Cataract formation mechanisms and risk in aviation and space crews

Aviation Space and Environmental Medicine

Volumn 78, Issue 4 II, 2007, Pages

  Jones, Jeffrey A ^a,b,e   McCarten, Michael ^b   Manuel, Keith ^c   Djojonegoro, Baby ^d   Murray, Jocelyn ^d   Feiversen, Al ^f   Wear, Mary ^d  

^a NASA JOHNSON SPACE CENTER   (United States)

^b Space and Naval Warfare Systems Center Pacific   (United States)

^c Kelsey Seybold Clinic   (United States)

^d WYLE LABORATORIES   (United States)

^e SD Space Medicine and Health Care Systems   (United States)

^f NONE

Author keywords

Aviator; Cataracts; Ionizing radiation; Occupational exposure; Oxidative damage; Spaceflight

Indexed keywords

ADULT; AEROSPACE MEDICINE; AGED; AIR FORCE; ARTICLE; AVIATION; CATARACT; CATARACTOGENESIS; CONFOUNDING VARIABLE; COSMONAUT; DIET; FEMALE; HUMAN; IONIZING RADIATION; LENS; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL EXPOSURE; OXIDATIVE STRESS; PREVALENCE; RADIATION EXPOSURE; RISK; RISK ASSESSMENT; SPACE FLIGHT; SUBCAPSULAR CATARACT; UNITED STATES;

ADULT; AEROSPACE MEDICINE; AGED; ASTRONAUTS; AVIATION; CATARACT; FEMALE; HUMANS; MALE; MIDDLE AGED; MILITARY MEDICINE; MILITARY PERSONNEL; OCCUPATIONAL EXPOSURE; OXIDATIVE STRESS; PREVALENCE; RADIATION, IONIZING; RETROSPECTIVE STUDIES; RISK FACTORS; SPACE FLIGHT; UNITED STATES; UNITED STATES NATIONAL AERONAUTICS AND SPACE ADMINISTRATION; WEIGHTLESSNESS;

EID: 34247123198     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (155)

