A CCR2/CCR5 antagonist attenuates an increase in angiotensin II-induced CD11b+ Monocytes from Atherogenic ApoE-/- Mice

Cardiovascular Drugs and Therapy

Volumn 23, Issue 2, 2009, Pages 113-120

  Major, Terry C ^a,c   Olszewski, Bronia ^a   Rosebury Smith, Wendy S ^b  

^a PFIZER INC   (United States)

^b Cutting Image Histology   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

Angiotensin II; ApoE mouse; Atherosclerosis; CCR2; CD11b; Integrin; Macrophage; Monocyte chemoattractant protein 1 (MCP 1)

Indexed keywords

ANGIOTENSIN II; CD11B ANTIGEN; CHEMOKINE RECEPTOR CCR2; MONOCYTE CHEMOTACTIC PROTEIN 2; NEUTRALIZING ANTIBODY; RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; C57BL 6 MOUSE; CELL INFILTRATION; CIRCULATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG INFUSION; FLOW CYTOMETRY; FLUORESCENCE; MACROPHAGE; MALE; MEASUREMENT; MONOCYTE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

ANGIOTENSIN II; ANIMALS; ANTIGENS, CD11B; APOLIPOPROTEINS E; ATHEROSCLEROSIS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; RATS; RECEPTORS, CCR2; RECEPTORS, CCR5;

EID: 62149131459     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10557-008-6157-0     Document Type: Article

References (44)

