Effect of gabapentin on cognitive processes in rats not exposed and exposed to tobacco smoke during fetal life

Human and Experimental Toxicology

Volumn 27, Issue 12, 2008, Pages 883-894

  Czubak, A ^a   Nowakowska, E ^a   Kus, K ^a   Sadowski, C ^a   Matschay, A ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Antidepressant effect; Antiepileptic effect; Gabapentin; Prenatal; Rats; Working memory

Indexed keywords

GABAPENTIN; TOBACCO SMOKE;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; COGNITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ELECTRIC SHOCK; FEMALE; IMMOBILIZATION; MALE; MEMORY; MOTOR ACTIVITY; MOTOR COORDINATION; NONHUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; RAT; SPATIAL MEMORY;

AMINES; ANIMALS; ANTICONVULSANTS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; COGNITION; CYCLOHEXANECARBOXYLIC ACIDS; DEPRESSION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GAMMA-AMINOBUTYRIC ACID; INHALATION EXPOSURE; INJECTIONS, INTRAPERITONEAL; MEMORY; MOTOR SKILLS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; SEIZURES; SMOKE; TIME FACTORS; TOBACCO;

ANIMALIA; NICOTIANA TABACUM; RATTUS;

EID: 62349108421     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327108098334     Document Type: Article

References (99)

