. J Immunol 1952; 68:131-45.
18. Amedei A, Cappon A, Codolo G, et al. The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses. J Clin Invest 2006; 116:1092-101.
19. Chanteau S, Rahalison L, Ralafiarisoa L, Foulon J, Ratsitorahina M, Ratsifasoamanana L, Carniel E, Nato F. Development and testing of a rapid diagnostic test for bubonic and pneumonic plague. Lancet 2003; 361:211-16.
20. Groupe d'études sur la peste: Boisier P, Carniel E, Chanteau S, et al. In Atlas de la peste à Madagascar. E. Chanteau, ed Institut Pasteur de Madagascar, 2002.
21. Rasoamanana B, Leroy F, Boisier P, Rasolomaharo M, Buchy P, Carniel E, Chanteau S. Field evaluation of an immunoglobulin G anti-F1 enzyme linked immunosorbent assay for diagnosis of human plague in Madagascar. Clin Diagn Lab Immunol 1997; 4: 587-91.
22. Sodhi A, Sharma RK, Harsh V, Batra HV, Tuteja U. Mechanism of rLcrV and rYopB mediated immunosuppression in murine peritoneal macrophages. Mol Immunol 2004; 41:767-74.
23. Sharma RK, Sodhi A, Batra HV, Tuteja U. Effect of rLcrV and rYopB from Yersinia pestis on murine peritoneal macrophages in vitro. Immunol Letters 2004; 93:179-87.
24. Glynn A, Freytag LC, Clements JD. Effect of homologous and heterologous prime-boost on the immune response to recombinant plague antigens. Vaccine 2005; 23:1957-65.
25. Eyles JE, Elvin SJ, Westwood A, LeButt CS, Alpar HO, Somavarapu S, Williamson ED. Immunisation against plague by transcutaneous and intradermal application of subunit antigens. Vaccine 2004; 22: 4365-73.
26. Williamson ED, Flick-Smith HC, LeButt C, et al. Human immune response to a plague vaccine comprising recombinant F1 and V antigens. Infect Immun 2005; 73:3598-608.
27. Tacket CO, Mason HS, Losonsky G, Clements JD, Levine MM, Arntzen CJ. Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato. Nat Med 1998; 4:607-9.
28. Thanavala Y, Mahoney M, Pal S, et al. Immunogenicity in humans of an edible vaccine for hepatitis B Proc Natl Acad Sci USA 2005; 102:3378-82.
29. van Laar JM, Melchers M, Teng YKO, et al. Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells. Am J Pathol 2007; 171:917-27.
30. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector Th17 and regulatory T cells. Nature 2006; 44:235-8.
31. Burrows TW. An antigen determining virulence in Pasteurella pestis. Nature 1956; 177:426-7.
32. Brubaker RR. Interleukin-10 and inhibition of innate immunity to Yersiniae: Roles of Yops and LcrV (V antigen). Infect Immun 2003; 71:3673-81.
33. Sing A, Rost D, Tvardovskaia N, et al. Yersinia V-antigen exploits Toll-like Receptor 2 and CD14 for interleukin 10-mediated immunosuppression. J Exp Med 2002; 196:1017-24.
34. Pouliot K, Pan N, Wang S, Lu S, Lien E, Goguen JD. Evaluation of the Role of LcrV-Toll-Like Receptor 2-Mediated Immunomodulation in the Virulence of Yersinia pestis. Infect Immun 2007; 75:3571-80.
35. Overheim KA, De Paolo W, De Bord K, et al. LcrV plague vaccine with altered immunomodulary properties. Infect Immun 2005; 73:5152-9.
36. Roggenkamp A, Geiger AM, Leitritz L, Kessler A, Heesemann J. Passive immunity to infection with Yersinia spp. Mediated by anti-recombinant V antigen is dependent on polymorphism of V antigen. Infect Immun 1997; 65:446-51.
37. Alvarez ML, Pinyerd HL, Crisantes JD, Rigano MM, Pinkhasov J, Walmsley AM, Mason HS, Cardineau G.A. Plant-made subunit vaccine against pneumonic and bubonic plague is orally immunogenic in mice. Vaccine 2006; 24:2477-90.