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Volumn 37, Issue 4, 2009, Pages 1269-1279

FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure

Author keywords

[No Author keywords available]

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X MENTAL RETARDATION PROTEIN 1; FRAGILE X MENTAL RETARDATION PROTEIN 2; MESSENGER RNA; RNA; RNA BINDING PROTEIN; RNA SC35; UNCLASSIFIED DRUG;

EID: 62549119174     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkn1058     Document Type: Article
Times cited : (66)

References (43)
  • 1
    • 0030137717 scopus 로고    scopus 로고
    • Identification of the gene FMR2, associated with FRAXE mental retardation
    • Gecz,J., Gedeon,A.K., Sutherland,G.R. and Mulley,J.C. (1996) Identification of the gene FMR2, associated with FRAXE mental retardation. Nat. Genet., 13, 105-108.
    • (1996) Nat. Genet , vol.13 , pp. 105-108
    • Gecz, J.1    Gedeon, A.K.2    Sutherland, G.R.3    Mulley, J.C.4
  • 2
    • 0030138905 scopus 로고    scopus 로고
    • Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island
    • Gu,Y., Shen,Y., Gibbs,R.A. and Nelson,D.L. (1996) Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG island. Nat. Genet., 13, 109-113.
    • (1996) Nat. Genet , vol.13 , pp. 109-113
    • Gu, Y.1    Shen, Y.2    Gibbs, R.A.3    Nelson, D.L.4
  • 6
    • 0031239275 scopus 로고    scopus 로고
    • Gene structure and subcellular localization of FMR2, a member of a new family of putative transcription activators
    • Gecz,J., Bielby,S., Sutherland,G.R. and Mulley,J.C. (1997) Gene structure and subcellular localization of FMR2, a member of a new family of putative transcription activators. Genomics, 44, 201-213.
    • (1997) Genomics , vol.44 , pp. 201-213
    • Gecz, J.1    Bielby, S.2    Sutherland, G.R.3    Mulley, J.C.4
  • 7
    • 0033973242 scopus 로고    scopus 로고
    • Localization of the fragile X mental retardation 2 (FMR2) protein in mammalian brain
    • Miller,W.J., Skinner,J.A., Foss,G.S. and Davies,K.E. (2000) Localization of the fragile X mental retardation 2 (FMR2) protein in mammalian brain. Eur. J. Neurosci., 12, 381-384.
    • (2000) Eur. J. Neurosci , vol.12 , pp. 381-384
    • Miller, W.J.1    Skinner, J.A.2    Foss, G.S.3    Davies, K.E.4
  • 8
  • 9
    • 0030050159 scopus 로고    scopus 로고
    • LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias
    • Ma,C. and Staudt,L.M. (1996) LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias. Blood, 87, 734-745.
    • (1996) Blood , vol.87 , pp. 734-745
    • Ma, C.1    Staudt, L.M.2
  • 10
    • 0033429143 scopus 로고    scopus 로고
    • AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)
    • Taki,T., Kano,H., Taniwaki,M., Sako,M., Yanagisawa,M. and Hayashi,Y. (1999) AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23). Proc. Natl Acad. Sci. USA, 96, 14535-14540.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 14535-14540
    • Taki, T.1    Kano, H.2    Taniwaki, M.3    Sako, M.4    Yanagisawa, M.5    Hayashi, Y.6
  • 11
    • 33846522525 scopus 로고    scopus 로고
    • The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling
    • Bitoun,E., Oliver,P.L. and Davies,K.E. (2007) The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. Hum. Mol. Genet., 16, 92-106.
    • (2007) Hum. Mol. Genet , vol.16 , pp. 92-106
    • Bitoun, E.1    Oliver, P.L.2    Davies, K.E.3
  • 12
    • 0034662218 scopus 로고    scopus 로고
    • Altered lymphoid development in mice deficient for the mAF4 proto-oncogene
    • Isnard,P., Core,N., Naquet,P. and Djabali,M. (2000) Altered lymphoid development in mice deficient for the mAF4 proto-oncogene. Blood, 96, 705-710.
    • (2000) Blood , vol.96 , pp. 705-710
    • Isnard, P.1    Core, N.2    Naquet, P.3    Djabali, M.4
  • 13
    • 0035093076 scopus 로고    scopus 로고
    • Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian
    • Tang,A.H., Neufeld,T.P., Rubin,G.M. and Muller,H.A. (2001) Transcriptional regulation of cytoskeletal functions and segmentation by a novel maternal pair-rule gene, lilliputian. Development, 128 801-813.