1. Aldenkamp AP. Dodson WE., (eds). Epilepsy and education; cognitive factors in learning behavior. Epilepsia 1990 ; 31: 9-20.
2. 2 Dodson WE. Pellock JM.. Pediatric epilepsy: diagnosis and treatment. New York: Demos Publications ; 1993.
3. Hirsch E. Schmitz B. Carreno M.. Epilepsy, antiepileptic drugs (AEDs) and cognition. Acta Neurol Scand 2003 ; 108: 23-32.
4. Aldenkamp AP. Krom DM. Reijs R.. Newer antiepileptic drugs and cognitive issues. Epilepsia 2003 ; 44: 21-29.
5. Meador KJ. Gilliam FG. Kanner AM.. Cognitive and behavioral effects of antiepileptic drugs. Epilepsy Behav 2001 ; 2: 1-17.
6. Meador KJ. Loring DW. Moore EE. Thompson WO. Nichols ME. Oberzan RE.. Comparative cognitive effects of phenobarbital, phenytoin, and valproate in healthy adults. Neurology 1995 ; 45: 1494-1499.
7. Loescher W. Schmidt D.. New horizons in the development of antiepileptic drugs. Epilepsy Res 2002 ; 50: 3-16.
8. Privitera M. Fincham R. Penry J. Reife R. Kramer L. Pledger G.. Topiramate placebocontrolled dose-ranging trial in refractory partial epilepsy using 600-, 800-, and 1000-mg daily dosages. Topiramate YE study group. Neurology 1996 ; 46: 1678-1683.
9. Brunbech L. Sabers A.. Effect of antiepileptic drugs on cognitive function in individuals with epilepsy. A comparative review of newer versus older agents. Drugs 2002 ; 62: 593-604.
10. 10 Trimble MR.. Quality of life and cognitive function. In: MR Trimble. WE Dodson., (eds), Epilepsy and quality of life. New York: Raven Press Ltd ; 1994.
11. 11 Aldenkamp AP. Hendriks M.. Managing cognitive and behavioural consequences of epilepsy. In: GA Baker. A Jacoby., (eds), Quality of life in epilepsy. Amsterdam: Harwood Academic Publishers ; 2000.
12. Mendez MF. Cummings JL. Benson DF.. Depression in epilepsy. Significance and phenomenology. Arch Neurol 1986 ; 43: 766-770.
13. Robertson M. Trimble M. Townsend H.. Phenomenology of depression in epilepsy. Epilepsia 1987 ; 28: 364-372.
14. Matthews W. Barabas G.. Suicide and epilepsy: a review of the literature. Psychosomatics 1981 ; 22: 515-524.
15. 15 Betts T.. Depression, anxiety, and epilepsy. In: E Reynolds. M Trimble., (eds), Eplepsy and psychiatry. New York: Churchill Livingstone ; 1981. p. 60-66.
16. Kanner AM. Balabanov A.. Depression and epilepsy. How closely related are they. Neurology 2002 ; 58: 27-39.
17. Rosenstein DL. Nelson JC. Jacobs SC.. Seizures associated with antidepressants: a review. J Clin Psychiatry 1993 ; 54: 289-299.
18. Skowron DM. Stimel GL.. Antidepressants and the risk of seizures. Pharmacotherapy 1992 ; 12: 18-22.
19. Dimond KR. Pande AC. Lamoreus L. Pierce MW.. Effect of gabapentin (Neurotin) on mood and well-being in patients with epilepsy. Prog Neuropsychopharmacol Biol Psychiatry 1996 ; 20: 407-417.
20. Harden CL. Pick LH.. Alterations in mood and anxiety in epilepsy patients treated with gabapentin. Epilepsia 1996 ; 37: 137 (Abstract).
21. Mortimore CM. Trimble M. Emmers E.. Effect of gabapentin on cognition and quality of life in patients with epilepsy. Seizure 1998 ; 7: 359-364.
22. Dodrill CB. Arnett JL. Hayes AG. Garofalo EA. Greeley CA. Greiner MJ.. Cognitive abilities and adjustment with gabapentin: results of a multisite study. Epilepsy Res 1999 ; 35: 109-121.
23. Nowakowska E. Kus K. Florek E. Czubak A. Jodynie-Liebert J.. The influence of tobacco smoke and nicotine on antidepressant and memory-improving effects of venlafaxine. Hum Exp Toxicol 2006 ; 25: 199-209.
24. 24 Fried PA.. Clinical implications of smoking: Determining long-term teratogenicity. In: IS Zagon. TA Slotkin., (eds), Maternal Substance abuse and the developing nervouse system. New York: Academic Press ; 1992. p. 77-96.
25. Dunn HG. McBurney AK.. Cigarette smoking and the fetus and child. Pediatrics 1977 ; 60: 772-773.
