γ-aminobutyric acidA (GABAA) receptor regulates ERK1/2 phosphorylation in rat hippocampus in high doses of Methyl Tert-Butyl Ether (MTBE)-induced impairment of spatial memory

Toxicology and Applied Pharmacology

Volumn 236, Issue 2, 2009, Pages 239-245

  Zheng, Gang ^a   Zhang, Wenbin ^a   Zhang, Yun ^b   Chen, Yaoming ^a   Liu, Mingchao ^a   Yao, Ting ^a   Yang, Yanxia ^a   Zhao, Fang ^a   Li, Jingxia ^c   Huang, Chuanshu ^c   Luo, Wenjing ^a   Chen, Jingyuan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b JILIN MEDICAL COLLEGE   (China)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ERK; GABAA receptor; Hippocampus; Memory; MTBE

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; BICUCULLINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RECEPTOR SUBUNIT; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; LEARNING DISORDER; MALE; MAZE TEST; MEMORY DISORDER; NONHUMAN; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SPATIAL MEMORY; TASK PERFORMANCE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HIPPOCAMPUS; MEMORY; METHYL ETHERS; PHOSPHORYLATION; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A;

RATTUS;

EID: 62549093923     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.01.004     Document Type: Article

References (41)

1. Atkins C.M., Selcher J.C., Petraitis J.J., Trzaskos J.M., and Sweatt J.D. The MAPK cascade is required for mammalian associative learning. Nat. Neurosci. 1 (1998) 602-609
2. Bachtell R.K., Tsivkovskaia N.O., and Ryabinin A.E. Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms. Pharmacol. Exp. Ther. 302 (2002) 516-524
3. Blednov Y.A., Jung S., Alva H., Wallace D., Rosahl T., Whiting P.J., and Harris R.A. Deletion of the alpha1 or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs. J. Pharmacol. Exp. Ther. 304 (2003) 30-36
4. Blum S., Moore A.N., Adams F., and Dash P.K. A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory. J. Neurosci. 19 (1999) 3535-3544
5. Chen J.Y., Shen C.P., and Meller E. 5-HT1A receptor-mediated regulation of mitogen-activated protein kinase phosphorylation in rat brain. Eur. J. Pharmacol. 452 (2002) 155-162
6. Daughtrey W.C., Gill M.W., Pritts I.M., Douglas J.F., Kneiss J.J., and Andrews L.S. Neurotoxicological evaluation of methyl tertiary-butyl ether in rats. J. Appl. Toxicol. 17 Suppl 1 (1997) S57-S64
7. Duggan M.J., and Stephenson F.A. Biochemical evidence for the existence of gamma-aminobutyrate A receptor iso-oligomers. J. Biol. Chem. 265 (1990) 3831-3835
8. English J.D., and Sweatt J.D. A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation. J. Biol. Chem. 272 (1997) 19103-19106
9. Fiedler N., Kelly-McNeil K., Mohr S., Lehrer P., Opiekun R.E., Lee C., Wainman T., Hamer R., Weisel C., Edelberg R., and Lioy P.J. Controlled human exposure to methyl tertiary butyl ether in gasoline: symptoms, psychophysiologic and neurobehavioral responses of self-reported sensitive persons. Environ. Health Perspect. 108 (2000) 753-763
10. Ghatan S., Larner S., Kinoshita Y., Hetman M., Patel L., Xia Z., Youle R.J., and Morrison R.S. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J. Cell Biol. 150 2 (2000) 335-347
11. Giovannini M.G., Cerbai F., Bellucci A., Melani C., Grossi C., Bartolozzi C., Nosi D., and Casamenti F. Differential activation of mitogen-activated protein kinase signalling pathways in the hippocampus of CRND8 transgenic mouse, a model of Alzheimer's disease. Neuroscience 153 3 (2008) 618-633
12. Hakkola M., Honkasalo M.L., and Pulkkinen P. Changes in neuropsychological symptoms and moods among tanker drivers exposed to gasoline during a work week. Occup. Med. (Lond). 47 (1997) 344-348
13. Hutcheon D.E., Arnold J.D., ten Hove W., and Boyle III J. Disposition, metabolism, and toxicity of methyl tertiary butyl ether, an oxygenate for reformulated gasoline. J. Toxicol. Environ. Health 47 (1996) 453-464 Review
14. Kalluri H.S., and Ticku M.K. Role of GABA(A) receptors in the ethanol-mediated inhibition of extracellular signal-regulated kinase. Eur. J. Pharmacol. 451 (2002) 51-54
15. Koya E., Uejima J.L., Wihbey K.A., Bossert, J.M., Hope B.T., and Shaham Y. Role of ventral medial prefrontal cortex in incubation of cocaine craving. Neuropharmacology 56 Suppl 1 (2009) 177-1785
16. Kralic J.E., Korpi E.R., O'Buckley T.K., Homanics G.E., and Morrow A.L. Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice. J. Pharmacol. Exp. Ther. 302 (2002) 1037-1045
17. Kralic J.E., O'Buckley T.K., Khisti R.T., Hodge C.W., Homanics G.E., and Morrow A.L. GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem. Neuropharmacology 43 (2002) 685-694
