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Volumn 46, Issue 3, 2009, Pages 262-267

An evaluation of the neuroprotective effects of melatonin in an in vitro experimental model of age-induced neuronal apoptosis

Author keywords

Aging; Cell cycle; Neurodegeneration; P53

Indexed keywords

CYCLIN D; DNA; MELATONIN; PROTEIN KINASE B; PROTEIN P53; TRANSCRIPTION FACTOR E2F1;

EID: 62449146689     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2008.00656.x     Document Type: Article
Times cited : (41)

References (46)
  • 1
    • 40849135716 scopus 로고    scopus 로고
    • Apoptotic mechanisms involved in neurodegenerative diseases: Experimental and therapeutic approaches
    • Camins A, Pallas M, Silvestre JS. Apoptotic mechanisms involved in neurodegenerative diseases: experimental and therapeutic approaches. Methods Find Exp Clin Pharmacol 2008 30 : 43 65.
    • (2008) Methods Find Exp Clin Pharmacol , vol.30 , pp. 43-65
    • Camins, A.1    Pallas, M.2    Silvestre, J.S.3
  • 2
    • 44949085340 scopus 로고    scopus 로고
    • The role of the DNA damage response in neuronal development, organization and maintenance
    • Barzilai A, Biton S, Shiloh Y. The role of the DNA damage response in neuronal development, organization and maintenance. DNA Repair (Amst) 2008 7 : 1010 1027.
    • (2008) DNA Repair (Amst) , vol.7 , pp. 1010-1027
    • Barzilai, A.1    Biton, S.2    Shiloh, Y.3
  • 3
    • 44949091276 scopus 로고    scopus 로고
    • Accumulation of nuclear DNA damage or neuron loss: Molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases
    • Brasnjevic I, Hof PR, Steinbusch HW, Schmitz C. Accumulation of nuclear DNA damage or neuron loss: molecular basis for a new approach to understanding selective neuronal vulnerability in neurodegenerative diseases. DNA Repair (Amst) 2008 7 : 1087 1097.
    • (2008) DNA Repair (Amst) , vol.7 , pp. 1087-1097
    • Brasnjevic, I.1    Hof, P.R.2    Steinbusch, H.W.3    Schmitz, C.4
  • 4
    • 43249118458 scopus 로고    scopus 로고
    • DNA damage and repair: Relevance to mechanisms of neurodegeneration
    • Martin LJ. DNA damage and repair: relevance to mechanisms of neurodegeneration. J Neuropathol Exp Neurol 2008 67 : 377 387.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 377-387
    • Martin, L.J.1
  • 5
    • 34548802393 scopus 로고    scopus 로고
    • Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment
    • Weissman L, Jo DG, Sørensen MM, De Souza-Pinto NC et al. Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment. Nucleic Acids Res 2007 35 : 5545 5555.
    • (2007) Nucleic Acids Res , vol.35 , pp. 5545-5555
    • Weissman, L.1    Jo, D.G.2    Sørensen, M.M.3    De Souza-Pinto, N.C.4
  • 8
    • 1342333775 scopus 로고    scopus 로고
    • Cell cycle activation linked to neuronal cell death initiated by DNA damage
    • Kruman II, Wersto RP, Cardozo-Pelaez F, Smilenov L et al. Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron 2004 41 : 549 561.
    • (2004) Neuron , vol.41 , pp. 549-561
    • Kruman, I.I.1    Wersto, R.P.2    Cardozo-Pelaez, F.3    Smilenov, L.4
  • 10
    • 35348889576 scopus 로고    scopus 로고
    • Inhibition of ataxia telangiectasia-p53-E2F-1 pathway in neurons as a target for the prevention of neuronal apoptosis
    • Camins A, Verdaguer E, Folch J et al. Inhibition of ataxia telangiectasia-p53-E2F-1 pathway in neurons as a target for the prevention of neuronal apoptosis. Curr Drug Metab 2007 8 : 709 715.
    • (2007) Curr Drug Metab , vol.8 , pp. 709-715
    • Camins, A.1    Verdaguer, E.2    Folch, J.3
  • 11
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 2005 9 : 59 71.
