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Volumn 25, Issue 1, 2009, Pages 73-79

Utility and application of urine drug testing in chronic pain management with opioids

Author keywords

Analgesics; Narcotics urine; Opioid therapeutic use; Pain drug therapy; Pharmacogenomics; Pharmacokinetics

Indexed keywords

CODEINE; CREATININE; FENTANYL; HYDROCODONE; HYDROMORPHONE; MORPHINE; OPIATE; OXYCODONE; PETHIDINE; TRAMADOL; NARCOTIC ANALGESIC AGENT;

EID: 62349107006     PISSN: 07498047     EISSN: 15365409     Source Type: Journal    
DOI: 10.1097/AJP.0b013e31817e13cc     Document Type: Review
Times cited : (56)

References (59)
  • 1
    • 0036329422 scopus 로고    scopus 로고
    • Role of urine toxicology testing in the management of chronic opioid therapy
    • 18: S76S82
    • Katz N, Fanciullo GJ. Role of urine toxicology testing in the management of chronic opioid therapy. Clin J Pain. 2002;18: S76S82.
    • (2002) Clin J Pain
    • Katz, N.1    Fanciullo, G.J.2
  • 2
    • 33144459220 scopus 로고    scopus 로고
    • Does adherence monitoring reduce controlled substance abuse in chronic pain patients?
    • Manchikanti L, Manchukonda R, Damron KS, et al. Does adherence monitoring reduce controlled substance abuse in chronic pain patients? Pain Physician. 2006;9:5760.
    • (2006) Pain Physician , vol.9 , pp. 5760
    • Manchikanti, L.1    Manchukonda, R.2    Damron, K.S.3
  • 3
    • 33646557959 scopus 로고    scopus 로고
    • Does random urine drug testing reduce illicit drug use in chronic pain patients receiving opioids?
    • Manchikanti L, Manchukonda R, Pampati V, et al. Does random urine drug testing reduce illicit drug use in chronic pain patients receiving opioids? Pain Physician. 2006;9: 123129.
    • (2006) Pain Physician , vol.9 , pp. 123129
    • Manchikanti, L.1    Manchukonda, R.2    Pampati, V.3
  • 4
    • 0042063650 scopus 로고    scopus 로고
    • Federation of State Medical Boards. Model policy guidelines for opioid addiction treatment in the medical o?ce
    • Center for Substance Abuse Work Force
    • Center for Substance Abuse Work Force, Federation of State Medical Boards. Model policy guidelines for opioid addiction treatment in the medical o?ce. Pain Physician. 2003;6:217221.
    • (2003) Pain Physician , vol.6 , pp. 217221
  • 5
    • 0041488732 scopus 로고    scopus 로고
    • Guidelines for the use of controlled substances in the management of chronic pain
    • Atluri S, Boswell MV, Hansen HC, et al. Guidelines for the use of controlled substances in the management of chronic pain. Pain Physician. 2003;6:233257.
    • (2003) Pain Physician , vol.6 , pp. 233257
    • Atluri, S.1    Boswell, M.V.2    Hansen, H.C.3
  • 7
    • 33749675348 scopus 로고    scopus 로고
    • Kahan M, Srivastava A, Wilson L, et al. Misuse of and dependence on opioids: study of chronic pain patients. Can Fam Physician. 2006;52:10811087.
    • Kahan M, Srivastava A, Wilson L, et al. Misuse of and dependence on opioids: study of chronic pain patients. Can Fam Physician. 2006;52:10811087.
  • 8
    • 0034886290 scopus 로고    scopus 로고
    • Opioids and the treatment of chronic pain in a primary care sample
    • Adams NJ, Plane MB, Fleming MF, et al. Opioids and the treatment of chronic pain in a primary care sample. J Pain Symptom Manage. 2001;22:791796.
    • (2001) J Pain Symptom Manage , vol.22 , pp. 791796
    • Adams, N.J.1    Plane, M.B.2    Fleming, M.F.3
  • 9
    • 0141681025 scopus 로고    scopus 로고
    • Katz NP, Sherburne S, Beach M, et al. Behavioral monitoring and urine toxicology testing in patients receiving long-term opioid therapy. Anesth Analg. 2003;97:10971102.
    • Katz NP, Sherburne S, Beach M, et al. Behavioral monitoring and urine toxicology testing in patients receiving long-term opioid therapy. Anesth Analg. 2003;97:10971102.
  • 11
    • 0025190756 scopus 로고
    • Morphine and metabolite behavior after di?erent routes of morphine administration: Demonstration of the importance of the active metabolite morphine-6-glucuronide
    • Osborne R, Joel S, Trew D, et al. Morphine and metabolite behavior after di?erent routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide. Clin Pharmacol Ther. 1990;47: 1219.
