Impaired mitochondria-dependent vasodilation in cerebral arteries of Zucker obese rats with insulin resistance

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 296, Issue 2, 2009, Pages

  Katakam, Prasad V G ^a   Domoki, Ferenc ^a,c   Snipes, James A ^a   Busija, Anna R ^a   Jarajapu, Yagna P R ^b   Busija, David W ^a  

^a WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Depolarization; Diazoxide; Mitochondrial ATP sensitive potassium channels; Zucker obese rats

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ACTIVATED POTASSIUM CHANNEL; DIAZOXIDE; MANGANESE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TETRAKIS(4 BENZOIC ACID)PORPHYRIN CHLORIDE; UNCLASSIFIED DRUG; 3 NITROPROPIONIC ACID; 3-NITROPROPIONIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENZYME INHIBITOR; IBERIOTOXIN; INDOMETACIN; MANGANESE(III) TETRAKIS(4 BENZOIC ACID)PORPHYRIN; MANGANESE(III)-TETRAKIS(4-BENZOIC ACID)PORPHYRIN; METALLOPORPHYRIN; MITOCHONDRIAL K(ATP) CHANNEL; N(G) NITROARGININE METHYL ESTER; NITRO DERIVATIVE; NOS3 PROTEIN, RAT; PEPTIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PROPIONIC ACID DERIVATIVE; PROSTAGLANDIN SYNTHASE INHIBITOR; SCAVENGER; SUCCINATE DEHYDROGENASE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY DIAMETER; ARTICLE; BRAIN ARTERY; CELL ACTIVITY; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOTHELIUM CELL; EXPERIMENTAL RAT; FLUORESCENCE MICROSCOPY; INSULIN RESISTANCE; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE; VASOCONSTRICTION; VASODILATATION; ZUCKER RAT; ANIMAL; DISEASE MODEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM; MITOCHONDRION; PATHOPHYSIOLOGY; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ANIMALS; CEREBRAL ARTERIES; CYCLOOXYGENASE INHIBITORS; DIAZOXIDE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; INDOMETHACIN; INSULIN RESISTANCE; MALE; METALLOPORPHYRINS; MITOCHONDRIA; MUSCLE, SMOOTH, VASCULAR; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; NITRO COMPOUNDS; OBESITY; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; PROPIONIC ACIDS; RATS; RATS, ZUCKER; REACTIVE OXYGEN SPECIES; SUCCINATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; VASODILATION; VASODILATOR AGENTS;

EID: 61949229935     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90656.2008     Document Type: Article

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