Lysosomal iron in pulmonary alveolar proteinosis: A case report

European Respiratory Journal

Volumn 33, Issue 3, 2009, Pages 673-679

  Persson, H L ^a,b   Vainikka, L K ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Alveolar macrophages; Ferritin; Lung lavage; Lysosomes; Oxidative stress

Indexed keywords

CASPASE 3; FERROUS GLUCONATE; GLUCOSE OXIDASE; GLUTATHIONE; HEMOSIDERIN; HYDROGEN PEROXIDE; IRON; LACTATE DEHYDROGENASE;

ADULT; APOPTOSIS; ARTICLE; BLOOD CELL COUNT; CASE REPORT; CELL DEATH; CELL ORGANELLE; COMPUTER ASSISTED TOMOGRAPHY; CULTURE MEDIUM; DISEASE COURSE; ENZYME ACTIVATION; ENZYME BLOOD LEVEL; HUMAN; LUNG ALVEOLUS PROTEINOSIS; LUNG FUNCTION TEST; LYSOSOME; LYSOSOME MEMBRANE; MACROPHAGE; MALE; NECROSIS; PRIORITY JOURNAL;

ADULT; ANIMALS; CELL LINE; HEMOSIDERIN; HUMANS; IRON; LYSOSOMES; MACROPHAGES, ALVEOLAR; MALE; MICE; NECROSIS; OXIDANTS; OXYGEN; PULMONARY ALVEOLAR PROTEINOSIS; RESPIRATORY FUNCTION TESTS;

EID: 61649118480     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00044108     Document Type: Article

References (29)

1. Rosen SH, Castleman B, Liebow AA. Pulmonary alveolar proteinosis. N Engl J Med 1958; 258: 1123-1142.
2. Doerschuk CM. Pulmonary alveolar proteinosis - is host defense awry? N Engl J Med 2007; 356: 547-549.
3. Shah PL, Hansell D, Lawson PR, Reid KB, Morgan C. Pulmonary alveolar proteinosis: clinical aspects and current concepts on pathogenesis. Thorax 2000; 55: 66-77.
4. De Duve C. In: F.H. Dingle JT ed. Lysosomes in Biology and Pathology (volume 1). Amsterdam, North-Holland Publishing Company, 1969; pp. 3-40.
5. Persson HL, Nilsson KJ, Brunk UT. Novel cellular defenses against iron and oxidation: ferritin and autophagocytosis preserve lysosomal stability in airway epithelium. Redox Rep 2001; 6: 57-63.
6. Kidane TZ, Sauble E, Linder MC. Release of iron from ferritin requires lysosomal activity. Am J Physiol Cell Physiol 2006; 291: C445-C455.
7. Persson HL, Svensson AI, Brunk UT. α-Lipoic acid and α-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis. Redox Rep 2001; 6: 327-334.
8. Persson HL, Yu Z, Tirosh O, Eaton JW, Brunk UT. Prevention of oxidant-induced cell death by lysosomotropic iron chelators. Free Radic Biol Med 2003; 34: 1295-1305.
9. Yu Z, Persson HL, Eaton JW, Brunk UT. Intralysosomal iron: a major determinant of oxidant-induced cell death. Free Radic Biol Med 2003; 34: 1243-1252.
10. Persson HL, Richardson DR. Iron-binding drugs targeted to lysosomes: a potential strategy to treat inflammatory lung disorders. Expert Opin Investig Drugs 2005; 14: 997-1008.
11. Persson HL. Radiation-induced lysosomal iron reactivity: implications for radioprotective therapy. IUBMB Life 2006; 58: 395-401.
12. Mateos F, Brock JH, Pérez-Arellano JL. Iron metabolism in the lower respiratory tract. Thorax 1998; 53: 594-600.
13. Prakash UB, Barham SS, Carpenter HA, Dines DE, Marsh HM. Pulmonary alveolar phospholipoproteinosis: experience with 34 cases and a review. Mayo Clin Proc 1987; 62: 499-518.
14. Sundberg RD, Broman H. The application of the Prussian blue stain to previously stained films of blood and bone marrow. Blood 1955; 10: 160-166.
15. Grebski E, Hess T, Hold G, Speich R, Russi E. Diagnostic value of hemosiderin-containing macrophages in bronchoalveolar lavage. Chest 1992; 102: 1794-1799.
16. Persson HL, Kurz T, Eaton JW, Brunk UT. Radiation-induced cell death: importance of lysosomal destabilization. Biochem J 2005; 389: 877-884.
17. Zdolsek JM, Roberg K, Brunk UT. Visualization of iron in cultured macrophages: A cytochemical light and electron microscopic study using autometallography. Free Radic Biol Med 1993; 15: 1-11.
18. Honegger CG, Langemann H, Krenger W, Kempf A. Liquid chromatographic determination of common water-soluble antioxidants in biological samples. J Chromatogr 1989; 487: 463-468.
19. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991; 139: 271-279.
20. Golde DW, Territo M, Finley TN, Cline MJ. Defective lung macrophages in pulmonary alveolar proteinosis. Ann Intern Med 1976; 85: 304-309.
21. Johansson A, Camner P. Adverse effects of metals on the alveolar part of the lung. Scan Electron Microsc 1986; 2: 631-637.
22. Lee KP, Gilles PJ. Pulmonary response and intrapulmonary lipids in rats exposed to bismuth orthovanadate dust by inhalation. Environ Res 1986; 40: 115-135.
23. Persson HL. Iron-dependent lysosomal destabilization initiates silica-induced apoptosis in murine macrophages. Toxicol Lett 2005; 159: 124-133.
24. Yu Z, Eaton JW, Persson HL. The radioprotective agent, amifostine, suppresses the reactivity of intralysosomal iron. Redox Rep 2003; 8: 347-355.
25. Epstein CE, Elidemir O, Colasurdo GN, Fan LL. Time course of hemosiderin production by alveolar macrophages in a murine model. Chest 2001; 120: 2013-2020.
26. Parto K, Mäki J, Pelliniemi LJ, Simell O. Abnormal pulmonary macrophages in lysinuric protein intolerance. Ultrastructural, morphometric, and x-ray microanalytic study. Arch Pathol Lab Med 1994; 118: 536-541.
27. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 2-2001. A 42-year-old woman with acute worsening of chronic dyspnea and cough. New Engl J Med 2001; 344: 212-220.
28. Ghio AJ, Stonehuerner J, Richards JH, et al. Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study. Resp Res 2008; 9: 10.
29. Koorts AM, Viljoen M. Ferritin and ferritin isoforms I: structure-function relationships, synthesis, degradation and secretion. Arch Physiol Biochem 2007; 113: 30-54.