    • (2005) J Cell Mol Med , vol.9 , pp. 59-71
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 12
    • 43649084933 scopus 로고    scopus 로고
    • Better cognitive performance in elderly taking antioxidant vitamins e and C supplements in combination with nonsteroidal anti-inflammatory drugs: The Cache County Study
    • Fotuhi M, Zandi PP, Hayden KM et al. Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: the Cache County Study. Alzheimers Dement 2008 4 : 223 227.
    • (2008) Alzheimers Dement , vol.4 , pp. 223-227
    • Fotuhi, M.1    Zandi, P.P.2    Hayden, K.M.3
  • 13
    • 47749113264 scopus 로고    scopus 로고
    • Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice
    • Rodríguez MI, Escames G, López LC et al. Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice. Exp Gerontol 2008 43 : 749 756.
    • (2008) Exp Gerontol , vol.43 , pp. 749-756
    • Rodríguez, M.I.1    Escames, G.2    López, L.C.3
  • 14
    • 33847314231 scopus 로고    scopus 로고
    • Melatonin and the aging brain
    • Bondy SC, Sharman EH. Melatonin and the aging brain. Neurochem Int 2007 50 : 571 580.
    • (2007) Neurochem Int , vol.50 , pp. 571-580
    • Bondy, S.C.1    Sharman, E.H.2
  • 16
    • 34548416796 scopus 로고    scopus 로고
    • Neural stem cell transplantation and melatonin treatment in a 6-hydroxydopamine model of Parkinson's disease
    • Sharma R, Mcmillan CR, Niles LP. Neural stem cell transplantation and melatonin treatment in a 6-hydroxydopamine model of Parkinson's disease. J Pineal Res 2007 43 : 245 254.
    • (2007) J Pineal Res , vol.43 , pp. 245-254
    • Sharma, R.1    McMillan, C.R.2    Niles, L.P.3
  • 17
    • 51649122290 scopus 로고    scopus 로고
    • Favourable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice
    • Caballero B, Vega-Naredo I, Sierra V et al. Favourable effects of a prolonged treatment with melatonin on the level of oxidative damage and neurodegeneration in senescence-accelerated mice. J Pineal Res 2008 45 : 302 311.
    • (2008) J Pineal Res , vol.45 , pp. 302-311
    • Caballero, B.1    Vega-Naredo, I.2    Sierra, V.3
  • 18
    • 34447577880 scopus 로고    scopus 로고
    • Melatonin inhibits MPP+-induced caspase-mediated death pathway and DNA fragmentation factor-45 cleavage in SK-N-SH cultured cells
    • Chetsawang J, Govitrapong P, Chetsawang B. Melatonin inhibits MPP+-induced caspase-mediated death pathway and DNA fragmentation factor-45 cleavage in SK-N-SH cultured cells. J Pineal Res 2007 43 : 115 120.
    • (2007) J Pineal Res , vol.43 , pp. 115-120
    • Chetsawang, J.1    Govitrapong, P.2    Chetsawang, B.3
  • 19
    • 0037565622 scopus 로고    scopus 로고
    • Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease
    • Matsubara E, Bryant-Thomas T, Pacheco Quinto J et al. Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease. J Neurochem 2003 85 : 1101 1108.
    • (2003) J Neurochem , vol.85 , pp. 1101-1108
    • Matsubara, E.1    Bryant-Thomas, T.2    Pacheco Quinto, J.3
  • 20
    • 35448974373 scopus 로고    scopus 로고
    • Protective action of melatonin against oxidative DNA damage: Chemical inactivation versus base-excision repair
    • Sliwinski T, Rozej W, Morawiec-Bajda A, Morawiec Z, Reiter RJ, Blasiak J. Protective action of melatonin against oxidative DNA damage: chemical inactivation versus base-excision repair. Mutat Res 2007 634 : 220 227.
    • (2007) Mutat Res , vol.634 , pp. 220-227
    • Sliwinski, T.1    Rozej, W.2    Morawiec-Bajda, A.3    Morawiec, Z.4    Reiter, R.J.5    Blasiak, J.6
  • 21
    • 15444363809 scopus 로고    scopus 로고
    • The human pineal gland and melatonin in aging and Alzheimer's disease
    • Wu YH, Swaab DF. The human pineal gland and melatonin in aging and Alzheimer's disease. J Pineal Res 2005 38 : 145 152.
