Non-traditional metabolic pathways of adrenal steroids

Reviews in Endocrine and Metabolic Disorders

Volumn 10, Issue 1 SPEC. ISS., 2009, Pages 27-32

  Auchus, Richard J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Adrenal gland; Androgens; Congenital adrenal hyperplasia; Steroid metabolism; Steroidogenesis

Indexed keywords

ANDROGEN; STEROID HORMONE;

ADRENAL GLAND; ANDROGEN SYNTHESIS; CONGENITAL ADRENAL HYPERPLASIA; PATHOPHYSIOLOGY; REVIEW; STEROID METABOLISM; STEROIDOGENESIS;

ADRENAL GLANDS; ADRENAL HYPERPLASIA, CONGENITAL; ANIMALS; FEMALE; HUMANS; MALE; METABOLIC NETWORKS AND PATHWAYS; PREGNANCY; STEROID 21-HYDROXYLASE; STEROIDS; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 62449244299     PISSN: 13899155     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11154-008-9095-z     Document Type: Review

References (46)

1. N Bruchovsky JD Wilson 1999 Discovery of the role of dihydrotestosterone in androgen action Steroids. 64 753 759
2. N Bruchovsky JD Wilson 1968 The intranuclear binding of testosterone and 5α-androstan-17β-ol-3-one by rat prostate J Biol Chem. 243 5953 5960
3. RJ Moore JD Wilson 1976 Steroid 5α-reductase in cultured human fibroblasts. Biochemical and genetic evidence for two distinct enzyme activities J Biol Chem. 251 5895 5900
4. S Andersson DM Berman EP Jenkins DW Russell 1991 Deletion of a steroid 5α-reductase 2 gene in male pseudohermaphroditism Nature. 354 159 161
5. DJ Chase AH Payne 1983 Changes in Leydig cell function during sexual maturation in the mouse Biol Reprod. 29 1194 1200
6. JW Sheffield PJ O'Shaughnessy 1988 Testicular steroid metabolism during development in the normal and hypogonadal mouse J Endocrinol. 119 257 264
7. RS Ge MP Hardy 1998 Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells Endocrinology. 139 3787 3795
8. RS Ge DO Hardy JF Catterall MP Hardy 1999 Opposing changes in 3α-hydroxysteroid dehydrogenase oxidative and reductive activities in rat leydig cells during pubertal development Biol Reprod. 60 855 860
9. MB Frungieri SI Gonzalez-Calvar A Bartke RS Calandra 1999 Influence of age and photoperiod on steroidogenic function of the testis in the golden hamster Int J Androl. 22 243 252
10. GP Risbriger A Davies 1994 Isolation of rat Leydig cells and precursor forms after administration of ethane dimethane sulfonate Am J Physiol. 266 E975 979
11. R Carmichael A Belanger L Cusan C Seguin S Caron F Labrie 1980 Increased testicular 5α-androstane-3α,17β-diol formation induced by treatment with [D-Ser (TBU) 6, des-Gly-NH2(10)] LHRH ethylamide in the rat Steroids. 36 383 391
12. WH Moger 1977 Serum 5α-androstane-3α,17β-diol, androsterone, and testosterone concentrations in the male rat. Influence of age and gonadotropin stimulation Endocrinology 100 1027 1032
13. MS Mahendroo JD Wilson JA Richardson RJ Auchus 2004 Steroid 5α-reductase 1 promotes 5α-androstane-3α,17β-diol synthesis in immature mouse testes by two pathways Mol Cell Endocrinol. 222 113 120
14. G Shaw MB Renfree MW Leihy CH Shackleton E Roitman JD Wilson 2000 Prostate formation in a marsupial is mediated by the testicular androgen 5α-androstane-3α,17β-diol Proc Natl Acad Sci U S A. 97 12256 12259
15. B Eckstein A Borut S Cohen 1987 Metabolic pathways for androstanediol formation in immature rat testis microsomes Biochim Biophys Acta. 924 1 6
16. JD Wilson RJ Auchus MW Leihy OL Guryev RW Estabrook SM Osborn 2003 5α-androstane-3α,17β-diol is formed in tammar wallaby pouch young testes by a pathway involving 5α-pregnane-3α,17α-diol- 20-one as a key intermediate Endocrinology. 144 575 580
17. DW Frederiksen JD Wilson 1971 Partial characterization of the nuclear reduced nicotinamide adenine dinucleotide phosphate: Δ 4-3-ketosteroid 5 α-oxidoreductase of rat prostate J Biol Chem 246 2584 2593
18. TM Penning ME Burczynski JM Jez CF Hung HK Lin H Ma 2000 Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones Biochem J. 351 67 77
19. 5 augments the 17,20 lyase activity of human P450c17 without direct electron transfer J Biol Chem. 273 3158 3165
20. 21 steroids are substrates for human cytochrome P450c17 Arch Biochem Biophys. 418 151 160
21. T Backstrom A Andersson DT Baird G Selstam 1986 The human corpus luteum secretes 5α-pregnane-3,20-dione Acta Endocrinol (Copenh). 111 116 121
22. L Milewich BB Mendonca I Arnhold AM Wallace MD Donaldson JD Wilson 1995 Women with steroid 5α-reductase 2 deficiency have normal concentrations of plasma 5α-dihydroprogesterone during the luteal phase J Clin Endocrinol Metab. 80 3136 3139