    • (1990) Clin Pharmacol Ther , vol.47 , pp. 1219
    • Osborne, R.1    Joel, S.2    Trew, D.3
  • 12
    • 85057350111 scopus 로고
    • Buccal morphinea new route for analgesia?
    • BellMD, Murray GR, Mishra P, et al. Buccal morphinea new route for analgesia? Lancet. 1985;1:7173.
    • (1985) Lancet , vol.1 , pp. 7173
    • Bell, M.D.1    Murray, G.R.2    Mishra, P.3
  • 13
    • 0021925872 scopus 로고
    • CSF and plasma pharmacokinetics of intramuscular morphine
    • Nordberg G, Borg L, Hedner T, et al. CSF and plasma pharmacokinetics of intramuscular morphine. Eur J Clin Pharmacol. 1985;27:677681.
    • (1985) Eur J Clin Pharmacol , vol.27 , pp. 677681
    • Nordberg, G.1    Borg, L.2    Hedner, T.3
  • 14
    • 66749124946 scopus 로고    scopus 로고
    • Oxycontin(R) Package Insert, 61 Edition. Montvale, Thompson Physicians Desk Reference, 2007
    • Oxycontin(R) Package Insert, 61 Edition. Montvale, Thompson Physicians Desk Reference, 2007.
  • 16
    • 15244342411 scopus 로고    scopus 로고
    • UDP-glucuronosyltrans-ferases and clinical drug-drug interactions
    • Kiang TK, Ensom MH, Chang TK. UDP-glucuronosyltrans-ferases and clinical drug-drug interactions. Pharmacol Ther. 2005;106:97132.
    • (2005) Pharmacol Ther , vol.106 , pp. 97132
    • Kiang, T.K.1    Ensom, M.H.2    Chang, T.K.3
  • 18
    • 33644684769 scopus 로고    scopus 로고
    • Transporters and drug discovery: Why, when, and how
    • Kim RB. Transporters and drug discovery: why, when, and how. Mol Pharm. 2006;3:2632.
    • (2006) Mol Pharm , vol.3 , pp. 2632
    • Kim, R.B.1
  • 19
    • 15744367808 scopus 로고    scopus 로고
    • Lee W, Glaeser H, Smith LH, et al. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. J Biol Chem. 2005;280:96109617.
    • Lee W, Glaeser H, Smith LH, et al. Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry. J Biol Chem. 2005;280:96109617.
  • 20
    • 34447560176 scopus 로고    scopus 로고
    • Genetic polymorphism of cytochrome P450s and P-glycoprotein in the Finnish population
    • Hilli J, Rane A, Lundgren S, et al. Genetic polymorphism of cytochrome P450s and P-glycoprotein in the Finnish population. Fundam Clin Pharmacol. 2007;21:379386.
    • (2007) Fundam Clin Pharmacol , vol.21 , pp. 379386
    • Hilli, J.1    Rane, A.2    Lundgren, S.3
  • 21
    • 27544454323 scopus 로고    scopus 로고
    • Fakhoury M, Litalien C, Medard Y, et al. Localization and mRNA expression of CYP3A and P-glycoprotein in human duodenum as a function of age. Drug Metab Dispos. 2005;33:16031607.
    • Fakhoury M, Litalien C, Medard Y, et al. Localization and mRNA expression of CYP3A and P-glycoprotein in human duodenum as a function of age. Drug Metab Dispos. 2005;33:16031607.
  • 22
    • 0037115525 scopus 로고    scopus 로고
    • Pharmacogenetics a?ects dosing, e?cacy, and toxicity of cytochrome P450- metabolized drugs
    • Rogers JF, Nafziger AN, Bertino JS Jr. Pharmacogenetics a?ects dosing, e?cacy, and toxicity of cytochrome P450- metabolized drugs. Am J Med. 2002;113:746750.
    • (2002) Am J Med , vol.113 , pp. 746750
    • Rogers, J.F.1    Nafziger, A.N.2    Bertino Jr., J.S.3
  • 23
    • 34547644659 scopus 로고    scopus 로고
    • Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication
    • Kirchheiner J, Schmidt H, Tzvetkov M, et al. Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. Pharmacogenomics J. 2007;7:257265.
    • (2007) Pharmacogenomics J , vol.7 , pp. 257265
    • Kirchheiner, J.1    Schmidt, H.2    Tzvetkov, M.3
  • 24
    • 38349167330 scopus 로고    scopus 로고
    • CYP2D6 phenotype prediction from genotype: Which system is the best?
