In vitro and in vivo phase II metabolism of combretastatin A-4: Evidence for the formation of a sulphate conjugate metabolite

Xenobiotica

Volumn 39, Issue 2, 2009, Pages 148-161

  Aprile, S ^a   Del Grosso, E ^a   Grosa, G ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Combretastatin A 4; Glucuronides; In vivo rat metabolism; Rat and human liver fractions; Sulphates

Indexed keywords

1 COMBRETASTATINYL 2,3,4 TRIACETOXY BETA DEXTRO GLUCURONIC ACID METHYL ESTER; 1 COMBRETASTATINYL BETA DEXTRO GLUCURONIC ACID; ADENOSINE 3' PHOSPHATE 5' PHOSPHOSULFATE; COMBRETASTATIN A4; COMBRETASTATIN A4 SULPHATE; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GALACTOSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG METABOLISM; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; NONHUMAN; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHROMATOGRAPHY, LIQUID; GLUCURONIDES; HUMANS; LIVER; MALE; MICROSOMES, LIVER; RATS; RATS, WISTAR; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STILBENES; SULFATES; TANDEM MASS SPECTROMETRY; URINE;

RATTUS;

EID: 61649126257     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250802566976     Document Type: Article

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