    • (2001) Development , vol.128 , pp. 801-813
    • Tang, A.H.1    Neufeld, T.P.2    Rubin, G.M.3    Muller, H.A.4
  • 14
    • 0035047263 scopus 로고    scopus 로고
    • Fragile XE-associated familial mental retardation protein 2 (FMR2) acts as a potent transcription activator
    • Hillman,M.A. and Gecz,J. (2001) Fragile XE-associated familial mental retardation protein 2 (FMR2) acts as a potent transcription activator. J. Hum. Genet., 46, 251-259.
    • (2001) J. Hum. Genet , vol.46 , pp. 251-259
    • Hillman, M.A.1    Gecz, J.2
  • 15
    • 50849092487 scopus 로고    scopus 로고
    • The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer
    • Didiot,M.C., Tian,Z., Schaeffer,C., Subramanian,M., Mandel,J.L. and Moine,H. (2008) The G-quartet containing FMRP binding site in FMR1 mRNA is a potent exonic splicing enhancer. Nucleic Acids Res., 36 4902-4912.
    • (2008) Nucleic Acids Res , vol.36 , pp. 4902-4912
    • Didiot, M.C.1    Tian, Z.2    Schaeffer, C.3    Subramanian, M.4    Mandel, J.L.5    Moine, H.6
  • 16
    • 0030051618 scopus 로고    scopus 로고
    • Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms
    • Sittler,A., Devys,D., Weber,C. and Mandel,J.L. (1996) Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmr1 protein isoforms. Hum. Mol. Genet., 5, 95-102.
    • (1996) Hum. Mol. Genet , vol.5 , pp. 95-102
    • Sittler, A.1    Devys, D.2    Weber, C.3    Mandel, J.L.4
  • 18
    • 0035801393 scopus 로고    scopus 로고
    • The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
    • Schaeffer,C., Bardoni,B., Mandel,J.L., Ehresmann,B., Ehresmann,C. and Moine,H. (2001) The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif. EMBO J., 20, 4803-4813.
    • (2001) EMBO J , vol.20 , pp. 4803-4813
    • Schaeffer, C.1    Bardoni, B.2    Mandel, J.L.3    Ehresmann, B.4    Ehresmann, C.5    Moine, H.6
  • 19
    • 0030988942 scopus 로고    scopus 로고
    • Identification of a new class of exonic splicing enhancers by in vivo selection
    • Coulter,L.R., Landree,M.A. and Cooper,T.A. (1997) Identification of a new class of exonic splicing enhancers by in vivo selection. Mol. Cell Biol., 17, 2143-2150.
    • (1997) Mol. Cell Biol , vol.17 , pp. 2143-2150
    • Coulter, L.R.1    Landree, M.A.2    Cooper, T.A.3
  • 20
    • 0032758839 scopus 로고    scopus 로고
    • A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein
    • Bardoni,B., Schenck,A. and Mandel,J.L. (1999) A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein. Hum. Mol. Genet., 8, 2557-2566.
    • (1999) Hum. Mol. Genet , vol.8 , pp. 2557-2566
    • Bardoni, B.1    Schenck, A.2    Mandel, J.L.3
  • 21
    • 0037022227 scopus 로고    scopus 로고
    • A direct role of SRY and SOX proteins in pre-mRNA splicing
    • Ohe,K., Lalli,E. and Sassone-Corsi,P. (2002) A direct role of SRY and SOX proteins in pre-mRNA splicing. Proc. Natl Acad. Sci. USA, 99, 1146-1151.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 1146-1151
    • Ohe, K.1    Lalli, E.2    Sassone-Corsi, P.3
  • 22
    • 33846665074 scopus 로고    scopus 로고
    • Fragile X related protein 1 isoforms differentially modulate the affinity of fragile X mental retardation protein for G-quartet RNA structure
    • Bechara,E., Davidovic,L., Melko,M., Bensaid,M., Tremblay,S., Grosgeorge,J., Khandjian,E.W., Lalli,E. and Bardoni,B. (2007) Fragile X related protein 1 isoforms differentially modulate the affinity of fragile X mental retardation protein for G-quartet RNA structure. Nucleic Acids Res., 35, 299-306.
    • (2007) Nucleic Acids Res , vol.35 , pp. 299-306
    • Bechara, E.1    Davidovic, L.2    Melko, M.3    Bensaid, M.4    Tremblay, S.5    Grosgeorge, J.6    Khandjian, E.W.7    Lalli, E.8    Bardoni, B.9
  • 23
    • 54049149937 scopus 로고    scopus 로고
    • Alteration of expression of muscle specific isoforms of the fragile X related protein 1 (FXR1P) in facioscapulohumeral muscular dystrophy patients
    • Davidovic,L., Sacconi,S., Bechara,E.G., Delplace,S., Allegra,M., Desnuelle,C. and Bardoni,B. (2008) Alteration of expression of muscle specific isoforms of the fragile X related protein 1 (FXR1P) in facioscapulohumeral muscular dystrophy patients. J. Med. Genet., 45, 679-685.