    • (2005) J Pineal Res , vol.38 , pp. 145-152
    • Wu, Y.H.1    Swaab, D.F.2
  • 22
    • 1942435951 scopus 로고    scopus 로고
    • Dietary supplementation with melatonin reduces levels of amyloid beta-peptides in the murine cerebral cortex
    • Lahiri DK, Chen D, Ge YW, Bondy SC, Sharman EH. Dietary supplementation with melatonin reduces levels of amyloid beta-peptides in the murine cerebral cortex. J Pineal Res 2004 36 : 224 231.
    • (2004) J Pineal Res , vol.36 , pp. 224-231
    • Lahiri, D.K.1    Chen, D.2    Ge, Y.W.3    Bondy, S.C.4    Sharman, E.H.5
  • 23
    • 1842609886 scopus 로고    scopus 로고
    • Age-related changes in murine CNS mRNA gene expression are modulated by dietary melatonin
    • Sharman EH, Sharman KG, Ge YW, Lahiri DK, Bondy SC. Age-related changes in murine CNS mRNA gene expression are modulated by dietary melatonin. J Pineal Res 2004 36 : 165 170.
    • (2004) J Pineal Res , vol.36 , pp. 165-170
    • Sharman, E.H.1    Sharman, K.G.2    Ge, Y.W.3    Lahiri, D.K.4    Bondy, S.C.5
  • 24
    • 39149122800 scopus 로고    scopus 로고
    • Melatonin reduces neuronal loss, down regulation of dopamine transporter, and up regulation of D2 receptor in rotenone-induced parkinsonian rats
    • Lin CH, Huang JY, Ching CH, Chuang JI. Melatonin reduces neuronal loss, down regulation of dopamine transporter, and up regulation of D2 receptor in rotenone-induced parkinsonian rats. J Pineal Res 2008 44 : 205 213.
    • (2008) J Pineal Res , vol.44 , pp. 205-213
    • Lin, C.H.1    Huang, J.Y.2    Ching, C.H.3    Chuang, J.I.4
  • 25
    • 24044466823 scopus 로고    scopus 로고
    • Age-dependent changes in Fibroblast growth factor 2 (FGF-2) expression in mouse cerebellar neurons
    • Reynolds J, Logan A, Berry M, Dent RG, Gonzales AM, Toescu EC. Age-dependent changes in Fibroblast growth factor 2 (FGF-2) expression in mouse cerebellar neurons. J Cell Mol Med 2005 9 : 398 406.
    • (2005) J Cell Mol Med , vol.9 , pp. 398-406
    • Reynolds, J.1    Logan, A.2    Berry, M.3    Dent, R.G.4    Gonzales, A.M.5    Toescu, E.C.6
  • 26
    • 3242696921 scopus 로고    scopus 로고
    • Metabolic substrates of neuronal aging
    • Toescu EC, Xiong J. Metabolic substrates of neuronal aging. Ann N Y Acad Sci 2004 1019 : 19 23.
    • (2004) Ann N y Acad Sci , vol.1019 , pp. 19-23
    • Toescu, E.C.1    Xiong, J.2
  • 27
    • 1242271240 scopus 로고    scopus 로고
    • Mitochondrial polarisation status and [Ca2+]i signalling in rat cerebellar granule neurones aged in vitro
    • Xiong J, Camello PJ, Verkhratsky A, Toescu EC. Mitochondrial polarisation status and [Ca2+]i signalling in rat cerebellar granule neurones aged in vitro. Neurobiol Aging 2004 25 : 349 359.
    • (2004) Neurobiol Aging , vol.25 , pp. 349-359
    • Xiong, J.1    Camello, P.J.2    Verkhratsky, A.3    Toescu, E.C.4
  • 28
    • 0037115050 scopus 로고    scopus 로고
    • 2+ homeostasis in aged cerebellar granule neurons in brain slices
    • 2+ homeostasis in aged cerebellar granule neurons in brain slices. J Neurosci 2002 22 : 10761 10771.
