Antifungal activity of a gel containing Thymus vulgaris essential oil against Candida species commonly involved in vulvovaginal candidosis

Pharmaceutical Biology

Volumn 47, Issue 2, 2009, Pages 151-153

  Das Neves, Jos ^a   Pinto, Eugnia ^a   Amaral, Maria Helena ^a   Bahia, Maria Fernanda ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

Candida spp; Drug formulation; Polycarbophil; Thymus vulgaris L.; Vulvovaginal candidosis

Indexed keywords

ANTIFUNGAL AGENT; ESSENTIAL OIL; PLACEBO; POLYCARBOPHIL; THYME OIL;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; DRUG FORMULATION; FUNGAL STRAIN; GEL; IN VITRO STUDY; NONHUMAN; PH; THYME; VAGINA; VAGINA CANDIDIASIS;

CANDIDA; LAMIACEAE; THYMUS VULGARIS;

EID: 61849129121     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880200802436232     Document Type: Article

References (19)

1. Ahmad N, Alam MK, Shehbaz A, Khan A, Mannan A, Hakim SR, Bight D, Wais M (2005): Antimicrobial activity of clove oil and its potential in the treatment of vaginal candidiasis. J Drug Target 13: 555-561.
2. Aligiannis N, Kalpoutzakis E, Mitaka S, Chinou IB (2001): Composition and antimicrobial activity of the essential oils of two Origanum species. J Agric Food Chem 49: 4168-4170. (Pubitemid 32896404)
3. Boskey ER, Cone RA, Whaley KJ, Moench TR (2001): Origins of vaginal acidity: High d/l lactate ratio is consistent with bacteria being the primary source. Hum Reprod 16: 1809-1813.
4. Cal K (2006): How does the type of vehicle influence the in vitro skin absorption and elimination kinetics of terpenes? Arch Dermatol Res 297: 311-315.
5. Chang JY, Oh YK, Kong HS, Kim EJ, Jang DD, Nam KT, Kim CK (2002): Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis. J Control Release 82: 39-50.
6. Cunha AP, Silva AP, Roque OR (2003). Plantas e Produtos Vegetais em Fitoterapia. Lisbon, Fundação Calouste Gulbenkian, pp. 606-607.
7. das Neves J, Bahia MF (2006): Gels as vaginal drug delivery systems. Int J Pharm 318: 1-14.
8. das Neves J, Amaral MH, Bahia MF (2007): Mechanical properties of a vaginal gel containing Thymus vulgaris essential oil (1% w/w), Third Pharmaceutical Sciences World Congress, Amsterdam, The Netherlands, Abstract DD-M-089.
9. das Neves J, Amaral MH, Bahia MF (2008): Vaginal drug delivery. In: ed. Gad SC, Pharmaceutical Manufacturing Handbook: Production and Processes, Hoboken, NJ, Wiley, pp. 809-878.
10. Duarte MC, Figueira GM, Sartoratto A, Reader VL, Delarmelina C (2005): Anti-Candida activity of Brazilian medicinal plants. J Ethnopharmacol 97: 305-311.
11. Maccioni AM, Anchisi C, Sanna A, Sardu C, Dessì S (2002): Preservative systems containing essential oils in cosmetic products. Int J Cosmet Sci 24: 53-59.
12. NCCLS (National Committee for Clinical Laboratory Standards) (2002): Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. Approved Standard M27-A2.
13. Wayne, PA, CLSI. Pappas PG, Rex JH, Sobel JD, Filler SG, Dismukes WE, Walsh TJ, Edwards JE (2004): Guidelines for treatment of candidiasis. Clin Infect Dis 38: 161-189.
14. Pauli A (2006): Anticandidal low molecular compounds from higher plants with special reference to compounds from essential oils. Med Res Rev 26: 223-268.
15. Pina-Vaz C, Gonçalves Rodrigues A, Pinto E, Costa-de-Oliveira S, Tavares C, Salgueiro L, Cavaleiro C, Gonçalves MJ, Martinezde- Oliveira J (2004): Antifungal activity of Thymus oils and their major compounds. J Eur Acad Dermatol Venereol 18: 73-78.
16. Robinson JR, Bologna WJ (1994): Vaginal and reproductive system treatments using a bioadhesive polymer. J Control Release 28: 87-94.
17. Sobel JD (2007): Vulvovaginal candidosis. Lancet 369: 1961-1971.
18. Spinillo A, Capuzzo E, Gulminetti R, Marone P, Colonna L, Piazzi G (1997): Prevalence of and risk factors for fungal vaginitis caused by non-albicans species. Am J Obstet Gynecol 176: 138-141. (Pubitemid 127780762)
19. Thorgeirsdottir TO, Thormar H, Kristmundsdottir T (2005): The influence of formulation variables on stability and microbicidal activity of monoglyceride monocaprin. J Drug Del Sci Tech 15: 233-236.