26. Naeye RL. Peters EC.. Mental development of children whose mothers smoked during pregnancy. J Am Coll Obstetricians Gynecologists 1984 ; 64: 601-607.
27. Rantakallio P.. A follow-up study up to the age of 14 of children whose mothers smoked during pregnancy. Acta Paediatr Scand 1983 ; 72: 747-753.
28. Jacobson SW. Fein GG. Jacobson JJ. Schwartz PM. Dowler JK.. Neonatal correlates of prenatal exposure to smoking, caffeine and alcohol. Infant Behav Dev 1984 ; 7: 253-265.
29. Landesman-Dwyer S. Emanuel I.. Smoking during pregnancy. Teratology 1979 ; 19: 119-126.
30. Picone AP. Allen LH. Olsen PN. Ferris ME.. Pregnancy out in North American women. II. Effects of diet, cigarette smoking, stress and weight gain on placentas and on neonatal physical and behavioral characteristics. Am J Clin Nutr 1982 ; 36: 1214-1224.
31. Streissguth AP. Martin DC. Barr HM. Sandman BM. Kirchner GL. Darby BL.. Intrauterine alcohol and nicotine exposure: attention and reaction time in 4-year-old children. Dev Psychol 1984 ; 20: 533-541.
32. Butler NR. Goldstein H.. Smoking in pregnancy and subsequent child development. Br Med J 1973 ; 4: 573-575.
33. DiFranza JR. Lew RA.. Effect of maternal cigarette smoking on pregnancy complications and sudden infant death syndrome. J Fam Pract 1995 ; 40: 385-394.
34. Milberger S. Biederman J. Faraone SV. Jones J.. Further evidence of an association between maternal smoking during pregnancy and attention deficit hyperactivity disorder: findings from a high-risk sample of siblings. J Clin Child Psychol 1998 ; 27: 352-358.
35. Niaura R. Bock B. Lloyd EE. Brown R. Lipsitt LP. Buka S.. Maternal transmission of nicotine dependence: psychiatric, neurocognitive and prenatal factors. Am J Addict 2001 ; 10: 16-29.
36. Orlebeke JF. Knol DL. Verhulst FC.. Child behavior problems increased by maternal smoking during pregnancy. Arch Environ Health 1999 ; 54: 15-19.
37. Wakschlag LS. Lahey BB. Loeber R. Green SM. Gordon RA. Leventhal BL.. Maternal smoking during pregnancy and the risk of conduct disorder in boys. Arch Gen Psychiatry 1997 ; 54: 670-676.
38. Kristjansson EA. Fried PA. Watkinson B.. Maternal smoking during pregnancy affects children's vigilance performance. Drug Alcohol Depend 1989 ; 24: 11-19.
39. Denson R. Nanson JL. McWatters MA.. Hyperkinesis and maternal smoking. Can Psychiatr Assoc J 1975 ; 20: 183-187.
40. Ernst M. Moolchan ET. Robinson ML.. Behavioral and neural consequences of prenatal exposure to nicotine. J Am Acad Child Adolesc Psychiatry 2001 ; 40: 630-641.
41. Lichtensteiger W. Ribary U. Schlumpf M. Odermatt B. Widmer HR.. Prenatal adverse effects of nicotine on the developing brain. Prog Brain Res 1988 ; 73: 137-157.
42. Olsen J.. Cigarette smoking in pregnancy and fetal growth. Does the type of tobacco play a role. Int J Epidemiol 1992 ; 21: 279-284.
43. Slikker WJ. Xu Alex Z. Levin ED. Slotkin TA.. Mode of action: Disruption of brain cell replication, second messenger, and neurotransmitter systems during development leading to cognitive dysfunction-developmental neurotoxicity of nicotine. Crit Rev Toxicol 2005 ; 35: 703-711.
44. Florek E. Marszalek A.. An experimental study of the in fluences of tobacco smoke on fertility and reproduction. Hum Exp Toxicol 1999 ; 18: 272-278.
45. Florek E. Marszaek A. Biczysko W. Szymanowski K.. The experimental investigations of the toxic influence of tobacco smoke affecting progeny during pregnancy. Hum Exp Toxicol 1999 ; 18: 245-251.
46. Lucki I.. The forced swimming test as a model for core and component behavioral effects of antidepressant drugs. Behav Pharmacol 1998 ; 8: 523-532.
47. Porsolt RD. Le Pichon M. Jalfre M.. Depression: a new model sensitive to antidepressant treatments. Nature 1977 ; 266: 730-732.
48. Porsolt RD. Anton G. Blavet N. Jalfre M.. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 1978 ; 47: 379-391.
