Tadalafil increases Akt and extracellular signal-regulated kinase 1/2 activation, and prevents apoptotic cell death in the penis following denervation

Journal of Urology

Volumn 179, Issue 2, 2008, Pages 779-785

  Lysiak, Jeffrey J ^a   Yang, Sang Kuk ^b   Klausner, Adam P ^a   Son, Hwancheol ^c   Tuttle, Jeremy B ^a   Steers, William D ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b Konkuk University School of Medicine   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Impotence; Mice; Nerves; Penis; Tadalafil

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TADALAFIL; CARBOLINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHODIESTERASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; CORPUS CAVERNOSUM; DENERVATION; DRUG BLOOD LEVEL; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; IMMUNOLOCALIZATION; MALE; NONHUMAN; PENIS; PRIORITY JOURNAL; RANK SUM TEST; RECOMMENDED DRUG DOSE; SMOOTH MUSCLE FIBER; STATISTICAL ANALYSIS; STUDENT T TEST; VAGOTOMY; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECT; INNERVATION; METABOLISM; MOUSE;

ANIMALS; APOPTOSIS; CARBOLINES; DENERVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MALE; MICE; MICE, INBRED BALB C; PENIS; PHOSPHODIESTERASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 38849119925     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2007.09.021     Document Type: Article

References (23)

1. Burnett AL: Strategies to promote recovery of cavernous nerve function after radical prostatectomy. World J Urol 2003;20:337.
2. Olsson CA and Goluboff ET: Detection and treatment of prostate cancer: perspective of the urologist. J Urol 1994;152:1695.
3. Walsh PC and Donker PJ: Impotence following radical prostatectomy: insight into etiology and prevention. J Urol 2002;167:1005.
4. Montorsi F, Briganti A, Salonia A, Rigatti P and Burnett AL: Current and future strategies for preventing and managing erectile dysfunction following radical prostatectomy. Eur Urol 2004;45:123.
5. Klein LT, Miller MI, Buttyan R, Raffo AJ, Burchard M, Devris G et al: Apoptosis in the rat penis after penile denervation. J Urol 1997;158:626.
6. User HM, Hairston JH, Zelner DJ, McKenna KE and McVary KT: Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction. J Urol 2003;169:1175.
7. Siu PM and Alway SE: Mitochondria-associated apoptotic signalling in denervated rat skeletal muscle. J Physiol 2005;565:309.
8. Iacono F, Giannella R, Somma P, Manno G, Fusco F and Mirone V: Histological alterations in cavernous tissue after radical prostatectomy. J Urol 2005;173:1673.
9. Burnett AL: Vasoactive pharmacotherapy to cure erectile dysfunction: fact or fiction? Urology 2005;65:224.
10. Musicki B, Champion HC, Becker RE, Liu T, Kramer MF and Burnett AL: Erection capability is potentiated by long-term sildenafil treatment: role of blood flow-induced endothelial nitric-oxide synthase phosphorylation. Mol Pharmacol 2005;68:226.
11. Schwartz EJ, Wong P and Graydon RJ: Sildenafil preserves intracorporeal smooth muscle after radical retropubic prostatectomy. J Urol 2004;171:771.
12. Shen HM and Liu ZG: JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic Biol Med 2006;40:928.
13. Podlasek CA, Zelner DJ, Harris JD, Meroz CL, Tang Y, McKenna KE et al: Altered Sonic hedgehog signaling is associated with morphological abnormalities in the penis of the BB/WOR diabetic rat. Biol Reprod 2003;69:816.
14. Fogarty MP, Emmenegger BA, Grasfeder LL, Oliver TG and Wechsler-Reya RJ: Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells. Proc Natl Acad Sci U S A 2007;104:2973.
15. Shen YH, Zhang L, Gan Y, Wang X, Wang J, LeMaire SA et al: Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling A crosstalk between stress signaling and insulin signaling in resistintreated human endothelial cells. J Biol Chem 2006;281:7727.
16. Bogoyevitch MA, Boehm I, Oakley A, Ketterman AJ and Barr RK: Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential. Biochim Biophys Acta 2004;1697:89.
17. Maroney AC, Glicksman MA, Basma AN, Walton KM, Knight E Jr, Murphy CA et al: Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway. J Neurosci 1998;18:104.
18. Nandipati K, Raina R, Agarwal A and Zippe CD: Early combination therapy: intracavernosal injections and sildenafil following radical prostatectomy increases sexual activity and the return of natural erections. Int J Impot Res 2006;18:446.
19. Raina R, Agarwal A, Ausmundson S, Lakin M, Nandipati KC, Montague DK et al: Early use of vacuum constriction device following radical prostatectomy facilitates early sexual activity and potentially earlier return of erectile function. Int J Impot Res 2006;18:77.
20. Martelli AM, Faenza I, Billi AM, Manzoli L, Evangelisti C, Fala F et al: Intranuclear 3'-phosphoinositide metabolism and Akt signaling: new mechanisms for tumorigenesis and protection against apoptosis? Cell Signal 2006;18:1101.
21. Jiang H, Zhang L, Koubi D, Kuo J, Groc L, Rodriguez AI et al: Roles of Ras-Erk in apoptosis of PC12 cells induced by trophic factor withdrawal or oxidative stress. J Mol Neurosci 2005;25:133.
22. Cheung EC and Slack RS: Emerging role for ERK as a key regulator of neuronal apoptosis. Sci STKE 2004;PE45.
23. Das A, Xi L and Kukreja RC: Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling. J Biol Chem 2005;280:12944.