-
1
-
-
33750998518
-
Common pharmacophores for uncharged human ether-a-go-go-related gene (hERG) blockers
-
Aronov A.M. Common pharmacophores for uncharged human ether-a-go-go-related gene (hERG) blockers. J. Med. Chem. 49 (2006) 6917-6921
-
(2006)
J. Med. Chem.
, vol.49
, pp. 6917-6921
-
-
Aronov, A.M.1
-
2
-
-
34248365064
-
-
Chen X., and Li Y.G. Effects of oxymatrine on sodium current in isolated ventricular cells in guinea-pig. J. N. Behtune Univ. Med. Sci. vol. 27 (2001) 41-42
-
(2001)
J. N. Behtune Univ. Med. Sci.
, vol.27
, pp. 41-42
-
-
Chen, X.1
Li, Y.G.2
-
3
-
-
8844266911
-
Liquid chromatography of active principles in Sophora flavescens root
-
Chen X., Yi C., Yang X., and Wang X. Liquid chromatography of active principles in Sophora flavescens root. J. Chromatogr., B. Anal. Technol. Biomed. Life Sci. 812 (2004) 149-163
-
(2004)
J. Chromatogr., B. Anal. Technol. Biomed. Life Sci.
, vol.812
, pp. 149-163
-
-
Chen, X.1
Yi, C.2
Yang, X.3
Wang, X.4
-
4
-
-
33646064120
-
A novel hypothesis for the binding mode of HERG channel blockers
-
Choe H., Nah K.H., Lee S.N., Lee H.S., Jo S.H., Leem C.H., and Jang Y.J. A novel hypothesis for the binding mode of HERG channel blockers. Biochem. Biophys. Res. Commun. 344 (2006) 72-78
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.344
, pp. 72-78
-
-
Choe, H.1
Nah, K.H.2
Lee, S.N.3
Lee, H.S.4
Jo, S.H.5
Leem, C.H.6
Jang, Y.J.7
-
5
-
-
18044381359
-
Pentamidine reduces hERG expression to prolong the QT interval
-
Cordes J.S., Sun Z., Lloyd D.B., Bradley J.A., Opsahl A.C., Tengowski M.W., Chen X., and Zhou J. Pentamidine reduces hERG expression to prolong the QT interval. Br. J. Pharmacol. 145 (2005) 15-23
-
(2005)
Br. J. Pharmacol.
, vol.145
, pp. 15-23
-
-
Cordes, J.S.1
Sun, Z.2
Lloyd, D.B.3
Bradley, J.A.4
Opsahl, A.C.5
Tengowski, M.W.6
Chen, X.7
Zhou, J.8
-
6
-
-
33747885208
-
Dimethyl sulfoxide effects on hERG channels expressed in HEK293 cells
-
Du X., Lu D., Daharsh E.D., Yao A., Dewoody R., and Yao J.A. Dimethyl sulfoxide effects on hERG channels expressed in HEK293 cells. J. Pharmacol. Toxicol. Methods 54 (2006) 164-172
-
(2006)
J. Pharmacol. Toxicol. Methods
, vol.54
, pp. 164-172
-
-
Du, X.1
Lu, D.2
Daharsh, E.D.3
Yao, A.4
Dewoody, R.5
Yao, J.A.6
-
7
-
-
34548537015
-
Action potential experiments complete hERG assay and QT-interval measurements in cardiac preclinical studies
-
Ducroq J., Printemps R., Guilbot S., Gardette J., Salvetat C., and Le G.M. Action potential experiments complete hERG assay and QT-interval measurements in cardiac preclinical studies. J. Pharmacol. Toxicol. Methods 56 (2007) 159-170
-
(2007)
J. Pharmacol. Toxicol. Methods
, vol.56
, pp. 159-170
-
-
Ducroq, J.1
Printemps, R.2
Guilbot, S.3
Gardette, J.4
Salvetat, C.5
Le, G.M.6
-
8
-
-
18744395493
-
Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome
-
Eckhardt L.L., Rajamani S., and January C.T. Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome. Br. J. Pharmacol. 145 (2005) 3-4
-
(2005)
Br. J. Pharmacol.
, vol.145
, pp. 3-4
-
-
Eckhardt, L.L.1
Rajamani, S.2
January, C.T.3
-
9
-
-
33750805511
-
On the molecular and electronic structure of matrine-type alkaloids
-
Galasso V., Asaro F., Berti F., Pergolese B., Kovač B., and Pichierri F. On the molecular and electronic structure of matrine-type alkaloids. Chem. Phys. 330 (2006) 457-468
-
(2006)
Chem. Phys.
, vol.330
, pp. 457-468
-
-
Galasso, V.1
Asaro, F.2
Berti, F.3
Pergolese, B.4
Kovač, B.5
Pichierri, F.6
-
11
-
-
1842432208
-
Antiarrhythmic efficancy of neferine assessed by programmed electrical stimulation in a canine model of electropharmacology
-
Guo Z.B., Li Q., Cao H.Y., and Xu Z. Antiarrhythmic efficancy of neferine assessed by programmed electrical stimulation in a canine model of electropharmacology. Chin. Pharm. Sci. 11 (2002) 35-42
-
(2002)
Chin. Pharm. Sci.
