A review on the management of epilepsy associated with hypothalamic hamartomas

Child's Nervous System

Volumn 25, Issue 4, 2009, Pages 423-432

  Frazier, James L ^a   Goodwin, C Rory ^a   Ahn, Edward S ^a   Jallo, George I ^a  

^a JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Epilepsy; Gelastic seizure; Hypothalamic hamartoma; Radiosurgery; Surgery

Indexed keywords

BRACHYTHERAPY; DEVELOPMENTAL DISORDER; ELECTROPHYSIOLOGY; ENDOSCOPY; EPILEPSY; GELASTIC SEIZURE; HAMARTOMA; HUMAN; HYPOTHALAMUS; NERVE STIMULATION; NEUROIMAGING; PATHOGENESIS; PATHOPHYSIOLOGY; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; RADIOFREQUENCY ABLATION; RADIOSURGERY; REVIEW; VAGUS NERVE;

BEHAVIOR; BRACHYTHERAPY; CATHETER ABLATION; COGNITION DISORDERS; ENDOSCOPY; EPILEPSY; HAMARTOMA; HUMANS; HYPOTHALAMIC DISEASES; HYPOTHALAMUS; NEUROSURGERY; RADIOSURGERY; SEIZURES; VAGUS NERVE STIMULATION;

EID: 62449268595     PISSN: 02567040     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00381-008-0798-y     Document Type: Review

References (93)

