The synthetic antioxidant, ethoxyquin, adversely affects immunity in tilapia (Oreochromis niloticus)

Aquaculture Nutrition

Volumn 15, Issue 2, 2009, Pages 144-151

  Yamashita, Y ^a   Katagiri, T ^a   Pirarat, N ^b   Futami, K ^a   Endo, M ^a   Maita, M ^a  

^a TOKYO UNIVERSITY OF MARINE SCIENCE AND TECHNOLOGY   (Japan)

^b CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Antioxidant; Ethoxyquin; Immunity; Phagocytic activity; Tilapia; Toxicity

Indexed keywords

ANIMALIA; OREOCHROMIS NILOTICUS; TILAPIA;

EID: 61849154307     PISSN: 13535773     EISSN: 13652095     Source Type: Journal    
DOI: 10.1111/j.1365-2095.2008.00577.x     Document Type: Article

References (25)

1. Aoshima, S., Ishitaka, Y. Okamoto, N. (2005) Discrepancy between in vitro non-specific defense activities of peripheral blood phagocytes and resistance against vibriosis in rainbow trout under temperature stress. Fish Pathol., 40, 47 51.
2. Bailey, C.A., Srinivasan, L.J. McGeachin, R.B. (1996) The effect of ethoxyquin on tissue peroxidation and immune status of single comb White Leghorn cockerels. Poult. Sci., 75, 1109 1112.
3. Blaszczyk, A. (2006) DNA damage induced by ethoxyquin in human peripheral lymphocytes. Toxicol. Lett., 163, 77 83.
4. Blaszczyk, A. Skolimowski, J. (2007) Apoptosis and cytotoxicity caused by ethoxyquin salts in human lymphocytes in vitro. Food. Chem., 105, 1159 1163.
5. Bohne, V.J.B., Hamre, K. Arukwe, A. (2006) Hepatic biotransformation and metabolite profile during a 2-week depuration period in Atlantic salmon fed graded levels of the synthetic antioxidant, ethoxyquin. Toxicol. Sci., 93, 11 21.
6. Culling, C.F.A. (1974) Handbook of Histopathological and Histochemical Techniques, 712 p. Butterworths, London, UK.
7. Dibner, J.J., Atwell, C.A., Kitchell, M.L., Shermer, W.D. Ivey, F.J. (1996) Feeding of oxidized fats to broilers and swine: effects on enterocyte turnover, hepatocyte proliferation and the gut associated lymphoid tissue. Anim. Feed Sci. Technol., 62, 1 13.
8. Eun, J.B., Hearnsberger, J.O. Kim, J.M. (1993) Antioxidants, activators and inhibitors affect the enzymatic lipid peroxidation system of catfish muscle microsomes. J. Food Sci., 58, 71 74.
9. van Gisbergen, K.P., Geijtenbeek, T.B. van Kooyk, Y. (2005) Close encounters of neutrophils and DCs. Trends Immunol., 26, 626 631.
10. He, P. Ackman, R.G. (2000) Residues of ethoxyquin and ethoxyquin dimer in ocean-farmed salmonids determined by high-pressure liquid chromatography. J. Food Sci., 65, 1312 1314.
11. Imazawa, T., Toyoda, K., Shinoda, K., Okamiya, H., Furukawa, F., Imaida, K., Takahashi, M. Hayashi, Y. (1989) Analysis of renal calcification and stone formation in rats treated with ethoxyquin. Eisei Shikenjo Hokoku., 107, 68 72.
12. Iverson, F. (1995) Phenolic antioxidants: health protection branch studies on butylated hydroxyanisole. Cancer Lett., 93, 49 54.
13. Jauncey, K. (2000) Nutritional requirements. In : Tilapias: Biology and Exploitation (Beveridge, M.C.M. McAndrew, B.J. eds pp. 327 375. Kluwer Academic Publishers, London, UK.
14. Little, A.D. Inc 1990) Chemical Evaluation Committee Draft Report, Ethoxyquin, CAS Number 91-53-2, Submitted to National Toxicology Program, Executive Summary of Safety and Toxicity Information.
15. Maita, M., Satoh, K., Fukuda, Y., Lee, H., Winton, J.R. Okamoto, N. (1998) Correlation between plasma component levels of cultured fish and resistance to bacterial infection. Fish Pathol., 33, 129 133.
16. Manson, M.M, Green, J.A. Driver, H.E. (1987) Ethoxyquin alone induces preneoplastic changes in rat kidney whilst preventing induction of such lesions in liver by aflatoxin B1. Carcinogenesis, 8, 723 728.
17. Matsuyama, T. Iida, T. (1999) Degranulation of eosinophilic granular cells with possible involvement in neutrophil migration to site of inflammation in tilapia. Dev. Comp. Immunol., 23, 451 457.
18. Milston, R.H., Fitzpatrick, M., Vella, A.T., Clements, S., Gundersen, D., Feist, G., Crippen, T.L., Leong, J. Schreck, C.B. (2003) Short-term exposure of Chinook salmon (Oncoryhnchus tshawytscha) to o,p-DDE or DMSO during early life-history stages causes long-term humoral immunosuppression. Environ. Health Perspect., 111, 1601 1607.
19. Miyata, Y., Fukushima, S., Hirose, M., Masui, T. Ito, N. (1985) Short-term screening of promoters of bladder carcinogenesis in N-butyl-N-(4-hydroxylbutyl) nitrosamine-initiated, unilaterally ureter-ligated rats. Jpn. J. Cancer Res., 76, 828 834.
20. Moccia, R., Hung, S.S.O., Slinger, S.J. Ferguson, H.W. (1984) Effect of oxidized fish oil, vitamin E and ethoxyquin on the histopathology and haematology of rainbow trout, Salmo gairdneri Richardson. J. Fish Dis., 7, 269 282.
21. Reyes, J.L., Hernandez, M.E., Melendez, E. Gomez-Lojero, C. (1995) Inhibitory effect of the antioxidiant ethoxyquin on electron transport in the mitochondrial respiratory chain. Biochem. Pharmacol., 49, 283 289.
22. Rossing, D., Kahl, R. Hildebrandt, A.G. (1985) Effect of synthetic antioxidants on hydrogen peroxide formation, oxyferro cytochrome P-450 concentration and oxygen consumption in liver microsomes. Toxicology, 34, 67 77.
23. Saxena, T.B., Zachariassen, K.E. Jorgensen, L. (2000) Effect of ethoxyquin on the blood composition of turbot, Scophthalmus maximus L. Comp. Biochem. Physiol. C Toxicol. Pharmacol., 127, 1 9.
24. Stoskopf, M.K. (1993) Clinical pathology. In : Fish Medicine (Stoskopf, M.K. ed pp. 113 131. W. B. Saunders Company, Pittsburgh, PA, USA.
25. Thorisson, S., Gunstone, F.D. Hardy, R. (1992) Some oxidation products of ethoxyquin including those found in autoxidising systems. Chem. Phys. Lipids, 60, 263 271.