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Volumn 10, Issue 2, 2009, Pages 157-163

Challenges in developing new antibacterial drugs

Author keywords

Antibacterial discovery; Drug development; Gram negative; Guidelines; Resistance

Indexed keywords

ANTIINFECTIVE AGENT; CARBAPENEM; GENERIC DRUG; LINEZOLID; POSIZOLID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; TETRACYCLINE DERIVATIVE;

EID: 62249124839     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (35)

References (58)
  • 1
    • 84877911547 scopus 로고    scopus 로고
    • Finch R: Innovation - drugs and diagnostics. J Antimicrob Chemother (2007) 60(Suppl 1):i79-i82. •• An EU perspective and details on the lack of new antibacterials.
    • Finch R: Innovation - drugs and diagnostics. J Antimicrob Chemother (2007) 60(Suppl 1):i79-i82. •• An EU perspective and details on the lack of new antibacterials.
  • 2
    • 0000479831 scopus 로고
    • ASM Task Force urges broad program on antimicrobial resistance
    • Cassell GH: ASM Task Force urges broad program on antimicrobial resistance. ASM News (1995) 61:116-120.
    • (1995) ASM News , vol.61 , pp. 116-120
    • Cassell, G.H.1
  • 3
    • 62249086061 scopus 로고    scopus 로고
    • Bad bugs, no drugs: As antibiotic discovery stagnates a public health crisis brews: Infectious Diseases Society of America, Arlington, VA, USA (2004). http://www.idsociety.org/badbugsnodrugs.html •• The initial IDSA paper discussing the lack of new antibacterial drugs. Since then there have been Congress hearings, but the industry awaits some encouragement.
    • Bad bugs, no drugs: As antibiotic discovery stagnates a public health crisis brews: Infectious Diseases Society of America, Arlington, VA, USA (2004). http://www.idsociety.org/badbugsnodrugs.html •• The initial IDSA paper discussing the lack of new antibacterial drugs. Since then there have been Congress hearings, but the industry awaits some encouragement.
  • 4
    • 33144473431 scopus 로고    scopus 로고
    • Bad bugs need drugs: An update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America
    • Antimicrobial Availability Task Force of the Infectious Diseases Society of America
    • Talbot GH, Bradley J, Edwards JE Jr, Gilbert D, Scheld M, Bartlett JG, Antimicrobial Availability Task Force of the Infectious Diseases Society of America: Bad bugs need drugs: An update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America. Clin Infect Dis (2006) 42(5):657-668.
    • (2006) Clin Infect Dis , vol.42 , Issue.5 , pp. 657-668
    • Talbot, G.H.1    Bradley, J.2    Edwards Jr, J.E.3    Gilbert, D.4    Scheld, M.5    Bartlett, J.G.6
  • 5
    • 39449103059 scopus 로고    scopus 로고
    • Spellberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM, Bartlett JG, Edwards J Jr, Infectious Diseases Society of America: The epidemic of antibiotic-resistant infections: A call to action for the medical community from the Infectious Diseases Society of America. Clin Infect Dis (2008) 46(2):155-164. •• A key update on antibacterial drugs from the IDSA.
    • Spellberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM, Bartlett JG, Edwards J Jr, Infectious Diseases Society of America: The epidemic of antibiotic-resistant infections: A call to action for the medical community from the Infectious Diseases Society of America. Clin Infect Dis (2008) 46(2):155-164. •• A key update on antibacterial drugs from the IDSA.
  • 7
    • 12944302098 scopus 로고    scopus 로고
    • Lack of development of new antimicrobial drugs: A potential serious threat to public health
    • This paper discusses the concerns of antibacterial resistance in Europe, European Society of Clinical Microbiology and Infectious Diseases:, ••
    • Norrby SR, Nord CE, Finch R, European Society of Clinical Microbiology and Infectious Diseases: Lack of development of new antimicrobial drugs: A potential serious threat to public health. Lancet Infect Dis (2005) 5(2):115-119. •• This paper discusses the concerns of antibacterial resistance in Europe.
