The rho1p exchange factor Rgf1p signals upstream from the Pmk1 mitogen-activated protein kinase pathway in fission yeast

Molecular Biology of the Cell

Volumn 20, Issue 2, 2009, Pages 721-731

  Garcia, Patricia ^a   Tajadura, Virginia ^a   Sanchez, Yolanda ^a  

^a CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLUCAN HYDROLASE; CALCINEURIN; CASPOFUNGIN; CHLORIDE ION; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR1; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE C; PROTEIN KINASE C2; RHO FACTOR; RHO1 FACTOR; UNCLASSIFIED DRUG; ANTIFUNGAL AGENT; ECHINOCANDIN; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; OXIDIZING AGENT; PMK1 PROTEIN, S POMBE; RGF1 PROTEIN, S POMBE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO1 PROTEIN, S POMBE; SCHIZOSACCHAROMYCES POMBE PROTEIN; SORBITOL; SPC1 PROTEIN, S POMBE;

ARTICLE; CELL DAMAGE; CELL WALL; CONTROLLED STUDY; DNA FLANKING REGION; ENZYME ACTIVATION; HOMEOSTASIS; NONHUMAN; OSMOTIC STRESS; OXIDATIVE STRESS; PRIORITY JOURNAL; SCHIZOSACCHAROMYCES POMBE; DRUG EFFECT; GENETICS; HEAT; METABOLISM; OSMOTIC PRESSURE; PHENOTYPE; PHYSIOLOGY; SCHIZOSACCHAROMYCES; SIGNAL TRANSDUCTION; ULTRASTRUCTURE;

SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

ANTIFUNGAL AGENTS; CELL WALL; ECHINOCANDINS; ENZYME ACTIVATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HOT TEMPERATURE; HYDROGEN PEROXIDE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; OSMOTIC PRESSURE; OXIDANTS; PHENOTYPE; RHO GTP-BINDING PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SORBITOL;

EID: 61949321279     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E08-07-0673     Document Type: Article

References (53)

