Sonic hedgehog, apoptosis, and the penis

Journal of Sexual Medicine

Volumn 6, Issue SUPPL. 3, 2009, Pages 334-339

  Podlasek, Carol A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Cavernous nerve injury; Erectile dysfunction; Smooth muscle apoptosis; Sonic hedgehog

Indexed keywords

PHOSPHODIESTERASE V INHIBITOR; SONIC HEDGEHOG PROTEIN;

APOPTOSIS; CONFERENCE PAPER; CORPUS CAVERNOSUM; ERECTILE DYSFUNCTION; HUMAN; NERVE INJURY; NERVE REGENERATION; NONHUMAN; ORGANOGENESIS; PATHOPHYSIOLOGY; PENIS ERECTION; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATECTOMY; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; QUALITY OF LIFE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; TISSUE REGENERATION;

EID: 61849122304     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2008.01192.x     Document Type: Conference Paper

References (62)

1. Korfage IJ, Essink-Bot ML, Borsboom GJ, Madalinska JB, Kirkels WJ, Habbema JD, Schroder FH, de Koning HJ. 5-year follow-up of health-related quality of life after primary treatment of localized prostate cancer. Int J Cancer 2005; 116: 291-6.
2. Katz A. What happened? Sexual consequences of prostate cancer and its treatment. Can Fam Physician 2005; 51: 977-82.
3. Alivizatos G, Skolarikos A, Incontinence and erectile dysfunction following radical prostatectomy: A review. Sci World J 2005; 5: 747-58.
4. Kendirci M, Hellstrom WJ. Current concepts in the management of erectile dysfunction in men with prostate cancer. Clin Prostate Cancer 2004; 3: 87-92.
5. Vale J. Erectile dysfunction following radical therapy for prostate cancer. Radiother Oncol 2000; 57: 301-5.
6. Carroll PR. Achieving optimal outcomes after radical prostatectomy. Urol Oncol 2005; 23: 461.
7. Penson DF, McLerran D, Feng Z, Li L, Albertsen PC, Gilliland FD, Hamilton A, Hoffman RM, Stephenson RA, Potosky AL, Stanford JL. 5-year urinary and sexual outcomes after radical prostatectomy: Results from the prostate cancer outcomes study. J Urol 2005; 173: 1701-5.
8. Crawford ED, Bennett CL, Stone NN, Kinght SL, DeAntoni E, Sharp L, Garnick MB, Porterfield HA. Comparison of perspectives on prostate cancer: Analyses of survey data. Urology 1997; 50: 366-72.
9. Burkhardt JH, Litwin MS, Rose CM, Correa RJ, Sunshine JH, Hogan C, Hayman JA. Comparing the costs of radiation therapy and radical prostatectomy for the initial treatment of early-stage prostate cancer. J Clin Oncol 2002; 20: 2869-75.
10. McCullough AR. Rehabilitation of erectile function following radical prostatectomy. Asian J Androl 2008; 10: 61-74.
11. Raina R, Agarwal A, Zippe CD. Management of erectile dysfunction after radical prostatectomy. Urology 2005; 66: 923-9.
12. Perimenis P, Markou S, Gyftopoulos K, Athanasopoulos A, Giannitsas K, Barbalias G. Switching from long-term treatment with self-injections to oral sildenafil in diabetic patients with severe erectile dysfunction. Eur Urol 2002; 41: 387-91.
13. Klein LT, Miller MI, Buttyan R, Raffo AJ, Burchard M, Devris G, Cao YC, Olsson C, Shabsigh R. Apoptosis in the rat penis after penile denervation. J Urology 1997; 158: 626-30.
14. User HM, Hairston JH, Zelner DJ, McKenna KE, McVary KT. Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction. J Urol 2003; 169: 1175-9.
15. Podlasek CA, Meroz CL, Tang Y, McKenna KE, McVary KT. Regulation of cavernous nerve injury induced apoptosis by sonic hedgehog. Biol Reprod 2007; 76: 19-28.
16. Lysiak JJ, Yang S-K, Klausner AP, Son H, Tuttle JB, Steers WD. Tadalafil increases akt and extracellular signal-regulated kinase activation, and prevents apoptotic cell death in the penis following denervation. J Urol 2008; 179: 779-85.
17. Iacono F, Giannella R, Somma P, etal. Histological alterations in cavernous tissue after radical prostatectomy. J Urol 2005; 173: 1673-6.
18. Schwartz EJ, Wong P, Graydon RJ. Sildenafil preserves intracorporeal smooth muscle after radical retropubic prostatectomy. J Urol 2004; 171: 771.
