Short term effects of doxycycline on matrix metalloproteinases 2 and 9

Cardiovascular Drugs and Therapy

Volumn 23, Issue 2, 2009, Pages 153-159

  Fiotti, Nicola ^a   Altamura, Nicola ^a   Moretti, Michèle ^a   Wassermann, Stella ^a   Zacchigna, Serena ^b   Farra, Rossella ^a   Dapas, Barbara ^a   Consoloni, Lara ^a   Giacca, Mauro ^b   Grassi, Gabriele ^a   Giansante, Carlo ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

Doxycycline; Metalloproteinase 9; Neutrophils degranulation; Nitrates

Indexed keywords

ACETYLSALICYLIC ACID; DOXYCYCLINE; ENALAPRIL; GELATINASE A; GELATINASE B; NITRATE;

ADULT; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; DEGRANULATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; MALE; NEUTROPHIL; NORMAL HUMAN; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL;

ADULT; ANTI-BACTERIAL AGENTS; ASPIRIN; CELL DEGRANULATION; DOXYCYCLINE; ENALAPRIL; FEMALE; HUMANS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEUTROPHILS; NITRATES; TIME FACTORS;

EID: 62149110424     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10557-008-6150-7     Document Type: Article

References (40)

1. H Birkedal-Hansen 1995 Proteolytic remodeling of extracellular matrix Curr Opin Cell Biol 7 728 735
2. GM Longo W Xiong TC Greiner Y Zhao N Fiotti BT Baxter 2002 Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms J Clin Invest 110 625 632
3. SJ George 2000 Therapeutic potential of matrix metalloproteinase inhibitors in atherosclerosis Expert Opin Investig Drugs 9 993 1007
4. G Pasterkamp AH Schoneveld DJ Hijnen DP de Kleijn H Teepen AC van der Wal 2000 Atherosclerotic arterial remodeling and the localization of macrophages and matrix metalloproteases 1, 2 and 9 in the human coronary artery Atherosclerosis 150 245 253
5. K Morishige H Shimokawa Y Matsumoto Y Eto T Uwatoku K Abe 2003 Overexpression of matrix metalloproteinase-9 promotes intravascular thrombus formation in porcine coronary arteries in vivo Cardiovasc Res 57 572 585
6. JFNH Woessner 2000
7. SM Wojtowicz-Praga RB Dickson MJ Hawkins 1997 Matrix metalloproteinase inhibitors Invest New Drugs 15 61 75
8. FR Burns MS Stack RD Gray CA Paterson 1989 Inhibition of purified collagenase from alkali-burned rabbit corneas Invest Ophthalmol Vis Sci 30 1569 1575
9. LH Nip VJ Uitto LM Golub 1993 Inhibition of epithelial cell matrix metalloproteinases by tetracyclines J Periodontal Res 28 379 385
10. AK Prall GM Longo WG Mayhan EA Waltke B Fleckten RW Thompson 2002 Doxycycline in patients with abdominal aortic aneurysms and in mice: comparison of serum levels and effect on aneurysm growth in mice J Vasc Surg 35 923 929
11. M Mosorin J Juvonen F Biancari J Satta HM Surcel M Leinonen 2001 Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study J Vasc Surg 34 606 610
12. M Rentschler BT Baxter 2006 Pharmacological approaches to prevent abdominal aortic aneurysm enlargement and rupture Ann N Y Acad Sci 1085 39 46
13. N Fiotti N Altamura C Orlando L Simi B Reimers P Pascotto 2008 Metalloproteinases-2, -9 and TIMP-1 expression in stable and unstable coronary plaques undergoing PCI Int J Cardiol 127 350 357
14. E Ronner E Boersma KM Akkerhuis RA Harrington AM Lincoff JW Deckers 2002 Patients with acute coronary syndromes without persistent ST elevation undergoing percutaneous coronary intervention benefit most from early intervention with protection by a glycoprotein IIb/IIIa receptor blocker Eur Heart J 23 239 246
15. JW Burrow JA Koch HH Chuang W Zhong DD Dean VL Sylvia 2007 Nitric oxide donors selectively reduce the expression of matrix metalloproteinases-8 and -9 by human diabetic skin fibroblasts J Surg Res 140 90 98
16. A Dobrina BR Schwartz TM Carlos HD Ochs PG Beatty JM Harlan 1989 CD11/CD18-independent neutrophil adherence to inducible endothelial-leucocyte adhesion molecules (E-LAM) in vitro Immunology 67 502 508
17. P Bellavite P Dri BV Della MC Serra 1983 The measurement of superoxide anion production by granulocytes In whole blood. A clinical test for the evaluation of phagocyte function and serum opsonic capacity Eur J Clin Invest 13 363 368
18. GP Riley V Curry J DeGroot B van El N Verzijl BL Hazleman 2002 Matrix metalloproteinase activities and their relationship with collagen remodelling in tendon pathology Matrix Biol 21 185 195