1. Arellano, M., Duran, A., and Perez, P. (1997). Localization of the Schizosaccharomyces pombe Rho1 GTPase and its involvement in the organization of the actin cytoskeleton. J. Cell Sci. 110, 2547-2555.
2. Arellano, M., Durán, A., and Pérez, P. (1996). Rhol GTPase activates the (1-3)β-D-glucan synthase and is involved in Schizosaccharomyces pombe morphogenesis. EMBO J. 15, 4584-4591.
3. Arellano, M., Valdivieso, M. H., Calonge, T. M., Coll, P. M., Durán, A., and Pérez, P. (1999b). Schizosaccharomyces pombe protein kinase C homologues, pck1p and pck2p, are targets of rho1p and rho2p and differentially regulate cell integrity. J. Cell Sci. 112, 3569-3578.
4. Ashe, M. P., De Long, S. K., and Sachs, A. L. (2000). Glucose depletion rapidly inhibits translation initiation in yeast. Mol. Biol. Cell 11, 833-848.
5. Barba, G., Soto, T., Madrid, M., Núñez, A., Vicente, J., Gacto, M., and Cansado, J. (2008). Activation of the cell integrity pathway is channelled through diverse signalling elements in fission yeast. Cell Signal. 20, 748-757.
6. Calonge, T. M., Arellano, M., Coll, P. M., and Perez, P. (2003). Rga5p is a specific Rho1p GTPase-activating protein that regulates cell integrity in Schizosaccharomyces pombe. Mol. Microbiol. 47, 507-518.
7. Calonge, T. M., Nakano, K., Arellano, M., Arai, R., Katayama, S., Toda, T., Mabuchi, I., and Perez, P. (2000). Schizosaccharomyces pombe Rho2 GTPase regulates the cell wall a-glucan biosynthesis, through the protein kinase Pck2. Mol. Biol. Cell 11, 4393-4401.
8. Carnero, E., Ribas, J. C., Garcia, B., Duran, A., and Sanchez, Y. (2000). Schizosaccharomyces pombe Ehs1p is involved in maintaining cell wall integrity and in calcium uptake. Mol. Gen. Genet. 264, 173-183.
9. Chang, F. (2001). Establishment of a cellular axis in fission yeast. Trends Genet. 15, 273-278.
10. Chen, S., and Hamm, H. E. (2006). DEP domains: more than just membrane anchors. Dev. Cell 11, 436-438.
11. Degols, G., Shiozaki, K., and Russell, P. (1996). Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe. Mol. Cell. Biol. 16, 2870-2877.
12. Ferrel, J.E.J. (1996). Tripping the switch fantastic: how a protein kinase cascade can convert graded imputs into switch-like outputs. Trends Biochem. Sci. 21, 460-466.
13. Forsburg, S. L. (1993). Comparison of Schizosaccharomyces pombe expression systems. Nucleic Acids Res. 21, 2955-2956.
14. Forsburg, S. L., and Sherman, D. A. (1997). General purpose tagging vectors for fission yeast. Gene 191, 191-195.
15. García, P., Tajadura, V., García, I., and Sánchez, Y. (2006a). Rgf1p is a specific Rho1-GEF that coordinates cell polarization with cell wall biogenesis in fission yeast. Mol. Biol. Cell 17, 1620-1631.
16. Garcia, P., Tajadura, V., Garcia, I., and Sanchez, Y. (2006b). Role of Rho GTPses and Rho-GEFs in the regulation of cell shape and integrity in fission yeast. Yeast 23, 1031-1043.
17. Hayles, J. A., and Nurse, P. (2001). A journey into space. Nat. Rev. Mol. Cell Biol. 2, 647-656.
18. Hirata, D., Nakano, K., Fukui, M., Takenaka, H., Miyakawa, T., and Mabuchi, I. (1998). Genes that cause aberrant cell morphology by overexpression in fission yeast: a role for a small GTP-binding protein Rho2 in cell moephogenesis. J. Cell Sci. 111, 149-159.
19. Jaffe, A. B., and Hall, A. (2005). Rho GTPases: biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21, 247-269.
20. Levin, D. (2005). Cell wall integrity signaling in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 69, 262-291.
21. Liu, X., Wang, H., Eberstadt, M., Schnuchel, A., Olejniczak, E. T., Meadows, R., and Fesik, S. W. (1998). NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio. Cell 95, 269-277.
22. Loewith, R., Hubberstey, A., and Young, D. (2000). Skh1, the MEK component of the Mkh1 signaling pathway in Schizosaccharomyces pombe. J. Cell Sci. 113, 153-160.
23. Ma, Y., Kuno, T., Kita, A., Asayama, Y., and Sugiura, R. (2006). Rho2 is a target of the farnesiltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast. Mol. Biol. Cell 17, 5028-5037.
24. Madrid, M., Soto, T., Khong, H. K., Franco, A., Vicente, J., Pérez, P., Gacto, M., and Cansado, J. (2006). Stress-induced response, localization, and regulation of the Pmk1 cell integrity pathway in Schizosaccharomyces pombe. J. Biol. Chem. 281, 2033-2043.
25. 2+-independent protein kinase C from fission yeast. J. Biol. Chem. 268, 7401-7406.
26. Mitchison, J. M., and Nurse, P. (1985). Growth in cell length in the fission yeast Schizosaccharomyces pombe. J. Cell Sci. 75, 357-376.
27. Moreno, S., Klar, A., and Nurse, P. (1991). Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol. 194, 795-823.