    • (2002) J Neurosci , vol.22 , pp. 10761-10771
    • Xiong, J.1    Verkhratsky, A.2    Toescu, E.C.3
  • 29
    • 0034722698 scopus 로고    scopus 로고
    • Neuronal ageing in long-term cultures: Alterations of Ca2+ homeostasis
    • Toescu EC, Verkhratsky A. Neuronal ageing in long-term cultures: alterations of Ca2+ homeostasis. Neuroreport 2000 11 : 3725 3729.
    • (2000) Neuroreport , vol.11 , pp. 3725-3729
    • Toescu, E.C.1    Verkhratsky, A.2
  • 30
    • 35848936298 scopus 로고    scopus 로고
    • Neuroprotective effects of caffeine against complex i inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons
    • Alvira D, Yeste-Velasco M, Folch J, Casadesús G et al. Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons. J Neurosci Res 2007 85 : 3079 3088.
    • (2007) J Neurosci Res , vol.85 , pp. 3079-3088
    • Alvira, D.1    Yeste-Velasco, M.2    Folch, J.3    Casadesús, G.4
  • 31
    • 0030045251 scopus 로고    scopus 로고
    • Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in age-induced apoptosis in mature cerebellar neurons in culture
    • Ishitani R, Sunaga K, Hirano A, Saunders P, Katsube N, Chuang DM. Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in age-induced apoptosis in mature cerebellar neurons in culture. J Neurochem 1996 66 : 928 935.
    • (1996) J Neurochem , vol.66 , pp. 928-935
    • Ishitani, R.1    Sunaga, K.2    Hirano, A.3    Saunders, P.4    Katsube, N.5    Chuang, D.M.6
  • 32
    • 0031968628 scopus 로고    scopus 로고
    • Nuclear localization of overexpressed glyceraldehyde-3-phosphate dehydrogenase in cultured cerebellar neurons undergoing apoptosis
    • Ishitani R, Tanaka M, Sunaga K, Katsube N, Chuang DM. Nuclear localization of overexpressed glyceraldehyde-3-phosphate dehydrogenase in cultured cerebellar neurons undergoing apoptosis. Mol Pharmacol 1998 53 : 701 707.
    • (1998) Mol Pharmacol , vol.53 , pp. 701-707
    • Ishitani, R.1    Tanaka, M.2    Sunaga, K.3    Katsube, N.4    Chuang, D.M.5
  • 33
    • 0033034786 scopus 로고    scopus 로고
    • Inhibition of excessive neuronal apoptosis by the calcium antagonist amlodipine and antioxidants in cerebellar granule cells
    • Mason RP, Leeds PR, Jacob RF, Hough CJ et al. Inhibition of excessive neuronal apoptosis by the calcium antagonist amlodipine and antioxidants in cerebellar granule cells. J Neurochem 1999 72 : 1448 1456.
    • (1999) J Neurochem , vol.72 , pp. 1448-1456
    • Mason, R.P.1    Leeds, P.R.2    Jacob, R.F.3    Hough, C.J.4
  • 34
    • 33644908054 scopus 로고    scopus 로고
    • Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus
    • Lee SH, Chun W, Kong PJ, Han JA et al. Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus. J Pineal Res 2006 40 : 79 85.
    • (2006) J Pineal Res , vol.40 , pp. 79-85
    • Lee, S.H.1    Chun, W.2    Kong, P.J.3    Han, J.A.4
  • 35
    • 12344307153 scopus 로고    scopus 로고
    • Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemia in mice
    • Kilic U, Kilic E, Reiter RJ, Bassetti CL, Hermann DM. Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemia in mice. J Pineal Res 2005 38 : 67 71.
    • (2005) J Pineal Res , vol.38 , pp. 67-71
    • Kilic, U.1    Kilic, E.2    Reiter, R.J.3    Bassetti, C.L.4    Hermann, D.M.5
  • 36
    • 28744450569 scopus 로고    scopus 로고
    • Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease
    • Feng Z, Qin C, Chang Y, Zhang JT. Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease. Free Radic Biol Med 2006 40 : 101 109.