1. Abrosimova AN, Shafirkin AV, Fedorenko BS. Probability of lens opacity and mature cataracts due to irradiation at various LET values. Aviakosm Ekolog Med 2000; 34:33-41.
2. Afaq F, Adhami VM, Mukhtar H. Photochemoprevention of ultraviolet B signaling and photocarcinogenesis. Mutat Res 2005; 571(1-2):153-73.
3. Andley UP, Fritz C, Morrison AR, Becker B. The role of prostaglandins E2 and F2 alpha in ultraviolet radiation-induced cortical cataracts in vivo. Invest Ophthalmol Vis Sci 1996; 37:1539-48.
4. Andley UP, Song Z, Mitchell DL. DNA repair and survival in human lens epithelial cells with extended lifespan. Curr Eye Res 1999; 18:224-30.
5. Andley UP, Weber JG. Ultraviolet action spectra for photobiological effects in cultured human lens epithelial cells. Photochem Photobiol 1995; 62:840-6.
6. Anduze AL. Ultraviolet radiation and cataract development in the U.S. Virgin Islands. J Cataract Refract Surg 1993; 19:298-300.
7. Ansari RR, Clark JI, King JF, and Seeberger T. Early detection of cataracts and response to therapy with non-invasive static and dynamic light scattering. Proc SPIE 2003; 4951:168-75.
8. Anwar MM, Moustafa MA. The effect of melatonin on eye lens of rats exposed to ultraviolet radiation. Comp Biochem Physiol C Toxicol Pharmacol 2001; 129:57-63.
9. Ayala MN, Michael R, Soderberg PG. In vivo cataract after repeated exposure to ultraviolet radiation. Exp Eye Res 2000; 70:451-6.
10. Ayala MN, Michael R, Soderberg PG. Influence of exposure time for UV radiation-induced cataract. Invest Ophthalmol Vis Sci 2000; 41:3539-43.
11. Ayala MN, Soderberg PG. Reversal of reciprocity failure for UVR-induced cataract with vitamin E. Ophthalmic Res 2005; 37:150-5.
12. Balasubramanian D. Ultraviolet radiation and cataract. J Ocul Pharmacol Ther 2000; 16:285-97.
13. Bantseev V, Bhardwaj R, Rathbun W, et al. Antioxidants and cataract: (cataract induction in space environment and application to terrestrial aging cataract). Biochem Mol Biol Int 1997; 42:1189-97.
14. Bardak Y. Effect of melatonin on lenticular calcium and magnesium in rats exposed to ultraviolet radiation. Ophthalmologica 2000; 214:350-3.
15. Bardak Y, Ozerturk Y, Ozguner F, et al. Effect of melatonin against oxidative stress in ultraviolet-B exposed rat lens. Curr Eye Res 2000; 20:225-30.
16. Baum J, Pitts DG. Posterior subcapsular cataract following intense ultraviolet radiation exposure: a case report. Eye 1997; 11(Pt 5):661-2.
17. Belkacemi Y, Touboul E, Meric JB, et al. [Radiation-induced cataract: physiopathologic, radiobiologic and clinical aspects]. Cancer Radiother 2001; 5(4):397-412.(Fre).
18. Bochow TW, West SK, Azar A, et al. Ultraviolet light exposure and risk of posterior subcapsular cataracts. Arch Ophthalmol 1989; 107:369-72.
19. Bonney CH, Hunter DM, Conley GE, Hardy KA. Heavy-ion-induced cataractogenesis. Aviat Space Environ Med 1977; 48:731-3.
20. Borkman RF. Cataracts and photochemical damage in the lens. Ciba Found Symp 1984; 106:88-109.
21. Brown NA, Shun-Shin GA, Lewis P, et al. Relationship of cataract to radiation sensitivity. Br J Ophthalmol 1989; 73:955-9.
22. Choshi K, Takaku I, Mishima H, et al. Ophthalmologic changes related to radiation exposure and age in adult health study sample, Hiroshima and Nagasaki. Radiat Res 1983; 96:560-79.
23. Clark JI, Livesey JC, Steele JE. Delay or inhibition of rat lens opacification using pantethine and WR-77913. Exp Eye Res 1996; 62:75-84.
24. Collman GW, Shore DL, Shy CM, et al. Sunlight and other risk factors for cataracts: an epidemiologic study. Am J Public Health 1988; 78:1459-62.
25. Cousin AJ, Lawdahl RB, Chakraborty DP, Koehler RE. The case for radioprotective eyewear/facewear. Practical implications and suggestions. Invest Radiol 1987; 22:688-92.
26. Cruickshanks KJ. Sunlight exposure and risk of lens opacities in a population-based study. Arch Ophthalmol 1998; 116:1666.