, vol.11
, pp. 35-42
-
-
Guo, Z.B.1
Li, Q.2
Cao, H.Y.3
Xu, Z.4
-
12
-
-
0035254470
-
Antiarrhythmic drug carvedilol inhibits HERG potassium channels
-
Karle C.A., Kreye V.A., Thomas D., Rockl K., Kathöfer S., Zhang W., and Kiehn J. Antiarrhythmic drug carvedilol inhibits HERG potassium channels. Cardiovasc. Res. 49 (2001) 361-370
-
(2001)
Cardiovasc. Res.
, vol.49
, pp. 361-370
-
-
Karle, C.A.1
Kreye, V.A.2
Thomas, D.3
Rockl, K.4
Kathöfer, S.5
Zhang, W.6
Kiehn, J.7
-
15
-
-
0038497465
-
Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652
-
Milnes J.T., Crociani O., Arcangeli A., Hancox J.C., and Witchel H.J. Blockade of HERG potassium currents by fluvoxamine: incomplete attenuation by S6 mutations at F656 or Y652. Br. J. Pharmacol. 139 (2003) 887-898
-
(2003)
Br. J. Pharmacol.
, vol.139
, pp. 887-898
-
-
Milnes, J.T.1
Crociani, O.2
Arcangeli, A.3
Hancox, J.C.4
Witchel, H.J.5
-
16
-
-
0034710933
-
A structural basis for drug-induced long QT syndrome
-
Mitcheson J.S., Chen J., Lin M., Culberson C., and Sanguinetti M.C. A structural basis for drug-induced long QT syndrome. Proc. Natl. Acad. Sci. U. S. A. 22 (2000) 12329-12333
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.22
, pp. 12329-12333
-
-
Mitcheson, J.S.1
Chen, J.2
Lin, M.3
Culberson, C.4
Sanguinetti, M.C.5
-
17
-
-
33750480200
-
+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine
-
+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine. Br. J. Pharmacol. 149 (2006) 481-489
-
(2006)
Br. J. Pharmacol.
, vol.149
, pp. 481-489
-
-
Rajamani, S.1
Eckhardt, L.L.2
Valdivia, C.R.3
Klemens, C.A.4
Gillman, B.M.5
Anderson, C.L.6
Holzem, K.M.7
Delisle, B.P.8
Anson, B.D.9
Makielski, J.C.10
January, C.T.11
-
18
-
-
0344492207
-
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
-
Redfern W.S., Carlsson L., Davis A.S., Lynch W.G., MacKenzie I., Palethorpe S., Siegl P.K.S., Strang I., Sullivan A.T., Wallis R., Camm A.J., and Hammond T.G. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc. Res. 58 (2003) 32-45
-
(2003)
Cardiovasc. Res.
, vol.58
, pp. 32-45
-
-
Redfern, W.S.1
Carlsson, L.2
Davis, A.S.3
Lynch, W.G.4
MacKenzie, I.5
Palethorpe, S.6
Siegl, P.K.S.7
Strang, I.8
Sullivan, A.T.9
Wallis, R.10
Camm, A.J.11
Hammond, T.G.12
-
19
-
-
33645317063
-
hERG potassium channels and cardiac arrhythmia
-
Sanguinetti M.C., and Tristani-Firouzi M. hERG potassium channels and cardiac arrhythmia. Nature 440 (2006) 463-469
-
(2006)
Nature
, vol.440
, pp. 463-469
-
-
Sanguinetti, M.C.1
Tristani-Firouzi, M.2
-
20
-
-
3042804963
-
i in single ventricular myocyte of guinea pig
-
i in single ventricular myocyte of guinea pig. Chin. Pharm. J. 39 (2004) 264-266
-
(2004)
Chin. Pharm. J.
, vol.39
, pp. 264-266
-
-
Sun, H.L.1
Xu, C.Q.2
Li, Z.3
-
21
-
-
11444255282
-
-
Xu C.Q., Dong D.L., Du Z.W., Chen Q.W., Gong D.M., and Yang B.F. Comparison of the anti-arrhythmic effects of matrine and berbamine with amiodarone and RP58866. Yao Xue Xue Bao vol. 39 (2004) 691-694
-
(2004)
Yao Xue Xue Bao
, vol.39
, pp. 691-694
-
-
Xu, C.Q.1
Dong, D.L.2
Du, Z.W.3
Chen, Q.W.4
Gong, D.M.5
Yang, B.F.6
-
22
-
-
33847115788
-
Torsades de pointes with a severely prolonged QT interval induced by an initial low dose sotalol intake
-
Yalta K., Turgut O., Yilmaz A., Yilmaz M.B., Kendirlioglu O., and Karadas F. Torsades de pointes with a severely prolonged QT interval induced by an initial low dose sotalol intake. Int. J. Cardiol. 116 (2007) e95-e97
-
(2007)
Int. J. Cardiol.
