Mechanistic analysis of macrophage response to IRAK-1 gene knockdown by a smart polymer-antisense oligonucleotide therapeutic

Journal of Biomaterials Science, Polymer Edition

Volumn 19, Issue 10, 2008, Pages 1333-1346

  Johns, Rachel E ^a   El Sayed, Mohamed E H ^a   Bulmus, Volga ^a   Cuschieri, Joseph ^b   Maier, Ronald ^b   Hoffman, Allan S ^a   Stayton, Patrick S ^a  

^a University of Washington   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Expression profiling; Intracellular drug delivery; Macrophage; Smart polymers

Indexed keywords

CELL PROLIFERATION; CONTROLLED DRUG DELIVERY; CYTOLOGY; FUNCTIONAL POLYMERS; GENE EXPRESSION; MACROPHAGES; MEDICAL APPLICATIONS; OLIGONUCLEOTIDES; PATHOLOGY; PROTEINS;

ACUTE RESPIRATORY DISTRESS SYNDROME; ANTI-INFLAMMATORY ACTIVITY; ANTISENSE OLIGONUCLEOTIDES; EXPRESSION PROFILING; INFLAMMATORY RESPONSE; INTRACELLULAR DRUG DELIVERY; MULTIPLE ORGAN FAILURE; SMART POLYMERS;

TARGETED DRUG DELIVERY;

ANTISENSE OLIGONUCLEOTIDE; COMPLEMENTARY DNA; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; POLYMER; TUMOR NECROSIS FACTOR; ANTISENSE OLIGODEOXYNUCLEOTIDE; CHEMOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN DERIVATIVE; METALLOTHIONEIN;

ANTIINFLAMMATORY ACTIVITY; ANTISENSE THERAPY; ARTICLE; CELL CULTURE; DNA FINGERPRINTING; DNA MICROARRAY; DRUG DELIVERY SYSTEM; ENDOSOME; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; KNOCKOUT GENE; MACROPHAGE; MICROARRAY ANALYSIS; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; QUANTITATIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; ANIMAL; CATTLE; CYTOLOGY; CYTOPLASM; DRUG EFFECT; GEL MOBILITY SHIFT ASSAY; GENE SILENCING; GENETICS; INFLAMMATION; METABOLISM; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; BASE SEQUENCE; CATTLE; CELL LINE, TUMOR; CHEMOKINES; CYTOPLASM; DNA, COMPLEMENTARY; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE KNOCKDOWN TECHNIQUES; HUMANS; INFLAMMATION; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKINS; LIPOPOLYSACCHARIDES; MACROPHAGES; METALLOTHIONEIN; NF-KAPPA B; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 61849183129     PISSN: 09205063     EISSN: 15685624     Source Type: Journal    
DOI: 10.1163/156856208786052326     Document Type: Article

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