    • (2005) Lancet Infect Dis , vol.5 , Issue.2 , pp. 115-119
    • Norrby, S.R.1    Nord, C.E.2    Finch, R.3
  • 9
    • 9144267751 scopus 로고    scopus 로고
    • The dearth of new antibiotic development: Why we should be worried and what we can do about it
    • An excellent summary on the lack of new antibiotic development and what can be done to address it, •
    • Charles PGP, Grayson ML: The dearth of new antibiotic development: Why we should be worried and what we can do about it. Med J Aust (2004) 181(10):549-553. • An excellent summary on the lack of new antibiotic development and what can be done to address it.
    • (2004) Med J Aust , vol.181 , Issue.10 , pp. 549-553
    • Charles, P.G.P.1    Grayson, M.L.2
  • 10
    • 0036467238 scopus 로고    scopus 로고
    • The United States Food and Drug Administration and the end of antibiotics
    • An industry perspective on the lack of new antibacterials, •
    • Shlaes DM, Moellering RC Jr: The United States Food and Drug Administration and the end of antibiotics. Clin Infect Dis (2002) 34(3):420-422. • An industry perspective on the lack of new antibacterials.
    • (2002) Clin Infect Dis , vol.34 , Issue.3 , pp. 420-422
    • Shlaes, D.M.1    Moellering Jr, R.C.2
  • 11
    • 43549127334 scopus 로고    scopus 로고
    • Antibiotic development: A victim of market forces?
    • An industry insight on antibiotic development, •
    • Tillotson GS: Antibiotic development: A victim of market forces? IDrugs (2008) 11(5):340-346. • An industry insight on antibiotic development.
    • (2008) IDrugs , vol.11 , Issue.5 , pp. 340-346
    • Tillotson, G.S.1
  • 12
    • 12844274375 scopus 로고    scopus 로고
    • Antibiotics: Where did we go wrong?
    • Overbye KM, Barrett JF: Antibiotics: Where did we go wrong? Drug Discov Today (2005) 10(1):45-52.
    • (2005) Drug Discov Today , vol.10 , Issue.1 , pp. 45-52
    • Overbye, K.M.1    Barrett, J.F.2
  • 13
    • 15444338513 scopus 로고    scopus 로고
    • Clinical trials of antimicrobial agents: A practical guide to design and analysis. Statisticians in the Pharmaceutical Industry Working Party
    • Smith C, Burley C, Ireson M, Johnson T, Jordan D, Knight S, Mason T, Massey D, Moss J, Williams K: Clinical trials of antimicrobial agents: A practical guide to design and analysis. Statisticians in the Pharmaceutical Industry Working Party. J Antimicrob Chemother (1998) 41(4):467-480.
    • (1998) J Antimicrob Chemother , vol.41 , Issue.4 , pp. 467-480
    • Smith, C.1    Burley, C.2    Ireson, M.3    Johnson, T.4    Jordan, D.5    Knight, S.6    Mason, T.7    Massey, D.8    Moss, J.9    Williams, K.10
  • 14
    • 0031012190 scopus 로고    scopus 로고
    • Antibiotic resistance: A view from the pharmaceutical industry
    • The development of cefuroxime, cefuroxime axetil, cefotaxime, ceftazidime, moxalactam, cefotetan, meropenem, daptomycin, AZD-2563 and other drugs that reached the market is presented, •
    • Bax RP: Antibiotic resistance: A view from the pharmaceutical industry. Clin Infect Dis (1997) 24(Suppl 1):S151-S153. • The development of cefuroxime, cefuroxime axetil, cefotaxime, ceftazidime, moxalactam, cefotetan, meropenem, daptomycin, AZD-2563 and other drugs that reached the market is presented.
