Estimation of drug solubility in polymers via differential scanning calorimetry and utilization of the fox equation

Pharmaceutical Development and Technology

Volumn 14, Issue 1, 2009, Pages 19-27

  Haddadin, Raja ^a   Qian, Feng ^a   Desikan, Sridhar ^a   Hussain, Munir ^a   Smith, Ronald L ^a,b  

^a BRISTOL MYERS SQUIBB   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Amorphous; Differential Scanning Calorimetry (DSC); Fox equation; Glass transition temperature; Solubility; Thermal analysis

Indexed keywords

IBUPROFEN; INDOMETACIN; MACROGOL 400; NAPROXEN;

ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; DRUG STRUCTURE; GLASS TRANSITION TEMPERATURE; HEAT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH TEMPERATURE; INTERMETHOD COMPARISON; PRIORITY JOURNAL; ROOM TEMPERATURE; THERMODYNAMICS;

EID: 61649084958     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.1080/10837450802409370     Document Type: Article

References (25)

1. Fahr A, Liu X. Drug delivery strategies for poorly water-soluble drugs. Expert Opin. Drug Deliv. 2007;4(4):403-416.
2. Kennedy T. Managing the drug discovery/development interface. Drug Disc. Today. 1997;2:(10):436-444.
3. Mustata G, Dinh SM. Approaches to oral drug delivery for challenging molecules. Crit. Rev. Therapeut. Drug Carrier Syst. 2006;23(2):111-135.
4. Chiou WL, Riegelman S. Pharmaceutical applications of solid dispersion systems. J. Pharm. Sci. 1971;60(9):1281-1302.
5. Hu J, Johnston KP, Williams RO III. Nanoparticle engineering processes for enhancing the dissolution rates of poorly water soluble drugs. Drug Develop. Industr. Pharm. 2004;30(3):233-245.
6. Kaushal AM, Gupta P, Bansal AK. Amorphous drug delivery systems: molecular aspects, design, and performance. Crit. Rev. Ther. Drug Carrier Syst. 2004;21(3):133-193.
7. Kharb V, Bhatia M, Dureja H, Kaushik D. Nanoparticle technology for the delivery of poorly water-soluble drugs. Pharmaceut. Technol. 2006;30(2):82-92.
8. Kocbek P, Baumgartner S, Kristl J. Preparation and evaluation of nanosuspensions for enhancing the dissolution of poorly soluble drugs. Int. J. Pharm. 2006;312(1-2):179-186.
9. Merisko-Liversidge E, Liversidge GG, Cooper ER. Nanosizing: a formulation approach for poorly-water-soluble compounds. Eur. J. Pharmaceut. Sci. 2003;18(2):113-120.
10. Serajuddin AT. Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. J. Pharm. Sci. 1999;88(10):1058-1066.
11. Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur. J. Pharm. Biopharm. 2000;50(1):47-60.
12. Miller DA, McConville JT, Yang W, Williams RO III, McGinity JW. Hot-melt extrusion for enhanced delivery of drug particles. J. Pharmaceut. Sci. 2007;96(2):361-376.
13. Vasanthavada M, Tong W, Joshi Y, Kislalioglu MS. Phase behavior of amorphous molecular dispersion I: determination of the degree and mechanism of solid solubility. Pharm. Res. 2004;21:1598-1606.
14. Vasanthavada M, Tong W, Joshi Y, Kislalioglu MS. Phase behavior of amorphous molecular dispersion II: role of hydrogen bonding in solid solubility and phase separation kinetics. Pharm. Res. 2005;22:440-448.
15. Marsac PJ, Shamblin SL, Taylor LS. Theoretical and practical approaches for prediction of drug-polymer miscibility and solubility. Pharm. Res. 2006;23(10):2417-2426.
16. Gramaglia D, Conway BR, Kett VL, Malcolm RK, Batchelor HK. High speed DSC (hyper-DSC) as a tool to measure the solubility of a drug within a solid or semi-solid matrix. Int. J. Pharm. 2005;301(1-2):1-5.
17. Mohan R, Lorenz H, Myerson AS. Solubility measurement using differential scanning calorimetry. Ind. Eng. Chem. Res. 2002;41:4854-4862.
18. Forster A, Hempenstall J, Tucker I, Rades T. Selection of excipients for melt extrusion with two poorly water-soluble drugs by solubility parameter calculation and thermal analysis. Int. J. Pharm. 2001;226(1-2):147-161.
19. Li J, Masso J, Guertin J. Prediction of drug solubility in an acrylate adhesive based on the drug-polymer interaction parameter and drug solubility in acetonitrile. J. Control Release. 2002;83(2):211-221.
20. Margarit MV, Marin MT, Contreras MD. Solubility of solid dispersions of pizotifen malate and povidone. Drug Dev. Ind. Pharm. 2001;27(6):517-522.
21. Panyam J, Williams D, Dash A, Leslie-Pelecky D, Labhasetwar V. Solid-state solubility influences encapsulation and release of hydrophobic drugs from PLGA/PLA nanoparticles. J. Pharm. Sci. 2004;93(7):1804-1814.
22. Fox TG. Influence of diluent and of copolymer composition on the glass transition temperature of a polymer system. Bull. Am. Phys. Soc. 1956;1:123.
23. Rytting E, Lentz KA, Chen XQ, Qian F, Vakatesh S. Aqueous and cosolvent solubility data for drug-like organic compounds. AAPS. J. 2005;7(1):E78-105.
24. Nokhodchi A, Javadzadeh Y, Siahi-Shadbad MR, Barzegar-Jalali M. The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug (indomethacin) from liquisolid compacts. J. Pharm. Pharm. Sci. 2005;8(1):18-25.
25. Martin A. Physical Pharmacy. Baltimore, MD: Lippincott Williams & Wilkins; 1993.