Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy

European Journal of Clinical Pharmacology

Volumn 58, Issue 5, 2002, Pages 353-356

  Holthe, Monica ^a   Klepstad, Pål ^a   Zahlsen, Kolbjørn ^c   Borchgrevink, Petter C ^a   Hagen, Lars ^a   Dale, Ola ^a   Kaasa, Stein ^b   Krokan, Hans E ^a   Skorpen, Frank ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

Author keywords

Morphine; UGT1A1; UGT2B7

Indexed keywords

ANALGESIC AGENT; DNA FRAGMENT; GLUCURONOSYLTRANSFERASE; ISOENZYME; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE;

ADULT; AGED; ALLELE; ARTICLE; CANCER PAIN; CANCER PATIENT; CONTROLLED STUDY; DELAYED DRUG RELEASE; DRUG BLOOD LEVEL; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION; GENE IDENTIFICATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; KIDNEY FUNCTION; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION MAPPING; WILD TYPE;

ADULT; AGED; AGED, 80 AND OVER; ANALGESICS, OPIOID; GENOTYPE; GLUCURONOSYLTRANSFERASE; HUMANS; ISOENZYMES; MIDDLE AGED; MORPHINE; MORPHINE DERIVATIVES; NEOPLASMS; PAIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0036373740     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-002-0490-1     Document Type: Article

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