    • (1997) Clin Infect Dis , vol.24 , Issue.SUPPL. 1
    • Bax, R.P.1
  • 15
    • 45949112254 scopus 로고    scopus 로고
    • Gram-negative antibiotic resistance: There is a price to pay
    • Slama TG: Gram-negative antibiotic resistance: There is a price to pay. Crit Care (2008) 12(Suppl 4):S4.
    • (2008) Crit Care , vol.12 , Issue.SUPPL. 4
    • Slama, T.G.1
  • 17
    • 0141646510 scopus 로고    scopus 로고
    • The abandonment of antibacterials: Why and wherefore?
    • Shlaes DM: The abandonment of antibacterials: Why and wherefore? Curr Opin Pharmacol (2003) 3(5):470-473.
    • (2003) Curr Opin Pharmacol , vol.3 , Issue.5 , pp. 470-473
    • Shlaes, D.M.1
  • 18
    • 0141716855 scopus 로고    scopus 로고
    • Drug companies snub antibiotics as pipeline threatens to run dry
    • Clarke T: Drug companies snub antibiotics as pipeline threatens to run dry. Nature (2003) 425(6955):225.
    • (2003) Nature , vol.425 , Issue.6955 , pp. 225
    • Clarke, T.1
  • 19
    • 7244245763 scopus 로고    scopus 로고
    • Antibiotics at the crossroads
    • Nathan C: Antibiotics at the crossroads. Nature (2004) 431(7011):899-902.
    • (2004) Nature , vol.431 , Issue.7011 , pp. 899-902
    • Nathan, C.1
  • 20
    • 4644242447 scopus 로고    scopus 로고
    • Antibacterial research and development in the 21st century - An industry perspective of the challenges
    • Thomson CJ, Power E, Ruebsamen-Waigmann H, Labischinski H: Antibacterial research and development in the 21st century - An industry perspective of the challenges. Curr Opin Microbiol (2004) 7(5):445-450.
    • (2004) Curr Opin Microbiol , vol.7 , Issue.5 , pp. 445-450
    • Thomson, C.J.1    Power, E.2    Ruebsamen-Waigmann, H.3    Labischinski, H.4
  • 21
    • 15544382241 scopus 로고    scopus 로고
    • Innovative antibacterial drugs: Nothing ventured, nothing gained
    • Stein J: Innovative antibacterial drugs: Nothing ventured, nothing gained. Expert Opin Investig Drugs (2005) 14(2):107-109.
    • (2005) Expert Opin Investig Drugs , vol.14 , Issue.2 , pp. 107-109
    • Stein, J.1
  • 22
    • 25144520617 scopus 로고    scopus 로고
    • Can biotech deliver new antibiotics?
    • Barrett JF: Can biotech deliver new antibiotics? Curr Opin Microbiol (2005) 8(5):498-503.
    • (2005) Curr Opin Microbiol , vol.8 , Issue.5 , pp. 498-503
    • Barrett, J.F.1
  • 23
    • 2442482962 scopus 로고    scopus 로고
    • Key factors in the rising cost of new drug discovery and development
    • Dickson M, Gagnon JP: Key factors in the rising cost of new drug discovery and development. Nat Rev Drug Discov (2004) 3(5):417-429.
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.5 , pp. 417-429
    • Dickson, M.1    Gagnon, J.P.2
  • 24
    • 1242314050 scopus 로고    scopus 로고
    • Introduction: Standards of antibacterial performance
    • Finch RG: Introduction: Standards of antibacterial performance. Clin Microbiol Infect (2004) 10(Suppl 2):1-5.
    • (2004) Clin Microbiol Infect , vol.10 , Issue.SUPPL. 2 , pp. 1-5
    • Finch, R.G.1
  • 25
    • 27744431659 scopus 로고    scopus 로고
    • Risk reduction in drug discovery and development
    • Mackay M, Street SD, McCall JM: Risk reduction in drug discovery and development. Curr Top Med Chem (2005) 5(11):1087-1090.