28. Morrell-Falvey, J. L., Ren, L., Feoktistova, A., Haese, G. D., and Gould, K. L. (2005). Cell wall remodeling at the fission yeast cell division site requires the Rho-GEF Rgf3p. J. Cell Sci. 118, 5563-5573.
29. Motegi, F., Arai, R., and Mabuchi, I. (2001). Identification of two type V myosins in fission yeast, one of which functions in polarized cell growth and moves rapidly in the cell. Mol. Biol. Cell 12, 1367-1380.
30. Mulvihill, D. P., Edward, S. R., and Hyams, J. S. (2006). A critical role for the type V myosin, Myo52, in septum deposition and cell fission during cytokinesis in Schizosaccharomyces pombe. Cell Motil. Cytoskelet. 63, 149-161.
31. Mutoh, T., Nakano, K., and Mabuchi, I. (2005). Rho1-GEFs Rgf1 and Rgf2 re involved in formation of cell wall and septum, while Rgf3 is involved in cytokinesis in fission yeast. Genes Cells 10, 1189-1202.
32. Nakano, K., Arai, R., and Mabuchi, I. (1997). The small GTP binding protein Rho1 is a multifunctional protein that regulates actin localization, cell polarity, and septum formation in the fission yeast Schizosaccharomyces pombe. Genes Cells 2, 679-694.
33. Reid, T., Furiyashiki, T., Ishizaki, T., Watanabe, G., Watanabe, N., Fujisawa, K., Morii, N., Madaule, P., and Nayumira, S. (1996). Rhotekin, a newputative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. J. Biol. Chem. 271, 13556-13560.
34. Ren, X. D., Kiosses, W. B., and Schwartz, M. A. (1999). Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J. 18, 578-585.
35. Ridley, A. J. (2006). Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking. Trends Cell Biol. 16, 522-529.
36. Rossman, K. L., Channing, J. D., and Sondek, J. (2005). GEF means go: turning on Rho GTPases with guanine nucleotide-exchange factors. Nat. Rev. Mol. Cell Biol. 6, 167-180.
37. Rossman, K. L., and Sondek, J. (2005). Larger than Dbl: new structural insights into RhoA activation. Trends Biochem. Sci. 30, 163-165.
38. Roux, P. P., and Blenis, J. (2004). ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 68, 320-344.
39. Sayers, L. G., Katayama, S., Nakano, K., Mellor, H., Mabuchi, I., Toda, T., and Parker, P. J. (2000). Rho-dependence of Schizosaccharomyces pombe Pck2. Genes Cells 5, 17-27.
40. Sengar, A. S., Markley, N. A., Marini, N. J., and Young, D. (1997). Mkh1, a MEK kinase required for cell wall integrity and proper response to osmotic and temperature stress in Schizosaccharomyces pombe. Mol. Cell. Biol. 17, 3508-3519.
41. Shiozaki, K., and Russell, P. (1995b). Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast. Nature 378, 739-743.
42. Soisson, S. M., Nimnual, A. S., Uy, M., Bar-Sagi, D., and Kuriyan, J. (1998). Crystal structure of the Dbl and pleckstrin homology domains from the human son of sevenless protein. Cell 95, 259 -268.
43. Sugiura, R. T. T., Dhut, S., Shuntoh, H., and Kuno, T. (1999). The MAP Kkinase Pek1 acts as a phosphorylation-dependent molecular switch. Nature 399, 479-483.
44. Tajadura, V., Garcia, B., Garcia, I., Garcia, P., and Sanchez, Y. (2004). Schizosaccharomyces pombe Rgf3p is a specific Rho1 GEF that regulates cell wall β-glucan biosynthesis through the GTPase Rho1p. J. Cell Sci. 117, 6163-6174.
45. Takada, H. et al. (2007). Atf1 is a target of the MAP kinase Pmk1 and regulates cell integrity in fission yeast. Mol. Biol. Cell 18, 4794-4802.
46. + encodes a transcription factor required for sexual development and entry into stationary phase. EMBO J. 14, 6193-6208.
47. + gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway. Mol. Cell. Biol. 16, 6752-6764.
48. Toda, T., Shimanuki, M., and Yanagida, M. (1993). Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control. EMBO J. 12, 1987-1995.
49. Vicente, M. F., Basilio, A., Cabello, A., and Pelaez, F. (2003). Microbial natural products as a source of antifungals. Clin. Microbiol. Infect. 9, 15-32.
50. Win, T. Z., Gachet, Y., Mulvihill, D. P., May, K. M., and Hyams, J. S. (2001). Two type V myosins with non-overlapping functions in the fission yeast Schizosaccharomyces pombe: Myo52 is concerned with growth polarity and cytokinesis, Myo 51 is a component of the cytokinetic actin ring. J. Cell Sci. 114, 69-79.
51. Yang, P., Qyang, Y., Bartholomeusz, G., Zhou, Z., and Marcus, S. (2003). The novel Rho1 GTPase-activating protein family, Rga8, provides a potential link between cdc42/p21-activated kinase and Rho signaling pathways in the fission yeast, Schizosaccharomyces pombe. J. Biol. Chem. 278, 48821-48830.
52. Yeh, B. J., Rutigliano, R. J., Deb, A., Bar-Sagi, D., and Lim, W. A. (2007). Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors. Nature 447, 596-600.
53. Zaitsevskaya-Carter, T., and Cooper, J. A. (1997). Spm1, a stress-activated MAP kinase that regulates morphogenesis in Schizosaccharomyces pombe. EMBO J. 16, 1318-1331.