19. M Karlsson S Hammers I Nilsson-Ehle AS Malmborg B Wretlind 1996 Concentrations of doxycycline and penicillin G in sera and cerebrospinal fluid of patients treated for neuroborreliosis Antimicrob Agents Chemother 40 1104 1107
20. WL Gabler HR Creamer 1991 Suppression of human neutrophil functions by tetracyclines J Periodontal Res 26 52 58
21. T Sorsa Y Ding T Salo A Lauhio O Teronen T Ingman 1994 Effects of tetracyclines on neutrophil, gingival, and salivary collagenases; a functional and western-blot assessment with special reference to their cellular sources in periodontal diseases Ann N Y Acad Sci 732 112 131
22. GN Smith Jr KD Brandt KA Hasty 1994 Procollagenase is reduced to inactive fragments upon activation in the presence of doxycycline Ann N Y Acad Sci 732 436 438
23. GN Smith Jr KD Brandt KA Hasty 1996 Activation of recombinant human neutrophil procollagenase in the presence of doxycycline results in fragmentation of the enzyme and loss of enzyme activity Arthritis Rheum 39 235 244
24. BT Baxter WH Pearce EA Waltke FN Littooy JW Hallett Jr KC Kent 2002 Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: report of a prospective (Phase II) multicenter study J Vasc Surg 36 1 12
25. DL Brown KK Desai BA Vakili C Nouneh HM Lee LM Golub 2004 Clinical and biochemical results of the metalloproteinase inhibition with subantimicrobial doses of doxycycline to prevent acute coronary syndromes (MIDAS) pilot trial Arterioscler Thromb Vasc Biol 24 733 738
26. R Ding CL McGuinness KG Burnand E Sullivan A Smith 2005 Matrix metalloproteinases in the aneurysm wall of patients treated with low-dose doxycycline Vascular 13 290 297
27. M Demestre G Parkin-Smith A Petzold AH Pullen 2005 The pro and the active form of matrix metalloproteinase-9 is increased in serum of patients with amyotrophic lateral sclerosis J Neuroimmunol 159 146 154
28. ZY Tao MA Cavasin F Yang YH Liu XP Yang 2004 Temporal changes in matrix metalloproteinase expression and inflammatory response associated with cardiac rupture after myocardial infarction in mice Life Sci 74 1561 1572
29. Y Yang Y Ma W Han J Li Y Xiang F Liu 2008 Age-related differences in postinfarct left ventricular rupture and remodeling Am J Physiol Heart Circ Physiol 294 H1815 H1822
30. JA Curci D Mao DG Bohner BT Allen BG Rubin JM Reilly 2000 Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms J Vasc Surg 31 325 342
31. J Liu W Xiong L Baca-Regen H Nagase BT Baxter 2003 Mechanism of inhibition of matrix metalloproteinase-2 expression by doxycycline in human aortic smooth muscle cells J Vasc Surg 38 1376 1383
32. P Chen Y Yuan S Wang L Zhan J Xu 2006 Captopril, an angiotensin- converting enzyme inhibitor, attenuates the severity of acute pancreatitis in rats by reducing expression of matrix metalloproteinase 9 Tohoku J Exp Med 209 99 107
33. JL Mehta J Chen F Yu DY Li 2004 Aspirin inhibits ox-LDL-mediated LOX-1 expression and metalloproteinase-1 in human coronary endothelial cells Cardiovasc Res 64 243 249
34. GL Vermeiren MJ Claeys D Van Bockstaele B Grobben H Slegers L Bossaert 2000 Reperfusion injury after focal myocardial ischaemia: polymorphonuclear leukocyte activation and its clinical implications Resuscitation 45 35 61
35. R Fridman M Toth I Chvyrkova SO Meroueh S Mobashery 2003 Cell surface association of matrix metalloproteinase-9 (gelatinase B) Cancer Metastasis Rev 22 153 166
36. H Ischiropoulos A Gow 2005 Pathophysiological functions of nitric oxide-mediated protein modifications Toxicology 208 299 303
37. B Axisa IM Loftus AR Naylor S Goodall L Jones PR Bell 2002 Prospective, randomized, double-blind trial investigating the effect of doxycycline on matrix metalloproteinase expression within atherosclerotic carotid plaques Stroke 33 2858 2864
38. MO Griffin M Jinno LA Miles FJ Villarreal 2005 Reduction of myocardial infarct size by doxycycline: a role for plasmin inhibition Mol Cell Biochem 270 1 11
39. LM Wu L Fan LL Chen 2007 Precondition with doxycycline administration abates ischemia/reperfusion injury and reduces the expression of matrix metalloproteinase-1/9 in myocardium in rat in vivo Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 19 679 682
40. J Hu PE Van den Steen C Dillen G Opdenakker 2005 Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock Biochem Pharmacol 70 535 544