1. T Akai K Okamoto H Iizuka H Kakinuma T Nojima 2002 Treatments of hamartoma with neuroendoscopic surgery and stereotactic radiosurgery: a case report Minim Invasive Neurosurg 45 235 239
2. K Arita F Ikawa K Kurisu M Sumida K Harada T Uozumi S Monden J Yoshida Y Nishi 1999 The relationship between magnetic resonance imaging findings and clinical manifestations of hypothalamic hamartoma J Neurosurg 91 212 220
3. K Arita K Kurisu K Iida R Hanaya T Akimitsu S Hibino B Pant M Hamasaki S Shinagawa 1998 Subsidence of seizure induced by stereotactic radiation in a patient with hypothalamic hamartoma. Case report J Neurosurg 89 645 648
4. AA Arzimanoglou E Hirsch J Aicardi 2003 Hypothalamic hamartoma and epilepsy in children: illustrative cases of possible evolutions Epileptic Disord 5 187 199
5. MA Barajas MG Ramirez-Guzman C Rodriguez-Vazquez V Toledo-Buenrostro A Cuevas-Solorzano G Rodriguez-Hernandez 2005 Gamma knife surgery for hypothalamic hamartomas accompanied by medically intractable epilepsy and precocious puberty: experience in Mexico J Neurosurg 102 Suppl 53 55
6. SF Berkovic F Andermann D Melanson RE Ethier W Feindel P Gloor 1988 Hypothalamic hamartomas and ictal laughter: evolution of a characteristic epileptic syndrome and diagnostic value of magnetic resonance imaging Ann Neurol 23 429 439
7. SF Berkovic A Arzimanoglou R Kuzniecky AS Harvey A Palmini F Andermann 2003 Hypothalamic hamartoma and seizures: a treatable epileptic encephalopathy Epilepsia 44 969 973
8. SF Berkovic RI Kuzniecky F Andermann 1997 Human epileptogenesis and hypothalamic hamartomas: new lessons from an experiment of nature Epilepsia 38 1 3
9. OB Boyko JT Curnes WJ Oakes PC Burger 1991 Hamartomas of the tuber cinereum: CT, MR, and pathologic findings AJNR Am J Neuroradiol 12 309 314
10. G Brandberg R Raininko O Eeg-Olofsson 2004 Hypothalamic hamartoma with gelastic seizures in Swedish children and adolescents Eur J Paediatr Neurol 8 35 44
11. GN Breningstall 1985 Gelastic seizures, precocious puberty, and hypothalamic hamartoma Neurology 35 1180 1183
12. GD Cascino F Andermann SF Berkovic RI Kuzniecky FW Sharbrough DL Keene PF Bladin PJ Kelly A Olivier W Feindel 1993 Gelastic seizures and hypothalamic hamartomas: evaluation of patients undergoing chronic intracranial EEG monitoring and outcome of surgical treatment Neurology 43 747 750
13. JU Choi KH Yang TG Kim JH Chang JW Chang BI Lee DS Kim 2004 Endoscopic disconnection for hypothalamic hamartoma with intractable seizure. Report of four cases J Neurosurg 100 506 511
14. D Coulter 1997
15. DD Daly DW Mulder 1957 Gelastic epilepsy Neurology 7 189 192
16. C Debeneix M Bourgeois C Trivin C Sainte-Rose R Brauner 2001 Hypothalamic hamartoma: comparison of clinical presentation and magnetic resonance images Horm Res 56 12 18
17. O Delalande M Fohlen 2003 Disconnecting surgical treatment of hypothalamic hamartoma in children and adults with refractory epilepsy and proposal of a new classification Neurol Med Chir (Tokyo) 43 61 68
18. T Deonna AL Ziegler 2000 Hypothalamic hamartoma, precocious puberty and gelastic seizures: a special model of "epileptic" developmental disorder Epileptic Disord 2 33 37
19. C Diebler G Ponsot 1983 Hamartomas of the tuber cinereum Neuroradiology 25 93 101
20. MP DiFazio RG Davis 2000 Utility of early single photon emission computed tomography (SPECT) in neonatal gelastic epilepsy associated with hypothalamic hamartoma J Child Neurol 15 414 417
21. C Dunoyer J Ragheb T Resnick L Alvarez P Jayakar N Altman A Wolf M Duchowny 2002 The use of stereotactic radiosurgery to treat intractable childhood partial epilepsy Epilepsia 43 292 300
22. I Feiz-Erfan EM Horn HL Rekate RF Spetzler YT Ng JV Rosenfeld JF Kerrigan 3rd 2005 Surgical strategies for approaching hypothalamic hamartomas causing gelastic seizures in the pediatric population: transventricular compared with skull base approaches J Neurosurg 103 325 332
23. M Fohlen A Lellouch O Delalande 2003 Hypothalamic hamartoma with refractory epilepsy: surgical procedures and results in 18 patients Epileptic Disord 5 267 273