49. Borsini F. Meli A.. Is the forced swimming test a suitable model for revealing antidepressant activity. Psychopharmacology 1988 ; 94: 147-160.
50. Morris R.. Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 1984 ; 11: 47-60.
51. Boissier PJR. Tardy J. Diverres JC.. Une nouvelle methode simple pour Explorer l'action "tranquillisante": le test de la cheminee. Med Exp 1960 ; 3: 423-425.
52. Swinyard E. Brown W. Godman L.. Comparative assays of antiepileptic drugs, mice and rats. J Pharmacol Exp Ther 1952 ; 106: 319-320.
53. Dougherty JA. Rhoney DH.. Gabapentin: a unique antiepileptic agent. Neurol Res 2001 ; 23: 821-829.
54. Pande AC. Davidson JR. Jefferson JW. Janney CA. Katzelnick DJ. Weisler RH.. Treatment of social phobia with gabapentin: a placebo-controlled study. J Clin Psychopharmacol 1999 ; 19: 341-348.
55. Altshuler LL. Keck PE. McElroy SL. Suppes T. Brown ES. Denicoff K.. Gabapentin in the acute treatment of refractory bipolar disorder. Bipolar Disord 1999 ; 1: 61-65.
56. 56 Halczuk I;.. Effects of new antiepileptic drugs on cognitive functions. Farmakoterapia w Psychiatrii i Neurologii 2005, 4: 363-379.
57. Meador KJ.. Can we treat cognitive deficits in patients with epilepsy. Epilepsy Behav 2001 ; 2: 307-378.
58. Motamedi G. Meador K.. Epilepsy and cognition. Epilepsy Behav 2003 ; 4: 825-838.
59. Elger EC. Helmstaedter C. Kurthen M.. Chronic epilepsy and cognition. Lancet Neurol 2004 ; 3: 663-672.
60. Ferrier C. Thompson JM.. Cognitive impairment in bipolar affective disorder: implications for the bipolar diathesis. Br J Psychiatry 2002 ; 180: 293-295.
61. Leach JP. Girvan J. Paul A. Brodie MJ.. Gabapentin and cognition: a double blind, dose ranging, placebo controlled study in refractory epilepsy. J Neurol Neurosurg Psychiatry 1997 ; 62: 372-376.
62. Shannon HE. Love PL.. Effects of antiepileptic drugs on working memory as assessed by spatial alternation performance in rats. Epilepsy Behav 2004 ; 5: 857-865.
63. Rizwan AN. Ali A. Dua Y. Pal SN. Pillai KK.. Effects of gabapentin and antidepressant drug combinations on convulsions and memory in mice. Pol J Pharmacol 2003 ; 55: 965-971.
64. Fried PA.. Cigarettes and marijuana: Are there measurable long-term neurobehavioral teratogenic effects. Neurotoxicology 1989 ; 10: 577-584.
65. Fogelman KR. Manor O.. Smoking in pregnancy and development into early adulthood. Br J Med 1988 ; 297: 1233-1236.
66. Hardy JB. Mellits ED.. Does maternal smoking during pregnancy have a long-term effect on the child. Lancet 1972 ; 7791: 1332-1336.
67. Lefkowitz MM.. Smoking during pregnancy: long-term effects on the offspring. Dev Psychol 1981 ; 17: 192-194.
68. Acosta GB. Boccia MM. Bartni CM.. Gabapentin, an antiepileptic drug, improves memory storage in mice. Neurosci Lett 2000 ; 279: 173-176.
69. Cilio MR. Bolano AR. Liu Z. Schmid R. Yang Y. Stafstrom CE.. Anticonvulsant action and long-term effects of gabapentin in the immature brain. Neuropharmacology 2001 ; 40: 139-147.
70. Brioni JD.. Role of GABA during the multiple consolidation of memory. Drug Develop Res 1993 ; 28: 3-27.
71. Brioni JD. McGaugh JL.. Post-training administration of GABAergic antagonists enhances retention of aversively motivated tasks. Psychopharmacology 1988 ; 96: 505-510.
72. Boccia MM. Kopf SR. Baratti CM.. The enhancement of retention performance induced by picrotoxin in mice may be mediated through a release of endogenous vasopressin. Behav Pharmacol 1996 ; 7: 254-260.
73. Saletu B. Grunberger J. Linzmayer L.. Evaluation of encephalotropic and psychotropic properties of gabapentin in man by pharmaco-EEG and psychometry. Int J Clin Pharmacol 1986 ; 24: 362-373.
74. Dodrill CB. Wilensky AJ. Ojemann LM.. Neuropsychological, mood, and psychosocial effects of gabapentin. Epilepsia 1992 ; 33: 117-118.