    • Kirchheiner J. CYP2D6 phenotype prediction from genotype: which system is the best? Clin Pharmacol Ther. 2008;83: 225227.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 225227
    • Kirchheiner, J.1
  • 25
    • 0034844646 scopus 로고    scopus 로고
    • Spear BB, Heath-Chiozzi M, Hu? J. Clinical application of pharmacogenetics. Trends Mol Med. 2001;7:201204.
    • Spear BB, Heath-Chiozzi M, Hu? J. Clinical application of pharmacogenetics. Trends Mol Med. 2001;7:201204.
  • 26
    • 1542359666 scopus 로고    scopus 로고
    • CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes
    • Hutchinson MR, Menelaou A, Foster DJ, et al. CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes. Br J Clin Pharmacol. 2004;57:287297.
    • (2004) Br J Clin Pharmacol , vol.57 , pp. 287297
    • Hutchinson, M.R.1    Menelaou, A.2    Foster, D.J.3
  • 27
    • 66749136573 scopus 로고    scopus 로고
    • Duragesic(R) Package Insert, 61 Edition. Montvale, Thompson Physicians Desk Reference, 2007
    • Duragesic(R) Package Insert, 61 Edition. Montvale, Thompson Physicians Desk Reference, 2007.
  • 28
    • 66749174223 scopus 로고    scopus 로고
    • AHFS Drug Information, American Society of Health-System Pharmacists
    • AHFS Drug Information. Bethesda, American Society of Health-System Pharmacists, 2004.
    • (2004) Bethesda
  • 29
    • 33947412998 scopus 로고    scopus 로고
    • Totah RA, Allen KE, She?els P, et al. Enantiomeric metabolic interactions and stereoselective human methadone metabolism. J Pharmacol Exp Ther. 2007;321:389399.
    • Totah RA, Allen KE, She?els P, et al. Enantiomeric metabolic interactions and stereoselective human methadone metabolism. J Pharmacol Exp Ther. 2007;321:389399.
  • 30
    • 66749105891 scopus 로고    scopus 로고
    • Kharasch ED, Ho?er C, Whittington D, et al. Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic e?ects of methadone. Clin Pharmacol Ther. 2004;76:250269.
    • Kharasch ED, Ho?er C, Whittington D, et al. Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic e?ects of methadone. Clin Pharmacol Ther. 2004;76:250269.
  • 31
    • 1842536807 scopus 로고    scopus 로고
    • Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes
    • Lalovic B, Phillips B, Risler LL, et al. Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab Dispos. 2004;32:447454.
    • (2004) Drug Metab Dispos , vol.32 , pp. 447454
    • Lalovic, B.1    Phillips, B.2    Risler, L.L.3
  • 32
    • 0031460240 scopus 로고    scopus 로고
    • Paar WD, Poche S, Gerlo? J, et al. Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol. Eur J Clin Pharmacol. 1997;53:235239.
    • Paar WD, Poche S, Gerlo? J, et al. Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol. Eur J Clin Pharmacol. 1997;53:235239.
  • 33
    • 0034946742 scopus 로고    scopus 로고
    • Subrahmanyam V, Renwick AB, Walters DG, et al. Identi?cation of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes. Drug Metab Dispos. 2001;29:11461155.
    • Subrahmanyam V, Renwick AB, Walters DG, et al. Identi?cation of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes. Drug Metab Dispos. 2001;29:11461155.
  • 34
    • 34447294529 scopus 로고    scopus 로고
    • Relationship between methadone and EDDP (2-ethylidene-1,5-dimethyl-3,3-diphe- nylpyrrolidine) in urine samples from Norwegian prisons
    • Bernard JP, OpdalMS, Karinen R, et al. Relationship between methadone and EDDP (2-ethylidene-1,5-dimethyl-3,3-diphe- nylpyrrolidine) in urine samples from Norwegian prisons. Eur J Clin Pharmacol. 2007;63:777782.
    • (2007) Eur J Clin Pharmacol , vol.63 , pp. 777782
    • Bernard, J.P.1    Opdal, M.S.2    Karinen, R.3
  • 35
    • 0036223831 scopus 로고    scopus 로고
    • Summary of information on human CYP enzymes: Human P450 metabolism data
    • Rendic S. Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002;34:83448.
    • (2002) Drug Metab Rev , vol.34 , pp. 83448
    • Rendic, S.1
  • 36
    • 0036439851 scopus 로고    scopus 로고
    • Eap CB, Buclin T, Baumann P. Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence. Clin Pharmacokinet. 2002;41:11531193.
    • Eap CB, Buclin T, Baumann P. Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence. Clin Pharmacokinet. 2002;41:11531193.
