Ablation of cathepsin K activity in the young mouse causes hypermineralization of long bone and growth plates

Calcified Tissue International

Volumn 84, Issue 3, 2009, Pages 229-239

  Boskey, Adele L ^a   Gelb, Bruce D ^b   Pourmand, Eric ^a   Kudrashov, Valery ^a   Doty, Stephen B ^a   Spevak, Lyudmila ^a   Schaffler, Mitchell B ^b,c  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c CITY COLLEGE OF NEW YORK   (United States)

Author keywords

Cathepsin K; FTIR spectroscopic imaging; Growth plate; Knockout mouse; Mineralization

Indexed keywords

CATHEPSIN K;

ANIMAL TISSUE; ARTICLE; BONE MINERALIZATION; CALCIFICATION; CHICK EMBRYO; EMBRYO; ENCHONDRAL OSSIFICATION; ENZYME DEFICIENCY; FOURIER TRANSFORMATION; GROWTH PLATE; INFRARED SPECTROSCOPY; KNOCKOUT MOUSE; LIMB BUD; LONG BONE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; PRIORITY JOURNAL; TIBIA;

ANIMALS; BONE DEVELOPMENT; CALCIFICATION, PHYSIOLOGIC; CALCINOSIS; CATHEPSINS; CELL DIFFERENTIATION; ENZYME INHIBITORS; GROWTH PLATE; MALE; MESODERM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OSTEOGENESIS; TIBIA;

EID: 62349132973     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-008-9214-6     Document Type: Article

References (47)