    • (2008) J. Med. Genet , vol.45 , pp. 679-685
    • Davidovic, L.1    Sacconi, S.2    Bechara, E.G.3    Delplace, S.4    Allegra, M.5    Desnuelle, C.6    Bardoni, B.7
  • 24
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak,K.J. and Schmittgen,T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 25, 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 25
    • 0041669439 scopus 로고    scopus 로고
    • Nuclear speckles: A model for nuclear organelles
    • Lamond,A.I. and Spector,D.L. (2003) Nuclear speckles: A model for nuclear organelles. Nat. Rev. Mol. Cell. Biol., 4, 605-612.
    • (2003) Nat. Rev. Mol. Cell. Biol , vol.4 , pp. 605-612
    • Lamond, A.I.1    Spector, D.L.2
  • 26
    • 0027953244 scopus 로고
    • Disruption of pre-mRNA in vivo results in reorganization of splicing factors
    • O'Keefe,R.T., Mayeda,A., Sadowski,C.L., Krainer,A.R. and Spector,D.L. (1994) Disruption of pre-mRNA in vivo results in reorganization of splicing factors. J. Cell Biol., 124, 249-260.
    • (1994) J. Cell Biol , vol.124 , pp. 249-260
    • O'Keefe, R.T.1    Mayeda, A.2    Sadowski, C.L.3    Krainer, A.R.4    Spector, D.L.5
  • 28
    • 34548726219 scopus 로고    scopus 로고
    • Interactions of the G-quartet forming semaphorin 3F RNA with the RGG box domain of the fragile X protein family
    • Menon,L. and Mihailescu,M.R. (2007) Interactions of the G-quartet forming semaphorin 3F RNA with the RGG box domain of the fragile X protein family. Nucleic Acids Res., 35, 5379-5392.
    • (2007) Nucleic Acids Res , vol.35 , pp. 5379-5392
    • Menon, L.1    Mihailescu, M.R.2
  • 29
    • 0024843757 scopus 로고
    • Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops
    • Sundquist,W.I. and Klug,A. (1989) Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops. Nature, 342, 825-829.
    • (1989) Nature , vol.342 , pp. 825-829
    • Sundquist, W.I.1    Klug, A.2
  • 30
    • 0034161419 scopus 로고    scopus 로고
    • Exonic splicing enhancers: Mechanism of action, diversity and role in human genetic diseases
    • Blencowe,B.J. (2000) Exonic splicing enhancers: Mechanism of action, diversity and role in human genetic diseases. Trends Biochem. Sci. 25, 106-110.
    • (2000) Trends Biochem. Sci , vol.25 , pp. 106-110
    • Blencowe, B.J.1
  • 31
    • 33947310727 scopus 로고    scopus 로고
    • An RNA G-quadruplex in the 5' UTR of the NRAS protooncogene modulates translation
    • Kumari,S., Bugaut,A., Huppert,J.L. and Balasubramianan,S. (2007) An RNA G-quadruplex in the 5' UTR of the NRAS protooncogene modulates translation. Nat. Chem. Biol., 3, 18-21.
    • (2007) Nat. Chem. Biol , vol.3 , pp. 18-21
    • Kumari, S.1    Bugaut, A.2    Huppert, J.L.3    Balasubramianan, S.4
  • 33
    • 33750053559 scopus 로고    scopus 로고
    • Nucleolar trafficking is essential for nuclear export of intronless herpesvirus mRNA
    • Boyne,J.R. and Whitehouse,A. (2006) Nucleolar trafficking is essential for nuclear export of intronless herpesvirus mRNA. Proc. Natl Acad. Sci. USA, 103, 15190-15195.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 15190-15195
    • Boyne, J.R.1    Whitehouse, A.2
  • 34
    • 0026527447 scopus 로고
    • Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm
    • Pinol-Roma,S. and Dreyfuss,G. (1992) Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature, 355, 730-732.
    • (1992) Nature , vol.355 , pp. 730-732
    • Pinol-Roma, S.1    Dreyfuss, G.2
  • 35
    • 0031445652 scopus 로고    scopus 로고
    • Analysis of domains affecting intracellular localization of the FMRP protein
    • Bardoni,B., Sittler,A., Shen,Y. and Mandel,J.L. (1997) Analysis of domains affecting intracellular localization of the FMRP protein. Neurobiol. Dis., 4, 329-336.
