Effect of buffers on the properties of microbicidal hydrogels containing monoglyceride as the active ingredient

Drug Development and Industrial Pharmacy

Volumn 29, Issue 2, 2003, Pages 121-129

  Kristmundsdottir T ^a   Sigurdsson, P ^a   Thormar, H ^a  

^a UNIVERSITY OF ICELAND   (Iceland)

Author keywords

Buffers; Carbomer; Hydrogel; Monocaprin; Sodium carboxymethylcellulose

Indexed keywords

ANTIVIRUS AGENT; BUFFER; CARBOMER; CARBOXYMETHYLCELLULOSE; CITRIC ACID; LACTIC ACID; MALEIC ACID; MONOACYLGLYCEROL; MONOCAPRIN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG RELEASE; GEL; HERPES SIMPLEX VIRUS 1; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYDROGEL; IN VITRO STUDY; INFECTION PREVENTION; NONHUMAN; PH; PHYSICAL CHEMISTRY; VIRUS TITRATION; VISCOSITY;

ACRYLIC RESINS; ANTIVIRAL AGENTS; BUFFERS; CARBOXYMETHYLCELLULOSE; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG COMPOUNDING; EXCIPIENTS; GLYCERIDES; HERPESVIRUS 1, HUMAN; HYDROGELS; HYDROGEN-ION CONCENTRATION; METHYLCELLULOSE; POVIDONE; VISCOSITY;

EID: 0037219748     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120016719     Document Type: Article

References (14)

1. Thormar, H.; Isaacs, C.E.; Brown, H.R.; Barshatzky, M.R.; Pessolano, T. Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrob. Agents Chemother. 1987, 31, 27-31.
2. Thormar, H.; Isaacs, C.E.; Kim, K.S.; Brown, H.R. Inactivation of visna virus and other enveloped viruses by free fatty acids and monoglycerides. Ann. N.Y. Acad. Sci. 1994, 724, 465-471.
3. Kristmundsdótir, T.; Árnadóttir, S.G.; Bergsson, G.; Thormar, H. Development and evaluation of microbicidal hydrogels containing monoglycerides as the active ingredient. J. Pharm. Sci. 1999, 88, 1011-1015.
4. Thormar, H.; Bergsson, G.; Gunnarsson, E.; Georgsson, G.; Witvrouw, M.; Steingrímsson, Ó.; De Clercq, E.; Kristmundsdóttir, T. Hydrogels containing monocaprin have potent microbicidal activities against sexually transmitted viruses and bacteria in vitro. Sex. Transm. Inf. 1999, 75, 181-185.
5. Neyts, J.; Kristmundsdóttir, T.; De Clercq, E.; Thormar, H. Hydrogels containing monocaprin prevent intravaginal and intracutaneous infection with HSV-2 in mice: impact on the search for vaginal microbicides. J. Med. Virol. 2000, 61 (1), 107-119.
6. Knuth, K.; Amiji, M.; Robinson, J.R. Hydrogel delivery systems for vaginal and oral applications. Advanced Drug Delivery Reviews 1993, 11, 137-167.
7. Smart, J.D.; Kellaway, I.W.; Worthington, H.E.C. An in vitro investigation of mucosaadhesive materials for use in controlled drug delivery. J. Pharm. Pharmacol. 1984, 36 (5), 295-299.
8. Jimenez-Catellanos, M.R.; Zia, H.; Rhodes, C.T. Mucoadhesive drug delivery systems. Drug Dev. Ind. Pharm. 1993, 19 (1&2), 143-194.
9. Singla, A.K.; Chawla, M.; Singh, A. Potential applications of carbomer in oral mucoadhesive controlled drug delivery system: a review. Drug Dev. Ind. Pharm. 2000, 26 (9), 913-924.
10. Voeller, B.; Anderson, D.J. Heterosexual transmission of HIV. JAMA 1992, 267 (14), 1917-1918.
11. Martin, L.S.; McDougal, J.S.; Losskoski, S.L. Disinfection and inactivation of the human T lymphotrophic virus type III/lymphadenophathy-associated virus. J. Infect. Dis. 1985, 152 (2), 400-403.
12. Brown, W.J. Microbial ecology of the normal vagina. In Human Reproductive Medicine: The Human Vagina; Hafez, E.S.E., Evans, T.N., Eds.; North-Holland Publishing Company: New York, 1978; Vol. 2, 407-422.
13. Ongradi, J.; Ceccherini-Nelli, L.; Pistello, M. Acid sensitivity of cell-free and cell-associated HIV-1: clinical implication. AIDS Res. Hum. Retroviruses 1990, 6, 1433-1436.
14. Popovic, M.; Sarngadharan, M.G.; Read, E.; Gallo, R.C. Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 1984, 224 (4648), 497-500.