Better cognitive performance in elderly taking antioxidant vitamins E and C supplements in combination with nonsteroidal anti-inflammatory drugs: The Cache County Study

Alzheimer's and Dementia

Volumn 4, Issue 3, 2008, Pages 223-227

  Fotuhi, Majid ^a   Zandi, Peter P ^b   Hayden, Kathleen M ^c   Khachaturian, Ara S ^d   Szekely, Christine A ^b   Wengreen, Heidi ^e   Munger, Ronald G ^e   Norton, Maria C ^e   Tschanz, JoAnn T ^e   Lyketsos, Constantine G ^f   Breitner, John C S ^g   Welsh Bohmer, Kathleen ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d Khachaturian and Associates Inc   (United States)

^e UTAH STATE UNIVERSITY   (United States)

^f JOHNS HOPKINS UNIVERSITY   (United States)

^g UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Antioxidant vitamins; Cognitive performance; Dementia prevention; NSAIDs; Random effect model

Indexed keywords

ALPHA TOCOPHEROL; APOLIPOPROTEIN E4; ASCORBIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT;

AGED; ALLELE; ARTICLE; COGNITIVE DEFECT; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG USE; ELDERLY CARE; FEMALE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; MONOTHERAPY; PRIMARY PREVENTION; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; UNITED STATES; VITAMIN SUPPLEMENTATION;

AGED; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; APOLIPOPROTEINS E; ASCORBIC ACID; BRAIN; COGNITION; DIETARY SUPPLEMENTS; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; VITAMIN E;

EID: 43649084933     PISSN: 15525260     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jalz.2008.01.004     Document Type: Article

References (12)

1. Zandi P.P., Anthony J.C., Khachaturian A.S., Stone S.V., Gustafson D., Tschanz J.T., et al. Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study. Arch Neurol 61 (2004) 82-88
2. Zandi P.P., Anthony J.C., Hayden K.M., Mehta K., Mayer L., and Breitner J.C. Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study. Neurology 59 (2002) 880-886
3. Wengreen H.J., Munger R.G., Corcoran C.D., Zandi P., Hayden K.M., Fotuhi M., et al. Antioxidant intake and cognitive function of elderly men and women: the cache county study. J Nutr Health Aging 11 (2007) 230-237
4. Hayden K.M., Zandi P.P., Khachaturian A.S., Szekely C.A., Fotuhi M., Norton M.C., et al. Does NSAID use modify cognitive trajectories in the elderly?. the Cache County Study. Neurology 69 (2007) 275-282
5. Tschanz J.T., Welsh-Bohmer K.A., Plassman B.L., Norton M.C., Wyse B.W., and Breitner J.C. An adaptation of the modified mini-mental state examination: analysis of demographic influences and normative data: the cache county study. Neuropsychiatry Neuropsychol Behav Neurol 15 (2002) 28-38
6. Breitner J.C., and Zandi P.P. Do nonsteroidal antiinflammatory drugs reduce the risk of Alzheimer's disease?. N Engl J Med 345 (2001) 1567-1568
7. Miech R.A., Breitner J.C., Zandi P.P., Khachaturian A.S., Anthony J.C., and Mayer L. Incidence of AD may decline in the early 90s for men, later for women: the Cache County study. Neurology 58 (2002) 209-218
8. Frautschy S.A., Hu W., Kim P., Miller S.A., Chu T., Harris-White M.E., et al. Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology. Neurobiol Aging 22 (2001) 993-1005
9. Halliwell B. Oxidative stress and neurodegeneration: where are we now?. J Neurochem 97 (2006) 1634-1658
10. Weggen S., Eriksen J.L., Sagi S.A., Pietrzik C.U., Ozols V., Fauq A., et al. Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J Biol Chem 278 (2003) 31831-31837
11. Bjelakovic G., Nikolova D., Gluud L.L., Simonetti R.G., and Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 297 (2007) 842-857
12. McGettigan P., and Henry D. Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2. JAMA 296 (2006) 1633-1644