Cellular analysis of disorazole C1 and structure-activity relationship of analogs of the natural product

Chemical Biology and Drug Design

Volumn 67, Issue 1, 2006, Pages 66-73

  Wipf, Peter ^a   Graham, Thomas H ^a   Vogt, Andreas ^b   Sikorski, Rachel P ^b   Ducruet, Alexander P ^b   Lazo, John S ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Cell cycle; Conformational analysis; Disorazoles; Gliding bacteria; Macrolide; Mitosis; Natural products; SAR; Tubulin

Indexed keywords

ANTIMITOTIC AGENT; COLCHICINE; DISORAZOLE C 1; FLUORESCENT DYE; FUNCTIONAL GROUP; NATURAL PRODUCT; PACLITAXEL; UNCLASSIFIED DRUG; VINBLASTINE; VINCRISTINE;

ARTICLE; AUTOMATION; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; HYPOTHESIS; MICROTUBULE; MITOSIS INDEX; MITOSIS INHIBITION; PRECURSOR; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; THREE DIMENSIONAL IMAGING;

ANTIMITOTIC AGENTS; BIOLOGICAL PRODUCTS; CELL CYCLE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HELA CELLS; HUMANS; MICROTUBULES; MITOSIS; OXAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33745112858     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2005.00313.x     Document Type: Article

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