    • (2006) Free Radic Biol Med , vol.40 , pp. 101-109
    • Feng, Z.1    Qin, C.2    Chang, Y.3    Zhang, J.T.4
  • 37
    • 34147199638 scopus 로고    scopus 로고
    • Chronic administration of melatonin reduces cerebral injury biomarkers in SAMP8
    • Gutierrez-Cuesta J, Sureda FX et al. Chronic administration of melatonin reduces cerebral injury biomarkers in SAMP8. J Pineal Res 2007 42 : 394 402.
    • (2007) J Pineal Res , vol.42 , pp. 394-402
    • Gutierrez-Cuesta, J.1    Sureda, F.X.2
  • 38
    • 33646493486 scopus 로고    scopus 로고
    • Changes in oxidative stress parameters and neurodegeneration markers in the brain of the senescence-accelerated mice SAMP-8
    • Sureda FX, Gutierrez-Cuesta J, Romeu M, Mulero M et al. Changes in oxidative stress parameters and neurodegeneration markers in the brain of the senescence-accelerated mice SAMP-8. Exp Gerontol 2006 41 : 360 367.
    • (2006) Exp Gerontol , vol.41 , pp. 360-367
    • Sureda, F.X.1    Gutierrez-Cuesta, J.2    Romeu, M.3    Mulero, M.4
  • 39
    • 0036592637 scopus 로고    scopus 로고
    • Cell cycle proteins in Alzheimer's disease: Plenty of wheels but no cycle
    • Bowser R, Smith MA. Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle. J. Alzheimers Dis 2002 4 : 249 254.
    • (2002) J. Alzheimers Dis , vol.4 , pp. 249-254
    • Bowser, R.1    Smith, M.A.2
  • 40
    • 38449084379 scopus 로고    scopus 로고
    • DNA damage response and neuroprotection
    • Kruman II, Schwartz EI. DNA damage response and neuroprotection. Front Biosci 2008 13 : 2504 2515.
    • (2008) Front Biosci , vol.13 , pp. 2504-2515
    • Kruman, I.I.1    Schwartz, E.I.2
  • 41
    • 33947151122 scopus 로고    scopus 로고
    • The cell cycle hypothesis of Alzheimer's disease: Suggestions for drug development
    • Woods J, Snape M, Smith MA. The cell cycle hypothesis of Alzheimer's disease: suggestions for drug development. Biochim Biophys Acta 2007 1772 : 503 508.
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 503-508
    • Woods, J.1    Snape, M.2    Smith, M.A.3
  • 42
    • 33947178563 scopus 로고    scopus 로고
    • Alzheimer disease, the two-hit hypothesis: An update
    • Zhu X, Lee HG, Perry G, Smith MA. Alzheimer disease, the two-hit hypothesis: an update. Biochim Biophys Acta 2007 1772 : 494 502.
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 494-502
    • Zhu, X.1    Lee, H.G.2    Perry, G.3    Smith, M.A.4
  • 44
    • 24344476294 scopus 로고    scopus 로고
    • The cell cycle in Alzheimer disease: A unique target for neuropharmacology
    • Webber KM, Raina AK, Marlatt MW et al. The cell cycle in Alzheimer disease: a unique target for neuropharmacology. Mech Ageing Dev 2005 126 : 1019 1025.
    • (2005) Mech Ageing Dev , vol.126 , pp. 1019-1025
    • Webber, K.M.1    Raina, A.K.2    Marlatt, M.W.3
  • 45
    • 0034086552 scopus 로고    scopus 로고
    • The transcription factor E2F1 modulates apoptosis of neurons
    • Hou ST, Callaghan D, Fournier MC, Hill I et al. The transcription factor E2F1 modulates apoptosis of neurons. J Neurochem 2000 75 : 91 100.
    • (2000) J Neurochem , vol.75 , pp. 91-100
    • Hou, S.T.1    Callaghan, D.2    Fournier, M.C.3    Hill, I.4
  • 46
    • 0034682777 scopus 로고    scopus 로고
    • Induction and modulation of cerebellar granule neuron death by E2F-1
    • O'hare MJ, Hou ST, Morris EJ, Cregan SP et al. Induction and modulation of cerebellar granule neuron death by E2F-1. J Biol Chem 2000 275 : 25358 25364.
    • (2000) J Biol Chem , vol.275 , pp. 25358-25364
    • O'Hare, M.J.1    Hou, S.T.2    Morris, E.J.3    Cregan, S.P.4


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