Opposing changes in 3α-hydroxysteroid dehydrogenase oxidative and reductive activities in rat Leydig cells during pubertal development

Biology of Reproduction

Volumn 60, Issue 4, 1999, Pages 855-860

  Ge, Ren Shan ^a   Hardy, Dianne O ^a   Catterall, James F ^a   Hardy, Matthew P ^a,b  

^a ROCKEFELLER UNIVERSITY   (United States)

^b POPULATION COUNCIL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXYSTEROID DEHYDROGENASE; ANDROGEN; ANDROSTANOLONE; 3 ALPHA HYDROXYSTEROID DEHYDROGENASE (B SPECIFIC); 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ANDROSTANEDIOL; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; ENZYME INDUCTION; LEYDIG CELL; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PUBERTY; RAT; TESTIS DEVELOPMENT; TESTOSTERONE SYNTHESIS; ANIMAL; CYTOSOL; ENZYMOLOGY; FEMALE; IMMUNOBLOTTING; MALE; METABOLISM; MICROSOME; SEXUAL MATURATION; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALIA;

3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC); 3-HYDROXYSTEROID DEHYDROGENASES; ANDROSTANE-3,17-DIOL; ANIMALS; CYTOSOL; DIHYDROTESTOSTERONE; FEMALE; IMMUNOBLOTTING; LEYDIG CELLS; MALE; MICROSOMES; NAD; NADP; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; SEXUAL MATURATION;

EID: 0032588278     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod60.4.855     Document Type: Article

References (41)

