Hypothalamic hamartoma and epilepsy in children: Illustrative cases of possible evolutions

Epileptic Disorders

Volumn 5, Issue 4, 2003, Pages 187-199

  Arzimanoglou, Alexis A ^a   Hirsch, Edouard ^b   Aicardi, Jean ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b UNIVERSITY HOSPITAL OF STRASBOURG   (France)

Author keywords

Child; Encephalopathy; Epilepsy; Epileptic; Hypothalamic hamartoma

Indexed keywords

ADOLESCENT; ADULT; BEHAVIOR DISORDER; BENIGN CHILDHOOD EPILEPSY; CHILD; CLINICAL ARTICLE; CLINICAL FEATURE; COGNITIVE DEFECT; DETERIORATION; DIAGNOSTIC ERROR; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; EARLY DIAGNOSIS; EEG ABNORMALITY; EPILEPTOGENESIS; FEMALE; FRONTAL LOBE EPILEPSY; GELASTIC SEIZURE; HAMARTOMA; HUMAN; HYPOTHALAMUS HAMARTOMA; HYPOTHALAMUS TUMOR; INTRACTABLE EPILEPSY; MALE; NEUROIMAGING; NONVERBAL COMMUNICATION; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; REVIEW; SYMPTOMATOLOGY; TEMPORAL LOBE EPILEPSY; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ANTICONVULSANTS; BRAIN DAMAGE, CHRONIC; CHILD; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; DEVELOPMENTAL DISABILITIES; DIAGNOSIS, DIFFERENTIAL; ELECTROENCEPHALOGRAPHY; EPILEPSIES, PARTIAL; EPILEPSY, GENERALIZED; FEMALE; FOLLOW-UP STUDIES; HAMARTOMA; HUMANS; HYPOTHALAMIC DISEASES; IMAGE PROCESSING, COMPUTER-ASSISTED; INFANT; INFANT, NEWBORN; MAGNETIC RESONANCE IMAGING; MALE; RADIOSURGERY; SYNDROME; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 1142310781     PISSN: 12949361     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (41)