    • (1997) Neurobiol. Dis , vol.4 , pp. 329-336
    • Bardoni, B.1    Sittler, A.2    Shen, Y.3    Mandel, J.L.4
  • 36
    • 30044441988 scopus 로고    scopus 로고
    • The human SWI/SNF subunit Brm is a regulator of alternative splicing
    • Batsche,E., Yaniv,M. and Muchardt,C. (2006) The human SWI/SNF subunit Brm is a regulator of alternative splicing. Nat. Struct. Mol. Biol. 13, 22-29.
    • (2006) Nat. Struct. Mol. Biol , vol.13 , pp. 22-29
    • Batsche, E.1    Yaniv, M.2    Muchardt, C.3
  • 37
    • 58149503693 scopus 로고    scopus 로고
    • Retinoic acid-gated sequencespecific translational control by RARα
    • Poon,M.M. and Chen,L. (2008) Retinoic acid-gated sequencespecific translational control by RARα. Proc. Natl Acad. Sci. USA, 105 20303-20308.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 20303-20308
    • Poon, M.M.1    Chen, L.2
  • 38
    • 0034083153 scopus 로고    scopus 로고
    • Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA
    • Lalli,E., Ohe,K., Hindelang,C. and Sassone-Corsi,P. (2000) Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA. Mol. Cell Biol., 20, 4910-4921.
    • (2000) Mol. Cell Biol , vol.20 , pp. 4910-4921
    • Lalli, E.1    Ohe, K.2    Hindelang, C.3    Sassone-Corsi, P.4
  • 39
    • 53149145051 scopus 로고    scopus 로고
    • RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition
    • Bonnal,S., Martinez,C., Forch,P., Bachi,A., Wilm,M. and Valcarcel,J. (2008) RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition. Mol. Cell, 32, 81-95.
    • (2008) Mol. Cell , vol.32 , pp. 81-95
    • Bonnal, S.1    Martinez, C.2    Forch, P.3    Bachi, A.4    Wilm, M.5    Valcarcel, J.6
  • 40
    • 32344440041 scopus 로고    scopus 로고
    • RNA binding proteins and the regulation of neuronal synaptic plasticity
    • Ule,J. and Darnell,R.B. (2006) RNA binding proteins and the regulation of neuronal synaptic plasticity. Curr. Opin. Neurobiol., 16, 102-110.
    • (2006) Curr. Opin. Neurobiol , vol.16 , pp. 102-110
    • Ule, J.1    Darnell, R.B.2
  • 41
    • 38549087401 scopus 로고    scopus 로고
    • GRSDB2 and GRS_UTRdb: Databases of quadruplex formi,g G-rich sequences in pre-mRNA and mRNAs
    • Kikin,O., Zappala,Z., D'Antonio,L. and Bagga,P.S. (2008) GRSDB2 and GRS_UTRdb: Databases of quadruplex formi,g G-rich sequences in pre-mRNA and mRNAs. Nucleic Acids Res., 36, D141-D148.
    • (2008) Nucleic Acids Res , vol.36
    • Kikin, O.1    Zappala, Z.2    D'Antonio, L.3    Bagga, P.S.4
  • 42
    • 0029919960 scopus 로고    scopus 로고
    • A novel mutation in the putative DNA helicase XH2 is responsible for male-to-female sex reversal associated with an atypical form of the ATR-X syndrome
    • Ion,A., Telvi,L., Chaussain,J.L., Galacteros,F., Valayer,J., Fellous,M. and McElreavey,K. (1996) A novel mutation in the putative DNA helicase XH2 is responsible for male-to-female sex reversal associated with an atypical form of the ATR-X syndrome. Am. J. Hum. Genet., 58, 1185-1191.
    • (1996) Am. J. Hum. Genet , vol.58 , pp. 1185-1191
    • Ion, A.1    Telvi, L.2    Chaussain, J.L.3    Galacteros, F.4    Valayer, J.5    Fellous, M.6    McElreavey, K.7
  • 43
    • 35148858044 scopus 로고    scopus 로고
    • A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice
    • Tabuchi,K., Blundell,J., Etherton,M.R., Hammer,R.E., Liu,X., Powell,C.M. and Sudhof,T.C. (2007) A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science, 318, 71-76.
    • (2007) Science , vol.318 , pp. 71-76
    • Tabuchi, K.1    Blundell, J.2    Etherton, M.R.3    Hammer, R.E.4    Liu, X.5    Powell, C.M.6    Sudhof, T.C.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.