1. Shan LX, Hardy MP. Developmental changes in the levels of luteinizing hormone receptor and androgen receptor in rat Leydig cells. Endocrinology 1992; 131:1107-1114.
2. Bremner WJ, Millar MR, Sharpe RM, Saunders PTK. Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens. Endocrinology 1994; 135:1227-1234.
3. Shan LX, Zhu LJ, Bardin CW, Hardy MP. Quantitative analysis of androgen receptor messenger ribonucleic acid in developing Leydig cells and Sertoli cells by in situ hybridization. Endocrinology 1995; 136:3856-3862.
4. Hardy MP, Kelce WR, Klinefelter GR, Ewing LL. Differentiation of Leydig cell precursors in vitro: a role for androgen. Endocrinology 1990; 127:488-490.
5. Hales DB, Sha L, Payne AH. Testosterone inhibits cAMP-induced de novo synthesis of Leydig cell cytochrome P-450 by an androgen receptor-mediated mechanism. J Biol Chem 1987; 262:11200-11206.
6. Liao S, Liang T, Fang S, Castaneda E, Shao TC. Steroid structure and androgenic activity: specificities involved in the receptor binding and nuclear retention of various androgens. J Biol Chem 1973; 248:6154-6162.
7. Siiteri PK, Wilson JD. Dihydrotestosterone in prostatic hypertrophy, I: the formation and content of dihydrotestosterone in the hypertrophic prostate of man. J Clin Invest 1970; 49:1737-1745.
8. Shan L-X, Phillips DM, Bardin CW, Hardy MP. Differential regulation of steroidogenic enzymes during differentiation optimizes testosterone production by adult rat Leydig cells. Endocrinology 1993; 133:2277-2283.
9. Stolz A, Rahimi-Kiani M, Ameis D, Chan E, Ronk M, Shively JE. Molecular structure of rat hepatic 3α-hydroxysteroid dehydrogenase: a member of the oxidoreductase gene family. J Biol Chem 1991; 266: 15253-15257.
10. Pawlowski JE, Huizinga M, Penning TM. Cloning and sequencing of the cDNA for rat liver 3α-hydroxysteroid, dihydrodiol dehydrogenase. J Biol Chem 1991; 266:8820-8825.
11. Cheng KC, White PC, Qin KN. Molecular cloning and expression of rat liver 3α-hydroxysteroid dehydrogenase. Mol Endocrinol 1991; 5: 823-828.
12. Del Bello B, Maellaro E, Sugherini L, Santucci A, Comporti M, Casini AF. Purification of NADPH-dependent dehydroascorbate reductase from rat liver and its identification with 3α-hydroxysteroid dehydrogenase. Biochem J 1994; 304:385-390.
13. Nanjo H, Terada T, Umemura T, Nishinaka T, Mizoguchi T, Nishihara T. Characterization of bovine liver cytosolic 3α-hydroxysteroid dehydrogenase and its aldo-keto reductase activity. Int J Biochem 1992; 24:815-820.
14. Hara A, Inoue Y, Nakagawa M, Naganeo F, Sawada H. Purification and characterization of NADP+-dependent 3α-hydroxysteroid dehydrogenase from mouse liver cytosol. J Biochem (Tokyo) 1988; 103: 1027-1034.
15. Penning TM, Smithgall TE, Askonas LJ, Sharp RB. Rat liver 3α-hydroxysteroid dehydrogenase. Steroids 1986; 47:221-247.
16. White PC, Mune T, Agarwal AK. 11β-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr Rev 1997; 18:135-156.
17. Zhou MY, Gomez-Sanchez EP, Cox DL, Cosby D, Gomez-Sanchez CE. Cloning, expression, and tissue distribution of the rat nicotinamide adenine dinucleotide-dependent 11β-hydroxysteroid dehydrogenase. Endocrinology 1995; 136:3729-373.
18. Duperrex H, Kenouch S, Gaeggeler HP, Seckl JR, Edwards CR, Farman N, Rossier BC. Rat liver 11β-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid encodes oxoreductase activity in a mineralocorticoid-responsive toad bladder cell line. Endocrinology 1993; 132:612-619.
19. Luu-The V, Zhang Y, Poirier D, Labrie F. Characteristics of human types 1, 2 and 3 17β-hydroxysteroid dehydrogenase activities: oxidation/reduction and inhibition. J Steroid Biochem Mol Biol 1995; 55:581-587.
20. Li XD, Bertics PJ, Karavolas HJ. Regional distribution of cytosolic and particulate 5α-dihydroprogesterone 3α-hydroxysteroid oxidoreductases in female rat brain. J Steroid Biochem Mol Biol 1997; 60: 311-318.
21. Ghraf R, Schneider K, Kirchhoff J, Hiemke C. Subcellular distribution of 3α-hydroxysteroid dehydrogenase and antiestrogen action on androgen-metabolizing enzymes in rat pituitary gland. J Neurochem 1982; 38:876-883.
22. Klinefelter GR, Kelce WR, Hardy MP. Isolation and culture of Leydig cells from adult rats. Methods Toxicol 1993; 3A:166-181.
23. Payne AH, Downing JR, Wong KL. Luteinizing hormone receptors and testosterone synthesis in two distinct population of Leydig cells. Endocrinology 1980; 106:1424-1429.
24. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl. Current Protocols in Molecular Biology. New York: Greene Publishing Associates and John Wiley & Sons; 1995: 10.0.1-10.20.11.
25. Smithgall TE, Penning TM. Electrophoretic and immunochemical characterization of 3α-hydroxysteroid/dihydrodiol dehydrogenases of rat tissues. Biochem J 1988; 254:715-721.
26. Sokal RR, Rohlf FJ. Biometry. New York: WH Freeman and Co.; 1981: 372-399.
27. Ge R-S, Hardy MP. Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat Leydig cells. Endocrinology 1998; 139:3787-3795.
28. Stubbs M, Veech RL, Krebs HA. Control of the redox state of the nicotinamide-adenine dinucleotide couple in the cytoplasm. Biochem J 1972; 126:59-65.
29. Aw TY. Postnatal changes in pyridine nucleotides in rat hepatocytes: composition and O2 dependence. Pediatr Res 1991; 30:112-117.
30. Deyashiki Y, Ogasawara A, Nakayama T, Nakanishi M, Miyabe Y, Sato K, Hara A. Molecular cloning of two human liver 3α-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder. Biochem J 1994; 299: 545-552.
31. Lin HK, Jez JM, Schlegel BP, Peehl DM, Pachter JA, Penning TM. Expression and characterization of recombinant type 2 3α-hydroxy-steroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3α/17β-HSD activity and cellular distribution. Mol Endocrinol 1997; 11:1971-1984.
32. Dufort I, Soucy P, Labrie F, Luu-The V. Molecular cloning of human type 3 3α-hydroxysteroid dehydrogenase that differs from 20α-hydroxysteroid dehydrogenase by seven amino acids. Biochem Biophys Res Commun 1996; 228:474-479.
33. Su J, Chai XY, Kahn B, Napoli JL. cDNA cloning, tissue distribution, and substrate characteristics of a cis-retinol/3α-hydroxysteroid dehydroxysterol short-chain dehydrogenase isozyme. J Biol Chem 1998; 273:17910-17916.
34. Chai XY, Zhai Y, Napoli JL. cDNA cloning and characterization of a cis-retinol/3α-hydroxysterol short-chain dehydrogenase. J Biol Chem 1997; 272:33125-33131.
35. Biswas MG, Russell DW. Expression cloning and characterization of oxidative 17β-and 3α-hydroxysteroid dehydrogenases from rat and human prostate. J Biol Chem 1997; 272:15959-15966.
36. Gough WH, VanOoteghem S, Sint T, Kedishvili NY. cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3α-hydroxysteroids. J Biol Chem 1998; 273:19778-19785.
37. Chubb C, Ewing LL. Steroid secretion by sexually immature rat and rabbit testis perfused in vitro. Endocrinology 1981; 109:1999-2003.
38. Corpechot C, Baulieu EE, Robel P. Testosterone, dihydrotestosterone and androstanediols in plasma, testes and prostates of rats during development. Acta Endocrinol (Copehn) 1981; 96:127-135.
39. Inano H, Tamaoki B-I. Bioconversion of steroids in immature rat testes in vitro. Endocrinology 1966; 79:579-590.
40. Viger RS, Robaire B. Steady state steroid 5α-reductase messenger ribonucleic acid levels and immunocytochemical localization of the type I protein in the rat testis during postnatal development. Endocrinology 1995; 136:5409-5415.
41. O'Donnell L, Stanton PG, Wreford NG, Robertson DM, McLachlan RI. Inhibition of 5α-reductase activity impairs the testosterone-dependent restoration of spermiogenesis in adult rats. Endocrinology 1996; 137:2703-2710.