19. Yaman O, Yilmaz E, Bozlu M, Anafarta K. Alterations of intracorporal structures in patients with erectile dysfunction. Urol Int 2003; 71: 87-90.
20. Fraiman MC, Lepor H, McCullough AR. Changes in penile morphometrics in men with erectile dysfunction after nerve-sparing radical retropublic prostatectomy. Mol Urol 1999; 3: 109-15.
21. Wespes E, Rammal A, Garbar C. Sildenafil non-responders: Haemodynamic and morphometric studies. Eur Urol 2005; 48: 1061-2.
22. Podlasek CA, Zelner DJ, Jiang HB, Tang Y, Houston J, McKenna KE, McVary KT. Shh cascade is required for penile postnatal morphogenesis, differentiation and adult homeostasis. Biol Reprod 2003; 68: 423-38.
23. Steers W. Pharmacologic treatment of erectile dysfunction. Rev Urol 2002; 4 (3 suppl): S17-25.
24. Hooper JE, Scott MP. The drosophila patched gene encodes a putative membrane protein required for segmental patterning. Cell 1989; 59: 751-65.
25. Nakano Y, Guerrero I, Hidalgo A, Taylor A, Whittle JRS, Ingham PWA. Protein with several possible membrane-spanning domains encoded by the drosophila segment polarity gene patched. Nature 1989; 341: 508-13.
26. Goodrich LV, Johnson RL, Milenkovic L, McMahon JA, Scott MP. Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by hedgehog. Genes Dev 1996; 10: 301-12.
27. Stone DM, Hynes M, Armanini M, Swanson TA, Gu Q, Johnson RL, Scott MP, Pennica D, Goddard A, Phillips H, Noll M, Hooper JE, deSauvage F, Rosenthal A. The tumor-suppressor gene patched encodes a Candidate receptor for sonic hedgehog. Nature 1996; 14: 129-34.
28. Taipale J, Cooper MK, Maiti T, Beachy PA. Patched acts catalytically to suppress the activity of smoothened. Nature 2002; 418: 892-7.
29. Hidalgo A, Ingham P. Cell patterning in the drosophila segment: Spatial regulation of the segment polarity gene patched. Development 1990; 110: 291-301.
30. Ingham PW, Taylor AM, Nakano Y. Role of the drosophila patched gene in positional signaling. Nature 1991; 353: 184-7.
31. Capdevila J, Estrada MP, Sanchez-Herrero E, Guerrero I. The drosophila segment polarity gene patched interacts with decapentaplegic in wing development. EMBO J 1994; 13: 71-82.
32. Alexandre C, Jacinto A, Ingham PW. Transcriptional activation of hedgehog target genes in drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev 1996; 10: 2003-13.
33. Dominguez M, Brunner M, Hafen E, Basler K. Sending and receiving the hedgehog signal: Control by the drosophila GLI protein cubitus interruptus. Science 1996; 272: 1621-5.
34. Hepker J, Wang I-T, Motzny CK, Holmgran R, Orenic TV. Drosophila cubitus interruptus forms a negative feedback loop with patched and expression regulates of hedgehog target genes. Development 1997; 124: 549-58.
35. Chen Y, Struhl G. Dual roles for patched in sequestering and transducing hedgehog. Cell 1996; 87: 553-63.
36. Karahira H, Ma NH, Tzanakakis ES, McMahon AP, Chuang P-T, Hebrok M. Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development 2003; 130: 4871-9.
37. Podlasek CA, Zelner DJ, Harris JD, Meroz CL, Tang Y, McKenna KE, McVary KT. Altered sonic hedgehog signaling is associated with morphological abnormalities in the BB/WOR diabetic penis. Biol Reprod 2003; 69: 816-27.
38. Podlasek CA, Barnett DH, Clemens JQ, Bak PM, Bushman W. Prostate development requires sonic hedgehog expressed by the urogenital sinus epithelium. Dev Biol 1999; 209: 28-39.
39. Haraguchi R, Mo R, Hui C, Motoyama J, Makino S, Shiroishi T, Gaffield W, Yamada G. Unique functions of sonic hedgehog signaling during external genitalia development. Development 2001; 128: 4241-50.
40. Perriton CL, Powles N, Chiang C, Maconochie MK, Cohn MJ. Sonic hedgehog signaling from the urethral epithelium controls external genital development. Dev Biol 2002; 247: 26-46.
41. Ericson J, Morton S, Kawakami A, Roelink H, Jessell TM. Two critical periods of long-range sonic hedgehog signaling required for the specification of motor neuron identity. Cell 1996; 87: 661-73.