    • (2005) Curr Top Med Chem , vol.5 , Issue.11 , pp. 1087-1090
    • Mackay, M.1    Street, S.D.2    McCall, J.M.3
  • 26
    • 6444230260 scopus 로고    scopus 로고
    • The influence of protein binding on the antibacterial activity of faropenem against Haemophilus influenzae
    • Gustafsson I, Cars O: The influence of protein binding on the antibacterial activity of faropenem against Haemophilus influenzae. Clin Microbiol Infect (2004) 10(10):934-937.
    • (2004) Clin Microbiol Infect , vol.10 , Issue.10 , pp. 934-937
    • Gustafsson, I.1    Cars, O.2
  • 27
    • 1842503232 scopus 로고    scopus 로고
    • Daptomycin: Another novel agent for treating infections due to drug-resistant Gram-positive pathogens
    • Carpenter CF, Chambers HF: Daptomycin: Another novel agent for treating infections due to drug-resistant Gram-positive pathogens. Clin Infect Dis (2004) 38(7):994-1000.
    • (2004) Clin Infect Dis , vol.38 , Issue.7 , pp. 994-1000
    • Carpenter, C.F.1    Chambers, H.F.2
  • 28
    • 0038811886 scopus 로고    scopus 로고
    • Oxazolidinone antibacterial agents: A critical review
    • Hutchinson DK: Oxazolidinone antibacterial agents: A critical review. Curr Top Med Chem (2003) 3(9):1021-1042.
    • (2003) Curr Top Med Chem , vol.3 , Issue.9 , pp. 1021-1042
    • Hutchinson, D.K.1
  • 29
    • 34547613493 scopus 로고    scopus 로고
    • The future of natural products as a source of new antibiotics
    • Luzhetskyy L, Pelzer S, Bechtold A: The future of natural products as a source of new antibiotics. Curr Opin Investig Drugs (2007) 8(8):808-813.
    • (2007) Curr Opin Investig Drugs , vol.8 , Issue.8 , pp. 808-813
    • Luzhetskyy, L.1    Pelzer, S.2    Bechtold, A.3
  • 30
    • 0036259397 scopus 로고    scopus 로고
    • Microbial genomics and novel antibiotic discovery: New technology to search for new drugs
    • Dougherty TJ, Barrett JF, Pucci MJ: Microbial genomics and novel antibiotic discovery: New technology to search for new drugs. Curr Pharm Des (2002) 8(13):1119-1135.
    • (2002) Curr Pharm Des , vol.8 , Issue.13 , pp. 1119-1135
    • Dougherty, T.J.1    Barrett, J.F.2    Pucci, M.J.3
  • 31
    • 12844279920 scopus 로고    scopus 로고
    • Transforming the work of early-stage drug discovery through bioprocess informatics
    • Holzman TF, Hebert EJ: Transforming the work of early-stage drug discovery through bioprocess informatics. Drug Disc Today (2005) 10(1):61-67.
    • (2005) Drug Disc Today , vol.10 , Issue.1 , pp. 61-67
    • Holzman, T.F.1    Hebert, E.J.2
  • 33
    • 22544433757 scopus 로고    scopus 로고
    • Genomics: Success or failure to deliver drug targets?
    • Betz UA, Farquhar R, Ziegelbauer K: Genomics: Success or failure to deliver drug targets? Curr Opin Chem Biol (2005) 9(4):387-391.
    • (2005) Curr Opin Chem Biol , vol.9 , Issue.4 , pp. 387-391
    • Betz, U.A.1    Farquhar, R.2    Ziegelbauer, K.3
  • 34
    • 1642286980 scopus 로고    scopus 로고
    • Challenges in antimicrobial drug discovery and the potential of nucleoside antibiotics
    • Rachakonda S, Cartee L: Challenges in antimicrobial drug discovery and the potential of nucleoside antibiotics. Curr Med Chem (2004) 11(6):775-793.