, vol.116
-
-
Yalta, K.1
Turgut, O.2
Yilmaz, A.3
Yilmaz, M.B.4
Kendirlioglu, O.5
Karadas, F.6
-
23
-
-
30544449076
-
Resveratrol, a natural ingredient of grape skin: antiarrhythmic efficacy and ionic mechanisms
-
Zhang Y., Liu Y.Y., Wang T., Li B.X., Li H.W., Wang Z.G., and Yang B.F. Resveratrol, a natural ingredient of grape skin: antiarrhythmic efficacy and ionic mechanisms. Biochem. Biophys. Res. Commun. 340 (2006) 1192-1199
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.340
, pp. 1192-1199
-
-
Zhang, Y.1
Liu, Y.Y.2
Wang, T.3
Li, B.X.4
Li, H.W.5
Wang, Z.G.6
Yang, B.F.7
-
24
-
-
34247166182
-
-
Zhang Y., Du J., Zhang Y., Sun H.L., Pan Z.W., Lu Y.J., Li B.X., and Yang B.F. Effects of matrine, oxymatrine and resveratrol on HERG channel expression. Yao Xue Xue Bao vol. 42 (2007) 139-144
-
(2007)
Yao Xue Xue Bao
, vol.42
, pp. 139-144
-
-
Zhang, Y.1
Du, J.2
Zhang, Y.3
Sun, H.L.4
Pan, Z.W.5
Lu, Y.J.6
Li, B.X.7
Yang, B.F.8
-
25
-
-
0021054783
-
The antiarrhythmic action of sophocarpine hydrobromide
-
Zhao Z.Y., Li Y.Q., and Lin Z.Y. The antiarrhythmic action of sophocarpine hydrobromide. Acta Pharm. Sin. 4 (1983) 173-176
-
(1983)
Acta Pharm. Sin.
, vol.4
, pp. 173-176
-
-
Zhao, Z.Y.1
Li, Y.Q.2
Lin, Z.Y.3
-
26
-
-
41849101073
-
HERG k(+) channel blockade by the novel antiviral drug sophocarpine
-
Zhao X.L., Qi Z.P., Fang C., Chen M.H., Lv Y.J., Li B.X., and Yang B.F. HERG k(+) channel blockade by the novel antiviral drug sophocarpine. Biol. Pharm. Bull. 31 (2008) 627-632
-
(2008)
Biol. Pharm. Bull.
, vol.31
, pp. 627-632
-
-
Zhao, X.L.1
Qi, Z.P.2
Fang, C.3
Chen, M.H.4
Lv, Y.J.5
Li, B.X.6
Yang, B.F.7
-
27
-
-
0031982513
-
Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature
-
Zhou Z., Gong Q., Ye B., Fan Z., Makielski J.C., Robertson G.A., and January C.T. Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. Biophys. J. 74 (1998) 230-241
-
(1998)
Biophys. J.
, vol.74
, pp. 230-241
-
-
Zhou, Z.1
Gong, Q.2
Ye, B.3
Fan, Z.4
Makielski, J.C.5
Robertson, G.A.6
January, C.T.7
-
28
-
-
0033615646
-
Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects
-
Zhou Z., Gong Q., and January C.T. Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects. J. Biol. Chem. 274 (1999) 31123-31126
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 31123-31126
-
-
Zhou, Z.1
Gong, Q.2
January, C.T.3
-
29
-
-
0036737544
-
Bertosamil blocks HERG potassium channels in their open and inactivated states
-
Zitron E., Karle C.A., Wendt-Nordahl G., Kathöfer S., Zhang W., Thomas D., Weretka S., and Kiehn J. Bertosamil blocks HERG potassium channels in their open and inactivated states. Br. J. Pharmacol. 137 (2002) 221-228
-
(2002)
Br. J. Pharmacol.
, vol.137
, pp. 221-228
-
-
Zitron, E.1
Karle, C.A.2
Wendt-Nordahl, G.3
Kathöfer, S.4
Zhang, W.5
Thomas, D.6
Weretka, S.7
Kiehn, J.8
-
30
-
-
4544287557
-
Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone
-
Zitron E., Kiesecker C., Scholz E., Lück S., Bloehs R., Kathöfer S., Thomas D., Kiehn J., Kreye V.A., Katus H.A., Schoels W., and Karle C.A. Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone. Naunyn-Schmiedeberg's Arch. Pharmacol. 370 (2004) 146-156
-
(2004)
Naunyn-Schmiedeberg's Arch. Pharmacol.
, vol.370
, pp. 146-156
-
-
Zitron, E.1
Kiesecker, C.2
Scholz, E.3
Lück, S.4
Bloehs, R.5
Kathöfer, S.6
Thomas, D.7
Kiehn, J.8
Kreye, V.A.9
Katus, H.A.10
Schoels, W.11
Karle, C.A.12
|