27. Cucinotta F, Manuel K, Jones JA, et al. Erratum. Radiat Res 2001; 156:811.
28. Cucinotta F, Manuel K, Jones JA, et al. Space radiation and cataracts in astronauts. Radiat Res 2001; 156(5 (Pt 1)):460-6.
29. Dairou J, Malecaze F, Dupret JM, Rodrigues-Lima F. The xenobiotic-metabolizing enzymes arylamine N-acetyltransferases in human lens epithelial cells: inactivation by cellular oxidants and UVB-induced oxidative stress. Mol Pharmacol 2005; 67:1299-306.
30. Datiles M, Ansari R. Chapter 73B: Clinical evaluation of cataracts. In: Jaeger E, Tasman W, eds. Duane's clinical ophthalmology, vol. 1. Philadelphia: Lippincott-Williams and Wilkins 2001: 1-10.
31. Datiles M, Magno BV. Chapter 73: Cataract clinical types. In: Jaeger E, Tasman W, eds. Duane's clinical ophthalmology, vol. 1. Philadelphia: Lippincott-Williams and Wilkins 2001:1-25.
32. Delcourt C, Carriere I, Ponton-Sanchez A, et al. Light exposure and the risk of cortical, nuclear, and posterior subcapsular cataracts: the Pathologies Oculaires Liees a l'Age (POLA) study. Arch Ophthalmol 2000; 118:385-92.
33. Dolin PJ. Assessment of epidemiological evidence that exposure to solar ultraviolet radiation causes cataract. Doc Ophthalmol 1994; 88(3-4):327-37.
34. Dolin PJ. Ultraviolet radiation and cataract: a review of the epidemiological evidence. Br J Ophthalmol 1994; 78:478-82.
35. Dong X, Soderberg PG, Ayala M, Lofgren S. The effect of exposure time on maximum acceptable dose for avoidance of ultraviolet radiation-induced cataract. Ophthalmic Res 2005; 37:197-201.
36. Durovic B, Durovic B, Spasic-Jokic V. [Occupational exposure to ionizing radiation and the occurrence of cataract]. Vojnosanit Pregl 2004; 61:387-90. (Serbian).
37. Elder JA. Ocular effects of radiofrequency energy. Bioelectromagnetics 2003; Suppl 6:S148-61.
38. Foster MR, Ferri ES, Hagan GJ. Dosimetric study of microwave cataractogenesis. Bioelectromagnetics 1986; 7:129-40.
39. Frey AH. Data analysis reveals significant microwave-induced eye damage in humans. J Microw Power Electromagn Energy 1985; 20:53-5.
40. Fry RJ. Deterministic effects. Health Phys 2001; 80:338-43.
41. Fry RJ. Radiations in space: risk estimates. Radiat Prot Dosimetry 2002; 100(1-4):475-7.
42. Giblin FJ, Leverenz VR, Padgaonkar VA, et al. UVA light in vivo reaches the nucleus of the guinea pig lens and produces deleterious, oxidative effects. Exp Eye Res 2002; 75:445-58.
43. Grambsch PM, Therneau TM. Proportional hazards tests and diagnostics based on weighted residuals. Biometrika 1994; 81:515-26.
44. Hanke C, Karsten H. [Cataract in welders. Contribution of occupational exposure, references for recognition as an occupational disease and presentation of preventive measures]. Z Gesamte Hyg 1990; 36(2):110-3. (Ger).
45. Hayashi LC, Hayashi S, Yamaoka K, et al. Ultraviolet B exposure and type of lens opacity in ophthalmic patients in Japan. Sci Total Environ 2003; 302(1-3):53-62.
46. Hayashi LC, Tamiya N, Yano E. Correlation between UVB irradiation and the proportion of cataract-an epidemiological study based on a nationwide patient survey in Japan. Ind Health 1998; 36:354-60.
47. Hayes BP, Fisher RF. Influence of a prolonged period of low-dosage X-rays on the optic and ultrastructural appearances of cataract of the human lens. Br J Ophthalmol 1979; 63:457-64.
48. Hu H. Effects of ultraviolet radiation. Med Clin North Am 1990; 74:509-14.
49. Jacobson BS. Cataracts in retired actinide-exposed radiation workers. Radiat Prot Dosimetry 2005; 113:123-5.
50. Jacques PF, Chylack LT Jr. Epidemiologic evidence of a role for the antioxidant vitamins and carotenoids in cataract prevention. Am J Clin Nutr 1991; 53(1, Suppl.):352S-5S.
51. Javitt JC, Taylor HR. Cataract and latitude. Doc Ophthalmol 1994; 88(3-4):307-25.
52. Javitt JC, Taylor HR. Chapter 55: Ocular protection from solar radiation. In: Jaeger E, Tasman W, eds. Duane's clinical ophthalmology, vol. 5. Philadelphia: Lippincott-Williams and Wilkins 2001: 1-13.