42. Pepinsky RB, Rayhorn P, Day ES, Dergay A, Williams KP, Galdes A, Taylor FR, Boriack-Sjodin PA, Garber EA. Mapping sonic hedgehog-receptor interactions by steric interference. J Biol Chem 2000; 275: 10995-1001.
43. Byers MR, O'Neill PC, Fink BR. Lidocaine (without epinephrine) does not affect the fine structure or microtubules of the trigeminal nerve in vivo. Anesthesiology 1979; 51: 55-7.
44. Fink BR, Kish SJ. Reversible inhibition of rapid axonal transport in vivo by lidocaine hydrochloride. Anesthesiology 1976; 44: 139-46.
45. Bond C, Tang Y, Podlasek CA. Neural regulation of sonic hedgehog and apoptosis in the penis. Biol Reprod 2008; 78: 947-56.
46. Angevine JB Jr. Nerve destruction by colchicines in mice and golden hamsters. J Exp Zool 1957; 136: 363-91.
47. Ginn SR, Peterson GM. Studies related to the use of colchicine as a neurotoxin in the septohippocampal cholinergic system. Brain Res 1992; 590: 144-52.
48. Singer M, Steinberg MC. Wallarian degeneration: A reevaluation based on transected and colchicine-poisoned nerves in the amphibiam triturus. Am J Anat 1972; 133: 51-83.
49. Aquino JB, Musolino PL, Coronel MF, Villar MJ, Setton-Avruj CP. Nerve degeneration is prevented by a single intraneural apotransferrin injection into colchicine-injured sciatic nerves in the rat. Brain Res 2006; 1117: 80-91.
50. Lecci A, Patacchini R, de Giorgio R, Corinaldesi R, Theodorsson E, Giuliani S, Santicioli P, Maggi CA. Functional, biochemical and anatomical changes in the rat urinary bladder induced by perigangliar injection of colchicines. Neuroscience 1996; 71: 285-96.
51. Campana WM. Schwann cells: Activated peripheral glia and their role in neuropathic pain. Behav Immun 2007; 21: 522-7.
52. Bhatheja K, Field J. Schwann cells: Origins and role in axonal maintenance and regeneration. Int J Biochem Cell Biol 2006; 38: 1995-9.
53. Mulhall JP, Muller A, Donohue JF, Mullerad M, Kobylarz K, Paduch DA, Tal R, Li PS, Cohen-Gould L, Scardino PT. The functional and structural consequences of cavernous nerve injury are ameliorated by sildenafil citrate. J Sex Med 2008; 5: 1126-36.
54. May F, Vroeman M, Matiasek K, Henke J, Brill T, Lehmer A, Apprich M, Erhardt W, Schoeler S, Paul R, Blesch A, Hartung R, Gansbacher B, Weidner N. Nerve replacement strategies for cavernous nerves. Eur Urol 2005; 48: 372-8.
55. May F, Weidner N, Matiasek K, Caspers C, Mrva T, Vroemen M, Henke J, Lehmer A, Schwaibold H, Erhardt W, Gansbacher B, Hartung R. Schwann cell seeded guidance tubes restore erectile function after ablation of cavernous nerves in rats. J Urol 2004; 172: 374-7.
56. Frostick SP, Yin Q, Kemp GJ. Schwann cells, neurotrophic factors, and peripheral nerve regeneration. Microsurgery 1998; 18: 397-405.
57. Rodriguez FJ, Verdu E, Ceballos D, Navarro X. Nerve guides seeded with autologous Schwann cells improve nerve regeneration. Exp Neurol 2000; 161: 571-84.
58. Liu MH. Growth factors and extracellular matrix in peripheral nerve regeneration, studies with a nerve chamber. J Periph Nerv Syst 1996; 2: 97-110.
59. Dahlin LB, Lundborg G. Use of tubes in peripheral nerve repair. Neurosurg Clin North Am 2001; 12: 341-52.
60. Hsieh PS, Bochinski DJ, Lin GT, Nunes L. Lin CS, Lue TF. The effect of vascular endothelial growth factor and brain-derived neurotrophic factor on cavernosal nerve regeneration in a nerve-crush rat model. BJU Int 2003; 92: 470-5.
61. Bakircioglu ME, Lin CS, Fan P, Sievert KD, Kan YW, Lue TF. The effect of adenoassociated virus mediated brain derived neurotrophic factor in an animal model of neurogenic impotence. J Urol 2001; 165: 2103-9.
62. Podlasek CA, Meroz CL, Korolis H, Tang Y, McKenna KE, McVary KT. Sonic hedgehog, the penis and erectile dysfunction: A review of sonic hedgehog signaling in the penis. Curr Pharm Design 2005; 11: 4011-27.