24. CM Frattali K Liow GH Craig LM Korenman F Makhlouf S Sato LG Biesecker WH Theodore 2001 Cognitive deficits in children with gelastic seizures and hypothalamic hamartoma Neurology 57 43 46
25. JL Freeman LT Coleman RM Wellard MJ Kean JV Rosenfeld GD Jackson SF Berkovic AS Harvey 2004 MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases AJNR Am J Neuroradiol 25 450 462
26. JL Freeman AS Harvey JV Rosenfeld JA Wrennall CA Bailey SF Berkovic 2003 Generalized epilepsy in hypothalamic hamartoma: evolution and postoperative resolution Neurology 60 762 767
27. Y Fujimoto A Kato Y Saitoh H Ninomiya K Imai RI Sakakibara M Maruno H Kishima K Yoshimura H Hasegawa T Yoshimine 2003 Stereotactic radiofrequency ablation for sessile hypothalamic hamartoma with an image fusion technique Acta Neurochir (Wien) 145 697 700
28. M Fukuda S Kameyama M Wachi R Tanaka 1999 Stereotaxy for hypothalamic hamartoma with intractable gelastic seizures: technical case report Neurosurgery 44 1347 1350
29. PA Gore P Nakaji V Deshmukh HL Rekate 2006 Synchronous endoscopy and microsurgery: a novel strategy to approach complex ventricular lesions. Report of three cases J Neurosurg 105 485 489
30. AS Harvey JL Freeman 2007 Epilepsy in hypothalamic hamartoma: clinical and EEG features Semin Pediatr Neurol 14 60 64
31. AS Harvey JL Freeman SF Berkovic JV Rosenfeld 2003 Transcallosal resection of hypothalamic hamartomas in patients with intractable epilepsy Epileptic Disord 5 257 265
32. J Homma S Kameyama H Masuda T Ueno A Fujimoto M Oishi M Fukuda 2007 Stereotactic radiofrequency thermocoagulation for hypothalamic hamartoma with intractable gelastic seizures Epilepsy Res 76 15 21
33. H Jung E Neumaier Probst BP Hauffa CJ Partsch O Dammann 2003 Association of morphological characteristics with precocious puberty and/or gelastic seizures in hypothalamic hamartoma J Clin Endocrinol Metab 88 4590 4595
34. P Kahane P Ryvlin D Hoffmann L Minotti AL Benabid 2003 From hypothalamic hamartoma to cortex: what can be learnt from depth recordings and stimulation? Epileptic Disord 5 205 217
35. JF Kerrigan YT Ng S Chung HL Rekate 2005 The hypothalamic hamartoma: a model of subcortical epileptogenesis and encephalopathy Semin Pediatr Neurol 12 119 131
36. U Kramer S Spector W Nasser V Siomin I Fried S Constantini 2001 Surgical treatment of hypothalamic hamartoma and refractory seizures: a case report and review of the literature Pediatr Neurosurg 34 40 42
37. R Kuzniecky B Guthrie J Mountz M Bebin E Faught F Gilliam HG Liu 1997 Intrinsic epileptogenesis of hypothalamic hamartomas in gelastic epilepsy Ann Neurol 42 60 67
38. RI Kuzniecky BL Guthrie 2003 Stereotactic surgical approach to hypothalamic hamartomas Epileptic Disord 5 275 280
39. AJ Leal A Moreira C Robalo C Ribeiro 2003 Different electroclinical manifestations of the epilepsy associated with hamartomas connecting to the middle or posterior hypothalamus Epilepsia 44 1191 1195
40. AM Likavec RD Dickerman JD Heiss K Liow 2000 Retrospective analysis of surgical treatment outcomes for gelastic seizures: a review of the literature Seizure 9 204 207
41. HR Machado HJ Hoffman PA Hwang 1991 Gelastic seizures treated by resection of a hypothalamic hamartoma Childs Nerv Syst 7 462 465
42. W Maixner 2006 Hypothalamic hamartomas-clinical, neuropathological, and surgical aspects Childs Nerv Syst 22 867 873
43. D Mathieu D Kondziolka A Niranjan J Flickinger LD Lunsford 2006 Gamma knife radiosurgery for refractory epilepsy caused by hypothalamic hamartomas Stereotact Funct Neurosurg 84 82 87
44. F Morrell 1985 Secondary epileptogenesis in man Arch Neurol 42 318 335
45. F Morrell 1989 Varieties of human secondary epileptogenesis J Clin Neurophysiol 6 227 275
46. C Mottolese H Stan P Bret P Berlier C Lapras 2001 Hypothalamic hamartoma: the role of surgery in a series of eight patients Childs Nerv Syst 17 229 236
47. N Mullatti 2003 Hypothalamic hamartoma in adults Epileptic Disord 5 201 204