18. Kralic J.E., Wheeler M., Renzi K., Ferguson C., O'Buckley T.K., Grobin A.C., Morrow A.L., and Homanics G.E. Deletion of GABAA receptor alpha 1 subunit-containing receptors alters responses to ethanol and other anesthetics. J. Pharmacol. Exp. Ther. 305 (2003) 600-607
19. Lu H., Guizzetti M., and Costa L.G. Inorganic lead activates the mitogen-activated protein kinase kinase-mitogen-activated protein kinase-p90(RSK) signaling pathway in human astrocytoma cells via a protein kinase C-dependent mechanism. J. Pharmacol. Exp. Ther. 300 3 (2002) 818-823
20. Marshall C.J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80 (1995) 179-185
21. Martin J.V., Bilgin N.M., and Iba M.M. Influence of oxygenated fuel additives and their metabolites on the binding of a convulsant ligand of the gamma-aminobutyric acid(A) (GABA(A)) receptor in rat brain membrane preparations. Toxicol. Lett. 129 (2002) 219-226
22. Martin J.V., Iyer S.V., McIlroy P.J., and Iba M.M. Influence of oxygenated fuel additives and their metabolites on gamma-aminobutyric acidA (GABAA) receptor function in rat brain synaptoneurosomes. Toxicol. Lett. 147 (2004) 209-217
23. McKernan R.M., Quirk K., Prince R., Cox P.A., Gillard N.P., Ragan C.I., and Whiting P. GABAA receptor subtypes immunopurified from rat brain with alpha subunit-specific antibodies have unique pharmacological properties. Neuron 7 (1991) 667-676
24. Mehta A.K., and Ticku M.K. An update on GABAA receptors. Brain Res. Brain Res. Rev. 29 (1999) 196-217 Review
25. Moolenaar R.L., Hefflin B.J., Ashley D.L., Middaugh J.P., and Etzel R.A. Methyl tertiary butyl ether in human blood after exposure to oxygenated fuel in Fairbanks, Alaska. Arch. Environ. Health. 49 (1994) 402-409
26. Nair A., and Bonneau R.H. Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation. J. Neuroimmunol. 171 (2006) 72-85
27. Nihlen A., Walinder R., Lof A., and Johanson G. Experimental exposure to methyl tertiary-butyl ether. II. Acute effects in humans. Toxicol. Appl. Pharmacol. 148 (1998) 281-287
28. Rao H.V., and Ginsberg G.L. A physiologically-based pharmacokinetic model assessment of methyl t-butyl ether in groundwater for a bathing and showering determination. Risk Anal. 17 (1997) 583-598
29. Robinson M., Bruner R.H., and Olson G.R. Fourteen and ninety-day oral toxicity studies of methyl tertiary-butyl ether in Sprague-Dawley rats. J. Am. Coll. Toxicol. 9 (1990) 525-540
30. Sarto-Jackson I., Furtmueller R., Ernst M., Huck S., and Sieghart W. Spontaneous cross-link of mutated alpha1 subunits during GABA(A) receptor assembly. J. Biol. Chem. 282 (2007) 4354-4363
31. Selcher J.C., Weeber E.J., Varga A.W., Sweatt J.D., and Swank M. Protein kinase signal transduction cascades in mammalian associative conditioning. Neuroscientist 8 (2002) 122-131
32. Sharma A.C., and Kulkarni S.K. Evidence for GABA-BZ receptor modulation in short-term memory passive avoidance task paradigm in mice. Methods Find. Exp. Clin. Pharmacol. 12 (1990) 175-180
33. Sharma A.C., and Kulkarni S.K. (+/-)Baclofen sensitive scopolamine-induced short-term memory deficits in mice. Indian J. Exp. Biol. 31 (1993) 348-352
34. Skolnick P., and Paul S.M. Buspirone: chemistry, pharmacology, and behavior. J. Clin. Psychiatry 43 (1982) 40-44
35. Wang Q., Luo W., Zhang W., Dai Z., Chen Y., and Chen J. Iron supplementation protects against lead-induced apoptosis through MAPK pathway in weanling rat cortex. Neurotoxicology 28 4 (2007) 850-859
36. White R.D., Daughtrey W.C., and Wells M.S. Health effects of inhaled tertiary amyl methyl ether and ethyl tertiary butyl ether. Toxicol. Lett. 82-Toxicol. Appl. Pharmacol.83 (1995) 719-724
37. Xia Z., Dickens M., Raingeaud J., Davis R.J., and Greenberg M.E. Opposing effects of ERK and JNK MAPK, p38 MAPKinase on apoptosis. Science 270 5240 (1995) 1326-1331
38. Zarrindast M.R., Bakhsha A., Rostami P., and Shafaghi B. Effects of intrahippocampal injection of GABAergic drugs on memory retention of passive avoidance learning in rats. J. Psychopharmacol. 16 (2002) 313-319
39. Zarrindast M.R., Shamsi T., Azarmina P., Rostami P., and Shafaghi B. GABAergic system and imipramine-induced impairment of memory retention in rats. Eur. Neuropsychopharmacol. 14 (2004) 59-64
40. Zhao F., Cai T., Liu M., Zheng G., Luo W., and Chen J. Manganese induces dopaminergic neurodegeneration via microglial activation in a rat model of manganism. Toxicol. Sci. 107 1 (2009) 156-164
41. Zheng G., Zhang X., Chen Y., Zhang Y., Luo W., and Chen J. Evidence for a role of GABAA receptor in the acute restraint stress-induced enhancement of spatial memory. Brain Res. 1181 (2007) 61-73