23. H Yokoi Y Tsuruo T Miyamoto K Ishimura 1998 Steroid 5α-reductase type 1 immunolocalized in the adrenal gland of normal, gonadectomized, and sex hormone-supplemented rats Histochem Cell Biol. 109 127 134
24. NA Hanley W Arlt 2006 The human fetal adrenal cortex and the window of sexual differentiation Trends Endocrinol Metab. 17 391 397
25. RE Peterson J Imperato-McGinley T Gautier C Shackleton 1985 Male pseudohermaphroditism due to multiple defects in steroid-biosynthetic microsomal mixed-function oxidases. A new variant of congenital adrenal hyperplasia N Engl J Med. 313 1182 1191
26. CE Flück T Tajima AV Pandey W Arlt K Okuhara CF Verge 2004 Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome Nat Genet. 36 228 230
27. W Arlt EA Walker N Draper HE Ivison JP Ride F Hammer 2004 Congenital adrenal hyperplasia caused by mutant P450 oxidoreductase and human androgen synthesis: analytical study Lancet. 363 2128 2135
28. N Huang AV Pandey V Agrawal W Reardon PD Lapunzina D Mowat 2005 Diversity and function of mutations in P450 oxidoreductase in patients with Antley-Bixler syndrome and disordered steroidogenesis Am J Hum Genet. 76 729 749
29. K Yanagibashi PF Hall 1986 Role of electron transport in the regulation of the lyase activity of C-21 side-chain cleavage P450 from porcine adrenal and testicular microsomes J Biol Chem 261 8429 8433
30. DH Geller RJ Auchus BB Mendonça WL Miller 1997 The genetic and functional basis of isolated 17,20 lyase deficiency Nat Genet. 17 201 205
31. RJ Auchus WL Miller 1999 Molecular modeling of human P450c17 (17α-hydroxylase/17,20-lyase): Insights into reaction mechanisms and effects of mutations Mol Endocrinol. 13 1169 1182
32. C Shackleton E Malunowicz 2003 Apparent pregnene hydroxylation deficiency (APHD): seeking the parentage of an orphan metabolome Steroids. 68 707 717
33. C Shackleton J Marcos W Arlt BP Hauffa 2004 Prenatal diagnosis of P450 oxidoreductase deficiency (ORD): A disorder causing low pregnancy estriol, maternal and fetal virilization, and the Antley-Bixler syndrome phenotype Am J Med Genet A. 129 105 112
34. K Homma T Hasegawa T Nagai M Adachi R Horikawa I Fujiwara 2006 Urine steroid hormone profile analysis in cytochrome P450 oxidoreductase deficiency: implication for the backdoor pathway to dihydrotestosterone J Clin Endocrinol Metab. 91 2643 2649
35. DA Ehrmann RL Rosenfield RB Barnes DF Brigell Z Sheikh 1992 Detection of functional ovarian hyperandrogenism in women with androgen excess N Engl J Med. 327 157 162
36. RL Rosenfield RB Barnes DA Ehrmann 1994 Studies of the nature of 17-hydroxyprogesterone hyperresonsiveness to gonadotropin-releasing hormone agonist challenge in functional ovarian hyperandrogenism J Clin Endocrinol Metab. 79 1686 1692
37. JE Nestler DJ Jakubowicz 1996 Decreases in ovarian cytochrome P450c17α activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome N Engl J Med. 335 617 623
38. M Fassnacht N Schlenz SB Schneider SA Wudy B Allolio W Arlt 2003 Beyond adrenal and ovarian androgen generation: Increased peripheral 5α-reductase activity in women with polycystic ovary syndrome J Clin Endocrinol Metab. 88 2760 2766
39. A Kumar KS Woods AA Bartolucci R Azziz 2005 Prevalence of adrenal androgen excess in patients with the polycystic ovary syndrome (PCOS) Clin Endocrinol (Oxf). 62 644 649
40. DL Thompson N Horton RS Rittmaster 1990 Androsterone glucuronide is a marker of adrenal hyperandrogenism in hirsute women Clin Endocrinol (Oxf). 32 283 292
41. PC White PW Speiser 2000 Congenital adrenal hyperplasia due to 21-hydroxylase deficiency Endocr Rev. 21 245 291
42. CB Whorwood H Ueshiba P del Blazo 1992 Plasma levels of C19 steroid glucuronides in pre-menopausal women with non-classical congenital adrenal hyperplasia J Steroid Biochem Mol Biol. 42 211 221
43. EE Baulieu 1997 Neurosteroids: of the nervous system, by the nervous system, for the nervous system Recent Prog Horm Res. 52 1 32
44. R Rupprecht CA Hauser T Trapp F Holsboer 1996 Neurosteroids: molecular mechanisms of action and psychopharmacological significance J Steroid Biochem Mol Biol. 56 163 168
45. LD Griffin SH Mellon 1999 Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes Proc Natl Acad Sci U S A. 96 13512 13517
46. AR Genazzani N Pluchino S Begliuomini M Stomati F Bernardi M Pieri 2006 Long-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal women Gynecol Endocrinol. 22 627 635