Biophysical analysis of prototype microbicidal gels

Journal of Pharmaceutical Sciences

Volumn 96, Issue 3, 2007, Pages 661-669

  Owen, Derek H ^a   Peters, Jennifer J ^a   Kieweg, Sarah L ^a   Geonnotti, Anthony R ^a   Schnaare, Roger L ^b   Katz, David F ^a,c  

^a Duke University   (United States)

^b Adamis Pharmaceuticals Corporation   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Biophysical models; Distribution; Formulation vehicle; Mathematical model; Microbicide; Polymeric drug delivery systems; Rheology; Vagina; Viscosity

Indexed keywords

MICROBICIDE;

ARTICLE; BIOPHYSICS; CONTROLLED STUDY; DISEASE TRANSMISSION; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG RETENTION; FEMALE; FLOW KINETICS; GEL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; PROPHYLAXIS; VAGINA;

EID: 33947508586     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20736     Document Type: Article

References (16)

1. Katz DF, Henderson MH, Owen DH, Plenys AM, Walmer DK. 1998. What is needed to advance vaginal formulation technology? In: Rencher WF, editor. Proceedings of the 5th contraceptive research and development program workshop. Philadelphia PA: Lippencott-Raven. pp 90-99.
2. Owen DH, Peters JJ, Katz DF. 2000. Rheological properties of contraceptive gels. Contraception 62:321-326.
3. Owen DH, Peters JJ, Lavine ML, Katz DF. 2003. Effect of temperature and pH on contraceptive gel viscosity. Contraception 67:57-64.
4. Geonnotti AR, Peters JJ, Katz DF. 2005. Erosion of microbicide formulation coating layers: Effect of contact and shearing with vaginal fluid or semen. J Pharm Sci 94:1705-1712.
5. Kieweg SL, Geonnotti AR, Katz DF. 2004. Gravity-induced coating flows of vaginal gel formulations: In vitro experimental analysis. J Pharm Sci 93:2941-2952.
6. Kieweg SL, Katz DF. 2006. Squeezing flows of vaginal gel formulations relevant to microbicide drug delivery. J Biomech Eng 128:540-553.
7. Kieweg SL, Katz DF. 2006. Interpreting properties of microbicide drug delivery gels: Analyzing deployment due to squeezing. J Pharm Sci (accepted).
8. Owen DH, Katz DF. 1999. A vaginal fluid simulant. Contraception 59:91-95.
9. Owen DH, Katz DF. 2005. A review of the physical and chemical properties of human semen and the formulation of a semen simulant. J Androl 26:459-469.
10. Meeten GH. 2002. Constant-force squeeze flow of soft solids. Rheol Acta 41:557-566.
11. Adams MJ, Edmondson B, Caughey DG, Yahya R. 1994. An experimental and theoretical study of the squeeze-film deformation and flow of elastoplastic fluids. J Non-Newtonian Fluid Mech 51:61-78.
12. Covey GH, Stanmore BR. 1981. Use of the parallel-plate plastometer for the characterisation of viscous fluids with a yield stress. J Non-Newtonian Fluid Mech 8:249-260.
13. Bird RB, Armstrong RC, Hassager O. 1987. Dynamics of polymeric liquids, Vol. 1, 2nd edn. Fluid mechanics. New York NY: John Wiley and Sons. pp 189-192.
14. Bohlen JG, Held JP, Sanderson MO. 1982. Response of the circumvaginal musculature during masturbation. In: Graber B, editor. Circumvaginal musculature and sexual function. New York NY: Karger. pp 43-60.
15. Dickinson RL. 1889. Studies of the levator ani muscle. Am J Obstet Dis Women Child 22:897-917.
16. Fox CA, Wolff HS, Baker JA. 1970. Measurement of intra-vaginal and intra-uterine pressures during human coitus by radio-telemetry. J Reprod Fertil 22:243-251.