1. th Edn. 1989; London: Edward Arnold.
2. Turjman F, Xavier JL, Froment JC, Tran-Minh VA, David L, Lapras C. Late MR follow-up of hypothalamic hamartomas. Childs Nerv Syst 1996; 12: 63-8.
3. Freeman JL. The anatomy and embryology of the hypothalamus in relation to hypothalamic hamartomas. Epileptic Disord 2003; 5: xx-yy (pages of this issue/to be completed)
4. Tassinari CA, Riguzzi P, Rizzi R, et al. Gelastic Seizures. In: Tuxhorn I, Holthausen H, Boenigk. eds. In: Paediatric Epilepsy Syndromes and their Surgical treatment. London, John Libbey, 1997 pp 429-46.
5. Berkovic SF, Arzimanoglou A, Kuzniecky R, Harvey S, Palmini A, Andermann F. Hypothalamic hamartoma and seizures: a treatable epileptic encephalopathy. Epilepsia 2003; 44: 969-73.
6. Berkovic SF, Andermann F, Melanson D, Ethier RE, Feindel W, Gloor P. Hypothalamic hamartomas and ictal laughter: Evolution of a characteristic epileptic syndrome and diagnostic value of magnetic resonance imaging. Ann Neurol 1988; 23: 429-39.
7. Mullatti N, Selway R, Nashef L, Elwes R, Honavar M, Chandler C, Morris R, Jarosz J, Buchanan C, Polkey C. The clinical spectrum of epilepsy in children and adults with hypothalamic hamartoma. Epilepsia 2003; 44: 1310-9.
8. Mullatti N. Hypothalamic hamartoma in adults. Epileptic Disord 2003; 5: xx-yy (pages of this issue/to be completed)
9. Berkovic SF, Kuzniecky RI, Andermann F. Human epileptogenesis and hypothalamic hamartomas: New lessons from an experiment of nature. Epilepsia 1997; 38: 1-3.
10. Deonna T, Ziegler AL. Hypothalamic hamartoma, precocious puberty and gelastic seizures: a special model of "epileptic" developmental disorder. Epileptic Disord 2000; 2: 33-7.
11. Schaff JL, Vignal JP, Biraben A, Vespignani H, Chauvel P, Weber M. Crises de fou rire chez un jeune garçon épileptique. Epilepsies 1997; 9: 183-9.
12. Plouin P, Ponsot G, Dulac O, Diebler C, Arthuis M. Hamartomes hypothalamiques et crises de rire. Rev EEG Neurophysiol 1983; 13: 312-6.
13. Ponsot G, Diebler P, Plouin P, et al. Hamartomes hypothalamiques et crises de rire: à propos de 7 observations. Arch Fr Pediatr 1983; 40: 757-61.
14. Machado HR, Hoffman HJ, Hwang PA. Gelastic seizures treated by resection of a hypothalamic hamartoma. Child Nerv Syst 1991; 7: 462-5.
15. Arroyo S, Lesser RP, Gordon B, Uematsu S, Hart J, Schwerdt P, Andreasson K, Fisher RS. Mirth, laughter, and gelastic seizures. Brain 1993; 116: 757-80.
16. Cascino GD, Andermann F, Berkovic SF et al. Gelastic seizures and hypothalamic hamartomas: evaluation of patients undergoing chronic intracranial EEG monitoring and outcome of surgical treatment. Neurology 1993; 43: 747-50.
17. Kahane P., Tassi L., Hoffmann D., Francione S., Gratadou-Juery G., Pasquier B., Munari C. Crises dacrystiques et hamartome hypothalamique: à propos d'une observation vidéo-stéréo-EEG. Epilepsies 1994; 6: 259-79.
18. Munari C, Kahane P, Francione S, et al. Role of the hypothalamic hamartoma in the genesis of gelastic fits (a video-stereo-EEG study). Electroencephalogr Clin Neurophysiol 1995; 95: 154-60.
19. Arroyo S, Santamaría J, Sanmartí F, Lomena F, Catafau A, Casamitjana R, Setoain J, Tolosa E. Ictal laughter associated with paroxysmal hypothalamopituitary dysfunction. Epilepsia 1997; 38: 114-17.
20. Kahane P, Munari C, Minotti L, Hoffmann D, Tassi L, Pasquier B, Grand S, Benabib AL. The role of the hypothalamic hamartoma in the genesis of gelastic and dacrystic seizures. In: Tuxhorn I, Holthausen H, Boenigk K (eds), Paediatric Epilepsy Styndromes and Their Surgical Treatment. London, John Libbey, 1997: 447-61.
21. Kuzniecky R, Guthrie B, Mountz J, et al. Intrinsic epileptogenicity of hypothalamic hamartomas in gelastic epilepsy. Ann Neurol 1997; 42: 60-7.
22. Sturm JW, Andermann F, Berkovic SF. "Pressure to laugh": an unusual epileptic symptom associated with small hypothalamic hamartomas. Neurology 2000; 54: 971-3.
23. Meyer MA. Temporal lobe hypometabolism ipsilateral to a hypothalamic mass. Relationship to gelastic seizures. Clin Positron Imaging 2000; 3: 75-7.
24. Frattali CM, Liow K, Craig GH, Korenman LM Makhlouf F, Sato S, Biesecker LG, Theodore WH. Cognitive deficits in children with hypothalamic hamartoma. Neurology 2001; 57: 43-6.
25. Perez-Jimenez A, Villarejo FJ, Fournier del Castillo MC, Garcia-Penas JJ, Carreno M. Continuous giggling and autistic disorder associated with hypothalamic hamartoma. Epileptic Disord 2003; 5: 31-7.
26. Striano S, Striano P, Cirillo S, Nocerino C, Bilo L, Meo R, Ruosi P, Boccella P, Briganti F. Small hypothalamic hamartomas and gelastic seizures. Epileptic Disord 2002; 4: 129-33.
27. Leal AJ, Moreira A, Robalo C, Ribeiro C. Different electroclinical manifestations of the epilepsy associated with hamartomas connecting to the middle or posterior hypothalamus. Epilepsia 2003; 44: 1191-5.
28. Rivarola, Belgorosky A, Mendilaharzu H, Vidal G. Precocious puberty in children with tumours of the suprasellar and pineal areas: organic central precocious puberty. Acta Paediatr 2001; 90: 751-6.
29. Pescovitz OH, Comite F, Hench K, Barnes K, McNemar A, Foster C, Kenigsberg D, Loriaux DL, Cutler GB Jr. The NIH experience with precocious puberty: diagnostic subgroups and response to short-term luteinizing hormone releasing hormone analogue therapy. J Pediatr 1986; 108: 47-54.
30. De Sanctis V, Corrias A, Rizzo V, Bertelloni S, Urso L, Galluzzi F, Pasquino AM, Pozzan G, Guarneri MP, Cisternino M, De Luca F, Gargantini L, Pilotta A, Sposito M, Tonini G. Etiology of central precocious puberty in males: the results of the Italian Study Group for Physiopathology of Puberty. J Pediatr Endocrinol Metab 2000; 13 Suppl 1: 687-93.
31. Valdueza JM, Cristante L, Dammann O, et al. Hypothalamic hamartomas: with special reference to gelastic epilepsy and surgery. Neurosurgery 1994; 34: 949-58.
32. Nishio S, Morioka T, Fukui M, Goto Y. Surgical treatment of intractable seizures due to hypothalamic hamartoma. Epilepsia 1994; 35: 514-9.
33. Stewart LS, Steinbok P, Daaboul J. Role of surgical resection in the treatment of HH causing precocious puberty. J Neurosurg 1998; 88: 340-5.
34. Rosenfeld JV, Harvey AS, Wrennall J, Zacharin M, Berkovic SF. Transcallosal resection of hypothalamic hamartomas, with control of seizures, in children with refractory epilepsy. Neurosurgery 2001; 48: 108-18.
35. Palmini A, Chandler C, Andermann F, et al. Resection of the lesion in patients with hypothalamic hamartomas and catastrophic epilepsy. Neurology 2002; 58: 1338-47.
36. Delalande O, Fohlen M. Disconnecting surgical treatment of hypothalamic hamartoma in children and adults with refractory epilepsy and proposal of a new classification. Neurol Med Chir (Tokyo). 2003; 43: 61-8.
37. Freeman JL, Harvey AS, Rosenfeld JV, Wrennall JA, Bailey CA, Berkovic SF. Generalized epilepsy in hypothalamic hamartoma: evolution and postoperative resolution. Neurology 2003 11; 60: 762-7.
38. Polkey C. Resective surgery for hypothalamic hamartoma. Epileptic Disord 2003; 5: xx-yy to be completed/this issue
39. Regis J, Bartolomei F, de Toffol B, et al. Gamma knife surgery for epilepsy related to hypothalamic hamartomas. Neurosurgery 2000; 47: 1343-51.
40. Unger F, Schrottner O, Haselsberger K, et al. Gamma knife radiosurgery for hypothalamic hamartomas in patients with medically intractable epilepsy and precocious puberty. Report of two cases. J Neurosurg 2000; 92: 726-31.
41. Regis J, Bartolomei F, Hayashi M, Roberts D, Chauvel P, Peragut JC. The role of gamma knife surgery in the treatment of severe epilepsies. Epileptic Disord 2000; 2: 113-22.