53. Jose JG. Posterior cataract induction by UV-B radiation in albino mice. Exp Eye Res 1986; 42:11-20.
54. Jose JG, Ainsworth EJ. Cataract production in mice by heavy charged argon, neon, and carbon particles. Radiat Res 1983; 94:513-28.
55. Junk AK, Egner P, Gottloeber P, et al. [Long-term radiation damage to the skin and eye after combined beta- and gamma-radiation exposure during the reactor accident in Chernobyl]. Klin Monatsbl Augenheilkd 1999; 215(6):355-60.(Ger).
56. Kabachenko AN, Fedorenko BS. [Cataractogenic effect of protons with energies of 25 and 50 MeV]. Kosm Biol Aviakosm Med 1977; 11(4)59-62. (Rus).
57. Kabachenko AN, Fedorenko BS. [Lens opacity in mice exposed to helium ions with energy of 4 GeV/nuclon and gamma-irradiation with Co-60]. Kosm Biol Aviakosm Med 1985; 19(1):56-8. (Rus).
58. Kahn HA LH, Ganley JP, Kini MM, et al. The Framingham Eye Study. I. Outline and major prevalence findings. Am J Epidemiol 1977; 106:17-32.
59. Kojima M, Okuno T, Miyakoshi M, et al. Environmental temperature and cataract progression in experimental rat cataract models. Dev Ophthalmol 2002; 35:125-34.
60. Kramar P, Harris C, Guy AW. Thermal cataract formation in rabbits. Bioelectromagnetics 1987; 8:397-406.
61. Kurz GH, Einaugler RB. Cataract secondary to microwave radiation. Am J Ophthalmol 1968; 66:866-9.
62. Langley RK, Mortimer CB, McCulloch C. The experimental production of cataracts by exposure to heat and light. Arch Ophthalmol 1960; 63:473-88.
63. Leibowitz HM, Kruger DE, Maunder LR, et al. The Framingham Eye Study monograph: An ophthalmological and epidemiological study of cataract, glaucoma, diabetic retinopathy, macular degeneration, and visual acuity in a general population of 2631 adults: 1973-1975. Surv Ophthalmol 1980; 24:335-610.
64. Lerman S. Chemical and physical properties of the normal and aging lens: spectroscopic (UV, fluorescence, phosphorescence, and NMR) analyses. Am J Optom Physiol Opt 1987; 64:11-22.
65. Lerman S. An experimental and clinical evaluation of lens transparency and aging. J Gerontol 1983; 38:293-301.
66. Lerman S. Ocular phototoxicity and psoralen plus ultraviolet radiation (320-400 nm) therapy: an experimental and clinical evaluation. J Natl Cancer Inst 1982; 69:287-302.
67. Lerman S. Potential ocular complications of psoralen-UV-A therapy. Derm Beruf Umwelt 1980; 28:5-7.
68. Leske MC, Wu SY, Hyman L, et al. Biochemical factors in the lens opacities. Case-control study. The Lens Opacities Case-Control Study Group. Arch Ophthalmol 1995; 113:1113-9.
69. Lett JT, Lee AC, Cox AB. Late cataractogenesis in rhesus monkeys irradiated with protons and radiogenic cataract in other species. Radiat Res 1991; 126:147-56.
70. Lipman RM, Tripathi BJ, Tripathi RC. Cataracts induced by microwave and ionizing radiation. Surv Ophthalmol 1988; 33:200-10.
71. Littleton JT, Durizch ML, Perry N. Radiation protection of the lens for patients and users. Radiology 1978; 129:795-8.
72. Lydahl E. Infrared radiation and cataract. Acta Ophthalmol Suppl 1984; 166:1-63.
73. Lydahl E, Glansholm A. Infrared radiation and cataract. III. Differences between the two eyes of glass workers. Acta Ophthalmol (Copenh) 1985; 63:39-44.
74. Lydahl E, Philipson B. Infrared radiation and cataract II. Epidemiologic investigation of glass workers. Acta Ophthalmol (Copenh) 1984; 62:976-92.
75. Lydahl E, Philipson B. Infrared radiation and cataract. I. Epidemiologic investigation of iron- and steel-workers. Acta Ophthalmol (Copenh) 1984; 62:961-75.
76. Machlin LJ, Bendich A. Free radical tissue damage: protective role of antioxidant nutrients. FASEB J 1987; 1:441-5.
77. Mayer UM, Muller Y, Bluthner K. [Vitamins C and E protect cultures of bovine lens epithelium from the damaging effects of blue light (430 nm) and UVA light (300-400 nm)]. [In German] Klin Monatsbl Augenheilkd 2001; 218:116-20.