48. N Mullatti R Selway L Nashef R Elwes M Honavar C Chandler R Morris J Jarosz C Buchanan C Polkey 2003 The clinical spectrum of epilepsy in children and adults with hypothalamic hamartoma Epilepsia 44 1310 1319
49. C Munari P Kahane S Francione D Hoffmann L Tassi R Cusmai F Vigevano B Pasquier OO Betti 1995 Role of the hypothalamic hamartoma in the genesis of gelastic fits (a video-stereo-EEG study) Electroencephalogr Clin Neurophysiol 95 154 160
50. JV Murphy JW Wheless CM Schmoll 2000 Left vagal nerve stimulation in six patients with hypothalamic hamartomas Pediatr Neurol 23 167 168
51. YT Ng JF Kerrigan EC Prenger WL White HL Rekate 2005 Successful resection of a hypothalamic hamartoma and a Rathke cleft cyst. Case report J Neurosurg 102 78 80
52. YT Ng HL Rekate 2007 Endoscopic resection of hypothalamic hamartoma for refractory epilepsy: preliminary report Semin Pediatr Neurol 14 99 105
53. Ng Y, Rekate H, Kerrigan J et al (2004) Transcallosal resection of hypothalamic hamartoma: case report. Barrow Quarterly 20:No 1
54. YT Ng HL Rekate EC Prenger SS Chung I Feiz-Erfan NC Wang MR Varland JF Kerrigan 2006 Transcallosal resection of hypothalamic hamartoma for intractable epilepsy Epilepsia 47 1192 1202
55. YT Ng HL Rekate EC Prenger NC Wang SS Chung I Feiz-Erfan RE Johnsonbaugh MR Varland JF Kerrigan 2008 Endoscopic resection of hypothalamic hamartomas for refractory symptomatic epilepsy Neurology 70 1543 1548
56. D Nguyen S Singh M Zaatreh E Novotny S Levy F Testa SS Spencer 2003 Hypothalamic hamartomas: seven cases and review of the literature Epilepsy Behav 4 246 258
57. S Nishio T Morioka M Fukui Y Goto 1994 Surgical treatment of intractable seizures due to hypothalamic hamartoma Epilepsia 35 514 519
58. DW Northfield DS Russell 1967 Pubertas praecox due to hypothalamic hamartoma: report of two cases surviving surgical removal of the tumour J Neurol Neurosurg Psychiatry 30 166 173
59. JE Paillas J Roger M Toga R Soulayrol G Salamon C Dravet M Bureau 1969 Hamartoma of the hypothalamus. Clinical, radiological and histological study. Results of excision Rev Neurol (Paris) 120 177 194
60. A Palmini C Chandler F Andermann J Costa Da Costa E Paglioli-Neto C Polkey B Rosenblatt J Montes JV Martinez JP Farmer B Sinclair K Aronyk E Paglioli L Coutinho S Raupp M Portuguez 2002 Resection of the lesion in patients with hypothalamic hamartomas and catastrophic epilepsy Neurology 58 1338 1347
61. A Palmini E Paglioli-Neto J Montes JP Farmer 2003 The treatment of patients with hypothalamic hamartomas, epilepsy and behavioural abnormalities: facts and hypotheses Epileptic Disord 5 249 255
62. A Palmini W Van Paesschen P Dupont K Van Laere G Van Driel 2005 Status gelasticus after temporal lobectomy: ictal FDG-PET findings and the question of dual pathology involving hypothalamic hamartomas Epilepsia 46 1313 1316
63. JW Papez 1995 A proposed mechanism of emotion. 1937 J Neuropsychiatry Clin Neurosci 7 103 112
64. AG Parrent 1999 Stereotactic radiofrequency ablation for the treatment of gelastic seizures associated with hypothalamic hamartoma. Case report J Neurosurg 91 881 884
65. JL Penfold JI Manson WM Caldicott 1978 Laughing seizures and precocious puberty (case report and review of the literature) Aust Paediatr J 14 185 190
66. GP Prigatano 2007 Cognitive and behavioral dysfunction in children with hypothalamic hamartoma and epilepsy Semin Pediatr Neurol 14 65 72
67. E Procaccini G Dorfmuller M Fohlen C Bulteau O Delalande 2006 Surgical management of hypothalamic hamartomas with epilepsy: the stereoendoscopic approach Neurosurgery 59 ONS336 ONS344
68. M Quigg NM Barbaro 2008 Stereotactic radiosurgery for treatment of epilepsy Arch Neurol 65 177 183
69. J Regis F Bartolomei B de Toffol P Genton T Kobayashi Y Mori K Takakura T Hori H Inoue O Schrottner G Pendl A Wolf K Arita P Chauvel 2000 Gamma knife surgery for epilepsy related to hypothalamic hamartomas Neurosurgery 47 1343 1351
70. J Regis F Bartolomei M Hayashi D Roberts P Chauvel JC Peragut 2000 The role of gamma knife surgery in the treatment of severe epilepsies Epileptic Disord 2 113 122