  • 37
    • 16344374909 scopus 로고    scopus 로고
    • Contribution to variability in response to opioids
    • Hanks GW, Reid C. Contribution to variability in response to opioids. Support Care Cancer. 2005;13:145152.
    • (2005) Support Care Cancer , vol.13 , pp. 145152
    • Hanks, G.W.1    Reid, C.2
  • 38
    • 10044297116 scopus 로고    scopus 로고
    • Lotsch J, Skarke C, Liefhold J, et al. Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives. Clin Pharmacokinet. 2004;43:9831013.
    • Lotsch J, Skarke C, Liefhold J, et al. Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives. Clin Pharmacokinet. 2004;43:9831013.
  • 39
    • 0031885736 scopus 로고    scopus 로고
    • Morphine formation from ethylmorphine: Implications for drugs-of-abuse testing in urine
    • Popa C, Beck O, Brodin K. Morphine formation from ethylmorphine: implications for drugs-of-abuse testing in urine. J Anal Toxicol. 1998;22:142147.
    • (1998) J Anal Toxicol , vol.22 , pp. 142147
    • Popa, C.1    Beck, O.2    Brodin, K.3
  • 40
    • 0032752586 scopus 로고    scopus 로고
    • Dose dependency of dextromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyping
    • Streetman DS, Ellis RE, Nafziger AN, et al. Dose dependency of dextromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyping. Clin Pharmacol Ther. 1999;66:535541.
    • (1999) Clin Pharmacol Ther , vol.66 , pp. 535541
    • Streetman, D.S.1    Ellis, R.E.2    Nafziger, A.N.3
  • 41
    • 21844474861 scopus 로고    scopus 로고
    • Evaluation of inhibitory drug interactions during drug development: Genetic polymorphisms must be considered
    • Lee LS, Nafziger AN, Bertino JS Jr. Evaluation of inhibitory drug interactions during drug development: genetic polymorphisms must be considered. Clin Pharmacol Ther. 2005;78:16.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 16
    • Lee, L.S.1    Nafziger, A.N.2    Bertino Jr., J.S.3
  • 42
    • 33750946415 scopus 로고    scopus 로고
    • Sex di?erences in CYP3A activity using intravenous and oral midazolam
    • Chen M, Ma L, Drusano GL, et al. Sex di?erences in CYP3A activity using intravenous and oral midazolam. Clin Pharmacol Ther. 2006;80:531538.
    • (2006) Clin Pharmacol Ther , vol.80 , pp. 531538
    • Chen, M.1    Ma, L.2    Drusano, G.L.3
  • 43
    • 0141532282 scopus 로고    scopus 로고
    • Sex is a major determinant of CYP3A4 expression in human liver
    • Wolbold R, Klein K, Burk O, et al. Sex is a major determinant of CYP3A4 expression in human liver. Hepatology. 2003;38: 978988.
    • (2003) Hepatology , vol.38 , pp. 978988
    • Wolbold, R.1    Klein, K.2    Burk, O.3
  • 44
    • 0030774527 scopus 로고    scopus 로고
    • Labroo RB, Paine MF, Thummel KE, et al. Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, e?cacy, and drug interactions. Drug Metab Dispos. 1997;25:10721080.
    • Labroo RB, Paine MF, Thummel KE, et al. Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: implications for interindividual variability in disposition, e?cacy, and drug interactions. Drug Metab Dispos. 1997;25:10721080.
  • 45
    • 0036373740 scopus 로고    scopus 로고
    • Morphine glucuronide-to-morphine plasma ratios are una?ected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy
    • Holthe M, Klepstad P, Zahlsen K, et al. Morphine glucuronide-to-morphine plasma ratios are una?ected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy. Eur J Clin Pharmacol. 2002;58:353356.
    • (2002) Eur J Clin Pharmacol , vol.58 , pp. 353356
    • Holthe, M.1    Klepstad, P.2    Zahlsen, K.3
  • 46
    • 0033645752 scopus 로고    scopus 로고
    • Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: Ethnic diversity of alleles and potential clinical signi?cance
    • Bhasker CR, McKinnon W, Stone A, et al. Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical signi?cance. Pharmacogenetics. 2000;10: 679685.
    • (2000) Pharmacogenetics , vol.10 , pp. 679685
    • Bhasker, C.R.1    McKinnon, W.2    Stone, A.3
  • 47
    • 0038209379 scopus 로고    scopus 로고
    • A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine
    • Sawyer MB, Innocenti F, Das S, et al. A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine. Clin Pharmacol Ther. 2003;73: 566574.