78. Medvedovsky C, Worgul BV. Neutron effects on the lens. Radiat Res 1991; 128(1, Suppl):S103-10.
79. Medvedovsky C, Worgul BV, Huang Y, et al. The influence of dose, dose-rate and particle fragmentation on cataract induction by energetic iron ions. Adv Space Res 1994; 14:475-82.
80. Meyer LM, Soderberg P, Dong X, Wegener A. UVR-B induced cataract development in C57 mice. Exp Eye Res 2005; 81:389-94.
81. Michael R. Development and repair of cataract induced by ultraviolet radiation. Ophthalmic Res 2000; 32 Suppl 1:ii-iii; 1-44.
82. Michael R, Soderberg PG, Chen E. Long-term development of lens opacities after exposure to ultraviolet radiation at 300 nm. Ophthalmic Res 1996; 28:209-18.
83. Michael R, Vrensen GF, van Marle J, et al. Repair in the rat lens after threshold ultraviolet radiation injury. Invest Ophthalmol Vis Sci 2000; 41:204-12.
84. Minamoto A, Taniguchi H, Yoshitani N, et al. Cataract in atomic bomb survivors. Int J Radiat Biol 2004; 80:339-45.
85. Morris D. Chapter 41: Cataracts and Systemic Disease. In: Jaeger E, Tasman W, eds. Duane's clinical ophthalmology, vol. 5. Philadelphia: Lippincott-Williams and Wilkins; 2001:1-16.
86. Nakashima E, Neriishi K, Minamoto A. A reanalysis of atomic-bomb cataract data, 2000-2002: a threshold analysis. Health Phys 2006; 90:154-60.
87. National Eye Institute N. Age-Related Eye Disease Study Group. A randomized placebo-controlled, clinical trial of high dose supplementation with vitamins C, and E, beta carotene, and zinc for age-related macular degeneration and vision loss. AREDS report No. 8. Arch Ophthalmol 2001; 119:1417-36.
88. Nicholas JS, Butler GC, Lackland DT, et al. Health among commercial airline pilots. Aviat, Space, and Environmental Medicine 2001; 72:821-6.
89. Odland LT. Observations on microwave hazards to USAF personnel. J Occup Med 1972; 14:544-7.
90. Odland LT. Radio-frequency energy: a hazard to workers? IMS Ind Med Surg 1973; 42:23-6.
91. Okuno T. Thermal effect of visible light and infra-red radiation (i.r.-A, i.r.-B and i.r.-C) on the eye: a study of infra-red cataract based on a model. Ann Occup Hyg 1994; 38:351-9.
92. Olmedilla B, Granado F, Blanco I, Vaquero M. Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study. Nutrition 2003; 19:21-4.
93. Otake M, Finch SC, Choshi K, et al. Radiation-related ophthalmological changes and aging among Hiroshima and Nagasaki A-bomb survivors: a reanalysis. Radiat Res 1992; 131:315-24.
94. Otake M, Schull WJ. A review of forty-five years study of Hiroshima and Nagasaki atomic bomb survivors. Radiation cataract. J Radiat Res (Tokyo) 1991; 32 (Suppl):283-93.
95. Pastor-Valero M. Antioxidant micronutrients and cataract: a review of epidemiological evidence. Gac Sanit 2002; 16(Suppl 2):29-40.
96. Perkins ES. The association between pinguecula, sunlight and cataract. Ophthalmic Res 1985; 17:325-30.
97. Pitts DG, Cullen AP. Determination of infrared radiation levels for acute ocular cataractogenesis. Albrecht Von Graefes Arch Klin Exp Ophthalmol 1981; 217:285-97.
98. Pitts DG, Cullen AP, Hacker PD. Ocular effects of near ultraviolet radiation: literature review. Am J Optom Physiol Opt 1977; 54:542-9.
99. Rafnsson V, Olafsdottir E, Hrafnkelsson J, et al. Cosmic radiation increases the risk of nuclear cataract in airline pilots: a population-based case-control study. Arch Ophthalmol 2005; 123(8):1102-5.
100. Rafnsson, V, Hrafnkelsson, J, Tulinius, H. Incidence of cancer among commercial airline pilots. Occup Environ Med 2000: 57:175-9.
101. Rafnsson V, Datiles M. Airline pilots have sky-high risk of cataracts. ESCRS Eurotimes 10-10 1-24, October 5, 2005
102. Rastegar N, Eckart P, Mertz M. Radiation-induced cataract in astronauts and cosmonauts. Graefes Arch Clin Exp Ophthalmol 2002; 240:543-7.
