Increased ribosomal biogenesis induces pancreatic β cell failure in mice model of type 2 diabetes

Biochemical and Biophysical Research Communications

Volumn 381, Issue 3, 2009, Pages 367-371

  Asahara, Shun ichiro ^a   Matsuda, Tomokazu ^a   Kido, Yoshiaki ^a,b   Kasuga, Masato ^a,c  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KOBE UNIVERSITY   (Japan)

^c NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

Cyclin D2; ER stress; Pancreatic cell failure; Ribosomal biogenesis; Type 2 diabetes

Indexed keywords

CYCLIN D2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CELL HYPERPLASIA; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; INSULIN RESISTANCE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIBOSOME;

ANIMALS; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION; INSULIN-SECRETING CELLS; MICE; MICE, INBRED STRAINS; RIBOSOMES;

MUS;

EID: 61949486978     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.02.047     Document Type: Article

References (15)

1. Weyer C., Bogardus C., Mott D.M., and Pratley R.E. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type2 diabetes mellitus. J. Clin. Invest. 104 (1999) 787-794
2. Butler A.E., Janson J., Weir S.B., Ritzel R., Rizza R.A., and Butler P.C. β Cell deficit and increased β-cell apoptosis in human with type2 diabetes. Diabetes 52 (2003) 102-110
3. Uchida T., Nakamura T., Hashimoto N., Matsuda T., Kotani K., Sakaue H., Kido Y., Hayashi Y., Nakayama K.I., White M.F., and Kasuga M. Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nat. Med. 11 (2005) 175-182
4. Hashimoto N., Kido Y., Uchida T., Asahara S., Shigeyama Y., Matsuda T., Takeda A., Tsuchihashi D., Nishizawa A., Ogawa W., Fujimoto Y., Okamura H., Arden K.C., Herrera P.L., Noda T., and Kasuga M. Ablation of PDK1 in pancreatic β cells induces diabetes as a result of loss of β cell mass. Nat. Genet. 38 (2006) 589-593
5. Shigeyama Y., Kobayashi T., Kido Y., Hashimoto N., Asahara S., Matsuda T., Takeda A., Inoue T., Shibutani Y., Koyanagi M., Uchida T., Inoue M., Hino O., Kasuga M., and Noda T. Biphasic response of pancreatic β cell mass to ablation of tuberous sclerosis complex 2 in mice. Mol. Cell. Biol. 28 (2008) 2971-2979
6. Matsuda T., Kido Y., Uchida T., and Kasuga M. Reduced insulin signaling and endoplasmic reticulum stress act synergetically to deteriorate pancreatic β cell function. Kobe J. Med. Sci. 54 (2008) E114-E121
7. Kido Y., Burks D.J., Withers D., Bruning J.C., Kahn C.R., White M.F., and Accili D. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J. Clin. Invest. 105 (2000) 199-205
8. Hashimoto N., Kido Y., Uchida T., Matsuda T., Suzuki K., Inoue H., Matsumoto M., Ogawa W., Maeda S., Fujihara H., Ueta Y., Uchiyama Y., Akimoto K., Ohno S., Noda T., and Kasuga M. PKCλ regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic β cells. J. Clin. Invest. 115 (2005) 138-145
9. Boyle E.I., Weng S., Gollub J., Jin H., Botstein D., Cherry J.M., and Sherlock G. GO::TermFinder-open source software for accessing Gene Ontology information and finding associated with a list of genes. Bioinfomatics 20 (2004) 3710-3715
10. Yamamoto Y., Banas A., Murata S., Ishikawa M., Lim C.R., Teratani T., Hatada I., Matsubara K., Kato T., and Ochiya T. A comparative analysis of the transcriptome and signal pathway in hepatic differentiation of human adipose mesenchymal stem cells. FEBS J. 275 (2008) 1260-1273
11. Georgia S., and Bhushan A. β Cell replication is the primary mechanism for maintaining postnatal β cell mass. J. Clin. Invest. 114 (2004) 963-968
12. Fonagy A., Swiderski C., Dunn M., and Freeman J.W. Antisense-mediated specific inhibition of p120 protein expression prevents g1-to-s phase transition. Cancer Res. 52 (1992) 5250-5256
13. Volarevic S., Stewart M.J., Ledermann B., Zilberman F., Terracciano L., Montini E., Grompe M., Kozma S.C., and Thomas G. Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6. Science 288 (2000) 2045-2047
14. Lindstrom M.S., and Zhang Y. Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation. J. Biol. Chem. 283 (2008) 15568-15576
15. Jorgensen P., Rupes I., Sharom J.R., Schneper L., Broach J.R., and Tyers M. A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size. Genes Dev. 18 (2004) 2431-2436