1. RA Dodds JR Connor F Drake J Feild M Gowen 1998 Cathepsin K mRNA detection is restricted to osteoclasts during fetal mouse development J Bone Miner Res 13 673 682
2. K Hollberg J Nordahl K Hultenby S Mengarelli-Widholm G Andersson FP Reinholt 2005 Polarization and secretion of cathepsin K precede tartrate-resistant acid phosphatase secretion to the ruffled border area during the activation of matrix-resorbing clasts J Bone Miner Metab 23 441 449
3. M Söderstrom H Salminen V Glumoff H Kirschke H Aro E Vuorio 1999 Cathepsin expression during skeletal development Biochim Biophys Acta 1446 35 46
4. BC Sondergaard K Henriksen H Wulf S Oestergaard U Schurigt R Brauer I Danielsen C Christiansen P Qvist MA Karsdal 2006 Relative contribution of matrix metalloprotease and cysteine protease activities to cytokine-stimulated articular cartilage degradation Osteoarthritis Cartilage 14 738 748
5. C Haeckel S Krueger F Buehling D Broemme K Franke A Schuetze I Roese A Roessner 1999 Expression of cathepsin K in the human embryo and fetus Dev Dyn 216 89 95
6. F Buhling U Peitz S Kruger D Kuster M Vieth I Gebert A Roessner E Weber P Malfertheiner T Wex 2004 Cathepsins K, L, B, X and W are differentially expressed in normal and chronically inflamed gastric mucosa Biol Chem 385 439 445
7. JH Lindeman R Hanemaaijer A Mulder PD Dijkstra K Szuhai D Bromme JH Verheijen PC Hogendoorn 2004 Cathepsin K is the principal protease in giant cell tumor of bone Am J Pathol 165 593 600
8. I Rapa M Volante S Cappia R Rosas GV Scagliotti M Papotti 2006 Cathepsin K is selectively expressed in the stroma of lung adenocarcinoma but not in bronchioloalveolar carcinoma. A useful marker of invasive growth Am J Clin Pathol 125 847 854
9. WS Hou Z Li FH Buttner E Bartnik D Bromme 2003 Cleavage site specificity of cathepsin K toward cartilage proteoglycans and protease complex formation Biol Chem 384 891 897
10. Y Fujita K Nakata N Yasui Y Matsui E Kataoka K Hiroshima RI Shiba T Ochi 2000 Novel mutations of the cathepsin K gene in patients with pycnodysostosis and their characterization J Clin Endocrinol Metab 85 425 431
11. N Fratzl-Zelman A Valenta P Roschger A Nader BD Gelb P Fratzl K Klaushofer 2004 Decreased bone turnover and deterioration of bone structure in two cases of pycnodysostosis J Clin Endocrinol Metab 89 1538 1547
12. BD Gelb K Moissoglu J Zhang JA Martignetti D Bromme RJ Desnick 1996 Cathepsin K: isolation and characterization of the murine cDNA and genomic sequence, the homologue of the human pycnodysostosis gene Biochem Mol Med 59 200 206
13. P Saftig E Hunziker O Wehmeyer S Jones A Boyde W Rommerskirch JD Moritz P Schu K von Figura 1998 Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice Proc Natl Acad Sci USA 95 13453 13458
14. M Gowen F Lazner R Dodds R Kapadia J Field M Tavaria I Bertoncello F Drake S Zavarselk I Tellis P Hertzog C Debouck I Kola 1999 Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization J Bone Miner 14 1654 1663
15. V Everts WS Hou X Rialland W Tigchelaar P Saftig D Bromme BD Gelb W Beertsen 2003 Cathepsin K deficiency in pycnodysostosis results in accumulation of non-digested phagocytosed collagen in fibroblasts Calcif Tissue Int 73 380 386
16. CY Li KJ Jepsen RJ Majeska J Zhang R Ni BD Gelb MB Schaffler 2006 Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass J Bone Miner Res 21 865 875
17. D Vanderschueren R Bouillon 1995 Androgens and bone Calcif Tissue Int 56 341 346
18. LL Tosi BD Boyan AL Boskey 2005 Does sex matter in musculoskeletal health? The influence of sex and gender on musculoskeletal health J Bone Joint Surg Am 87 1631 1647
19. AL Boskey DJ Moore M Amling E Canalis AM Delany 2003 Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls J Bone Miner Res 18 1005 1011
20. AL Boskey L Spevak E Paschalis SB Doty MD McKee 2002 Osteopontin deficiency increases mineral content and mineral crystallinity in mouse bone Calcif Tissue Int 71 145 154
21. D Faibish A Gomes G Boivin I Binderman A Boskey 2005 Infrared imaging of calcified tissue in bone biopsies from adults with osteomalacia Bone 36 6 12
22. RY Huang LM Miller CS Carlson MR Chance 2002 Characterization of bone mineral composition in the proximal tibia of cynomolgus monkeys: effect of ovariectomy and nandrolone decanoate treatment Bone 30 492 497
23. AL Boskey R Mendelsohn 2005 Infrared spectroscopic characterization of mineralized tissues Vib Spectrosc 38 107 114
24. V Hamburger HL Hamilton 1951 A series of normal stages in the development of the chick embryo J Morphol 88 49 92
25. D Wang M Pechar W Li P Kopecková D Brömme J Kopecek 2002 Inhibition of cathepsin K with lysosomotropic macromolecular inhibitors Biochemistry 41 8849 8859
26. F Lecaille S Chowdhury E Purisma D Bromme G Lalmanach 2007 The S2 subsites of cathepsins K and L and their contribution to collagen degradation Protein Sci 16 662 670
27. HU Demuth A Schierhorn P Bryan R Höfke H Kirschke D Brömme 1996 N-Peptidyl, O-acyl hydroxamates: comparison of the selective inhibition of serine and cysteine proteinases Biochim Biophys Acta 1295 179 186
28. D Bromme H-U Demuth 1994 N, O-Diacyl hydroxamates as selective and irreversible inhibitors of cysteine proteinases Methods Enzymol 244 671 685
29. YJ Kim RLY Sah JYH Doong AJ Grodzinsky 1988 Fluorometric assay of DNA in cartilage explants using Hoechst 33258 Anal Biochem 174 168 176
30. EP Pourmand I Binderman SB Doty V Kudryashov AL Boskey 2006 Chondrocyte apoptosis is not essential for cartilage calcification: evidence from an in vitro avian model J Cell Biochem 100 43 57
31. AL Boskey D Stiner I Binderman SB Doty 1997 Effects of proteoglycan modification on mineral formation in a differentiating chick limb-bud mesenchymal cell culture system J Cell Biochem 64 632 643
32. AL Boskey D Stiner I Binderman SB Doty 2000 Type I collagen influences cartilage calcification: an immunoblocking study in differentiating chick limb-bud mesenchymal cell cultures J Cell Biochem 79 89 102
33. AL Boskey D Stiner SB Doty I Binderman P Leboy 1992 Studies of mineralization in tissue culture: optimal conditions for cartilage calcification Bone Miner 16 11 36
34. A Boskey 2003 Mineral changes in osteopetrosis Crit Rev Eukaryot Gene Expr 13 109 116
35. AL Boskey SC Marks Jr 1985 Mineral and matrix alterations in the bones of incisors-absent (ia/ia) osteopetrotic rats Calcif Tissue Int 37 287 292
36. A Boskey 2007
37. R Chiusaroli A Sanjay K Henriksen MT Engsig WC Horne H Gu R Baron 2003 Deletion of the gene encoding c-Cbl alters the ability of osteoclasts to migrate, delaying resorption and ossification of cartilage during the development of long bones Dev Biol 261 537 547
38. K Hoshi T Komori H Ozawa 1999 Morphological characterization of skeletal cells in Cbfa1-deficient mice Bone 25 639 651
39. J Rantakokko HT Aro M Savontaus E Vuorio 1996 Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development FEBS Lett 393 307 313
40. CP Tarnowski MA Ignelzi Jr MD Morris 2002 Mineralization of developing mouse calvaria as revealed by Raman microspectroscopy J Bone Miner Res 17 1118 1126
41. MA Mello RS Tuan 2006 Effects of TGF-beta1 and triiodothyronine on cartilage maturation: in vitro analysis using long-term high-density micromass cultures of chick embryonic limb mesenchymal cells J Orthop Res 24 2095 2105
42. IE James MW Lark D Zembryki EV Lee-Rykaczewski SM Hwang TA Tomaszek P Belfiore M Gowen 1999 Development and characterization of a human in vitro resorption assay: demonstration of utility using novel antiresorptive agents J Bone Miner Res 14 1562 1569
43. AL Boskey M Maresca AL Armstrong MG Ehrlich 1992 Treatment of proteoglycan aggregates with physeal enzymes reduces their ability to inhibit hydroxyapatite proliferation in a gelatin gel J Orthop Res 10 313 319
44. AL Boskey L Spevak SB Doty L Rosenberg 1997 Effects of bone CS-proteoglycans, DS-decorin, and DS-biglycan on hydroxyapatite formation in a gelatin gel Calcif Tissue Int 61 298 305
45. GK Hunter 1991 Role of proteoglycan in the provisional calcification of cartilage. A review and reinterpretation Clin Orthop Relat Res 262 256 280
46. R Kiviranta J Morko SL Alatalo R NicAmhlaoibh J Risteli T Laitala-Leinonen E Vuorio 2005 Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio Bone 36 159 172
47. Y Ling HF Rios ER Myers Y Lu JQ Feng AL Boskey 2005 DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis J Bone Miner Res 20 2169 2177