75. Schmid G. Sala R. Bonanno G. Ruther M.. Neurosteroids may differentially affect the function of two native GABA (A) receptor subtypes in the rat brain. Naunyn Schmiedebergs Arch Pharmacol 1998 ; 357: 401-407.
76. Fassio A. Bonanno G. Fontana G. Usai C. Machi M. Raiteri M.. Role of external and internal calcium on heterocarriermediated transmitter release. J Neurochem 1996 ; 66: 1468-1474.
77. Ramasubbu R.. Antidepressant treatment-associated behavioural expression of hypomania: a case series. Prog Neuropsychopharmacol Biol Psychiatry 2004 ; 28: 1201-1207.
78. Southam E. Kirkby D. Higgens GA. Hagan RM.. Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytriptamine uptake in rats. Eur J Pharmacol 1998 ; 358: 19-24.
79. McElroy SL. Soutullo CA. Keck PE. Kmetz GF.. A pilot trial of adjunctive gabapentin in the treatment of bipolar disorder. Ann Clin Psychiatry 1997 ; 9: 99-103.
80. 80 Bowden CL.. Pharmacological treatment of bipolar disorder. In: Bipolar Disorders. Chichester, Ed., M Maj, HS Akiskal, JJ Lopez-Ibor, N Sartorious. UK: John Wiley and Sons Ltd ; 2002. p. 191-221.
81. Pande AC. Crockatt JG. Janney CA. Werth JL. Tsaroucha G.. Gabapentin in bipolar disorder: a placebo-controlled trial of adjunctive therapy. Bipolar Disord 2000 ; 2: 249-255.
82. Srivastava SK.. Facilitation of behavioural depression by antiepileptic drugs. Indian J Pharmacol 2000 ; 32: 31-33.
83. Post RM. Ketter TA. Joffe RT. Kramlinger KL.. Lack of beneficial effects of L-baclofen in affective disorders. Int Clin Psychopharmacol 1991 ; 6: 197-207.
84. Lloyd KG. Morselli PL. Bartholin G.. GABA and affective disorders. Med Biol 1987 ; 65: 159-165.
85. Navarro HA. Seidler FJ. Schwartz RD. Baker FE. Dobbins SS. Slotkin TA.. Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth. Brain Res Bull 1989 ; 23: 187-192.
86. Wonnacott S.. Presynaptic nicotinic ACh receptors. Trends Neurosci 1997 ; 20: 92-98.
87. Muneoka K. Nakatsu T. Fuji J. Ogawa T. Takigawa M.. Prenatal administration of nicotine results in dopaminergic alterations in the neocortex. Neurotoxicol Teratol 1999 ; 21: 603-609.
88. Muneoka K. Ogawa T. Kamei K. Mimura Y. Kato H. Takigawa M.. Nicotine exposure during pregnancy is a factor which influences serotonin transporter density in the rat brain. Eur J Pharmacol 2001 ; 411: 279-282.
89. Carr LA. Walters DE. Meyer DC.. Postnatal development in the rat following pre- or postnatal exposure to nicotine. Res Commun Subst Abuse 1985 ; 6: 151-164.
90. Benwell MEM. Balfour DJK.. Effects of nicotine administration on the uptake and biosynthesis of 5-HT in rat brain synaptosomes. Eur J Pharmacol 1982 ; 84: 71-77.
91. Vetulani J. Sulser F.. Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain. Nature 1975 ; 257: 495-496.
92. Ortinski P. Meador KJ.. Cognitive side effects of antiepileptic drugs. Epilepsy Behav 2004 ; 5: 60-65.
93. Dalby NO. Nielsen EB.. Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin. Epilepsy Res 1997 ; 28: 63-72.
94. De Sarro G. Spagnolo C. Gareri P. Gallelli L. De Sarro A.. Gabapentin potentiates the antiseizure activity of certain anticonvulsants in DBA/2 mice. Eur J Pharmacol 1998 ; 349: 179-185.
95. Czapiski P. Blaszczyk B. Czuczwar SJ.. Mechanisms of action of antiepileptic drugs. Curr Top Med Chem 2005 ; 5: 1-9.
96. Britos SA. Orsingher OA.. Prenatal nicotine exposure increased susceptibility to electroconvulsive shock (ECS) in adult rats. Neurotoxicol Teratol 1991 ; 13: 271-273.
97. Taylor CP. Gee NS. Su TZ. Kocsis JD. Welty DF. Brown JP.. A summary of mechanistic hypotheses of gabapentin pharmacology. Epilepsy Res 1998 ; 29: 233-249.
98. Taylor CP.. Mechanisms of action of gabapentin. Drugs Today 1998 ; 34: 3-11.
99. Luszczki JJ. Czuczwar SJ.. Isobolographic profile of interactions between tiagabine and gabapentin: a preclinical study. Naunyn Schmiedebergs Arch Pharmacol 2004 ; 369: 434-446.