    • (2004) Curr Med Chem , vol.11 , Issue.6 , pp. 775-793
    • Rachakonda, S.1    Cartee, L.2
  • 35
    • 16644389654 scopus 로고    scopus 로고
    • Antibacterial drug discovery in the 21st century
    • Bush K: Antibacterial drug discovery in the 21st century. Clin Microbiol Infect (2004) 10(Suppl 4):10-17.
    • (2004) Clin Microbiol Infect , vol.10 , Issue.SUPPL. 4 , pp. 10-17
    • Bush, K.1
  • 36
    • 62249119834 scopus 로고    scopus 로고
    • Showalter HDH: Outwitting nature: Future trends for antimicrobial therapy. Tom D Rowe 55th Annual Pharmacy Lectures, University of Michigan, Ann Arbor, MI, USA (2006). http://sitemaker.umich.edu/cop. continuing.ed/files/showalter- additional-handout-materials.pdf • A good summary of recently developed antibacterials.
    • Showalter HDH: Outwitting nature: Future trends for antimicrobial therapy. Tom D Rowe 55th Annual Pharmacy Lectures, University of Michigan, Ann Arbor, MI, USA (2006). http://sitemaker.umich.edu/cop. continuing.ed/files/showalter- additional-handout-materials.pdf • A good summary of recently developed antibacterials.
  • 37
    • 0036090890 scopus 로고    scopus 로고
    • Exploiting current understanding of antibiotic action for discovery of new drugs
    • Chopra I, Hesse L, O'Neill AJ: Exploiting current understanding of antibiotic action for discovery of new drugs. J Appl Microbiol (2002) 92(Suppl):4S-15S.
    • (2002) J Appl Microbiol , vol.92 , Issue.SUPPL.
    • Chopra, I.1    Hesse, L.2    O'Neill, A.J.3
  • 38
    • 0036259397 scopus 로고    scopus 로고
    • Microbial genomics and novel antibiotic discovery: New technology to search for new drugs
    • Dougherty TJ, Barrett JF, Pucci MJ: Microbial genomics and novel antibiotic discovery: New technology to search for new drugs. Curr Pharm Des (2002) 8(13):1119-1135.
    • (2002) Curr Pharm Des , vol.8 , Issue.13 , pp. 1119-1135
    • Dougherty, T.J.1    Barrett, J.F.2    Pucci, M.J.3
  • 39
    • 0036266395 scopus 로고    scopus 로고
    • Genomics and the prospects for the discovery of new targets for antibacterial and antifungal agents
    • Isaacson RE: Genomics and the prospects for the discovery of new targets for antibacterial and antifungal agents. Curr Pharm Des (2002) 8(13):1091-1098.
    • (2002) Curr Pharm Des , vol.8 , Issue.13 , pp. 1091-1098
    • Isaacson, R.E.1
  • 40
    • 62249177712 scopus 로고    scopus 로고
    • Lieberman LB, Wootan MG: Protecting the crown jewels of medicine. Center for Science in the Public Interest (1998). http://www.cspinet. org/reports/abiotic.htm
    • Lieberman LB, Wootan MG: Protecting the crown jewels of medicine. Center for Science in the Public Interest (1998). http://www.cspinet. org/reports/abiotic.htm
  • 42
    • 0025075006 scopus 로고
    • The clinical evaluation of antibacterial drugs: Guidelines of the British Society for Antimicrobial Chemotherapy
    • Finch RG: The clinical evaluation of antibacterial drugs: Guidelines of the British Society for Antimicrobial Chemotherapy. Eur J Clin Microbiol Infect Dis (1990) 9(7):542-547.