71. J Regis F Bartolomei M Rey M Hayashi D Porcheron P Chauvel JC Peragut 2002 Gamma knife radiosurgery for the treatment of severe epilepsy Rev Neurol (Paris) 158 405 411
72. J Regis M Hayashi LP Eupierre N Villeneuve F Bartolomei T Brue P Chauvel 2004 Gamma knife surgery for epilepsy related to hypothalamic hamartomas Acta Neurochir Suppl 91 33 50
73. J Regis D Scavarda M Tamura N Villeneuve F Bartolomei T Brue I Morange D Dafonseca P Chauvel 2007 Gamma knife surgery for epilepsy related to hypothalamic hamartomas Semin Pediatr Neurol 14 73 79
74. HL Rekate I Feiz-Erfan YT Ng LF Gonzalez JF Kerrigan 2006 Endoscopic surgery for hypothalamic hamartomas causing medically refractory gelastic epilepsy Childs Nerv Syst 22 874 880
75. JV Rosenfeld AS Harvey J Wrennall M Zacharin SF Berkovic 2001 Transcallosal resection of hypothalamic hamartomas, with control of seizures, in children with gelastic epilepsy Neurosurgery 48 108 118
76. P Ryvlin C Ravier S Bouvard F Mauguire D Le Bars A Arzimanoglou J Petit P Kahane 2003 Positron emission tomography in epileptogenic hypothalamic hamartomas Epileptic Disord 5 219 227
77. M Sato Y Ushio N Arita H Mogami 1985 Hypothalamic hamartoma: report of two cases Neurosurgery 16 198 206
78. G Savard NH Bhanji F Dubeau F Andermann A Sadikot 2003 Psychiatric aspects of patients with hypothalamic hamartoma and epilepsy Epileptic Disord 5 229 234
79. A Schulze-Bonhage V Homberg M Trippel R Keimer CE Elger PC Warnke C Ostertag 2004 Interstitial radiosurgery in the treatment of gelastic epilepsy due to hypothalamic hamartomas Neurology 62 644 647
80. A Schulze-Bonhage C Ostertag 2007 Treatment options for gelastic epilepsy due to hypothalamic hamartoma: interstitial radiosurgery Semin Pediatr Neurol 14 80 87
81. A Schulze-Bonhage M Trippel K Wagner T Bast FV Deimling A Ebner C Elger T Mayer R Keimer BJ Steinhoff J Spreer S Fauser C Ostertag 2008 Outcome and predictors of interstitial radiosurgery in the treatment of gelastic epilepsy Neurology 71 277 282
82. MT Selch A Gorgulho C Mattozo TD Solberg C Cabatan-Awang AA DeSalles 2005 Linear accelerator stereotactic radiosurgery for the treatment of gelastic seizures due to hypothalamic hamartoma Minim Invasive Neurosurg 48 310 314
83. PK Sher SB Brown 1976 Gelastic epilepsy. Onset in neonatal period Am J Dis Child 130 1126 1131
84. KW Shim JH Chang YG Park HD Kim JU Choi DS Kim 2008 Treatment modality for intractable epilepsy in hypothalamic hamartomatous lesions Neurosurgery 62 847 856
85. V Siomin S Spektor L Beni-Adani S Constantini 2001 Application of the orbito-cranial approach in pediatric neurosurgery Childs Nerv Syst 17 612 617
86. R Siwanuwatn P Deshmukh I Feiz-Erfan HL Rekate JM Zabramski RF Spetzler JV Rosenfeld 2005 Microsurgical anatomy of the transcallosal anterior interforniceal approach to the third ventricle Neurosurgery 56 390 396
87. S Striano R Meo L Bilo S Cirillo C Nocerino P Ruosi P Striano A Estraneo 1999 Gelastic epilepsy: symptomatic and cryptogenic cases Epilepsia 40 294 302
88. JW Sturm F Andermann SF Berkovic 2000 "Pressure to laugh": an unusual epileptic symptom associated with small hypothalamic hamartomas Neurology 54 971 973
89. CA Tassinari P Riguzzi R Rizzi 1997
90. F Unger O Schrottner M Feichtinger G Bone K Haselsberger B Sutter 2002 Stereotactic radiosurgery for hypothalamic hamartomas Acta Neurochir Suppl 84 57 63
91. JM Valdueza L Cristante O Dammann K Bentele A Vortmeyer W Saeger B Padberg J Freitag HD Herrmann 1994 Hypothalamic hamartomas: with special reference to gelastic epilepsy and surgery Neurosurgery 34 949 958
92. AA Weissenberger ML Dell K Liow W Theodore CM Frattali D Hernandez AJ Zametkin 2001 Aggression and psychiatric comorbidity in children with hypothalamic hamartomas and their unaffected siblings J Am Acad Child Adolesc Psychiatry 40 696 703
93. J Wu L Xu DY Kim JM Rho PA St John LF Lue S Coons K Ellsworth L Nowak E Johnson H Rekate JF Kerrigan 2005 Electrophysiological properties of human hypothalamic hamartomas Ann Neurol 58 371 382