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 566574
    • Sawyer, M.B.1    Innocenti, F.2    Das, S.3
  • 48
    • 0033736408 scopus 로고    scopus 로고
    • When enough is not enough: New perspectives on optimal methadone maintenance dose
    • Leavitt SB, Shinderman M, Maxwell S, et al. When enough is not enough: new perspectives on optimal methadone maintenance dose. Mt Sinai J Med. 2000;67:404411.
    • (2000) Mt Sinai J Med , vol.67 , pp. 404411
    • Leavitt, S.B.1    Shinderman, M.2    Maxwell, S.3
  • 49
    • 40949150784 scopus 로고    scopus 로고
    • Association of ABCB1/ MDR1 and OPRM1 Gene Polymorphisms With Morphine Pain Relief
    • Campa D, Gioia A, Tomei A, et al. Association of ABCB1/ MDR1 and OPRM1 Gene Polymorphisms With Morphine Pain Relief. Clin Pharmacol Ther. 2008;83:559566.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 559566
    • Campa, D.1    Gioia, A.2    Tomei, A.3
  • 50
    • 0037332007 scopus 로고    scopus 로고
    • The e?ect of food components on the absorption of P-gp substrates: A review
    • Deferme S, Augustijns P. The e?ect of food components on the absorption of P-gp substrates: a review. J Pharm Pharmacol. 2003;55:153162.
    • (2003) J Pharm Pharmacol , vol.55 , pp. 153162
    • Deferme, S.1    Augustijns, P.2
  • 51
    • 0033984820 scopus 로고    scopus 로고
    • Start of oral morphine to cancer patients: E?ective serum morphine concentrations and contribution from morphine-6-glucuronide to the analgesia produced by morphine
    • Klepstad P, Kaasa S, Borchgrevink PC. Start of oral morphine to cancer patients: e?ective serum morphine concentrations and contribution from morphine-6-glucuronide to the analgesia produced by morphine. Eur J Clin Pharmacol. 2000;55: 713719.
    • (2000) Eur J Clin Pharmacol , vol.55 , pp. 713719
    • Klepstad, P.1    Kaasa, S.2    Borchgrevink, P.C.3
  • 52
    • 66749185453 scopus 로고    scopus 로고
    • Paradigm Management Services, LLC and Ameritox An-nounce a Partnership in Using RxGuardian to Manage Chronic Pain Cases, 2008, pp press release. 53. Janicki P. Interindividual Di?erences in Opioid Analgesic Usage in Chronic Pain Patients in Relationship to A118G Mu- Opioid Receptor Polymorphism
    • Paradigm Management Services, LLC and Ameritox An-nounce a Partnership in Using RxGuardian to Manage Chronic Pain Cases, 2008, pp press release. 53. Janicki P. Interindividual Di?erences in Opioid Analgesic Usage in Chronic Pain Patients in Relationship to A118G Mu- Opioid Receptor Polymorphism. Pain Med. 2005;6:176177.
    • (2005) Pain Med , vol.6 , pp. 176177
  • 53
    • 33646116562 scopus 로고    scopus 로고
    • Environmental and genetic factors associated with morphine response in the postoperative period
    • Coulbault L, Beaussier M, Verstuyft C, et al. Environmental and genetic factors associated with morphine response in the postoperative period. Clin Pharmacol Ther. 2006;79:316324.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 316324
    • Coulbault, L.1    Beaussier, M.2    Verstuyft, C.3
  • 55
    • 0033814551 scopus 로고    scopus 로고
    • The characterization of human urine for specimen validity determination in work- place drug testing: A review
    • Cook JD, Caplan YH, LoDico CP, et al. The characterization of human urine for specimen validity determination in work- place drug testing: a review. J Anal Toxicol. 2000;24:579588.
    • (2000) J Anal Toxicol , vol.24 , pp. 579588
    • Cook, J.D.1    Caplan, Y.H.2    LoDico, C.P.3
  • 56
    • 59249099164 scopus 로고    scopus 로고
    • Springhouse Corporation, 2nd ed. Springhouse: Springhouse Corporation;
    • Springhouse Corporation. Handbook of Diagnostic Tests. 2nd ed. Springhouse: Springhouse Corporation; 1999.
    • (1999) Handbook of Diagnostic Tests
  • 57
    • 0034749333 scopus 로고    scopus 로고
    • Ceder G, Jones AW. Concentration ratios of morphine to codeine in blood of impaired drivers as evidence of heroin use and not medication with codeine. Clin Chem. 2001;47: 19801984.
    • Ceder G, Jones AW. Concentration ratios of morphine to codeine in blood of impaired drivers as evidence of heroin use and not medication with codeine. Clin Chem. 2001;47: 19801984.


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