    • (1990) Eur J Clin Microbiol Infect Dis , vol.9 , Issue.7 , pp. 542-547
    • Finch, R.G.1
  • 43
    • 0026492838 scopus 로고
    • General guidelines for the clinical evaluation of anti-infective drug products
    • Beam TR Jr, Gilbert DN, Kunin CM: General guidelines for the clinical evaluation of anti-infective drug products. Clin Infect Dis (1992) 15(Suppl 1):S5-S32.
    • (1992) Clin Infect Dis , vol.15 , Issue.SUPPL. 1
    • Beam Jr, T.R.1    Gilbert, D.N.2    Kunin, C.M.3
  • 44
    • 0027488448 scopus 로고
    • European guidelines for antiinfective drug products. Introduction
    • Beam TR Jr, Gilbert DN, Kunin CM: European guidelines for antiinfective drug products. Introduction. Clin Infect Dis (1993) 17(4):787-788.
    • (1993) Clin Infect Dis , vol.17 , Issue.4 , pp. 787-788
    • Beam Jr, T.R.1    Gilbert, D.N.2    Kunin, C.M.3
  • 45
    • 62249092991 scopus 로고    scopus 로고
    • FDA, Rockville, MD, USA
    • Published guidance documents: FDA, Rockville, MD, USA (1998). http://www.fda.gov/cvm/Guidance/published.htm
    • (1998) Published guidance documents
  • 51
    • 0036242014 scopus 로고    scopus 로고
    • Safety of fluoroquinolones: An update
    • Mandell L, Tillotson G: Safety of fluoroquinolones: An update. Can J Infect Dis (2002) 13(1):54-61.
    • (2002) Can J Infect Dis , vol.13 , Issue.1 , pp. 54-61
    • Mandell, L.1    Tillotson, G.2
  • 53
    • 56049084881 scopus 로고    scopus 로고
    • The IDSA Emerging Infections Network: Toxicity of extended courses of linezolid: Results of an Infectious Diseases Society of America emerging infection network survey
    • B eekmann SK, Gilbert DN, Polgreen PM; The IDSA Emerging Infections Network: Toxicity of extended courses of linezolid: Results of an Infectious Diseases Society of America emerging infection network survey. Diagnostic Micro Inf Dis (2008) 62:407-410.
    • (2008) Diagnostic Micro Inf Dis , vol.62 , pp. 407-410
    • eekmann SK, B.1    Gilbert, D.N.2    Polgreen, P.M.3
  • 54
    • 62249114801 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention, Atlanta, GA, USA
    • A public health action plan to combat antimicrobial resistance: Centers for Disease Control and Prevention, Atlanta, GA, USA (2008). http://www.cdc.gov/drugresistance/actionplan/aractionplan.pdf
    • (2008) A public health action plan to combat antimicrobial resistance
  • 55
    • 2342534392 scopus 로고    scopus 로고
    • Development of drugs for antimicrobial-resistant pathogens
    • Powers JH: Development of drugs for antimicrobial-resistant pathogens. Curr Opin Infect Dis (2003) 16(6):547-551.
    • (2003) Curr Opin Infect Dis , vol.16 , Issue.6 , pp. 547-551
    • Powers, J.H.1
  • 57
    • 0033920653 scopus 로고    scopus 로고
    • New safe medicines faster: A proposal for a key action within the European Union's 6th framework programme
    • Bjerrum OJ: New safe medicines faster: A proposal for a key action within the European Union's 6th framework programme. Pharmacol Toxicol (2000) 86(Suppl 1):23-26.
    • (2000) Pharmacol Toxicol , vol.86 , Issue.SUPPL. 1 , pp. 23-26
    • Bjerrum, O.J.1
  • 58
    • 0037443798 scopus 로고    scopus 로고
    • A new model for drug discovery - meeting our societal obligation
    • Stein RL: A new model for drug discovery - meeting our societal obligation. Drug Discov Today (2003) 8(6):245-248.
    • (2003) Drug Discov Today , vol.8 , Issue.6 , pp. 245-248
    • Stein, R.L.1


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