1. N Kher JD Marsh 2004 Pathobiology of atherosclerosis-a brief review Semin Thromb Hemost. 30 665 672
2. L Lind 2003 Circulating markers of inflammation and atherosclerosis Atherosclerosis. 169 203 214
3. K Egashira 2003 Molecular mechanisms mediating inflammation in vascular disease: special reference to monocyte chemoattractant protein-1 Hypertension. 41 834 841
4. U Ikeda 2003 Inflammation and coronary artery disease Curr Vasc Pharmacol. 1 65 70
5. T Ito U Ikeda 2003 Inflammatory cytokines and cardiovascular disease Curr Drug Targets Inflamm Allergy. 2 257 265
6. H Ulbrich EE Eriksson L Lindbom 2003 Leukocyte and endothelial cell adhesion molecules as targets for therapeutic interventions in inflammatory disease Trends Pharmacol Sci. 24 640 647
7. CS Baker S Gupta 2001 Chemokines: the link between inflammation, restenosis and atherosclerosis? Int J Cardiol. 80 107 108
8. P Libby 2001 What have we learned about the biology of atherosclerosis? The role of inflammation Am J Cardiol. 88 3J 6J
9. P Libby 2000 Coronary artery injury and the biology of atherosclerosis: inflammation, thrombosis, and stabilization Am J Cardiol. 86 3J 8J
10. JA Berliner M Navab AM Fogelman JS Frank LL Demer PA Edwards 1995 Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics Circulation. 91 2488 2496
11. KH Han RK Tangirala SR Green O Quehenberger 1998 Chemokine receptor CCR2 expression and monocyte chemoattractant protein-1-mediated chemotaxis in human monocytes. A regulatory role for plasma LDL Arterioscler Thromb Vasc Biol 18 1983 1991
12. LA Tylaska L Boring W Weng R Aiello IF Charo BJ Rollins 2002 Ccr2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen Cytokine. 18 184 190
13. MC Kowala R Recce S Beyer C Gu M Valentine 2000 Characterization of atherosclerosis in LDL receptor knockout mice: macrophage accumulation correlates with rapid and sustained expression of aortic MCP-1/JE Atherosclerosis. 149 323 330
14. RE Gerszten EA Garcia-Zepeda YC Lim M Yoshida HA Ding MA Gimbrone Jr 1999 MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions Nature. 398 718 723
15. CM Ferrario WB Strawn 2006 Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease Am J Cardiol. 98 121 128
16. T Mateo YN Abu Nabah TM Abu M Mata M Cerda-Nicolas AE Proudfoot 2006 Angiotensin II-induced mononuclear leukocyte interactions with arteriolar and venular endothelium are mediated by the release of different CC chemokines J Immunol. 176 5577 5586
17. K Sasaki M Taniguchi M Miyoshi O Goto K Sato T Watanabe 2005 Are transcription factors (NF-{kappa}B and AP-1) involved in the angiotensin II-stimulated production of proinflammatory cytokines induced by LPS in dehydrated rats? Am J Physiol Regul Integr Comp Physiol. 289 R1599 R1608
18. EL Schiffrin RM Touyz 2003 Inflammation and vascular hypertrophy induced by angiotensin II: role of NADPH oxidase-derived reactive oxygen species independently of blood pressure elevation? Arterioscler Thromb Vasc Biol. 23 707 709
19. A Virdis EL Schiffrin 2003 Vascular inflammation: a role in vascular disease in hypertension? Curr Opin Nephrol Hypertens. 12 181 187
20. MI Phillips S Kagiyama 2002 Angiotensin II as a pro-inflammatory mediator Curr Opin Investig Drugs. 3 569 577
21. AR Brasier A Recinos III MS Eledrisi 2002 Vascular inflammation and the renin-angiotensin system Arterioscler Thromb Vasc Biol. 22 1257 1266
22. J Galle T Quaschning 2001 Angiotensin II and atherosclerosis: relevance for renal disease Contrib Nephrol. 135 235 249
23. A Prasad KK Koh WH Schenke R Mincemoyer G Csako TA Fleischer 2001 Role of angiotensin II type 1 receptor in the regulation of cellular adhesion molecules in atherosclerosis Am Heart J. 142 248 253
24. M Ruiz-Ortega O Lorenzo Y Suzuki M Ruperez J Egido 2001 Proinflammatory actions of angiotensins Curr Opin Nephrol Hypertens. 10 321 329
25. D Weiss JJ Kools WR Taylor 2001 Angiotensin II-induced hypertension accelerates the development of atherosclerosis in apoE-deficient mice Circulation. 103 448 454
26. Y Suzuki M Ruiz-Ortega J Egido 2000 Angiotensin II: a double-edged sword in inflammation J Nephrol. 13 S101 S110
27. R Kranzhofer M Browatzki J Schmidt W Kubler 1999 Angiotensin II activates the proinflammatory transcription factor nuclear factor-kappaB in human monocytes Biochem Biophys Res Commun. 257 826 828
28. XL Chen PE Tummala MT Olbrych RW Alexander RM Medford 1998 Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells Circ Res. 83 952 959
29. M Mellado JM Rodriguez-Frade A Aragay G del Real AM Martin AJ Vila-Coro 1998 The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor J Immunol. 161 805 813
30. M Baba O Nishimura N Kanzaki M Okamoto H Sawada Y Iizawa 1999 A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity Proc Natl Acad Sci U S A. 96 5698 5703
31. H Repo SE Jansson M Leirisalo-Repo 1995 Anticoagulant selection influences flow cytometric determination of CD11b upregulation in vivo and ex vivo J Immunol Methods. 185 65 79
32. IF Charo MB Taubman 2004 Chemokines in the pathogenesis of vascular disease Circ Res. 95 858 866
33. S Inoue K Egashira W Ni S Kitamoto M Usui K Otani 2002 Anti-monocyte chemoattractant protein-1 gene therapy limits progression and destabilization of established atherosclerosis in apolipoprotein E-knockout mice Circulation. 106 2700 2706
34. TJ Reape PH Groot 1999 Chemokines and atherosclerosis Atherosclerosis. 147 213 225
35. T Watanabe J Fan 1998 Atherosclerosis and inflammation mononuclear cell recruitment and adhesion molecules with reference to the implication of ICAM-1/LFA-1 pathway in atherogenesis Int J Cardiol. 66 S45 S53
36. L Gu B Rutledge J Fiorillo C Ernst I Grewal R Flavell 1997 In vivo properties of monocyte chemoattractant protein-1 J Leukoc Biol. 62 577 580
37. JN Wilcox NA Nelken SR Coughlin D Gordon TJ Schall 1994 Local expression of inflammatory cytokines in human atherosclerotic plaques J Atheroscler Thromb. 1 S10 S13
38. SK Clinton P Libby 1992 Cytokines and growth factors in atherogenesis Arch Pathol Lab Med. 116 1292 1300
39. Q Capers RW Alexander P Lou H De Leon JN Wilcox N Ishizaka 1997 Monocyte chemoattractant protein-1 expression in aortic tissues of hypertensive rats Hypertension. 30 1397 1402
40. WB Strawn CM Ferrario 2008 Angiotensin II AT1 receptor blockade normalizes CD11b+ monocyte production in bone marrow of hypercholesterolemic monkeys Atherosclerosis. 196 624 632
41. U Syrbe A Moebes J Scholze A Swidsinski Y Dorffel 2007 Effects of the angiotensin II type 1 receptor antagonist telmisartan on monocyte adhesion and activation in patients with essential hypertension Hypertens Res. 30 521 528
42. A Daugherty MW Manning LA Cassis 2001 Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis Br J Pharmacol. 134 865 870
43. GC Nicholson RC Tennant DC Carpenter HM Sarau OM Kon PJ Barnes 2007 A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist Pulm Pharmacol Ther. 20 52 59
44. E Bush N Maeda WA Kuziel TC Dawson JN Wilcox H DeLeon 2000 CC chemokine receptor 2 is required for macrophage infiltration and vascular hypertrophy in angiotensin II-induced hypertension Hypertension. 36 360 363