103. Rini FJ, Worgul BV, Merriam GR, Jr. Scanning electron microscopic analysis of radiation cataracts in rat lenses. I. X-radiation cataractogenesis as a function of dose Ophthalmic Res 1983; 15:146-59.
104. Roberts NJ Jr, Michaelson SM. Epidemiological studies of human exposures to radiofrequency radiation. A critical review. Int Arch Occup Environ Health 1985; 56:169-78.
105. Robman L, Taylor H. External factors in the development of cataract. Eye 2005; 19:1074-82.
106. Rosmini F, Stazi MA, Milton RC, et al. A dose-response effect between a sunlight index and age-related cataracts. Italian-American Cataract Study Group. Ann Epidemiol 1994; 4:266-70.
107. Ross WM, Creighton MO, Inch WR, Trevithick JR. Radiation cataract formation diminished by vitamin E in rat lenses in vitro. Exp Eye Res 1983; 36:645-53.
108. Ross WM, Creighton MO, Trevithick JR. Radiation cataractogenesis induced by neutron or gamma irradiation in the rat lens is reduced by vitamin E. Scanning Microsc 1990; 4:641-9; discussion 9-50.
109. Ruther W, Jacobi KW, Kovacs G, et al. [Chemical radiation protection of rabbit eyes following exposure to 60Co gamma rays]. Klin Monatsbl Augenheilkd 1969; 154:232-8. (Ger).
110. Sasaki K, Kojima M, Sakamoto Y, et al. A current UV-B-related cataract epidemiology study in Japan. Dev Ophthalmol 1997; 27:32-41.
111. Schull WJ. Late radiation responses in man: current evaluation from results from Hiroshima and Nagasaki. Adv Space Res 1983; 3:231-9.
112. Schull WJ. The somatic effects of exposure to atomic radiation: the Japanese experience, 1947-1997. Proc Natl Acad Sci USA 1998; 95:5437-41.
113. Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamin A, C, and E. and advanced age-related macular degeneration. JAMA 1994; 272:1413-20.
114. Shacklett DE, Tredici TJ, Epstein DL. Evaluation of possible microwave-induced lens changes in the United States Air Force. Aviat Space Environ Med 1975; 46:1403-6.
115. Shichi H. Cataract formation and prevention. Expert Opin Investig Drugs 2004; 13:691-701.
116. Shubik VM, Kvasova MD. [Immunological studies on cataracts under conditions of exposure to low-dose radiation]. Vestn Oftalmol 1996; 112:21-3. (Rus).
117. Sliney DH. Epidemiological studies of sunlight and cataract: the critical factor of ultraviolet exposure geometry. Ophthalmic Epidemiol 1994; 1:107-19.
118. Sliney DH. UV radiation ocular exposure dosimetry. Doc Ophthalmol 1994; 88(3-4):243-54.
119. Sliney DH, Vorpahl KW, Winburn DC. Environmental health hazards from high-powered, infrared, laser devices. Arch Environ Health 1975; 30:174-9.
120. Soderberg PG. Acute cataract in the rat after exposure to radiation in the 300 nm wavelength region. A study of the macro-, micro- and ultrastructure. Acta Ophthalmol (Copenh) 1988; 66:141-52.
121. Spector A, Wang GM, Wang RR, et al. The prevention of cataract caused by oxidative stress in cultured rat lenses. I. H2O2 and photochemically induced cataract. Curr Eye Res 1993; 12:163-79.
122. Sperduto R. Chapter 73A: Epidemiologic aspects of age-related cataracts. In: Jaeger E, Tasman W, eds. Duane's clinical ophthalmology, vol. 1. Philadelphia: Lippincott-Williams and Wilkins 2001:1-15.
123. Stewart-DeHaan PJ, Creighton MO, Larsen LE, et al. In vitro studies of microwave-induced cataract: reciprocity between exposure duration and dose rate for pulsed microwaves. Exp Eye Res 1985; 40:1-13.
124. Strzhizhovskii AD. [Ultraviolet radiation as a risk factor on the Earth and outer space]. Aviakosm Ekolog Med 1998; 32:4-13. (Rus).
125. Tao F, Powers-Risius P, Alpen EL, et al. Radiation effects on late cytopathological parameters in the murine lens relative to particle fluence. Adv Space Res 1994; 14:483-91.
126. Taylor HR. The biological effects of UV-B on the eye. Photochem Photobiol 1989; 50:489-92.
127. Taylor HR. Epidemiology of age-related cataract. Eye 1999; 13(Pt 3b):445-8.
128. Taylor HR. Ocular effects of UV-B exposure. Doc Ophthalmol 1994; 88(3-4):285-93.
129. Taylor HR. Ultraviolet radiation and the eye: an epidemiologic study. Trans Am Ophthalmol Soc 1989; 87:802-53.
130. Taylor HR, West SK, Rosenthal FS, et al. Effect of ultraviolet radiation on cataract formation. N Engl J Med 1988; 319:1429-33.
131. Turner ND, Braby LA, Ford J, Lupton JR. Opportunities for nutritional amelioration of radiation-induced cellular damage. Nutrition 2002; 18:904-12.
132. van Kuijk FJ. Effects of ultraviolet light on the eye: role of protective glasses. Environ Health Perspect 1991; 96:177-84.
133. Varma SD, Richards RD. Ascorbic acid and the eye lens. Ophthalmic Res 1988; 20:164-73.
134. Varma SD, Srivastava VK, Richards RD. Photoperoxidation in lens and cataract formation: preventive role of superoxide dismutase, catalase and vitamin C. Ophthalmic Res 1982; 14:167-75.
135. Voelz GL. Eye-survey study of nuclear-reactor workers. J Occup Med 1967; 9:286-92.
136. Vos JJ, van Norren D. Thermal cataract, from furnaces to lasers. Clin Exp Optom 2004; 87:372-6.
137. Vrensen GF. UV-B and early cortical and nuclear changes in the human lens. Doc Ophthalmol 1994; 88(3-4):255-61.
138. West SK. Daylight, diet, and age-related cataract. Optom Vis Sci 1993; 70:869-72.
139. West SK, Duncan DD, Munoz B, et al. Sunlight exposure and risk of lens opacities in a population-based study: the Salisbury Eye Evaluation project. JAMA 1998; 280:714-8.
140. Wolff K. Side-effects of psoralen photochemotherapy (PUVA). Br J Dermatol 1990; 122 (Suppl 36):117-25.
141. Wolff SP. Cataract and UV radiation. Doc Ophthalmol 1994; 88(3-4):201-4.
142. Worgul BV. Accelerated heavy particles and the lens. V. Theoretical basis of cataract enhancement by dose fractionation. Ophthalmic Res 1988; 20:143-8.
143. Worgul BV, Brenner DJ, Medvedovsky C, et al. Accelerated heavy particles and the lens. VII: The cataractogenic potential of 450 MeV/amu iron ions. Invest Ophthalmol Vis Sci 1993; 34:184-93.
144. Worgul BV, Kundiev Y, Likhtarev I, et al. Use of subjective and nonsubjective methodologies to evaluate lens radiation damage in exposed populations-an overview. Radiat Environ Biophys 1996; 35:137-44.
145. Worgul BV, Medvedovsky C, Huang Y, et al. Quantitative assessment of the cataractogenic potential of very low doses of neutrons. Radiat Res 1996; 145:343-9.
146. Worgul BV, Medvedovsky C, Powers-Risius P, Alpen E. Accelerated heavy ions and the lens. IV. Biomicroscopic and cytopathological analyses of the lenses of mice irradiated with 600 MeV/amu 56Fe ions. Radiat Res 1989; 120:280-93.
147. Worgul BV, Merriam GR Jr, Medvedovsky C, Brenner DJ. Accelerated heavy particles and the lens. III. Cataract enhancement by dose fractionation. Radiat Res 1989; 118:93-100.
148. Worgul BV, Smilenov L, Brenner DJ, et al. Mice heterozygous for the ATM gene are more sensitive to both X-ray and heavy ion exposure than are wildtypes. Adv Space Res 2005; 35:254-9.
149. Yang VC, Ainsworth EJ. A histological study on the cataractogenic effects of heavy charged particles. Proc Natl Sci Counc Repub China B 1987; 11:18-28.
150. Zaret MM, Snyder WZ. Cataracts and avionic radiations. Br J Ophthalmol 1977; 61:380-4.
151. Zaret MM, Snyder WZ, Birenbaum L. Cataract after exposure to non-ionizing radiant energy. Br J Ophthalmol 1976; 60:632-7.
152. Zigler JS, Datiles, III, MB. Chapter 72B: Pathogenesis of Cataracts In: Jaeger E, Tasman W, eds. Duane's Clinical Ophthalmology Vol 1. Philadelphia: Lippincott- Williams and Wilkins 2001:1-15.
153. Zigman S. Environmental near-UV radiation and cataracts. Optom Vis Sci 1995; 72:899-901.
154. Zintz C, Beebe DC. Morphological and cell volume changes in the rat lens during the formation of radiation cataracts. Exp Eye Res 1986; 42:43-54.
155. Zuclich JA. Ultraviolet-induced photochemical damage in ocular tissues. Health Phys 1989; 56:671-82.